Socio-economic disparities in the appropriateness of diabetes care in an Italian region: findings of AEQUITAS study by Rosaria Gesuita, Francesca Piraccini, Edlira Skrami, Italo Paolini, Giuliano Sebastianelli, Carlo Stramenga, Dario Bartolucci, Alberico Marcobelli, Fabio Romagnoli, Giulia Silvestrini, Walter Ricciardi, Gianfranco Damiani, Flavia Carle

“…Background: To evaluate socio-economic disparities in diabetes prevalence and care in Marches (a region of central Italy) in 2003-2010 through a cross-sectional study. Methods: The databases of 52 general practitioners were mined for people with diabetes (age ≥20 years). …”
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Can the Methotrexate Therapy Prevent the Development of Uveitis in Patients with Juvenile Idiopathic Arthritis: Results of a Retrospective Study by M. M. Kostik, E. V. Gaydar, M. F. Dubko, V. V. Masalova, L. S. Snegireva, I. A. Chikova, E. A. Isupova, T. N. Nikitina, E. D. Serogodskaya, O. V. Kalashnikova, A. Ravelli, V. G. Chasnyk

“…Currently, the possibility of reducing the risk of uveitis in children with JIA by using methotrexate has been studied.Objective: Our aim was to analyze the results of treatment of children with JIA by studying the relation between the use of methotrexate and the risk of uveitis.Methods: A retrospective uncontrolled study. The case histories of patients with JIA who were treated for at least 2 years after the onset of the disease were studied. …”
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Effects of a 6-Week Concurrent Training Program Combining Resistance and Various Modalities of Aerobic Exercise in Obese Women with Prehypertension: A Randomized Controlled Trial by Jinhyuk Yu, Eunjoo Lee, Jae-Ho Choi, Yerin Sun, Seungyeon Woo, Sohyang Cho, Deunsol Hwang, Sung-Woo Kim, Jisu Kim, Kiwon Lim, Hun-Young Park

“…<b>Background/Objectives</b>: Our study aimed to verify the effects of 6 weeks of concurrent training composed of resistance training (RT) and different modalities of aerobic exercise (moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT)) on body composition, blood pressure, vascular function, autonomic nervous system (ANS) function, blood lipid levels, cardiometabolic index (CMI), and health-related fitness in obese middle-aged women with prehypertension. <b>Methods</b>: We selected 26 middle-aged women with obesity and prehypertension and divided them equally into the RT + MICT (n = 13) and RT + HIIT (n = 13) groups. …”
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Pregabalin produces analgesia in males but not females in an animal model of chronic widespread muscle pain by Ashley N. Plumb, Kazuhiro Hayashi, Adam Janowski, Angela Smith, Lynn Rasmussen, Kathleen A. Sluka, Joseph B. Lesnak

“…The purpose of our study was to investigate potential sex differences in the analgesic efficacy of pregabalin that may contribute to disparities in human outcomes. Methods:. We used a mouse model of chronic widespread muscle pain (CWP) to test the effects of pregabalin on muscle hyperalgesia, nonreflexive pain, and motor behaviors. …”
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Strategies for men’s engagement and its effectiveness in improving child health and immunization—a rapid review by Sarah Nabia, Myra Betron, Elizabeth Arlotti-Parish, Amanda Varnauskas, Chinelo Cynthia Nduka, Angioha Pius, Jean Munro, Katharine Bagshaw, Chizoba Barbara Wonodi

“…The goal of this rapid review is to identify and summarize effective and promising strategies for men’s engagement in child health and immunization in low-and-middle-income countries (LMICs) and further categorize the strategies into its potential for gender transformative outcomes.MethodsWe searched PubMed, Embase and CINAHL databases for peer-reviewed literature and identified grey literature sources through key informant interviews. …”
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Analysis of modified sitting positions for subarachnoid block: A prospective observational study by Nousheen Chowdhary, Ajaiz Rasool, Raja Suhail Shounthoo, Majid Jehangir, Rohey Jan, Showkat Ahmad Gurcoo

“…Aims and Objectives: Comparison of three different sitting positions including classical sitting position (CSP), hamstring stretch position (HSP), and riders sitting position (RSP), for SAB. Materials and Methods: A total of 207 patients, divided equally into three groups (CSP, HSP and RSP) with 69 patients in each group. …”
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Three-Dimensional Printed Model of the Mediastinum for Cardiothoracic Surgery Resident Education by Catherine T. Byrd, MD, Winston L. Trope, BE, H. Henry Guo, MD, PhD, Kyle Gifford, BA, Prasha Bhandari, MPH, Jalen Benson, AB, Douglas Z. Liou, MD, Leah M. Backhus, MD, MPH, Mark F. Berry, MD, Joseph B. Shrager, MD, Natalie S. Lui, MD, MAS

“…We hypothesized that a 3-dimensional printed model of the mediastinum would be an effective tool for teaching residents the anatomy and techniques for mediastinoscopy. Methods: A color model of the mediastinum was 3-dimensionally printed based on segmented computed tomographic images. …”
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Comparison of analytical sensitivity of automated microbiological blood culture systems by Lyamin A.V., Ismatullin D.D., Kozlov A.V., Alekseev D.V., Kayumov K.A., Bochkareva P.V., Antipov V.A.

