Clinical characteristics and knowledge of diabetic retinopathy patients at a tertiary hospital in Aceh, Indonesia by Lia M. Zaini, Arief S. Kartasasmita, Tjahjono D. Gondhowiardjo, Maimun Syukri, Putri N. Mulya

“…Setting: The study was conducted at Zainoel Abidin General Hospital, Banda Aceh, Indonesia. Methods: A prospective cross-sectional study using consecutive sampling was conducted. …”
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Validation and Comparison of Pediatric Appendicitis Scores and Management Strategies (Project SPASMS): Protocol for a Prospective Multicenter Observational Study by Wei Hao Lee, Sharon O'Brien, Elizabeth J Mckinnon, Simon Craig, Stuart Dalziel, Michael Collin, Natalie Phillips, Franz E Babl, Sarah Julia Davidson, Shane George, Shefali Jani, Doris Tham, Viet Tran, Meredith L Borland

“…ObjectiveThis study aims to compare and validate various CPSs for diagnosing pediatric appendicitis in children presenting to ANZ EDs. MethodsThis prospective multicenter observational study across 10 ANZ EDs is recruiting children 5-17 years presenting to participating EDs with acute right-sided or generalized abdominal pain lasting ≤7 days and clinician suspicion of appendicitis. …”
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Is the fluorescence optical imaging (FOI) able to discriminate between rheumatoid arthritis patients with and without need of rituximab retherapy? A cohort study by Sandra Hermann, Gerd R Burmester, Sarah Ohrndorf, Marina Backhaus, Paula Hoff, Jens Klotsche, Anne-Marie Glimm, Schahrasad Lisa Ridha Ali, Gabriela Schmittat

“…Objective To evaluate the ability of fluorescence optical imaging (FOI) Xiralite in the discrimination between rheumatoid arthritis (RA) patients with and without need of rituximab (RTX) retherapy—in comparison to clinical, laboratory and musculoskeletal ultrasound parameters.Patients and methods Patients with established RA were prospectively followed over 1 year by Disease Activity Score 28, patient’s global disease activity (visual analogue scale 0–100 mm), C reactive protein and erythrocyte sedimentation rate, ultrasound seven joint (US7) score and FOI in phases 1–3 and automatically generated PrimaVista mode (PVM) at baseline (before RTX) and after 3, 6 and 12 months. …”
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Comparing the Effectiveness of Intra-articular Injection with Autologous Platelet-rich Plasma vs Hyaluronic Acid vs Platelet-derived Growth Factors in Early Osteoarthritis of Knee... by Vidya S Konana, Harish S Yallapura, Sriharsha Bettaswamy, Srinivas P Sivaram, Darshan G Thimmegowda

“…Aims: To compare the effectiveness between intra-articular injection (IAI) of autologous platelet-rich plasma (PRP) vs hyaluronic acid (HA) vs activated PRP in primary osteoarthritis (OA) of the knee grades 1 and 2, in terms of pre- and postinjection functional outcome by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) scale, and pre- and postinjection pain by visual analog scale (VAS). Materials and methods: The patients were divided into three groups based on the treatment they received. …”
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Impact of Oral Citicoline, Antioxidant Vitamins, and Blackcurrant Supplementation on Primary Open-Angle Glaucoma: An OCT and OCTA Study by Piera Giunta, Luca D’Andrea, Michele Rinaldi, Maria Paola Laezza, Raffaele Piscopo, Ciro Costagliola

“…<b>Purpose:</b> We sought to evaluate the long-term effects of oral citicoline; vitamins A, B, C, and E; and blackcurrant therapy in patients with primary open-angle glaucoma (POAG) using optical coherence tomography (OCT), OCT angiography (OCTA), and microperimetry parameters. <b>Materials and Methods:</b> Fifteen patients with POAG (the treated group) received one soluble liquid sachet of a complementary dietary supplement containing, in a fixed combination, citicoline; vitamins A, B, C, and E; and blackcurrant (Citizin^®, Bruschettini s.r.l., Genova, Italy) daily for 20 days a month for 1 year. …”
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“Less is More, is R-LESS More?”—The Use of Robotic Laparoendoscopic Single-Site Surgery in Gynaecology: A Scoping Review by Liliana Mereu, Giorgia Gaia, Margarita Afonina, Stefano Terzoni, Saverio Tateo, Arsenio Spinillo

