FAM105B Promotes Hepatocellular Carcinoma Progression and Metastasis by Activating the PI3K/AKT/MTOR Signaling Pathway and Inducing Epithelial-Mesenchymal Transition by Yang LL, Chen X, Tang ST, Huang KT, Ye GY, Wang JL

“…However, its role in HCC is not well understood.Methods: FAM105B expression in HCC patients was validated using public clinical datasets. …”
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Amelioration of Inflammation and Metabolic Blockage in GALC Deficient Mice After Enzyme Replacement Therapy via Extracellular Vesicles by Zelada D, Saldivia N, Samano S, George D, Chaudhari K, Nguyen D, Simchuk D, Van Breemen RB, Givogri MI

“…Early intervention is critical to mitigate disease progression and limit neurological injury.Methods: To assess the therapeutic potential of early enzyme replacement therapy (ERT), HeLa cells were genetically engineered to overexpress GALC, and extracellular vesicles (EVs) containing GALC were isolated. …”
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Anti-Inflammatory Regulatory Role of Signal Transducer and Activator of Transcription 3 Phosphorylation in Regulating Hypersensitivity Responses to Echinococcus granulosus Hydatid... by Li SS, Zhou JR, Wang CS, Wang JL, Li YQ, Kulaixi X, Cao LW, Batesurong B, Ye JR

“…Shan-Shan Li,1,2,* Jing-Ru Zhou,3,* Chun-Sheng Wang,1,2 Jia-Ling Wang,1 Yu-Qian Li,1,2 Xilizati Kulaixi,1 Li-Wei Cao,1,2 Bayina Batesurong,1,2 Jian-Rong Ye1 1Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, 830054, People’s Republic of China; 2The First Clinical Medical College of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, 830054, People’s Republic of China; 3Department of Anesthesiology, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, 830063, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian-Rong Ye, Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan South Road, Urumqi, Xinjiang Uygur Autonomous Region, 830054, People’s Republic of China, Tel +86 18999938777, Email ywjianrongym@126.comObjective: This study aims to investigate the anti-inflammatory regulatory function of signal transducer and activator of transcription 3 (STAT3) phosphorylation in hypersensitivity responses triggered by Echinococcus granulosus hydatid cyst fluid through in vitro RBL-2H3 cell culture.Methods: RBL-2H3 cells were cultured in vitro and sensitized with immunoglobulin E (IgE), followed by intervention with STAT3 inhibitors Stattic and JSI-124. …”
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Prescription of essential medication during the final hospitalization of patients with heart failure or cancer by Valentina González-Jaramillo, Monika Hagemann, Lukas Hunziker, Maud Maessen, Steffen Eychmüller

“…Aim To assess the prescription frequency of each of the four medication types during the final hospitalization of patients with HF and compare it with the prescription frequency in patients with cancer (CA), considering both PC + and PC- patients in each disease group. Methods A retrospective cohort study included all patients dying in a tertiary hospital between 2016 and 2022. …”
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Indicators Of Morbidity And Mortality From Diseases of the Digestive System in the Krasnodar Krai and the Quality of Medical Care for Gastroenterological Patients by N. V. Korochanskaya, V. M. Durleshter, O. V. Kovalevskaya, S. N. Serikova, K. I. Popandopulo

“…To analyse the dynamics of morbidity and mortality from diseases of the digestive system, as well as the quality of medical care for gastroenterological patients in the Krasnodar Krai.Materials and methods. The analysis was carried out according to C 51 “Distribution of deaths by gender, age groups and causes of death” form of the Territorial Authority of the Federal State Statistics Service for the Krasnodar Krai for the period from 2006 to 2018, as well as on the basis of the “Demography” block database of the Parus software of the healthcare management system of the Krasnodar Krai for 6 months of 2019. 1341 medical records of patients receiving outpatient medical care and the medical records of people who had died from digestive diseases in 2017-2019 were reviewed.Results. …”
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Elucidating Molecule-Crosstalk of Neutrophil Extracellular Traps Between Cardiovascular Disease and Psoriasis: Insights Into Mendelian Randomization, Single-Cell RNA Analysis, Shar... by Jin X, Zhang Y, Qin G, Fang X, Zhang X, Sun J, Zhou M, Tong X, Xue Y, Yang H, Tian W