“…To compare analytical parameters and sensitivity between BACT/ALERT® 3D 60 and Yunon® Labstar 50. Materials and Methods. The study included 20 species of clinically significant microorganisms isolated from blood (20 strains for each facultative anaerobic species and 10 strains for each aerobic species). …”
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Enhanced levels of IL-6 and PAI-1 and decreased levels of MMP-3 in cytomegalovirus seropositive patients with prior myocardial infarction by Xinling Xu, Angela Silveira, Pia Lundman, Afsar Rahbar, Cecilia Söderberg-Nauclér

“…While CMV seroprevalence was equal, the CMV-IgG levels were higher in controls. …”
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Dominant RDH12-retinitis pigmentosa impairs photoreceptor development and implicates cone involvement in retinal organoids by Cécile Méjécase, Cécile Méjécase, Ya Zhou, Nicholas Owen, Pablo Soro-Barrio, Riccardo Cheloni, Riccardo Cheloni, Neelima Nair, Hajrah Sarkar, Hajrah Sarkar, Lyes Toualbi, Lyes Toualbi, Mariya Moosajee, Mariya Moosajee, Mariya Moosajee

“…Heterozygous variants in RDH12 cause a rare autosomal dominant (AD) retinitis pigmentosa.MethodsAs no disease models exist, we generated human induced pluripotent stem cell-derived retinal organoids (RO) from an RDH12-AD patient (with pathogenic variant c.759del, p.Phe254Leufs*24) alongside a healthy, unaffected control.ResultsRDH12-AD RO exhibited correct localization of RDH12 to the photoreceptor inner segments up to week 44; however, transmission electron microscopy at week 37 showed that photoreceptors were less abundant and shorter in length. …”
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Development of Bimodal Emotion Recognition System Based on Skin Temperature and Heart Rate Variability Using Hybrid Neural Networks by Sayat Orynbassar, Duygun Erol Barkana, Evan Yershov, Madiyar Nurgaliyev, Ahmet Saymbetov, Batyrbek Zholamanov, Gulbakhar Dosymbetova, Ainur Kapparova, Nursultan Koshkarbay, Nurzhigit Kuttybay, Askhat Bolatbek, Kymbat Kopbay, Dinara Almen

“…Notably, these physiological signals can be measured remotely, addressing the limitations of direct measurement methods. The integration of these modalities enables the model to effectively utilize both spatial and temporal features for robust emotion classification. …”
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An artificial intelligence accelerated ab initio molecular dynamics dataset for electrochemical interfaces by Yong-Bin Zhuang, Chang Liu, Jia-Xin Zhu, Jin-Yuan Hu, Jia-Bo Le, Jie-Qiong Li, Xiao-Jian Wen, Xue-Ting Fan, Mei Jia, Xiang-Ying Li, Ao Chen, Lang Li, Zhi-Li Lin, Wei-Hong Xu, Jun Cheng

“…Complementing experimental approaches, computational methods, such as ab initio molecular dynamics and machine learning-accelerated molecular dynamics, offer an efficient means of obtaining microscopic information. …”
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Effects of Route Complexity and Lighting on Route Following in Alzheimer’s Disease and Posterior Cortical Atrophy by Amelia M. Carton, Chris Frost, Teresa Poole, Biao Yang, Ian D. McCarthy, Tatsuto Suzuki, Catherine Holloway, Robin Serougne, Derrick Boampong, Mary Pat Sullivan, Nick Tyler, Sebastian Crutch, Keir X. X. Yong

“…This study aimed to investigate the effects of the built environment on mobility and navigation in people with dementia-related visual loss. Methods: Participants with posterior cortical atrophy (PCA; “visual-variant Alzheimer’s”; n = 11), typical Alzheimer’s disease (tAD; N = 10), and controls (n = 13) repeatedly walked down routes within a simplified real-world setting. …”
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Ayahuasca-inspired DMT/HAR formulation reduces brain differentiation between self and other faces by Dila Suay, Helena D. Aicher, Micheal Kometer, Michael J. Mueller, Luzia Caflisch, Alexandra Hempe, Camilla P. Steinhart, Claudius Elsner, Ilhui A. Wicki, Jovin Müller, Daniel Meling, Dario A. Dornbierer, Milan Scheidegger, Davide Bottari

