Role of tumor mutational burden in patients with urothelial carcinoma treated with immune checkpoint inhibitors: a systematic review and meta-analysis by Zhe Wang, Danxue Huang, Su Li, Liyuan Ke

“…We conducted this meta-analysis to evaluate the role of TMB in patients with UC treated with ICIs.MethodsTwo investigators independently searched the literature, screened eligible studies, extracted valid data, and scored quality assessments. …”
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Comparison of thoracoscopy-guided thoracic paravertebral block and patient-controlled intravenous analgesia for postoperative analgesia after uniportal thoracoscopic pulmonary wedg... by Jianhui Du, Luyao Wei, Jinxian He, Xia Xu, Lihong Hu

“…Herein, we compared the analgesic effects of TG-TPB and PCIA post-UTPWR.MethodsSixty patients allocated into two groups: T and P. …”
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Rethinking 2S/LGBTQI+ food security with co-design: a study protocol by Joanie Thériault, Phillip Joy, Sana Boudhraâ, Min Gao

“…The team also seeks to identify how to improve food security services with and for 2S/LGBTQI+ communities and to co-create a prototype service model representing safe and inclusive services that communities and food security stakeholders can utilize to make improvements in that direction.MethodsThis protocol is based on a co-design methodology inspired by design thinking. …”
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FEATURES OF THE CHRONIC PAIN SYNDROME IN PATIENTS WITH RHEUMATOID ARTHRITIS AND MEDICAL DIAGNOSTIC TACTICS by M. A. Gromova, S. E. Myasoedova

“…Objective: to establish features of a chronic pain syndrome disorders in patients with rheumatoid arthritis, to reveal correlation with psychoemotional disorders and to develop the differential approach to maintaining patients. Materials and methods. 101 patients at the age of 60.6 ± 11.8 years, 92 % of women, with reliable rheumatoid arthritis (American College of Rheumatology – ACR, 1987), were examined. …”
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Acute Effects of Different Alcohol Doses on Psychomotor Performance and Subjective Responses among Healthy Young Women in China by Xiaoqin Yi, Li Xiao, Jin Xiang, Weihao Fan, Yingqiang Fu, Linchuan Liao, Yi Ye

“…This study aims to investigate the influence of three different alcohol doses on changes in alcohol metabolism, psychomotor performance, and subjective response in Chinese females. Materials and Methods: Three dosage levels (0.2 g/kg, 0.6 g/kg, and 1.0 g/kg) were administered to 11 subjects with the genotype ADH1B*1/*2-ADH1C*1/*1-ALDH2*1/*1 in an acute drinking challenge. …”
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Transverse abdominis plane block under different guidance in laparoscopic cholecystectomy: anatomy and technique, systematic review and double meta-analysis by S.M. Chooklin, S.S. Chuklin, R.V. Barylyak

“…However, their comparative effectiveness remains a subject of debate. Materials and methods. A systematic search for randomized controlled trials published up to January 2025 that compared TAPB under ultrasound and laparoscopic guidance was performed in PubMed, Scopus, and Cochrane databases. …”
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CLINICAL-IMMUNOLOGIC CHARACTERISTICS OF ACUTE BRUCELLOSIS IN CHILDREN by D. R. Atakhodjayeva

“…Object of the research: to study peculiarities of the progress of acute brucellosis in children taking into account clinical-immunologic data. Materials and methods of the research: the research was based on the results of examinations of 23 children from 3 to 14 years old with brucellosis mostly living in endemic foci of the Republic of Uzbekistan. …”
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Multimodal Imaging Features of Bilateral Choroidal Ganglioneuroma by Zhaoxin Jiang, Ting Zhang, Xing Liu, Dan Liang, Yimin Zhong, Chi-chao Chan, Xiaoyan Ding

“…Here, we evaluated multimodal images in the early stage of choroidal ganglioneuroma. Methods. A 6-year-old boy was recruited who had experienced gradually progressive vision loss and rapidly progressive myopia in both eyes over the past 2 years. …”
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Contribution and significance of Heidelberg retinal tomography II in diagnostics of ocular hypertension and its conversion into primary open-angle glaucoma by Marković Vujica, Kontić Đorđe, Hentova-Senćanić Paraskeva, Božić Marija, Marjanović Ivan, Krstić Vera, Kovačević Dragana

“…Also, when the results of the functional tests remain unchanged, that confirms the conversion of ocular hypertension into glaucoma. Methods. During a 5-year study period (2002-2007), 29 patients with ocular hypertension were examined. …”
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A Single-Center Case-Control Study of Glaucoma Severity on Initial Presentation in Haitian Americans by Vu DM, Persad PJ, Rothman AL, Feuer WJ, Chang TC

“…Daniel M Vu,1,2 Patrice J Persad,1 Adam L Rothman,1 William J Feuer,1 Ta C Chang1 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; 2Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USACorrespondence: Daniel M Vu, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA, Tel +1 617-573-3670, Fax +1 617-573-3707, Email daniel_vu@meei.harvard.eduPurpose: To assess relative glaucoma severity between Haitians and non-Haitians upon presentation to a tertiary referral practice using a retrospective case-control design.Patients and Methods: All Haitian descent patients were age- and zip code-matched with non-Haitian Hispanic American controls from a tertiary glaucoma service in a 1:1 ratio. …”
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Spatiotemporal Changes in the Urban Heat Island Intensity of Distinct Local Climate Zones: Case Study of Zhongshan District, Dalian, China by Jun Han, Jiatong Liu, Liang Liu, Yuanzhi Ye

