Characterization of a Novel Sequence Type (ST) 6758 Klebsiella Pneumoniae and the Role of IncX3 Plasmid in the Transmission of blaNDM by Zhang Y, Li Q, Li L, Guo H, He F

“…In this study, we report a novel sequence type 6758 of K. pneumoniae harboring the blaNDM-1 gene.Material and Methods: Antimicrobial susceptibility testing was conducted according to the guidelines of the Clinical and Laboratory Standards Institute (CLSI). …”
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Possibilities of transition of the strategy from glucosecentricity to organoprotection when prescribing antidiabetic drugs in patients with type 2 diabetes mellitus in the perimena... by V. V. Smirnov, Yu. B. Semenova, A. B. Shapovalova, N. N. Matveeva, V. A. Zubarev

“…In this article, we examined the possibility of using various groups of incretinomimetics (DPP-4 inhibitors and GLP-1 agonists) in the primary prevention of cardiovascular diseases in patients with type 2 diabetes mellitus in perimenopause, and comparing their effects with traditional metformin therapy.The aim of the study was to evaluate the effect of non – insulin antidiabetic drugs from the class of incretinomimetics on risk factors for the development of cardiovascular diseases in patients with type 2 diabetes mellitus in perimenopause.Object and methods. A dynamic examination of three groups of patients was carried out. …”
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Influencing Factors of Disordered Eating Behavior Among Chinese University Students: The Moderating Role of Physical Activity in the Body Status Chain Mediation Model by Ma C, Chen BC, Chen MY

“…Cheng Ma,1,* Bo-Ching Chen,2,* Mei-Yen Chen3 1Department of Physical Education, University of Shanghai for Science and Technology, Shanghai 200093, People’s Republic of China; 2Undergraduate Program of Sports Coaching, CTBC Business School, Tainan 709301, Taiwan; 3Graduate Institute of Sport, Leisure and Hospitality Management, National Taiwan Normal University, Taipei 106308, Taiwan*These authors contributed equally to this workCorrespondence: Mei-Yen Chen, Email meiyen686@gmail.comPurpose: To explore the impact and mechanism of weight status on the disordered eating behavior of university students, this study conducted a moderated chain mediation model based on the Escape Theory and the Strength Model of Self-Control.Methods: This was a cross-sectional online study conducted at a university in Shanghai. …”
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Accounting for racial bias and social determinants of health in a model of hypertension control by Yang Hu, Nicholas Cordella, Rebecca G. Mishuris, Ioannis Ch. Paschalidis

“…This study aims to identify patients with not well-controlled hypertension using readily available demographic and socioeconomic features and elucidate important predictive variables. Methods In this retrospective cohort study, records from 1/1/2012 to 1/1/2020 at the Boston Medical Center were used. …”
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AIM2-Driven Inflammation in Periodontitis: Mechanisms and Systemic Implications by Fan Z, Chen R, Xie X, Chen Z, Yang D, Hao C, Wang S

“…This study investigates the role of AIM2, a key inflammasome component, in periodontitis, focusing on its involvement in inflammation, DNA repair, and systemic disease links.Methods: AIM2 expression was analyzed in saliva and gingival crevicular fluid (GCF) from periodontitis patients. …”
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The characteristics of peripheral blood lymphocyte main subsets in rheumatoid arthritis patients concurrent with hepatitis b virus infection: a retrospective cohort study by Lijia Shao, Lihong Shen, Junqi Wu

“…This study aims to investigate the impact of Hepatitis B virus (HBV) infection on the distribution of peripheral blood lymphocyte subsets in patients with Rheumatoid Arthritis (RA). Methods Two hundred ninety-eight patients were recruited from a retrospective cohort of patients with RA. …”
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A Prospective Study for the Assessment of Frailty in Elderly Chronic Kidney Disease Patients by Narinder Pal Singh, Mohd Qasim Khan, Pankaj Nand Choudhary, Anish Kumar Gupta, Shaurya Kaul

“…Hence, the aim of the present study was to find out the occurrence of frailty in elderly patients with CKD. Methods: The present prospective cross-sectional study was conducted from an outpatient clinic of a tertiary care hospital. …”
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Performance of Four Screening Tools for Identifying Obstructive Sleep Apnea Among Patients with Insomnia by Shi C, Wang Y, Luo J, Huang R, Xiao Y

