Isoliquiritigenin Alleviates Periodontitis by Suppressing Inflammation via NF-κB Signaling Pathway of Immune Cell by Wang X, Zhao T, Liang B, Fang J, Dong Q, Chen Q

“…., Ltd, Hangzhou, 310051, People’s Republic of China; 5Centre for Bone, Joint and Sports Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, 510000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qianqian Chen; Qiu Dong, Email 18221767137@163.com; dong1005@stu2019.jnu.edu.cnBackground: Periodontitis, a chronic infectious disease, presents significant treatment challenges due to antibiotic resistance and high recurrence rates, necessitating novel therapeutics.Methods: Network pharmacology identified ISL’s potential targets in periodontitis, focusing on NF-κB signaling pathway. …”
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Inhibition of Ovarian Cancer Growth, Metastasis and Reverse the Tumor Microenvironment by Dual Drug-Loaded Polymer Micelle Targeting Tumor Microenvironment by Zhang L, Guo R, Chen M, Liu M, Liu Y, Yu Y, Zang J, Kong L, Li X

“…Transforming the immune environment from an immunosuppressive state to an anti-tumor state through the phenotypic transformation of tumor-associated macrophages is crucial for inhibiting the growth, metastasis, and recurrence of ovarian cancer.Methods: A polymer micelle (RC-PH-Ms) containing paclitaxel (PTX) and honokiol (HNK) was designed based on high expression of reactive oxygen species in the tumor microenvironment. …”
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Enhancing Periodontal Ligament Regeneration via PDLSC Delivery Using Electrospun PCL/Collagen/Cellulose Acetate Scaffolds and Collagen Hydrogel Incorporated with Curcumin-Loaded ZI... by Lan X, Wang Y, Yin M

“…This study explores a tissue engineering strategy that combines polycaprolactone (PCL)/collagen/cellulose acetate electrospun scaffolds with collagen hydrogels to deliver curcumin-loaded ZIF-8 nanoparticles fand periodontal ligament stem cells (PDLSCs).Methods: Scaffolds were fabricated via electrospinningand collagen hydrogels incorporated PDLSCs and curcumin-loaded ZIF-8 nanoparticles (CURZIF-8) were developed using cross-linking. …”
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Intravenous Versus Oral Omadacycline or Linezolid for Acute Bacterial Skin and Skin Infections: A post hoc Analysis of the OASIS Trials by George D. Rodriguez, Nathan Warren, Roman Yashayev, Surya Chitra, Maria Amodio-Groton, Kelly Wright

“…Both linezolid and omadacycline are available as intravenous or bioequivalent oral formulations. Materials and methods This post hoc analysis of the OASIS-1 (ClinicalTrials.gov identifier NCT02378480) and OASIS-2 (ClinicalTrials.gov identifier NCT02877927) phase 3 trials assessed safety and clinical efficacy of intravenous (IV)-start versus oral (PO)-start therapy in patients treated with omadacycline or linezolid for ABSSSI. …”
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Obesity Prevalence, Associated Factors and Complications among Adult Population Attending Family Medicine Clinic in Hatta Hospital, United Arab Emirates by Ayesha Rashid, Uzma Farheen, Zahid Nabi Qureshi, Muhammad Ejaz

“…Objective: To determine the prevalence of obesity, it’s associated factors, and complications among adults presenting to the primary care clinic at Hatta Hospital, located in the Hatta area UAE. Materials and Methods: This cross-sectional study enrolled adult Emirati patients aged between 18-55 year. …”
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Excess winter cardiovascular morbidity in Ivanovo Region in 2009-2013 years by A. V. Kontsevaya, J. A. Balanova, M. M. Loukianov, M. B. Khudyakov, O. A. Belova, S. V. Romanchuk

“…To study excess cardiovascular morbidity during winter in Ivanovo Region in 2009-2013 years. Material and methods. Excess winter morbidity index (EWMI) was calculated using special formula. …”
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Exploring the Mechanism of Action of Xuebijing Injection in Treating Acute Respiratory Distress Syndrome Based on Network Pharmacology and Animal Experiments by Li J, Shen M, Yin Z

