The Temporal Changes in Ankle Joint Pathology, Pain and Secondary Osteoporosis in Collagen-Induced Arthritis Rats by Liu Q, Nan N, Li W, Dong M, Pu W, Liu Y, Zhao J, Hao H

“…Pain is the most important symptom of RA, and some patients with well-controlled inflammation may still experience pain.Purpose: To explore the relationship and dynamic changes between synovial inflammation and pain and bone destruction in collagen-induced arthritis (CIA) model rats, and to choose a better time window for drug treatment.Methods: The CIA model rats were constructed for 1, 2, 3, and 4-week groups. …”
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Comparative long-term efficacy of short-term spinal cord stimulation versus bipolar pulsed radiofrequency for refractory postherpetic neuralgia: a 24 month prospective study by Yun Li, Junnan Wang, Yang Chen, Feng Qiu, Tao Sun, Xuli Zhao

“…This study compares the long-term efficacy and safety of short-term spinal cord stimulation (stSCS) versus bipolar pulsed radiofrequency (bPRF) in managing refractory PHN. Methods In this prospective, controlled observational study, 140 PHN patients (aged ≥ 18 years; PHN duration ≥ 3 months) with inadequate pain relief from standard therapies were enrolled and randomized equally into two groups (n = 70 each). …”
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Mendelian Randomization Analysis Supports a Causal Relationship Between Circulating Inflammatory Proteins and Basal Cell Carcinoma by Fu ZD, Wang Y, Yan HL, Wu JH

“…Zhi-da Fu,1,2,* Yao Wang,3,* Hong-li Yan,2 Jian-hua Wu1 1Department of Dermatology, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China; 2Center for Reproductive Medicine, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China; 3Shanghai International Travel Healthcare Center, Shanghai Customs District, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian-hua Wu, Department of Dermatology, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China, Email wujh_chyy@163.com Hong-li Yan, Center for Reproductive Medicine, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China, Email hongliyan@smmu.edu.cnBackground: It has been shown that the Basal cell carcinoma (BCC) is associated with chronic inflammation of skin conditions, the circulating inflammatory protein levels may be a more intuitive index in response to inflammation, however, the cause-and-effect relationship between circulating inflammatory proteins and BCC is currently unknown.Methods: This study performed a Mendelian randomization (MR) analysis using the plasma inflammatory protein levels from a large genome-wide protein quantitative trait loci study as the exposure data, and the outcome data from a GWAS for BCC. …”
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The Value of Common Laboratory Markers in Predicting the Severity of COVID-19 Patients by Chen L, Jiang YH, Li MY, Huang B, Yuan L, Wan JH, Qin TY, Zeng TT, Chen QG

“…Lian Chen,1,* Yu-Huan Jiang,2,* Mei-Yong Li,3 Bo Huang,3 Lei Yuan,2 Jin-Hua Wan,2 Ting-Yu Qin,2 Ting-Ting Zeng,2 Qing-Gen Chen2 1Department of Ultrasound Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 2Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 3Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China*These authors contributed equally to this studyCorrespondence: Qing-Gen Chen, Department of Clinical Laboratory, the First Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of China, Tel/Fax +86 0791-86319420, Email 272880243@qq.comPurpose: The aim of the present study was to identify more effective laboratory markers to assess the severity of corona virus disease 2019 and predict the progression of the disease by collecting more laboratory markers and variables.Patients and Methods: In this study, most risk factors, including epidemiological characteristics, blood cell counts, cytokines, and infection markers, were collected from 126 patients with COVID-19 to assess their predictive value.Results: The area under curve (AUC) of Albumin (Alb) to fibrinogen (Fib) ratio (AFR) (0.791), Lactate dehydrogenase (LDH) (0.792), myoglobin (MYO) (0.795), C-reactive protein (CRP) (0.801) and lymphocyte count (0.859) were higher than other markers to distinguish severe from non-severe patients in receiver operating characteristic (ROC) analysis. …”
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Mexiletine in the Treatment of LQT2, LQT3, and Acquired LQTS: A Meta-Analysis by Dhiya Ihsan, Mohammad Iqbal, Charlotte Johanna Cool, Chaerul Achmad, Miftah Pramudyo, Hawani Sasmaya Prameswari, Mohammad Rizki Akbar

“…Methods: A meta-analysis was conducted using systematic electronic searches of PubMed, Embase, and Cochrane Library. …”
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Patterns of prescription antihypertensive drug utilization and adherence to treatment guidelines in the city of Novi Sad by Tomas Ana, Tomić Zdenko, Milijašević Boris, Ban Milica, Horvat Olga, Vukmirović Saša, Sabo Ana

