In Vitro Fertilization and Dichorionic-Diamniotic Twin Pregnancies in Nulliparous Women: A Retrospective Cohort Study Comparing Pregnancy Outcomes Between Advanced and Younger Mate... by He MP, Jian WQ, Yuan CL, He SM, He MR, Yan J, Huang JC, Zhao KS

“…Mei Ping He,* Wen Qian Jian,* Chun Lan Yuan, Shi Mei He, Mei Rong He, Jian Yan, Jian Chun Huang, Kai Sun Zhao Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, The Second Nanning People’s Hospital, Nanning, Guangxi, 530031, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kai Sun Zhao, Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, The Second Nanning People’s Hospital, No. 13, Dancun Road, Jiangnan District, Nanning City, Guangxi Zhuang Autonomous Region, People’s Republic of China, Tel +86 13737085418, Email 339609234@qq.com Jian Chun Huang, Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, The Second Nanning People’s Hospital, No. 13, Dancun Road, Jiangnan District, Nanning City, Guangxi Zhuang Autonomous Region, People’s Republic of China, Tel +86 13207801809, Email huangjc3081@163.comObjective: To compare pregnancy outcomes between advanced maternal age (AMA, ≥ 35 years) and younger maternal age (YMA, 20– 34 years) nulliparous women with IVF-conceived dichorionic-diamniotic (DCDA) twin pregnancies.Methods: We conducted a retrospective analysis on 141 nulliparous women undergoing cesarean delivery at The Second Nanning People’s Hospital (2020– 2024). …”
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Co-Assembled Nanoparticles Comprising Sorafenib and Hederagenin Derivative for Enhanced Anti-Hepatic Fibrosis Activity by Lu M, Dai Z, Lin Y, Sun C, Li S, Guo Z, Liu Y, Liu X, Li S, Liu R, Xu B, Lei H

“…Recent findings suggest that targeting the STING signaling pathway may provide an alternative strategy for slowing the progression of fibrosis.Methods: We synthesized liver-targeted co-assembled SHG nanoparticles (SHG NPs) that incorporate sorafenib and a hederagenin derivative (Hed), which acted as a STING pathway inhibitor. …”
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Association Between High-Sensitivity C-Reactive Protein Trajectories and the Incidence of Metabolic Syndrome:A Retrospective Cohort Study by Pan J, Cai X, Chen J, Xu M, Hu J, Mao Y, Chen T, Li L, Jin M, Chen L

“…JianJiang Pan,1,* XiXuan Cai,1,* JieRu Chen,1 MingYing Xu,1 JingYu Hu,1 YueChun Mao,1 Tao Chen,2 LuSha Li,1 MengQi Jin,1 LiYing Chen1 1Department of General Practice, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310020, People’s Republic of China; 2Department of General Practice, Jianqiao Community Health Service Center, Hangzhou, Zhejiang, 310021, People’s Republic of China*These authors contributed equally to this workCorrespondence: LiYing Chen, Department of General Practice, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, Email 3197020@zju.edu.cnPurpose: Understanding the role of systemic inflammation in the development of Metabolic Syndrome (MetS) is crucial for identifying individuals at a higher risk of this cluster of conditions that increase the risk of heart disease, stroke, and diabetes.Patients and Methods: A retrospective cohort study was conducted with 4,312 participants who were free from MetS at the study’s onset and had high-sensitivity C-reactive protein (hsCRP) levels measured. …”
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Clinical and Microbiological Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Associated Recurrent Urinary Tract Infections by Cao H, Cheng H, Zhou J, Zhao J, Xu M, Fei Y

“…Investigating its features in rUTIs may provide insights into effective prevention strategies.Methods: We analyzed a cohort of patients with rUTIs caused by Klebsiella pneumoniae from April 2020 to April 2024. …”
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Clinical Features and Outcomes of Pediatric Intraspinal Paragonimiasis by Jiang Y, Yang Y, Zheng H, Hong S, Li X, Jiang L, Tan C

“…This study aimed to provide experience for diagnosis and treatment strategies of pediatric intraspinal paragonimiasis.Methods: We performed a retrospective clinical analysis of patients hospitalized for intraspinal paragonimiasis between January 1, 2015, and December 31, 2021.Results: Nine patients were included. …”
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Lean Mass Longitudinally Confounds Sedentary Time and Physical Activity With Blood Pressure Progression in 2513 Children by Andrew O. Agbaje