“…Neutrophil extracellular traps (NETs) are implicated in both conditions, but the mechanisms remain unclear.Methods: We integrated bulk and single-cell RNA sequencing, mendelian randomization, immune microenvironment analysis, and molecular docking to explore the molecular interactions between LVH and PSO, focusing on NET-related pathways. …”
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Impact of preoperative mild cognitive impairment on cerebrovascular events and cognitive status in patients undergoing coronary artery bypass grafting: data from 5-year follow-up by I. D. Syrova, O. A. Trubnikova, I. V. Tarasova, O. V. Maleva, S. E. Semenov, I. S. Lozhkin, O. L. Barbarash

“…To assess the incidence of cerebrovascular events and cognitive status in the long-term period after coronary artery bypass grafting (CABG) in patients with and without preoperative mild cognitive impairment (MCI).Material and methods. This prospective study involved 115 patients aged 45 to 69 years, who were admitted to the hospital for elective on-pump CABG. …”
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Long-Term Administration of Anthraquinone Rhein on Induction of Constipation in Sprague-Dawley Rats via SCF/c-Kit Signaling Pathways by Bo Zhang, Mingdong Huo, Zhicheng Chen, Feng Gao, Yan Liu, Xingxin Zhou

“…Herein, we aimed to investigate the long-term stimulation of rhein on induction of constipation in rats and its underlying mechanisms. Materials and Methods. After establishing rat models of constipation, the rats were randomly divided into two equal subgroups and administered daily with normal saline (model control group) or 10 ml/kg PEG4,000 (PEG-treated group). …”
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Profile of the geriatric patient hospitalised at Universitas Hospital, South Africa by Anna M. van Staden, Dirk J.V. Weich

“…Thus, there is an urgent need for profiles of elderly patients in order for adequate training to be implemented and for beds and equipment to be ready when needed. Methods: A retrospective study was undertaken of all data available from a clinical audit done at Universitas Hospital's Geriatric Unit. …”
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Preoperative chronic opiate use associated with a worse joint-specific function and quality of life before and after total hip and knee arthroplasty by Eliott S. Martinson, Nick D. Clement, Deborah J. MacDonald, Chloe E. H. Scott, Colin R. Howie

“…Aims: The aim of this study was to assess whether chronic pre-arthroplasty use of strong opiates impacted the pre- and postoperative joint-specific function, quality of life (QoL), pain scores, and satisfaction in those undergoing total hip arthroplasty (THA) or total knee arthroplasty (TKA). Methods: This prospective study assessed 1,487 patients (THA n = 729; TKA n = 758). …”
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Novel Obstetric Air Cushion for the Prevention of Hypotension During Spinal Anesthesia for Cesarean Section: A Randomized Controlled Clinical Trial by Dong Y, Cao WW, Weng H, Liu R, Huang DD

“…We assessed the effect of a novel obstetric air cushion pretreatment on the incidence of hypotension after spinal anesthesia.Patients and Methods: Eighty parturients were randomly assigned to the air cushion or blank control group (Group A or B, respectively). …”
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Prognostic Value of the Triglyceride-Glucose Index Combined with Non-HDL-C/HDL-C Ratio for Predicting Coronary Microvascular Dysfunction in ACS Patients Post-PCI by Hang S, Tang N, Li K, Zhang Q, Hao J, Zhang Y, Qi C

“…This study aimed to evaluate the combined predictive value of the triglyceride-glucose index (TyG) and non-HDL-C/HDL-C ratio (NHHR) for CMD in ACS patients post-PCI.Methods: A retrospective analysis of 542 ACS patients undergoing PCI (2021– 2023) was conducted. …”
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Impact of root canal shaping using TruNatomy on postoperative pain and operative torque generation: a randomized clinical trial by Tarek Ali Al-Mosalmy, Heba Maged El-Far, Madiha Mahmoud Gomaa, Dina Ahmed Morsy

