Neutrophil Extracellular Traps and Endometriosis: Insights from a Case-Control Study by Xu Z, Ji R, Wang M, Li T, Hu H

“…Therefore, this study aimed to explore the potential link that exists between NETs and endometriosis.Methods: A total of 190 patients were selected and divided into control and endometriosis groups (95 patients each) based on inclusion and exclusion criteria. …”
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Rational Analysis of the Utilization of Pentoxifylline in a Tertiary Hospital: Central Hospital Affiliated to Shandong First Medical University by Zheng Y, Yin Y, Liu H, Gao W, Wang Q

“…Yuanyuan Zheng,1,2,* Yanhui Yin,1,* Hong Liu,3 Wenwen Gao,1 Qian Wang1 1Department of Pharmacy, Central Hospital Affiliated to Shandong First Medical University, Jinan, 250013, People’s Republic of China; 2The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, People’s Republic of China; 3Department of Pharmacy, Laiwu District People’s Hospital, Jinan, 271100, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qian Wang, Department of Pharmacy, Central Hospital Affiliated to Shandong First Medical University, No. 105 Jiefang Road, Lixia District, Jinan City, Shandong Province, 252213, People’s Republic of China, Email 13165131021@163.comObjective: This study aimed to evaluate the rational use, safety, and economic implications of pentoxifylline in a hospital setting and provide recommendations for its appropriate clinical application.Methods: A retrospective analysis was conducted on 322 patients discharged from September to December 2020, who received pentoxifylline. …”
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Novel Composite Scoring System for Predicting Prognosis in Stage IV Gastric Cancer Patients Treated with Immune Checkpoint Inhibitors by Yang L, Li H, Xia M, Pu X

“…This study aimed to identify effective prognostic markers that can predict the treatment effect of ICIs in patients with stage IV GC.Methods: This study included 256 patients with GC with distant metastases who had received treatment with ICIs. …”
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Comparative analysis of various clinical specimens in detection of SARS-CoV-2 using rRT-PCR in new and follow up cases of COVID-19 infection: Quest for the best choice. by Kuldeep Sharma, Pragya Aggarwala, Deepa Gandhi, Anuniti Mathias, Priyanka Singh, Somya Sharma, Sanjay Singh Negi, Anudita Bhargava, Padma Das, Ujjwala Gaikwad, Archana Wankhede, Ajoy Behra, Nitin M Nagarkar

“…Thus, it's pertinent to evaluate various diversified clinical specimens' diagnostic utility in both diagnosis and follow-up of COVID-19.<h4>Methods</h4>A total of 924 initial specimens from 130 COVID-19 symptomatic cases before initiation of treatment and 665 follow up specimens from 15 randomly selected cases comprising of equal number of nasopharyngeal swab (NPS), oropharyngeal swab (OPS), combined NPS and OPS (Combined swab), sputum, plasma, serum and urine were evaluated by rRT-PCR.…”
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Relationship Between Postoperative Oxidative Stress Levels and Corneal Endothelial Cell Loss After Phacoemulsification in Diabetic Patients with Cataract by Gao Y, Yang N, Wei L, Yan Y, Li L

“…Yuan Gao,&ast; Ning Yang,&ast; LiJuan Wei, YiJie Yan, Lei Li Department of Ophthalmology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City, Hainan Province, 570311, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lei Li, Department of Ophthalmology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), No. 19 Xiuhua Road, Xiuying District, Haikou City, Hainan Province, 570311, People’s Republic of China, Email dr.li123lilei@outlook.comObjective: To investigate the relationship between postoperative oxidative stress and corneal endothelial cell loss in diabetic patients with cataract.Methods: One hundred and twenty patients who underwent phacoemulsification were selected, including 80 diabetic patients with cataract and 40 patients with ordinary cataracts. …”
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ATP6V1A deletion leads to impaired clearance of septic cardiac resident macrophages by YANG Shunxin, ZHOU Yuanqun, XIANG Xinming

“…Objective To investigate the clearance capacity of cardiac resident macrophages in post-sepsis and its underlying mechanism. Methods A mouse model of sepsis was established using cecum perforation ligation. …”
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Identifying KL-6-Associated Immune Cell Signatures and Key Genes in Emphysematous COPD by Xiao X, Guo W, Li N, Chen N, Zhang Q