“…This study examined the longitudinal effect of sedentary time (ST), light PA (LPA) and MVPA on BP in 11‐year‐old children followed up for 13 years to determine the confounding and mediating role of body composition. Methods Data included 2513 children from the Avon Longitudinal Study of Parents and Children (ALSPAC), UK birth cohort who had data on at least one time‐point measure of accelerometer‐based movement behaviour across the follow‐up and complete BP measures at ages 11, 15 and 24 years. …”
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Antimicrobial-Resistant <i>Staphylococcus</i> spp. Harbored by Hedgehogs (<i>Erinaceus europaeus</i>) in Central Italy by Fabrizio Bertelloni, Francesca Pauselli, Giulia Cagnoli, Roberto Biscontri, Renato Ceccherelli, Valentina Virginia Ebani

“…Background/Objectives: European hedgehogs (<i>Erinaceus europaeus</i>) are present in areas where there is human activity; therefore, they can be a source of pathogens for other animals and humans. Methods: Eighteen hedgehog carcasses were collected and analyzed for <i>Staphylococcus</i> spp. …”
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The Recovery of Ciprofol, Remimazolam and Remimazolam-Flumazenil for General Anesthesia Undergoing Fundus Surgery: A Single-Center, Prospective, Randomized, Controlled Clinical Stu... by Zhang S, Liu Y, Liu Y, Xu T

“…The primary objective of this study was to compare the recovery of HSK3486 with that of remimazolam during successful general anesthesia.Patients and Methods: This prospective, randomized, double-blind study included 93 patients who had undergone fundus surgery. …”
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Bergenin Alleviates Myocardial Ischemia/Reperfusion Injury via Regulating SIRT1 Through Ferroptosis by Jia L, Yang S, Yin J, Feng O, Wang Z, Jia M

“…Lingmei Jia,1,* Siqi Yang,1,* Jun Yin,2 Ouhua Feng,2 Zhigang Wang,1&nbsp;Min Jia,1&nbsp;1Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, People&rsquo;s Republic of China; 2Cardiovascular Medicine Department, Jingxing County Hospital, Shijiazhuang, People&rsquo;s Republic of China*These authors contributed equally to this workCorrespondence: Min Jia; Zhigang Wang, Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, People&rsquo;s Republic of China, Tel +86-13732219367 ; +86-15131127511, Email jiamin10086@163.com; 15131127511@163.comObjective: This study aimed to investigate the protective effect of bergenin on myocardial ischemia/reperfusion (I/R) injury and to elucidate its underlying mechanism.Methods: The in vivo model of myocardial I/R injury was established by transient ligation of the left anterior descending coronary artery in Sprague-Dawley rats, which were divided into sham, I/R, I/R+bergenin, and I/R+bergenin+erastin (an agonist of ferroptosis) groups.After the model was established, the rats underwent echocardiography to assess the cardiac function. …”
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Clinical Characteristics Analysis of 30 Cases of Interferon-&gamma; Autoantibody-Positive Patients with Concurrent Mycobacterial Infection: A 6-Year Retrospective Study by Zhao CY, Song C, He HW, Huang XZ, Meng XY, Huang AC, Xu CY, Luo LL, Xi SY, Lan YQ, Li WW, Lin YR, Zhu QD

“…Chun-Yan Zhao,1,2,&ast; Chang Song,1,2,&ast; Hua-Wei He,1,&ast; Xian-Zhen Huang,1 Xia-Yan Meng,1 Ai-Chun Huang,1 Chao-Yan Xu,1 Li-Li Luo,1 Shao-Yong Xi,3 Yan-Qun Lan,1 Wei-Wen Li,1 Yan-Rong Lin,1 Qing-Dong Zhu1 1Department of Tuberculosis, The Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China; 2Clinical Medical School, Guangxi Medical University, Nanning, People’s Republic of China; 3Department of Clinical Laboratory, The Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qing-Dong Zhu; Yan-Rong Lin, Department of Tuberculosis, The Fourth People’s Hospital of Nanning, No. 1 Changgang Two-Li, Xingning District, Nanning, 530023, People’s Republic of China, Tel +8615207717261 ; +860771-5636973, Email zhuqingdong2003@163.com; linyanrong2009@126.comPurpose: This study aimed to investigate and elucidate the clinical characteristics, immune status, infection types and patterns, treatment responses, and disease progression in patients with positive anti-interferon-gamma (IFN-γ) autoantibodies in combination with Mycobacterium infections.Patients and Methods: We conducted a retrospective analysis of clinical data from patients with positive anti-IFN-γ autoantibodies and concurrent Mycobacterial infections, including Mycobacterial infections (MTB) and non-tuberculous mycobacteria (NTM). …”
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Immune pre-stimulation by injected yeast beta-glucan as a strategy to prevent calf diarrhea and bovine respiratory disease during the first 74 days of age by Fang Yan, Zhihong Zhang, Xiaorong Zhan, Wenqian Yang, Junhu Yao, Xiurong Xu

