Enhanced Broad-Spectrum Efficacy of an L2-Based mRNA Vaccine Targeting HPV Types 6, 11, 16, 18, with Cross-Protection Against Multiple Additional High-Risk Types by Kosuke Tsukamoto, Akio Yamashita, Masatoshi Maeki, Manabu Tokeshi, Hirotatsu Imai, Akira Fukao, Toshinobu Fujiwara, Koji Okudera, Nobuhisa Mizuki, Kenji Okuda, Masaru Shimada

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The D-score: a metric for interpreting the early development of infants and toddlers across global settings by Girmay Medhin, Charlotte Hanlon, Susan P Walker, Iris Eekhout, Gary L Darmstadt, Linda Richter, Maureen M Black, Ann M Weber, Marta Rubio-Codina, Stef van Buuren, Sally M Grantham-McGregor, Maria Caridad Araujo, Susan M Chang, Lia CH Fernald, Jena Derakhshani Hamadani, Simone M Karam, Betsy Lozoff, Lisy Ratsifandrihamanana, Orazio Attanasio, Bernice M Doove, Emanuela Galasso, Pamela Jervis, Ana M B Menezes, Helen Pitchik, Sarah Reynolds, Norbert Schady

“…We constructed and validated a new metric, the Developmental Score (D-score), using existing data from 16 longitudinal studies.Methods Studies had item-level developmental assessment data for children 0–48 months and longitudinal outcomes at ages >4–18 years, including measures of IQ and receptive vocabulary. …”
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Agreement between Gonioscopic Examination and Swept Source Fourier Domain Anterior Segment Optical Coherence Tomography Imaging by Mohammed Rigi, Nicholas P. Bell, David A. Lee, Laura A. Baker, Alice Z. Chuang, Donna Nguyen, Vandana R. Minnal, Robert M. Feldman, Lauren S. Blieden

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Clinical and laboratory manifestations of systemic lupus erythematosus in patients with neuropsychiatric disorders (eurasian renaissance register) by G. M. Koilubaeva, E. A. Aseeva, S. K. Solovyev, N. Yu. Nikishina, E. L. Nasonov, N. P. Tkachenko, E. R. Karimova, A. Zh. Zhumakadyrova, A. A. Moldobaeva, E. Zh. Dzhishambaev

“…Objective: to investigate the clinical and laboratory manifestations of systemic lupus erythematosus (SLE) with nervous system lesions in a Kyrgyz cohort.Subjects and methods. The prospective study enrolled 460 patients with SLE who fulfilled American College of Rheumatology (ACR) 1987 and SLICC 2012 criteria, and had been followed up at Academician M. …”
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Forecasting the diabetic retinopathy progression using generative adversarial networks by Huiyu Qiao, Feilong Tang, Huanfen Zhou, Yun Cai, Kairou Guo, Jin Wang, Tong Ma, Lie Ju, Wei Feng, Zhiqiang Ma, Juan Chen, Yuan Luo, Bin Wang, Zongyuan Ge, Qiansu Yang

“…Methods DRForecastGAN model, consisting of a generator, discriminator, and registration network, was trained, validated, and tested in training (12,852 images), internal validation (2734 images), and external test (8523 images) datasets. …”
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The effects of color and neutral density filters on dynamic accommodation in individuals with mild traumatic brain injury by Nawaf M. Almutairi, John Hayes, Yu-Chi Tai, Khawlah Alfaifi, Mohammed M. Alnawmasi, Muteb K. Alanazi, Bandar M. Alenezi, Sulaiman Aldakhil, Chunming Liu

“…This study objectively measured dynamic accommodation in individuals with mTBI and healthy controls under various filter conditions to determine if visual performance could be improved.MethodsThirty participants with a medically diagnosed history of mTBI (age range 18–33 years) and 54 healthy controls (age range 21–30 years) completed monocular dynamic accommodation testing under three randomized viewing conditions: baseline with no filter (NF), a subjectively selected color filter (CF), and a luminance-matched neutral density filter (ND). …”
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Stepwise Total Hip Arthroplasty with Lateral and Posterolateral Approaches: Intraoperative Imaging, Fixation Strategy, and Early Functional Outcomes by Roland Fazakas, Laura Ioana Bondar, Csongor Toth, Brigitte Osser, Iosif Ilia, Gabriel Roberto Marconi, Victor Niculescu, Ramona Nicoleta Suciu, Liviu Gavrila-Ardelean, Alexandru Pop