“…Methods: A scoping review was conducted on Pubmed, Scopus, Web of Science, and Embase. …”
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Activin levels correlate with lymphocytic infiltration in epithelial ovarian cancer by Elizabeth T. Evans, Emily F. Page, Alex Seok Choi, Zainab Shonibare, Andrea G. Kahn, Rebecca C. Arend, Karthikeyan Mythreye

“…We sought to explore differences in activin (INHBA/ Inhibin‐βA and INHBB/ Inhibin‐βB) between malignant and ovarian tissues at the RNA and protein level and assess the relationship between activin and immune cells in EOC. Methods Publicly available RNA sequencing data were accessed from GEO (#GSE143897) with normalization and quantification performed via DESeq2. …”
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Assessing the Impact of Closed and Open Kinetic Chain Hydrotherapy on Vertical Ground Reaction Force, Rate of Loading, Lumbo-Pelvic Stability, Pain Intensity, and Kinesiophobia in... by Hossien Ashoury, Ali Yalfani, Mahdi Arjipour

“…This study aimed to assess the impact of hydrotherapy-based closed and open kinetic chain exercises on lumbo-pelvic stability, pain intensity, kinesiophobia, rate of loading (ROL), and vertical ground reaction force (vGRF) in men with CNSLBP. Methods: The double-blind randomized controlled trial was designed with a pre-post test in men aged 40–60 (48.10 ± 5.97) with CNSLBP. …”
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Analysis of prevalence, aetio-pathology of tinnitus and role of caroverine as a primary treatment option among the patients attending a tertiary care hospital by Alfisha Sulthana, Abhilash Reddy, S. Muneeruddin Ahmed, Shahul Hameed, S. Abida Ashroff Fathima

“…Aim of the Study: To determine the prevalence, aetiopathology, and evaluate the clinical efficacy of Tinnicar in alleviating tinnitus symptoms among patients attending a tertiary care Hospital. Methods: This was a prospective observational study conducted on 135 patients aged above 18 years presenting with subjective tinnitus to the ENT outpatient department. …”
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Predictors of pain reduction following manual therapy in patients with temporomandibular disorders: a protocol for a prospective observational study by Alison B Rushton, Nicola R Heneghan, Deborah Falla, Giacomo Asquini, Andrea Edoardo Bianchi, Giulia Borromeo, Matteo Locatelli

“…Such knowledge will support a more personalised management approach by facilitating clinical decision-making.Methods/analysis An observational prospective design will recruit a cohort of 100 adults with a diagnosis of TMD (according to Axis I of the Diagnostic Criteria for TMD) at a Dental Hospital in Italy. …”
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Effect of Live Environmental Music Therapy and Prerecorded Music on State Anxiety, Stress, Pain, and Well-Being Levels of Patients and Caregivers in the Emergency Department Waitin... by Angélica Hernández, Ana María Díaz, Ornella Fiorillo Moreno, Raúl Suárez, Moshé Amarillo, Ana María Moreno, Bryan Alonso Ríos Suarez, Lina Marcela Gómez González, Guiselle Alexandra Cristancho Olaya, Mark Ettenberger

“…ObjectiveThe aim of this study is to determine the effect of live Environmental Music Therapy and prerecorded music on state anxiety, stress, pain, and well-being levels in patients and caregivers in the emergency unit waiting areas of 2 hospitals in Colombia. MethodsThis study is a multicenter randomized clinical trial, with 3 arms: standard care + live Environmental Music Therapy, standard care + prerecorded music, and standard care only. …”
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Identifying a Role for the Sodium Hydrogen Exchanger Isoform 1 in Idiopathic Pulmonary Fibrosis: A Potential Strategy to Modulate Profibrotic Pathways by Trina T. Nguyentu, Danielle G. Vigilante, Mishika Manchanda, Meera S. Iyer, Sara Desalegne, Joseph J. Provost

“…This study investigates the role of NHE1 in actin stress fiber formation, fibroblast-to-myofibroblast differentiation, and cytokine secretion in IPF progression. <b>Methods</b>: Fibroblasts were treated with profibrotic agonists, including transforming growth factor-beta (TGFβ), lysophosphatidic acid (LPA), and serotonin (THT), in the presence or absence of the NHE1-specific inhibitor, EIPA. …”
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Relationship Between Physical Performance and Strength of the Ankle Muscles, Pain, and Kinesiophobia in Taekwondo Athletes With Chronic Ankle Instability by Beom-jun Kim, Ui-jae Hwang, Oh-yun Kwon