“…Intensified due to rapid urbanization and global warming-induced high temperature extremes, the urban heat island effect has become a major environmental concern for urban residents. Scientific methods used to calculate the urban heat island intensity (UHII) and its alleviation have become urgent requirements for urban development. …”
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Shared decision making for ovarian cancer survivors with different levels of health literacy: a qualitative interview study on knowledge and comprehension by D. D. Seeratan, D. Wouters, L. R. C. W. van Lonkhuijzen, J. W. M. Aarts

“…To optimise SDM about follow-up care for patients with ovarian cancer, a better understanding of their knowledge and comprehension is needed.Aims This study investigates the knowledge and comprehension of women with ovarian cancer and varying levels of HL required for SDM about their follow-up care.Methods A two-part qualitative design was used. First, knowledge gaps were identified through the evaluation of prior interview transcripts, leading to the creation of frequently-asked questions (FAQs) and an interview guide. …”
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The clinical efficacy of proprioceptive neuromuscular facilitation technique in the treatment of scapulohumeral periarthritis: a systematic review and meta-analysis by Chengyu Zhu, Xueyan Huang, Jiaying Yu, Ying Feng, Haifang Zhou

“…Objectives The purpose of this study was to systematically evaluate the effect of proprioceptive neuromuscular facilitation (PNF) stretching technique in the treatment of SP. Methods A systematic search of 10 databases such as China National Knowledge Infrastructure (CNKI), China Biomedical Literature Database, Weipu, Wanfang, PubMed, Embase, Web of Science, Cochrane Library, Clinical Trials, and China Clinical Trial Registry Platform was performed. …”
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Wearable Smartphone-Based Multisensory Feedback System for Torso Posture Correction: Iterative Design and Within-Subjects Study by Amanda Polin Pereira, Olibario Jose Machado Neto, Valeria Meirelles Carril Elui, Maria da Graca Campos Pimentel

“…MethodsTo design the Postural SmartVest, we conducted brainstorming sessions, therapist interviews, gathered requirements, and developed the first prototype. …”
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Innovative gene delivery systems for retinal disease therapy by Hongguang Wu, Ling Dong, Shibo Jin, Yongwang Zhao, Lili Zhu

“…Conversely, adeno-associated viruses are safer, as they exist as episomes in the nucleus, yet their limited packaging capacity constrains their application to a narrower spectrum of diseases, which necessitates the exploration of alternative delivery methods. In parallel, progress has also occurred in the development of novel non-viral delivery systems, particularly those based on liposomal technology. …”
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Platelet rich plasma versus corticosteroids for lateral epicondylitis: a meta-analysis of randomized clinical trials by Ralph Maroun, Mohammad Daher, Peter Boufadel, Ryan Lopez, Adam Z Khan, Joseph A. Abboud

“…This article aims to compare the clinical effectiveness of platelet-rich plasma (PRP) and corticosteroid (CS) injections in managing lateral epicondylitis. Methods PubMed, Cochrane, and Google Scholar (pages 1–20) were searched up to March 2024. …”
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Evaluation of ebony as a potential selectable marker for genetic sexing in Aedes aegypti by Katerina Nikolouli, Austin Compton, Zhijian Jake Tu, Kostas Bourtzis

“…The ebony gene is known to be involved in the pigmentation pathway of several dipteran insects, including Ae. aegypti. Methods An ebony gene knockout was developed though CRISPR/Cas9 mutagenesis. …”
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Progressive Self-Prompting Segment Anything Model for Salient Object Detection in Optical Remote Sensing Images by Xiaoning Zhang, Yi Yu, Daqun Li, Yuqing Wang

“…Most existing ORSI-SOD methods rely on pre-trained CNN- or Transformer-based backbones to extract features from ORSIs, followed by multi-level feature aggregation. …”
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An oropharyngeal device for airway management of conscious and semiconscious patients: A randomized clinical trial by Kalev Freeman, Zachary D. Miller, Robert Ramsey Herrington, Nathan T. Dreyfus, Philip Buttaravoli, Adam Burgess, Joshua P. Nickerson, Nirav Daphtary, Jason H. T. Bates

“…We aimed to test the hypotheses that the ManMaxAirway (MMA) is better tolerated than the standard Guedel‐style device in awake volunteers and that it produces a jaw thrust and improves air flow. Methods This was a randomized cross‐over study of healthy volunteers with either the MMA or standard device. …”
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Clinical Effect Analysis of Laparoscopic Nerve-Sparing Radical Hysterectomy in Patients with Early-Stage Cervical Cancer by Hong Xue, Meng Chen, Shuqin Li, Yongchun Zhou

“…The main objective of this study was to determine the utility of laparoscopic nerve-sparing radical hysterectomy (LNSRH) in improvement of postoperative bladder and rectal function and clinical outcomes of patients with common types of early-stage cervical cancer and tumor diameters <2 cm. Methods: Ninety cases of common types of early-stage cervical cancer with tumor diameters <2 cm were primarily treated with surgery from 2015 to 2021. …”
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