“…Methods: A prospective observational study was conducted at Arad Clinical Emergency County Hospital between March 2023 and March 2024, involving 23 patients undergoing primary THA. …”
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Meta-analysis: long/short-term efficacy of anti-VEGF vs. panretinal photocoagulation in preventing severe complications in proliferative diabetic retinopathy by Tiago N. O. Rassi, Lucas M. Barbosa, Dillan Cunha Amaral, Ricardo N. Louzada, Helvécio N. F. Filho, Guilherme N. Marques, Breno C. Vieira, Sobha Sivaprasad, Mauricio Maia

“…We aim to assess this dispute through a meta-analysis. Methods We searched PubMed, Embase, and Cochrane databases until August 2024 for studies comparing anti-VEGF with PRP in PDR. …”
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Understanding basic and social emotions in Alzheimer's disease and frontotemporal dementia by Carlotta Sola, Vanessa Zanelli, Maria Angela Molinari, Claudia Casadio, Francesco Ricci, Omar Carpentiero, Manuela Tondelli, Fausta Lui, Paolo Frigio Nichelli, Francesca Benuzzi

“…The present study aims to investigate emotion understanding (both basic and social emotions), using different tasks with visual and auditory stimuli, to identify supramodal deficits in AD and FTD to provide a reliable tool to better outline their behavioral and emotional profile and useful instruments for their management.MethodsEighteen patients with AD and 15 patients with FTD were included in the study. …”
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Comparative evaluation of antimicrobial peptides: effect on formation, metabolic activity and viability of Klebsiella pneumoniae biofilms by Sophia Hanstein, Thomas Grochow, Marina Mötzing, Marina Mötzing, Simone A. Fietz, Ralf Hoffmann, Ralf Hoffmann, Christoph G. Baums, Sophie Kähl

“…The objective of this study was to comparatively evaluate the effect of selected AMPs on the formation, metabolic activity and viability of Klebsiella pneumoniae biofilms of veterinary and human origin.MethodsBiofilm formation of three K. pneumoniae strains was quantified using the crystal violet assay and visualized by scanning electron microscopy (SEM). …”
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Effects of Self-Assisted Manual Therapy Combined with a High-Intensity Walking Program on Musculoskeletal Pain, Functionality, and Posture in Older Adults: A Multicentre Randomized... by Gemma Victoria Espí-López, Laura Fuentes-Aparicio, Rocío Cogollos-de-la-Peña, Lucas Monzani, Elena Marques-Sule, Dagmar Pavlu, Anna Arnal-Gómez

“…This study aims to analyse the effect of a combined protocol of self-assisted manual therapy and high-intensity walking on musculoskeletal back pain, functionality, and shoulder posture in older adults, and to establish the short- and medium-term effects of this program. Methods: A multicentre, double-blind, randomized trial was conducted on older adults. …”
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InP/ZnS core/shell quantum dots: Synthesis, characterization and their application in fullerene derivative based flexible solar cells by Chen Zhichu, Muhammad Tahir, Fida Muhammad, Fakhra Aziz, Ambreen Ayub, Fazal Badshah, Moamen S. Refat, Sadiye M. Cakmak, Shanza Rehan, Abdel Majid A. Adam, Amnah Mohammed Alsuhaibani, Afida Ayob, Mahidur R Sarker, Adam Khan

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Artificial Intelligence‐Based Detection of Central Retinal Artery Occlusion Within 4.5 Hours on Standard Fundus Photographs by Ayse Gungor, Ilias Sarbout, Aubrey L. Gilbert, Steffen Hamann, Pierre Lebranchu, Cristina Hobeanu, Philippe Gohier, Catherine Vignal‐Clermont, Oana M. Dumitrascu, Salomon‐Yves Cohen, Wolf A. Lagrèze, Nicolas Feltgen, Frank van der Heide, Cédric Lamirel, Jost B. Jonas, Michael Obadia, Daniel Racoceanu, Dan Milea