“…This study aims to validate the performance of four commonly used OSA screening tools among individuals with and without insomnia.Participants and Methods: A cross-sectional survey was conducted in individuals with suspected OSA referred for sleep studies from December 2021 to December 2023. …”
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A 3D Printing-Based Transcatheter Pulmonary Valve Replacement Simulator: Development and Validation by Yuanzhang Liu, Yu Mao, Yiwei Wang, Ping Jin, Mengen Zhai, Yang Liu, Jian Yang

“…The purpose of this study was to use the TPVR simulator to help doctors improve their surgical skills by simulating the surgical process in vitro. Methods: The TPVR simulator was developed using three-dimensional (3D) printing technology under computer-aided design. …”
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Effect of Pomegranate Juice and Sildenafil on Intrauterine Growth Retardation: A Randomized Controlled Trial by Khadijeh Nasri, Fatemeh Ghaedi, Fatemeh Safi, SeyedAmirhossein Latifi, Amir Almasi-Hashiani

“…Therefore; this study aimed to compare the effect of pomegranate juice and sildenafil on Doppler ultrasound findings, Apgar score and fetal estimated weight (FEW) in cases with intrauterine growth retardation (IUGR).Materials and Methods: This randomized clinical trial conducted on a population of naturally pregnant women with IUGR in Arak city (Arak, Iran) during October 2021 to January 2022. …”
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Urban slum housing quality, and its public health implications in Nigeria: a case of urban slum residents in Enugu metropolis, South East, Nigeria by Salomey N. Ogbonna, Casmir N. Ochie, Elias C. Aniwada

“…This study assessed the housing conditions of the slums of Enugu metropolis and the public health implications. Methods This is a community-based cross-sectional study of 459 slum residents of the Enugu metropolis. …”
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Polyethylenimine-Conjugated Au-NPs as an Efficient Vehicle for in vitro and in vivo DNA Vaccine Delivery by Kartouzian A, Heiz A, Shameli K, Moeini H

“…Aras Kartouzian,1 Alexandra Heiz,1 Kamyar Shameli,2,* Hassan Moeini3,* 1Catalysis Research Center, School of Natural Sciences, Technical University of Munich, Munich, Germany; 2Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany; 3Iguana Biotechnology GmbH, Munich, Germany*These authors contributed equally to this workCorrespondence: Kamyar Shameli; Hassan Moeini, Email kamyarshameli@gmail.com; moeini82@yahoo.comPurpose: This study aimed to develop green-synthesized gold nanoparticles (Au-NPs) conjugated with polyethyleneimine (PEI) to overcome challenges in intracellular DNA vaccine delivery, focusing on enhancing cellular uptake and immune responses against the human norovirus (HuNoV) GII.4 variants.Methods: Au-NPs were synthesized using a citrate-ion-mediated green approach, with size and morphology analyzed via UV-vis spectroscopy and transmission electron microscopy (TEM). …”
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Impact of Jordanian Pharmacists’ Knowledge of the Human Microbiome: Has the Practice of Antibiotics and Probiotics Dispensing Been Affected? A Cross-Sectional Study by Sawan HM, Shroukh W, Abutaima R, Al Omari SM, Abdel-Qader DH, Binsuwaidan R

“…Hana M Sawan,1 Wejdan Shroukh,2 Rana Abutaima,3 Shatha M Al Omari,1 Derar H Abdel-Qader,4 Reem Binsuwaidan5 1Pharmaceutical Sciences Department, Faculty of Pharmacy, Zarqa University, Zqrqa, Jordan; 2Faculty of Pharmacy, Middle East University, Amman, Jordan; 3Faculty of Pharmacy, Zarqa Private University, Zarqa, Jordan; 4Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan; 5Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi ArabiaCorrespondence: Hana M Sawan, Email habusawan@zu.edu.joObjective: This study aimed to assess Jordanian pharmacists’ knowledge of the human microbiome and the impact of their knowledge on their attitudes and practices toward antibiotics and probiotics.Methods: A self-administered survey was designed after reviewing the literature. …”
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Association of Six Complex Inflammatory Indicators with Prognosis in Patients with Intravenous Thrombolysis Stroke by Li Y, Xi L, Sun H, Yu F, Liang Q, Qie T, Dai B