“…The CON group received an equal volume of sterile saline at the same time. …”
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Impact of Probiotics Supplementation on Enteral Feed Tolerance in Very Low Birth Weight Neonates: An Open Label Randomised Controlled Trial by Narain Das Vaswani, Hunny Verma, Jagjit Singh Dalal, Seema Lekhwani, Kirty Verma, Neeraj Kumar, Mohan Lal Kundu, Dinkar Yadav

“…Aim: To study the impact of probiotics supplementation on enteral feed tolerance in very low birth weight neonates. Materials and Methods: An open-label, randomised-controlled trial was conducted at the Neonatal Intensive Care Unit of a tertiary care center, PGIMS, Rohtak, Haryana. …”
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Role of Antimicrobial Stewardship in Modulating Antibiotic Use and Mitigating Bacterial Resistance in a Tertiary Care Setting During COVID-19 by Zhang X, Zhou L, Peng P, Zhang W, Liang C

“…This study aimed to assess the impact of AMS at a Chinese tertiary care hospital on inpatient antimicrobial use and bacterial resistance during the COVID-19 outbreak.Methods: An interrupted time-series regression analysis was conducted to compare inpatient antimicrobial use between pre- and post-intervention periods. …”
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Distribution of Pathogenic Bacteria and Drug Resistance in ICU of a Newly Built Hospital by Zeng H, Liu R, Cheng C, Yang N, Luo L, Long S, Zhou R, Yan K, Huang H

“…Hui Zeng,1,&ast; Rong Liu,1,2,&ast; Chuanli Cheng,2,&ast; Nana Yang,2 Luwen Luo,1,2 Shengshuang Long,3 Renjia Zhou,4 Kai Yan,1 Huantao Huang1 1Nursing Department of the Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 2School of Nursing of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 3Infection Department of the Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 4ICU of the Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hui Zeng, Email zenghui.1221@163.comObjective: This study investigated the distribution and resistance patterns of pathogens in the intensive care unit of a newly established hospital in Guizhou Province to promote the rational use of antibiotics to reduce multidrug resistance.Methods: A retrospective analysis was conducted on the distribution of pathogens and changes in drug resistance in the ICU of a newly built hospital in Guizhou Province from March 2019 to December 2023. …”
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Differential Diagnosis Value of Neutrophil Gelatinase Associated Lipocalin as a Noninvasive Biomarker in Perianal Fistulizing Crohn&rsquo;s Disease by Ma K, Li Y, Wu J, Fu Y, Yin L, Xu S, Weng F, Yao Y, Wang C

“…This study aimed to evaluate NGAL’s potential as a noninvasive diagnostic biomarker between pfCD and cryptoglandular (CG) perianal fistula, and its correlation with disease severity in pfCD.Methods: Serum, fecal, and fistula tissue samples were collected from 96 patients with pfCD and 97 patients with CG perianal fistula as controls. …”
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Identification of Cuproptosis-Related Genes and Their Potential Role in COPD Pathogenesis: A Bioinformatics Analysis by Shen Q, Huang JB, Zhu M, Ji DJ, Huang SJ, Li J

“…Imbalance in copper (Cu2+) metabolism is related to a series of diseases, but its role in COPD has not been specified.Methods: A dataset relevant to COPD was downloaded from Gene Expression Omnibus database, among which a total of 18 cuproptosis-related genes (CRGs) were screened. …”
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MUC1 and glycan probing of CA19-9 captured biomarkers from cyst fluids and serum provides enhanced recognition of ovarian cancer by Shamima Afrin Ruma, Rufus Vinod, Shruti Jain, Kaisa Huhtinen, Johanna Hynninen, Janne Leivo, Kim Pettersson, Karin Sundfeldt, Kamlesh Gidwani