“…Jin Li,1,* Meirong Shen,2,* Zuan Yin3 1Department of Intensive Care Unit, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang City, Jiangxi Province, 330006, People’s Republic of China; 2Department of Intensive Care Unit, Ganzhou People’s Hospital, Ganzhou City, Jiangxi Province, 341000, People’s Republic of China; 3Department of Emergency, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang City, Jiangxi Province, 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zuan Yin, Department of Emergency, Jiangxi Provincial People’s Hospital, 152 Aiguo Road, Donghu District, Nanchang City, Jiangxi Province, 330006, People’s Republic of China, Email yuzan201709@126.comObjective: To explore the mechanism of Xuebijing injection (XBJ) in treating acute respiratory distress syndrome (ARDS) using network pharmacology and animal experiments.Methods: Active ingredients of XBJ were analyzed via TCMSP, and ARDS-related targets were identified through DisGENET and Genecard. …”
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The Influence of Subclinical Hypothyroidism on Endocrine and Metabolic Characteristics in Patients with Polycystic Ovary Syndrome by Dai F, Wu Z, Qin S, Wu F, Wang M, Liu X, Liu F

“…Fang Dai,1,* Zijian Wu,2,* Shuai Qin,1 Fang Wu,3 Mingqiang Wang,4 Xiangxiu Liu,1 Fen Liu1 1Department of Endocrinology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, People’s Republic of China; 2Department of Brain surgery, The Second People’s Hospital of Guizhou Province, Guiyang, People’s Republic of China; 3Department of Obstetrics, The First People’s Hospital of Guizhou Province, Guiyang, People’s Republic of China; 4Teaching Evaluation Center, Guizhou University of Traditional Chinese Medicine, Guiyang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fang Dai, Department of Endocrinology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Baoshan North Road, Guiyang, Guizhou, 550001, People’s Republic of China, Email 13765063256@163.comObjective: To analyze the influence of subclinical hypothyroidism (SCH) on endocrine and metabolic characteristics in patients with polycystic ovary syndrome (PCOS).Methods: A total of 198 cases of PCOS patients admitted to our hospital from January 2022 to December 2023 were selected for the study. …”
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Supporting implementation of universal prevention initiatives in K-12 schools: impacts on fidelity through organizational readiness and team functioning in a cluster-randomized tri... by Christopher M. Fleming, Hannah G. Calvert, Lindsey Turner

“…This study addresses mechanisms of action, exploring whether positive effects of RS3 on implementation fidelity are attributable to improvements in functioning of school implementation teams, and increases in organizational readiness. Methods Data are from a cluster-randomized hybrid Type 3 implementation-effectiveness trial of RS3 among rural Idaho schools implementing Positive Behavioral Interventions and Supports (PBIS). …”
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PREVALENCE OF DENTAL CARIES AND CHRONIC CATARRHAL GINGIVITIS IN SCHOOL-AGE CHILDREN IN DIFFERENT REGIONS OF UKRAINE by I.O. Trubka, O.A. Udod, N.O. Savychuk, L.V. Korniienko, S.I. Dramaretska, A.О. Savychuk

“…The purpose of the study is to determine the prevalence of dental caries and CCG in school-age children living in the cities of the central and northern regions. Materials and methods. 503 children aged 7 to 15 years old were examined, among them 150 children (29.2%) were examined in the city of Vinnytsia (central region), 148 children (29.4%) in the city of Chernihiv (northern region), and 148 children (29.4%) in the city of Kyiv (northern region) – 205 children (40.8%). …”
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Relationship Between the ZJU Index and Infertility Risk in Reproductive-Aged US Women: An Analysis of NHANES 2013–2018 by Tian L, Qin X, Yang M, Tang W, Feng L, Huang J, Hu H

“…This study aims to examine the association between the ZJU index and infertility in reproductive-aged women.Methods: We conducted a cross-sectional study using data from the 2013– 2018 National Health and Nutrition Examination Survey (NHANES). …”
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Assessment of a patient safety culture: a nationwide cross-sectional study comparing public and private hospitals in Kuwait by Fatemah M. Alsaleh, Shaikha Albraikan, Hadeel Alzoubi, Eman A. Abahussain, Hossam Elamir

“…This study aims to assess and compare patient safety culture across public and private hospitals in Kuwait. Methods A cross-sectional study was conducted utilising the Hospital Survey of Patient Safety Culture. …”
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Dynamic risk and protective factors in mentally disordered offenders: forensic psychiatry treatment monitoring, prison release and length of stay by Kerstin Weber, Lena Magnenat, Sandrine Morier, Christophe Menu, Philippe Bertschy, François R. Herrmann, Panteleimon Giannakopoulos