“…Xinru Xiao,1,&amp;ast; Wenwen Guo,1,&amp;ast; Na Li,1 Nuo Chen,1 Qian Zhang1,2 1Department of Respiratory and Critical Care Medicine, The Second People’s Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, 213003, People’s Republic of China; 2Changzhou Medical Center, Nanjing Medical University, Changzhou, 213003, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Qian Zhang, Email qianzhang@njmu.edu.cnBackground: This study aimed to evaluate the potential of Krebs von den lungen-6 (KL-6) as a biomarker for distinguishing emphysematous chronic obstructive pulmonary disease (COPD-E) from non-emphysematous COPD (COPD-NE), and to explore the underlying mechanisms associated with KL-6 expression.Methods: We enrolled 154 patients with COPD and 170 healthy controls to assess serum KL-6 levels. …”
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Ambivalent User Needs as a Challenge and Chance for the Design of a Web-Based Intervention for Gaming Disorder: Qualitative Interview Study With Adolescents and Young Adults by Birte Linny Geisler, Kay Uwe Petersen, Sara Hanke, Simon Schurer, Anne Schreiber, Christine Lämmle, Anil Batra, Tobias Renner, Isabel Brandhorst

“…ObjectiveThe aim of this study was to explore the treatment needs of young people with GD in Germany and derive implications for the development of a self-guided WBI for GD. MethodsUsing a qualitative study design, we conducted a focus group with 3 young male adults and semistructured individual interviews with 3 male adolescents. …”
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Beliefs about COVID-19 testing and treatment: A national survey of Black and White adults by Laura A. Siminoff, K. Laura Barker, Ryan Blunt, Diana Litsas, Gerard P. Alolod, Jay S. Patel

“…Study design: Cross-sectional structured survey. Methods: Respondents were randomly selected from an opt-in national panel in December 2022. …”
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TRIB3 Is a Hub Gene in Steatohepatitis and Aggravates Lipid Deposition and Inflammation in Hepatocytes by Xia W, Xiao L, Cheng H, Feng Y

“…Wen Xia,1,&ast; Li Xiao,1,&ast; Huan Cheng,1 Yuwei Feng2 1Department of Cardiovascular Medicine, Wuhan No.1 Hospital, Wuhan, Hubei, People’s Republic of China; 2Department of Hepatology with Integrated Traditional Chinese and Western Medicine, Hubei No.3 People’s Hospital of Jianghan University, Wuhan, Hubei, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yuwei Feng, Department of Hepatology with Integrated Traditional Chinese and Western Medicine, Hubei No.3 People’s Hospital of Jianghan University, &num;26 Zhongshan Avenue, Wuhan, 430022, People’s Republic of China, Tel +86-27-85332356, Email fengyw92@163.comBackground: Non-alcoholic fatty liver disease (NAFLD), also known as Metabolic dysfunction–associated fatty liver disease (MASLD), has become one of the most common chronic liver diseases worldwide, approximately 30% of adults and 70%~80% of patients with obesity and diabetes suffer from NAFLD.Objective: We attempted to find a potential hub gene in NAFLD hepatocyte cell model induced by palmitic acid and oil acid (PAOA), and investigated the function of the hub–gene.Methods: We searched and downloaded the GSE122660 dataset from GEO-DataSets, and differentially expressed genes (DEGs) were analyzed using R software. …”
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Apixaban versus enoxaparin to prevent venous thromboembolism in post-operative patients with gynecologic cancers at an urban academic medical center by Victoria Diamond, Katherine Gerber, Geno Merli, Rebecca Mercier, Aaron Shafer, Norman Rosenblum

“…Objective: A recent clinical trial demonstrated that the use of apixaban was safe and equal to enoxaparin (LMWH) in post-operative gynecologic oncology patients. …”
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Comprehensive Analysis of Multi-Omics Data on RNA Polymerase as an Adverse Factor in Head and Neck Squamous Cell Carcinoma by Gu YJ, Zhang J, Liu YJ, Zhang Q, Geng QF

“…While RNA polymerases (POLRs) have been implicated in various transcriptional mechanisms, their impact on the tumor microenvironment (TME) remains poorly understood.Methods: We analyzed publicly available pan-cancer cohorts to evaluate the expression and genomic alterations of POLRs. …”
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A Population Pharmacokinetics Study of Venetoclax Concomitant with Voriconazole in Patients with Hematologic Malignancies by Yang J, Wang H, Liu D, Cao W, Xing H, Wang P