“…Abstract Glycosylation changes of circulating proteins carrying the CA19-9 antigen may offer new targets for detection methods to be explored for the diagnosis of epithelial ovarian cancer (EOC). …”
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Global, regional, and national burden of cutaneous malignant melanoma from 1990 to 2021 and prediction to 2045 by Chengling Liu, Xingchen Liu, Li Hu, Xin Li, Haiming Xin, Sailin Zhu

“…To address this, we analyzed epidemiological patterns and investigated risk factors for CMM-related mortality.MethodsThis study analyzed CMM using data from the 2021 Global Burden of Diseases survey, covering 204 countries and territories. …”
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Protective effect of erythropoietin preconditioning on kidney ischemia-reperfusion injury by ZHANG Jiong, WANG Jia, WANG Fang, LI Gui-sen

“…Objective To explore the protective effect of erythropoietin(EPO)on renal ischemia-reperfusion injury(IRI)in rats.Methods Thirty male SD rats were randomly divided into sham operation group(Sham),renal IRI group(IRI)and EPO pretreatment group(EPO),10 rats in each group.The renal IRI model was constructed by clamping the left renal pedicle for 1h,removing the right kidney,and reperfusion for 24 h.In EPO group,EPO(1 000U/kg)was intraperitoneally injected at 1hbefore operation,while Sham group and IRI group were intraperitoneally injected with equal volume of normal saline.The left renal pedicle was clamped for 45 min in EPO and IRI groups,but not in Sham group.Renal perfusion was restored for 24 h,and then kidneys and serum were obtained.Enzyme linked immunosorbent assay(ELISA)was used to detect serum creatinine(SCr),blood urea nitrogen(BUN),pro-inflammatory cytokines [interleukin-6(IL-6);interferon gamma(IFN-γ)and tumor necrosis factor alpha(TNF-α)]and anti-inflammatory cytokine(IL-10 and TGF-β).The reverse transcriptase polymerase chain reaction(RT-PCR)was used to detect renal pro-inflammatory cytokines(IL-6,IFN-γand TNF-α)and anti-inflammatory cytokines[IL-10 and transforming growth factor beta(TGF-β)]mRNA expression levels.Western blotting was used to detect EPO receptor(EPOR),phosphorylated EPOR(p-EPOR),tyrosine kinase-2(JAK2),signal transducer and activator of transcription 3(STAT3),phosphorylated JAK2(p-JAK2),phosphorylated STAT3(pSTAT3)protein expression levels.Periodic acid Schiff staining(PAS)was used to examine the pathological changes of renal tissues.Results As compared with Sham group,the expression levels of pEPOR,p-JAK2,p-STAT3,SCr,BUN,IL-6,TNF-αand IFN-γwere significantly increased,pathological changes of renal tissues obviously alleviated,and expression levels of IL-10 and TGF-βwere markedly reduced in IRI group.There was no significant difference in EPOR,JAK2 and STAT3levels between Sham group and IRI group.As compared with IRI group,the expression levels of p-EPOR,p-JAK2,p-STAT3,IL-10 and TGF-βwere significantly increased,the levels of SCr,BUN,IL-6,TNF-αand IFN-γwere significantly reduced,and the pathological changes of renal tissues were significantly alleviated in EPO group,but there was no significant difference in EPOR,JAK2 and STAT3expression between IRI group and EPO group.Conclusions EPO preconditioning can alleviate inflammation by inhibiting renal IRI,which may be related with the activation of EPOR/JAK2/STAT3 signaling pathway.…”
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Global Burden of Alzheimer&rsquo;s Disease Attributable to High Fasting Plasma Glucose: Epidemiological Trends and Machine Learning Insights by Ma Y, Huang S, Dong Y, Jin Q

“…This study aims to analyze global trends in AD death rates and disability-adjusted life years (DALYs) rates attributable to HFPG from 1990 to 2021 and assess the potential of glucose-related biomarkers in predicting cognitive impairment.Methods: Data from the Global Burden of Disease 2021 database were used to analyze AD death rates and DALY rates due to HFPG across 204 countries. …”
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