“…Integrated risk-protection assessment is thought to facilitate prediction of treatment outcome. Methods In a two-year prospective observational cohort study using a repeated measures design, we monitored treatment as usual induced changes in violence and protective factors, in 117 offenders of a medium-security forensic clinic in Switzerland. …”
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Clinicopathological and imaging features of struma ovarii: a retrospective study by Mei Chen, Shusheng Liao, Youfeng Xu, Xianwang Ye, Xiupeng Jia, Shengmin Zhang

“…The cystic wall and septation showed equal enhancement and slow regression. Two patients showed low enhancement in the protrusion and with slow regression. …”
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Exploring gender disparities: a survey among orthopedic residents by Rossella Ravaglia, Vittoria Mazzola, Paolo Ferrua, Luca La Verde, Matteo Formica, Pietro Simone Randelli

“…This study investigates gender discrimination and disparities in Italian orthopedic residency programs, expanding on existing literature, which indicates that female surgeons worldwide face challenges such as fewer promotions, lower salaries, and higher rates of harassment. Materials and methods From June to August 2024, the SIAGASCOT Junior Committee conducted a voluntary and anonymous survey among registered male and female orthopedic residents. …”
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Comparison of microcurrent and low level laser therapy on matrix metalloproteinases and tissue inhibitors of metalloproteinases expressions in surgical wound healing by Ayman Mohammed El Makakey, Mohammed H. Hassan, Nehad A. Abo-zaid, Bakheet E. M. Elsadek, Mahmoud A. Hifny, Radwa Mahmoud Elsharaby, Mohammed E. Ali

“…Abstract Purpose The purpose of this study was to compare the modulation effects of Microcurrent Therapy (MT) and Low-Level Laser Therapy (LLLT) on Matrix Metalloproteinases (MMPs) and tissue inhibitors of Metalloproteinases (TIMPs) expressions during healing of surgical wounds using appendectomy wound as a model. Methods Ninety patients who recently underwent appendectomy were randomly divided into 3 main groups of equal numbers. …”
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Web-based machine learning application for interpretable prediction of prolonged length of stay after lumbar spinal stenosis surgery: a retrospective cohort study with explainable... by Paierhati Yasheng, Paierhati Yasheng, Alimujiang Yusufu, Yasenjiang Yimiti, Haopeng Luan, Cong Peng, Xinghua Song

“…This study aimed to develop a machine learning-based tool that can calculate the risk of prolonged length of stay (PLOS) after surgery and interpret the results.MethodsPatients were registered from the spine surgery department in our hospital. …”
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Effect of Noises and GSM Codings on Pre-Trained Speaker Embedding Models in Forensic Voice Comparison by Mohammed Hamzah Alsalihi, David Sztaho

“…This study delves into examining the impact of noise and Global System for Mobile Communications (GSM) coding, with a particular emphasis on metrics relevant to forensic voice comparison, and examining how enrollment methods (averaging embeddings) can mitigate these adverse effects. …”
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5-HTR1A and 5-HTR2A genetic polymorphisms and SSRI antidepressant response in depressive Chinese patients by Dong Z, Li X, He L, He G, Yu T, Sun X

“…In this study, we analyzed the correlation between 5-HTR1A and 5-HTR2A polymorphisms and response or remission to selective serotonin reuptake inhibitors (SSRIs) drugs. Methods: Two hundred and ninety patients who met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for major depressive disorder were involved in this study. …”
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Disease Burden of Neck Pain in China from 1990 to 2021 and Its Prediction for 2042: The Global Burden of Disease Study 2021 by Wei J, Yang K, Xue J, Luo M, Peng W, Yin X, Sun W, Gao C, Teng G, Yin H, Feng M, Li L, Sun K, Zhang W

“…Jiaming Wei,* Kexin Yang,* Jiarui Xue, MingYi Luo, Wei Peng, Xunlu Yin, Wu Sun, Chunyu Gao, Guangfei Teng, He Yin, Minshan Feng, Luguang Li, Kai Sun, Wei Zhang Department of SpineII, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xunlu Yin, Email yin_xun_lu@163.com Kexin Yang, Email 13611261137@163.comPurpose: This study, aimed to report the rates and trends of the prevalence, incidence, and years lived with disability caused by neck pain in the general population of China from 1990 to 2021 and forecast the incidence, prevalence, and disability-adjusted life Years (DALYs) from 2022 to 2042.Methods: We used data from the Global Burden of Diseases Study (GBD) 2021. …”
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