“…The aim of this study was to identify the antihypertensive drug utilization patterns among hypertensive outpatients in the city of Novi Sad, Serbia, determine the adherence to clinical guidelines and address the economic aspects of current prescribing practices. Methods. This retrospective observational study was conducted in Novi Sad over a period of six months. …”
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Impact of 30-minute and 90-minute Naps on Aerobic and Anaerobic Intermittent Performance in Collegiate Soccer Players by Xu A, Wang N, Gao Y, Li X

“…Anran Xu,1,* Ning Wang,1,* Yang Gao,1 Xiaotian Li1,2 1Department of Physical Education and Research, Central South University, Changsha, 410083, People’s Republic of China; 2School of Sports Training, Wuhan Sport University, Wuhan, 430079, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yang Gao, Department of Physical Education and Research, Central South University, Changsha, 410083, People’s Republic of China, Email 1062065203@qq.com Xiaotian Li, Department of Physical Education and Research, Central South University, Changsha, 410083, People’s Republic of China, Email xiaotianli@csu.edu.cnPurpose: This study aims to investigate the effects of 30-minute and 90-minute naps on collegiate soccer players’ aerobic and anaerobic performance following a normal night of sleep, and to compare the performance differences between the two nap durations.Patients and Methods: A total of 25 male collegiate soccer players (age: 20 ± 1 years, height: 180.4 ± 5.6 cm, weight: 72.1 ± 4.2 kg, BMI: 22.1 ± 2.2 kg·m⁻²) participated in the RAST and 30– 15. …”
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Antibiofilm and Anticancer Activity of Multi-Walled Carbon Nanotubes Fabricated with Hot-Melt Extruded Astaxanthin-Mediated Synthesized Silver Nanoparticles by You HS, Jang YS, Sathiyaseelan A, Ryu SJ, Lee HY, Baek JS

“…The antibiofilm and anticancer effects were studied comprehensively by loading the AST AgNPs onto MWCNT-Silica.Methods: AgNPs-loaded MWCNT-silica (MWCNT-Ag) was prepared through the binding reaction of TSD and silanol groups and the aggregation interaction of Ag and TSD. …”
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Ultrasound guided thoracic dorsal root ganglia pulsed radiofrequency verified by fluroscopy for patients with lung cancer and metastatic thoracic cage pain: a randomized controlled... by Dina Kamel Abdel Maksoud, Sahar Ahmed El Karadway, Nagwa Ahmed Ibrahim, Dina Nabil Abbbas

“…The current study aimed to investigate the effect of ultrasound guided pulsed radiofrequency (PRF) of thoracic DRG on metastatic thoracic cage pain intensity and impact of pain on daily life of patients with lung cancer.Materials and Methods 30 patients with lung cancer thoracic cage metastatic pain were randomized equally to receive active PRF plus 0.5 ml lidocaine 2% for each thoracic DRG modulation (group 1) or non-active PRF plus 0.5 ml of lidocaine 2% (group 2). …”
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Evaluation of comparative efficacy of Celastrus paniculatus (Jyotishmati) capsule versus sertraline capsule in the management of Chittodvega (generalized anxiety disorder): protoco... by Sadhana Misar, Mayank Rai, Reeya Gamne

“…Aim and objectives To evaluate the comparative efficacy of Jyotishmati versus sertraline in the management of Chittodvega. Methods In this randomized active controlled double blind equivalence trial a total of 70 patients will be enrolled and divided into two equal groups. …”
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EPIDEMIOLOGICAL ANALYSIS OF CARIES IN CHILDREN DURING OUT-PATIENT TREATMENT IN DONETSK REGION by A. V. Makhniova

“…The purpose of this work is an epidemiological analysis of caries in children during out-patient treatment at the dentist`s in Donetsk region. Material and methods. The data of 33 697 children of three age groups were analyzed. …”
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Unveiling Ventilator-Associated Pneumonia: S100A8 as a Promising Biomarker Through Integrated RNA-Seq Analysis by Wang Q, Dong J, Jing X, Long Y, Jia H, Li Y, Wang J

“…There was an urgent need for new diagnostic biomarkers for VAP.Methods: The transcriptome of VAP patients was analyzed and computed using bioinformatics techniques in this study. …”
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Plasma Fetuin-B Levels are Associated with Nervous Symptoms and Conduction Velocity in Patients with Painful DPN by Lin K, Wang X, Gu T, Feng K, Zeng W, Yang L