“…Aim To compare the effect of canal shaping using TruNatomy (TN) rotary system to RaCe (RC) rotary system on post-operative pain in necrotic maxillary bi-rooted premolars, while simultaneously inspecting the real-time dynamic forces produced during instrumentation. Methods In this parallel group superiority trial, following power calculation, 40 patients diagnosed with pulp necrosis in asymptomatic bi-rooted maxillary premolars were recruited and randomly allocated into two equal groups (n = 20) according to the instrumentation system used. …”
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PANoptosis-Relevant Subgroups Predicts Prognosis and Characterizes the Tumour Microenvironment in Ovarian Cancer by Chen Y, Deng Z, Chen J, Lin J, Zou J, Li S, Sun Y

“…However, its prognostic relevance in OC remains unclear.Methods: Utilizing data from The Cancer Genome Atlas (TCGA), we analyzed transcriptomic and clinical signatures of OC patients. …”
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A randomised trial to compare the safety, tolerability and efficacy of three drug combinations for intermittent preventive treatment in children. by Kalifa Bojang, Francis Akor, Ousman Bittaye, David Conway, Christian Bottomley, Paul Milligan, Brian Greenwood

“…<h4>Methods</h4>During the 2007 malaria transmission season, 1008 Gambian children were individually randomized to receive SP plus amodiaquine (AQ), SP plus piperaquine (PQ) or dihydroartemisinin (DHA) plus PQ at monthly intervals on three occasions during the peak malaria transmission season. …”
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Physical development and sociocultural context influences on children’s physical activity by Alessandro Hervaldo Nicolai Ré, Maria Teresa Cattuzzo, David Stodden, Guilherme dos Santos, Albert Lucas Olinto Tertuliano, Carlos Bandeira de Mello Monteiro, Diogo Henrique Constantino Coledam, Anthony David Okely

“…Abstract Objective: To examine the predictive strength of cardiorespiratory fitness (CRF), motor competence (MC), maternal educational status, and parental perception of their children’s favorite leisure activities for meeting physical activity (PA) guidelines of each gender among children aged 3–6 years. Methods: This is a cross-sectional study with 367 preschoolers (53% girls), assessing CRF (PREFIT 20m shuttle run), MC (battery of motor skills), PA (accelerometry), maternal education and parental perception of children’s preferred leisure (questionnaires). …”
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Determination of administered activities for the treatment of Graves' disease with iodine-131: Proposition of a simplified dosimetric procedure by Idrissa Adamou Soli, Djibrillou Moussa Issoufou, Skander Rahabi, Ada Ali, Eric Adehossi, Salah Eddine Bouyoucef

“…Empirical determination of activity in the treatment of GD gives higher activities (1.5 times) to patients than dosimetric methods based on the determination of extrapolated effective half-life.…”
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Increased Stress Hyperglycemia Ratio Predicts Poor Clinical Outcome in Critically Ill COPD Patients: A Retrospective Study by Qiao M, Yang H, Qin M, Li Y, Wang H

“…The present study aimed to investigate the relationship between SHR and adverse clinical outcomes in critically ill COPD patients.Methods: A total of 1,580 patients diagnosed with COPD were included in this retrospective cohort study. …”
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Awareness, Beliefs, and Psychological Impact of Patients with Alopecia Areata in Saudi Arabia: A Multi-Center Study by Almulhim NA, Alojail HY, Aljughayman MA, Almarri FH, Alsultan NH, Albash LA, Almukhaimar SK, Alkhamis AA, Albaqshi MA, Alkhawajah AA

“…This study aims to assess the awareness, beliefs, and psychological impact of patients with Alopecia Areata.Patients and Methods: This cross-sectional study was conducted in Eastern and Central provinces of Saudi Arabia and utilized online questionnaires to evaluate knowledge, beliefs, and psychological effects of patients with Alopecia Areata. …”
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OBJECTIVE ACCOMMODATION RESPONSE VALUE (COMPLETENESS OF CYCLOPLEGIA) AFTER DIAGNOSTIC INSTILLATIONS OF DIVERSE MEDICATIONS by N. A. Tarasova, E. P. Tarutta, G. A. Markosian, M. V. Maksimova

“…Purpose: to compare the extent of cycloplegia by residual accommodation response after instillations of various medications. Materials and methods. 54 patients, aged 8 to 23, with varied degrees of myopia were instilled twice, with an interval of 10 minutes, with one of the following medications: Cyclopentolate 1 %, Tropicamide 1 %, Midrimax, and Phenylephrine 2.5 %. …”
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