“…Objects: This study aimed to examine the relationship between ankle muscle strength, pain, kinesiophobia, and physical performance in Taekwondo athletes with CAI. Methods: Forty Taekwondo athletes with CAI participated in the study. …”

Birthweight of the subsequent singleton pregnancy following a first twin or singleton pregnancy by Prativa Basnet, Rolv Skjærven, Quaker E. Harmon, Allen J. Wilcox, Kari Klungsøyr, Linn Marie Sørbye, Nils‐Halvdan Morken, Liv G. Kvalvik

“…We aimed to compare birthweight in singleton pregnancies following a first twin pregnancy relative to a first singleton pregnancy. Material and Methods This was a prospective registry‐based cohort study using maternally linked offspring with first and subsequent pregnancies registered in the Medical Birth Registry of Norway between 1967 and 2020. …”
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Spinal Cord Stimulation for Spinal Cord Injury-Related Pain: A Pilot Study by Alexander Alamri, Meredith MacDonald, Alaa Al-Mohammad, Lucia Ricciardi, Michael G. Hart, Erlick A. Pereira

“…This study aims to assess the efficacy of SCS in alleviating SCI-related pain and improving patients’ quality of life, filling a gap in the existing literature. Methods: This cohort study included 15 adult patients with traumatic and non-traumatic SCIs, treated between 2016 and 2022. …”
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In Vitro Activity of Nisin A Against Staphylococci Isolated from Periprosthetic Joint Infection by Melissa J. Karau, Christina A. Koscianski, Andrew D. Badley, Nicholas A. Bedard, John W. Zinckgraf, Robin Patel

“…Here, the in vitro nisin A susceptibility of PJI-associated staphylococci was assessed. <b>Methods</b>: The minimum inhibitory concentrations (MICs), minimum biofilm inhibitory concentrations (MBICs), and minimum biofilm bactericidal concentrations (MBBCs) of nisin A were measured by broth microdilution against 106 staphylococcus isolates isolated from PJI. …”
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In Silico Approach for Identification of PI3K/mTOR Dual Inhibitors for Multiple Myeloma Treatment by İlke Maşalacı, Yaren Akdoğan, Özge Mutlu, Hande Eyvaz, Yağmur Kiraz

“…Therefore, the focus in this study is built around the specific targeting of the PI3Kδ and PI3Kγ isoforms from the multiple myeloma perspective. Materials and Methods: In silico docking experiments were conducted to determine the binding energies for different ligands that target mTOR, PI3Kδ, and PI3Kγ. …”
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Safety and feasibility of deep brain stimulation of the anterior cingulate and thalamus in chronic refractory neuropathic pain: a pilot and randomized study by Denys Fontaine, Aurélie Leplus, Anne Donnet, Nelly Darmon, Anne Balossier, Bruno Giordana, Benoit Simonet, Petru Isan, Jean Regis, Michel Lanteri-Minet

“…Changes on pain intensity (Visual Analogic Scale) and quality of life (EQ-5D scale) were used to evaluate DBS efficacy. …”
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Serum Interleukin-17 and Its Association with Inflammation and Bone Remodeling in Rheumatoid Arthritis and Hand Osteoarthritis: Insights from Musculoskeletal Ultrasound by Amany M. Ebaid, Essam Atwa, Mohamed A. Mortada, Hibah Abdulrahim Bahri, Noura Almadani, Noha M. Hammad

“…<b>Objectives</b>: The objective of this study was to evaluate the relationship between interleukin-17 (IL-17) serum levels, musculoskeletal ultrasound (MSUS) observations, and clinical disease activity in patients with rheumatoid arthritis (RA) and hand osteoarthritis (OA). <b>Methods</b>: This case–control study involved 120 participants, with 40 individuals assigned to each of the three groups: RA, OA, and control. …”
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Clinic and diagnosis of encephalopathy of critical conditions in children with infectious diseases by E. S. Egorova, A. V. Klimkin, A. A. Vilnits, N. V. Skripchenko, V. B. Voitenkov, Yu. P. Vasilyeva, M. A. Bedova

“…Purpose: to assess the functional state of the brain in critically ill encephalopathy in children with infectious diseases.Materials and methods: 75 patients aged from 1 month to 17 years 11 months with infectious diseases, who were in the intensive care unit of the clinic, were examined, divided into two groups: the main group and the comparison group. …”
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