“…Ke Lin,1,* Xiaocui Wang,2,* Tao Gu,3,* Keduo Feng,1 Wang Zeng,1 Liu Yang1 1Department of Neurology, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, People’s Republic of China; 2Department of Endocrinology, Translational Research of Diabetes Key Laboratory of Chongqing Education Commission of China, Second Affiliated Hospital of Army Medical University, Chongqing, People’s Republic of China; 3Department of Radiology, Second Affiliated Hospital of Army Medical University, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ke Lin; Liu Yang, Department of Neurology, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, People’s Republic of China, Email ayalinke@126.com; 510586640@qq.comAim: To assess the plasma concentrations of the novel hepatokine fetuin-B in individuals with type 2 diabetes with or without diabetic peripheral neuropathy (DPN), and to evaluate the relationship among fetuin-B levels, nervous function, and metabolic parameters.Methods: A total of 333 participants were recruited and divided into three groups: DPN, painful DPN (pDPN), and non-DPN. …”
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Ursolic Acid Ameliorates Diabetic Nephropathy by Inhibiting JAK2/STAT3-Driven Ferroptosis: Mechanistic Insights from Network Pharmacology and Experimental Validation by Zhou Y, Lou C, Xu X, Feng B, Fan X, Wang X

“…Yijing Zhou,* Chengli Lou,* Xiuqin Xu, Bo Feng, Xiaoping Fan, Xiangjing Wang Department of Nephropathy, Jiaxing Traditional Chinese Medicine Hospital, Jiaxing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yijing Zhou, Email zyj13967332522@163.comPurpose: Ursolic acid (UA) improves diabetic nephropathy (DN), but its regulatory mechanism requires further verification.Methods: The bioactive component-target network of UA in DN was determined using a network pharmacology approach. …”
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Real-World Pharmacovigilance Analysis of Adverse Events Associated with Liposomal Bupivacaine and Bupivacaine by Chen DX, Chen XM, Chen SM, Wang YD

“…The primary goal of this study was to conduct a thorough safety evaluation of liposomal bupivacaine and bupivacaine.Patients and Methods: This study analyzed adverse events (AEs) associated with liposomal bupivacaine and bupivacaine using the FDA Adverse Event Reporting System (FAERS) database from Q1 2004 to Q2 2024. …”
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Exploring Ototoxicity Associated with Capmatinib: Insights from a Real-World Data Analysis of the FDA Adverse Event Reporting System (FAERS) Database by Lin Y, Xu S, Deng M, Cao Y, Ding J, Lin T

“…The aim of this study was to explore the significant adverse drug reactions (ADRs) associated with Capmatinib through the FDA Adverse Event Reporting System (FAERS) database.Methods: We employed the reported odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and the Empirical Bayes Geometric Mean (EBGM) as primary algorithms for the disproportionality analysis. …”
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Development of a capability framework for Allied Health research careers in health services by Caitlin Brandenburg, Elizabeth C. Ward, Susan Stoikov, Rachelle Pitt, Liza-Jane McBride

“…Hence, this study aimed to develop a research career capability framework for AH research careers within health services, using the specific setting of Queensland Health, a state-wide Australian public health service. Methods This research involved four sequential phases: 1) A rapid review to identify potential capabilities for inclusion in the framework; 2) Refinement of the rapid review findings into an initial set of capabilities and domains by a Project Reference Group (PRG); 3) An e-Delphi survey with a broad range of stakeholders to gain consensus on included capabilities; and 4) A survey of and consultation with the PRG to refine capabilities and develop final framework elements. …”
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Possibilities of a software-based hybrid single photon emission computed tomography/ magnetic resonance imaging in the diagnosis of complicated diabetic foot syndrome by V. D. Zavadovskaya, M. A. Zorkal’tsev, V. D. Udodov, M. A. Zamyshevskaya, O. Yu. Kilina, A. P. Kurazhov, K. M. Popov

“…Objective: to give the results of a software-based hybrid single photon emission computed tomography/magnetic resonance imaging (SPECT/MRI) in detecting osteomyelitis (OM) in patients with diabetic foot syndrome (DFS).Material and methods. Seventy-six patients (35 men and 41 women) (mean age, 59.4±7.1 years) with type 1 and 2 diabetes mellitus and suspected OM were examined. …”
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Six weeks of either EPA-rich or DHA-rich Omega-3 supplementation alters submaximal exercise physiology in endurance trained male amateurs by Andrew Blannin, George Boulton, Frank Thielecke, Frank Thielecke

“…The current study aimed to investigate if EPA-rich or DHA-rich supplements are equally efficient at modifying physiological responses to submaximal exercise and potentially improving performance.MethodsFifty-five endurance trained amateurs participated in a submaximal exercise test followed by a 24 km time trial (TT) before and after a six-week supplementation period. …”
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An Evidence-Based Medical Review on Preoperative Exercise Prehabilitation in Lung Cancer Patients by Zhang R, Wu M, Cheng Y, Xu Y, Xia L

“…To integrate and evaluate the evidence related to preoperative exercise prehabilitation in patients with lung cancer.Methods: Conducted utilizing the “ 6S” model of evidence resources, according to the search strategy searching for relevant guidelines, evidence summaries, best practices, systematic reviews, and expert consensuses on preoperative exercise prehabilitation for lung cancer patients. …”
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