“…Yinglei Li,1,* Lingyun Xi,2,* Haichuan Sun,1 Feifei Yu,1 Qing Liang,1 Tao Qie,1 Bing Dai1 1Department of Emergency Medicine, Baoding NO.1 Central Hospital, Baoding, People’s Republic of China; 2Department of Laboratory and Pathology, The Hospital of 82nd Group Army PLA, Baoding, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bing Dai, Department of Emergency Medicine, Baoding NO.1 Central Hospital, Baoding, People’s Republic of China, Email 447023235@qq.comObjective: The objective of this study is to examine the correlation between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune inflammation index (SII), systemic inflammation response index (SIRI) and pan-immune-inflammation value (PIV) with the outcome following 3 months of thrombolysis in individuals diagnosed with acute ischemic stroke.Methods: A retrospective analysis was conducted on a cohort of 762 patients who received intravenous thrombolysis between January 2019 and December 2022. …”
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Nudging Health Behavior Change Among Home-Based Cardiac Rehabilitation Patients: A Scoping Review by Yang Z, Jin D, Huang H, Zheng X, Liu S, Wang A

“…The literature on nudging strategy is fragmented and lacks comprehensive reviews.Objective: This study aimed to identify nudging interventions to promote health behavior change among patients undergoing home-based cardiac rehabilitation, focusing on the scope, characteristics and delivery.Methods: A scoping review was conducted from July to September 2023, during which databases including PubMed, Web of Science, and OVID (Embase, Cochrane Library, JBI) were searched. …”
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The Dose-Dependent Effects of Fluorocitrate on the Metabolism and Activity of Astrocytes and Neurons by Huiling Zhuang, Deliang Yuan, Fuxiu Shi, Xujun Wu, Zhen Luo, Wenbiao Gan

“…Whether FC at such concentrations may affect neuronal metabolism and function <i>in vivo</i> remains unclear. Methods: We examined the effects of FC on the ATP levels and Ca²⁺ activity of the astrocytes and neurons in the motor cortices of living mice using two-photon microscopy. …”
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Acupuncture Ameliorates Alzheimer&rsquo;s-Like Cognitive Impairment and Pathological Changes via Regulating the Intestinal Fungal Community in APP/PS1 Mice by Hao X, Ding N, Zhang Y, Wu M, Tao Y, Li Z

“…However, the potential regulatory effects of acupuncture on the fungal microbiota have been largely overlooked.Methods: APP/PS1 mice were used as AD animal model and randomly divided into the AD model (AD) group, the acupuncture (Ac) group, and the probiotics (Pr) group. …”
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Screening results correlating to personality disorder traits in a new employee population of People&amp;#39;s Republic of China by Tan Y, Liu Y, Wu L

“…To understand the current mental status and further improve the mental health level of the new employee population of People&amp;rsquo;s Republic of China, we conducted a cross-sectional study to screen the prevalence and correlates of personality disorder (PD) traits in this population.Methods: This study included all male participants who were new employees (those who had started working in approximately the last three months) from 12 machinery factories in People&amp;rsquo;s Republic of China. …”
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Identifying Key Prognostic Indicators for Relapse and Chronic Epilepsy in Autoimmune Encephalitis: Insights from a Multicenter Retrospective Study by Lai Q, Chen Y, Wang W, Lian Z, Liu T, Wen C

“…Qingwei Lai,1,&ast; Yue Chen,1,&ast; Wei Wang,2,&ast; Zhangxu Lian,3,&ast; Tengfei Liu,4 Chunmei Wen5 1Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of China; 2Department of Neurology, Yancheng First People’s Hospital, Yancheng, People’s Republic of China; 3Department of Neurology, Xuzhou Central Hospital, Xuzhou, People’s Republic of China; 4Department of Neurology, Xuzhou Mining Group General Hospital, Xuzhou, People’s Republic of China; 5Department of Neurology, Yancheng Third People’s Hospital, Yancheng, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qingwei Lai, Department of Neurology, Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, Jiangsu, 221002, People’s Republic of China, Tel +8651685802193, Email lqw8696@163.comObjective: The aims of this study were to investigate clinical factors associated with encephalitis relapse and chronic epilepsy development, and to evaluate the effectiveness of immunotherapy on encephalitis relapse.Methods: Patients with autoimmune encephalitis diagnosed as positive for neuronal surface antibodies in five general hospitals were included. …”
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Strategic Optimization of Nanoparticle Characteristics to Enhance Tumor Targeting and Doxorubicin Delivery by Lee YJ, Hong J, Seo BY, Lee BH, Sarangthem V, Park RW

“…To improve its specificity and therapeutic efficacy, multivalent targeting strategies are being developed.Methods: A chimeric polypeptide consisting of an elastin-like polypeptides (ELP) copolymer with a repeating IL-4 receptor-specific targeting peptide, AP-1, and a (GGCGSCGSC)2 sequence encoding 6 cysteine residues (C6) at the carboxyl-terminus for Dox conjugation was designed. …”
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