“…This study aimed to develop a population pharmacokinetics (PopPK) model to characterize the PK properties of venetoclax when co-administered with voriconazole.Methods: Patients (≥ 18 years of age) treated with venetoclax for hematologic malignancies and concomitant with voriconazole were enrolled. …”
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Pressure makes diamonds? The impact of closed incision negative pressure wound therapy on complications following abdominoplasty in patients with massive weight loss—results from a... by Torsten Schulz, Toralf Kirsten, Katharina Theresa Vogel, Stefan Langer, Rima Nuwayhid

“…The objective of this research was to assess the influence of ciNPWT on post-operative wound complications in this demanding patient collective. Methods: We conducted a retrospective case-control study. …”
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Mechanical behavior of hybrid glenoid components compared to all‐PE components: a finite element analysis by Nicolas Bonnevialle, Julien Berhouet, Paul Pôtel, Jacobus Hendrik Müller, Shoulder Friends Institute, Arnaud Godenèche

“…The hypothesis was that, compared to all‐PE components, hybrid components yield lower bone and cement stresses with smaller micromotions. Methods Implant micromotions and cement and bone stresses were compared among 4 all PE (U‐PG, U‐KG, A‐KG, I‐KG) and 2 hybrid (E‐hCG, I‐hPG) virtually implanted glenoid components. …”
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Exploring Potential Causal Links: How Parkinson&amp;rsquo;s Disease Brain Damage Impacts Liver Health&amp;ndash;A Mendelian Randomization and Transcriptomic Study by Liu T, Chen Q, Wu H, Li J, Xian M, Lu K, Zhu C, Wei J

“…Clinical studies have demonstrated a close association between PD and liver disease, but most research has focused on the impact of liver disorders on brain damage in PD, and further exploration is needed to understand the pathways and mechanisms underlying liver damage in patients with PD.Methods: This study employs Mendelian Randomization (MR) and transcriptomic analysis to investigate the causal impact of PD-related brain damage on liver health, identifying serum metabolites (eg, cysteine) and shared immune-inflammatory pathways as mediators.Results: The study indicates that PD-related brain damage does indeed have an impact on liver metabolic function. …”
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Application and Analysis of Random Forest and Support Vector Classification in Risk Prediction of Childhood Obesity and Hyperuricemia by Wang Y, Shi S, Wei X, Wu Y, Shi Y, Cai J

“…Machine learning (ML) offers an effective framework for constructing efficient risk prediction models in pediatric populations.Objective: This study aimed to develop and evaluate two ML models—Random Forest (RF) and Support Vector Classification (SVC)—to predict the risk of childhood obesity and hyperuricemia by integrating clinical and biochemical variables.Methods: A total of 101 children were enrolled, including 60 with obesity and 41 with obesity plus hyperuricemia. …”
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Effects of Xuefu Zhuyu Decoction on Inflammatory Factors and the NF-kappaB Signaling Pathway in Rats Model of Radicular Pain by Liu X, Jiang T, Lu B

“…The rats in the treatment groups received different doses of XFZYD via oral administration, while the control and model groups received an equal volume of normal saline once daily for 7 days. …”
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Age and Sex Differences in Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis by Veronika A. Myasoedova, Alessio L. Ravani, Beatrice Frigerio, Donato Moschetta, Vincenza Valerio, Ilaria Massaiu, Mauro Amato, Damiano Baldassarre, Paolo Poggio

“…For this purpose, we analyzed the differences in cIMT, the impact of patient characteristics, and the influence of age on cIMT in men and women. Methods: A systematic search related to cIMT measured by an ultrasound and gender-specific differences was conducted according to the PRISMA 2020 guidelines. …”
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Male sexuality and the risk of developing benign prostatic hyperplasia and prostate cancer: is there a connection? by M. I. Kogan, M. E. Efremov, V. L. Medvedev, A. D. Anosov, T. P. Agapova, T. G. Sinyavskaya

“…To assess male sexuality (sexual constitution) as a potential risk factor for BPH or PCa.Materials &amp; methods. The study included 47 men (Group 1) aged 49 – 71 years with Lower Urinary Tract Symptoms (LUTS) caused by BPH, as well as 87 patients aged 47 – 70 years with a newly diagnosed PCa T 1c-3b N 0-1 M 0-1a. …”
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