“…Methods Our retrospective, cross‐sectional study included 1322 color fundus photographs from 771 patients with acute visual loss due to CRAO, central retinal vein occlusion, nonarteritic anterior ischemic optic neuropathy, and healthy controls. …”
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Quantitative lung ultrasound to guide surfactant retreatment in preterm neonates born at ≤30 weeks’ gestation: a multicentre retrospective non-inferiority diagnostic accuracy study... by Daniele De Luca, Almudena Alonso-Ojembarrena, Davide Sarcina, Irene Gutierrez-Rosa, Barbara Loi, Fiorella Migliaro, Letizia Capasso, Francesco Raimondi

“…Methods: This was a multicentre, retrospective, non-inferiority, diagnostic accuracy study. …”
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Machine learning discrimination of Gleason scores below GG3 and above GG4 for HSPC patients diagnosis by Bingyu Zhu, Longguo Dai, Huijian Wang, Kun Zhang, Chongjian Zhang, Yang Wang, Feiyu Yin, Ji Li, Enfa Ning, Qilin Wang, Libo Yang, Hong Yang, Ruiqian Li, Jun Li, Chen Hu, Hongyi Wu, Haiyang Jiang, Yu Bai

“…Among the ensemble learning methods, RF, XGBoost, and Adaboost performed the best. …”
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OCT Angiography Analysis of Retinal and Choroidal Flow after Proton Beam Therapy for Choroidal Melanoma by Su-Kyung Jung, MD, Edward H. Lee, MD, Kavita K. Mishra, MD, Inder K. Daftari, PhD, Susanna S. Park, MD, PhD

“…Methods: After a comprehensive eye examination, including BCVA, Optovue AngioVue was used to obtain the 4.5-mm optic disc and 6.0-mm macular OCT/OCT angiography (OCTA) images of both eyes. …”
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Efficacy and safety of intravitreal anti-VEGF for myopic choroidal neovascularization by Jing-Yao Liu, Ju-Ping Liu, Xiao-Rong Li

“…AIM: To report the 24mo outcomes of vascular endothelial growth factor (VEGF) inhibitors for myopic choroidal neovascularization (mCNV) in routine clinical practice and simultaneously evaluated the real-world safety. METHODS: The patients who received intravitreal injections of VEGF inhibitors of either ranibizumab (0.5 mg) or conbercept (0.5 mg) for mCNV were analyzed from 1 January 2017 to 1 January 2022. …”
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Efficacy of aerobic exercises for knee osteoarthritis: a network meta analysis of randomized clinical trials by Yuan Luo, Xiao Chen, Haibo Gong, Li Chen, Liyue Zhang, Shuqiang Li

“…To address this knowledge gap, we performed a systematic network meta-analysis to compare and rank the clinical efficacy of various aerobic exercise regimens for managing KOA. Methods A systematic literature search was conducted across five electronic databases (PubMed, Cochrane Library, Web of Science, Embase, and Scopus) from database inception through June 2024. …”
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Brain temperature, brain metabolites, and immune system phenotypes in temporal lobe epilepsy by Christina Mueller, Huixian Hong, Ayushe A. Sharma, Hongwei Qin, Etty N. Benveniste, Jerzy P. Szaflarski

“…Methods Thirty‐six (36) participants, 18 with temporal lobe epilepsy (13 females) and 18 age‐matched healthy controls (nine females), were enrolled prospectively and underwent MRSI/MRSI‐t; TLE participants also provided blood samples. …”
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Perceived Risks, Mitigation Strategies, and Modifiability of Telehealth in Rural and Remote Emergency Departments: Qualitative Exploration Study by Christina Tsou, Justin Yeung, Melanie Goode, Josephine Mcdonnell, Aled Williams, Stephen Colin Andrew, Jenny Tetlow, Andrew Jamieson, Delia Hendrie, Christopher Reid, Sandra Thompson

“…Objective This study explores the perceptions of ETS clinicians regarding acceptability, appropriateness, and clinical decision-making when delivering emergency telemedicine in rural and remote settings. MethodsThis qualitative study used semistructured interviews to explore the perspectives of ETS clinicians regarding the factors influencing their clinical decision-making. …”
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