“…Objective: This study investigates the effects of an ayahuasca-inspired novel DMT/HAR (N,N-dimethyltryptamine/Harmine) formulation and Harmine alone on face recognition and self-referential processing, as measured by event-related potentials (ERPs) and subjective behavioral measures. Methods: In a within-subject, double-blind, placebo-controlled design, 30 healthy male participants underwent EEG recording during a visual oddball task involving Self, Familiar, and Unknown Faces. …”
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PD-L1 deficiency exacerbates colitis severity by remodeling gut microbiota in inflammatory bowel disease by Yixian Ma, Yixian Ma, Yixian Ma, Jinshan Suo, Siqi Sheng, Siqi Sheng, Siqi Sheng, Ling Chen, Ling Chen, Ling Chen, Ling Chen

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Adalimumab vs placebo as add-on to Standard Therapy for autoimmune Uveitis: Tolerability, Effectiveness and cost-effectiveness—a protocol for a randomised controlled trial (ASTUTE... by Chris A Rogers, Andrew Dick, Tunde Peto, Robert Wilson, Pearse A Keane, Alastair K Denniston, Srilakshmi M Sharma, Lucy Culliford, Katie Pike, Sarah Baos, Carlos Pavesio, Sarah Wordsworth, Barnaby Reeves, Annie Folkard, Mae Hazell, Mandy P Y Lui, Nicholas A V Beare

“…Secondary outcomes include individual TF components, retinal morphology, adverse events, health-related quality of life, patient-reported side effects and visual function, best-corrected visual acuity, employment status and resource use. …”
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Course of uveitis in children with juvenile idiopathic arthritis (JIA): Five years follow-up data from a prospective multicenter Inception Cohort of Newly diagnosed patients with J... by Karoline Baquet-Walscheid, Kirsten Minden, Martina Niewerth, Frank Dressler, Ivan Foeldvari, Dirk Foell, Johannes-Peter Haas, Gerd Horneff, Anton Hospach, Tilmann Kallinich, Jasmin Kümmerle-Deschner, Kirsten Mönkemöller, Christoph Tappeiner, Daniel Windschall, Jens Klotsche, Arnd Heiligenhaus

“…The present study assesses the 5-years outcome of JIAU by analyzing data from a prospective study initiated in 2010. Methods Data from 75 patients with onset of uveitis after study enrollment, and with a documentation at 5-years follow-up (5yFU) were available for analysis of uveitis characteristics, frequency and predictors of „inactivity on medication “ (defined as inactive uveitis for ≥ 6 months) and „inactivity off medication “ (defined as inactive uveitis for ≥ 6 months off medication). …”
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Effects of repeated low-level red-light therapy on macular retinal thickness and microvascular system in children with myopia by Linlin Liu, Yuchuan Wang, Fang Liu, Xinghui Yu, Lianfeng Xie, Shuxiang Tan, Jing Liu, Yanfang Liu, Jiaxing Huang, Shuang Zhang, Yiping Jiang

“…Objective: The objective of the study was to use optical coherence tomography angiography (OCTA) to analyze the effects of repeated low-level red-light (LLLT) therapy on macular retinal thickness and the microvascular system in children with myopia to evaluate the safety of this therapy. Methods: This prospective study included 40 school-age children with myopia (80 eyes), aged 7–14 years, who received therapy using a LLLT instrument. …”
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Prefrontal cortex activity during binocular color fusion and rivalry: an fNIRS study by Xiang Liu, Xiang Liu, Xiang Liu, Xuesong Jin, Xuesong Jin, Lijun Yun, Lijun Yun, Zaiqing Chen, Zaiqing Chen, Zaiqing Chen, Zaiqing Chen

“…Binocular color fusion and rivalry, which involve advanced cognitive functions in the prefrontal cortex (PFC), provide a unique perspective for exploring brain activity.MethodsThis study used functional near-infrared spectroscopy (fNIRS) to examine PFC activity during binocular color fusion and rivalry conditions. …”
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The association between myopia and mental health among Chinese children in primary and secondary school: a cross-sectional study by Shijie Yu, Hongpo Yin, Wei Sun, Ruosong Yang, Ronghua Lai, Yushan Yu, Hongsheng Bi, Hongsheng Bi, Jianfeng Wu, Jianfeng Wu, Jianfeng Wu

“…ObjectiveThis study aimed to investigate the association between myopia and mental health among Chinese children in primary and secondary school.MethodsThis study employed a cross-sectional study design, including 1,640 children and their parents, via an online survey. …”
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