Temporal association of neuropsychological test performance using unsupervised learning reveals a distinct signature of Alzheimer's disease status by Prajakta S. Joshi, Megan Heydari, Shruti Kannan, Ting Fang Alvin Ang, Qiuyuan Qin, Xue Liu, Jesse Mez, Sherral Devine, Rhoda Au, Vijaya B. Kolachalama

“…Neuropsychological (NP) testing is an attractive modality for screening early evidence of AD. Methods Longitudinal NP and demographic data from the Framingham Heart Study (FHS; N = 1696) and the National Alzheimer's Coordinating Center (NACC; N = 689) were analyzed using an unsupervised machine learning framework. …”
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Effects of music listening on anaerobic performance and motivation in healthy young adults by Luca Cavaggioni, Luca Cavaggioni, Damiano Formenti, Ibrahim Ouergui, Ibrahim Ouergui, David Perpetuini, Paolo Castiglioni, Paolo Castiglioni, Alessandro Berengan, Athos Trecroci, Luca Paolo Ardigò, Giampiero Merati, Giampiero Merati

“…IntroductionThe study aimed to investigate and confirm from a physiological and psychological perspective whether preferred music would influence anaerobic performance during the Running-Based Anaerobic Sprint Test (RAST).MethodsA total of 18 (men, n = 12, women, n = 6) sub-élite track-and-field and football athletes (mean age 22.2 ± 2.1 years, mean height 175.3 ± 8.0 cm, mean weight 66.4 ± 10.6 kg, mean BMI 21.5 ± 2.2 kg/m2) were voluntarily recruited. …”
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Population dynamics analysis of the interaction between tacrolimus and voriconazole in renal transplant recipients by Zhi-Hua Sun, Zhi-Hua Sun, Yi-Chang Zhao, Yi-Chang Zhao, Jia-Kai Li, Jia-Kai Li, Fenghua Peng, Feng Yu, Bi-Kui Zhang, Bi-Kui Zhang, Miao Yan, Miao Yan

“…This study aimed to establish a robust population pharmacokinetic model to explore the interaction between tacrolimus and voriconazole in greater depth.MethodsTacrolimus blood samples and laboratory data were prospectively collected from eligible patients enrolled between April 2023 and April 2024, following predefined inclusion and exclusion criteria. …”
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A Comparison of Oxycodone and Alfentanil in Intravenous Patient-Controlled Analgesia with a Time-Scheduled Decremental Infusion after Laparoscopic Cholecystectomy by Young Suk Kwon, Ji Su Jang, Na Rea Lee, Seong Su Kim, Young Ki Kim, Byeong Mun Hwang, Seong Sik Kang, Hee Jeong Son, So Young Lim

“…The aim of this study was to compare the analgesic and adverse effects of oxycodone and alfentanil on postoperative pain after laparoscopic cholecystectomy. Methods. This was a prospective, randomized, double-blind study. …”
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Optic Neuritis as Isolated Manifestation of Leptomeningeal Carcinomatosis: A Case Report and Systematic Review of Ocular Manifestations of Neoplastic Meningitis by Silvia Lanfranconi, Paola Basilico, Ilaria Trezzi, Linda Borellini, Giulia Franco, Vittorio Civelli, Francesco Pallotti, Nereo Bresolin, Pierluigi Baron

“…Ocular involvement is a common clinical manifestation and often the presenting clinical feature. Materials and Methods. We report the case of a 52-year old lady with optic neuritis as isolated manifestation of neoplastic meningitis and a review of ocular involvement in neoplastic meningitis. …”
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Comparison of the pH- and NH3-sensitivity of chitosan/polyvinyl alcohol smart films containing anthocyanins or betacyanins for monitoring fish freshness by Reza Abedi-Firoozjah, Shamimeh Azimi-Salim, Arvin Afrah, Mohammad Hadi Moradiyan, Elham Assadpour, Zahra Sarlak, Maryam Azizi-Lalabadi, Danial Dehnad, Seid Mahdi Jafari

“…In the Persian Gulf and Oman Sea, where silver pomfret (Pampus argenteus) is widely consumed, monitoring its freshness is highly important to guarantee its safety, quality, and economic value. Traditional methods of assessing seafood freshness are usually subjective or involve complicated lab analyses that can hardly be viable within a supply chain environment. …”
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Growth and development of two predator species fed a diet of genetically engineered mosquitoes by Claire M. Egan, Lisa Chamberland, Robert E. Ditter, Melina Campos, Fatima Batchelor, Aleena Bosky, Christine H. Coleman, Andrew J. Goffinet, Ariana Hosseini, Morgan Kammersgard, Brian Leetakubuulidde, Danspaid P. Mabuka, Ivan Mulongo Mugeni, Gregory C. Lanzaro

“…Predators consuming GEMs represent a group that interacts closely with these modified mosquitoes. Methods Here, we examine the effect of GEM and wild-type Anopheles coluzzii diets on the growth of two predator species: the aquatic mosquitofish (Gambusia affinis) and the terrestrial bold jumping spider (Phidippus audax). …”
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Preoperative Evaluation with fMRI of Patients with Intracranial Gliomas by Ioannis Z. Kapsalakis, Eftychia Z. Kapsalaki, Efstathios D. Gotsis, Dimitrios Verganelakis, Panagiotis Toulas, Georgios Hadjigeorgiou, Indug Chung, Ioannis Fezoulidis, Alexandros Papadimitriou, Joe Sam Robinson, Gregory P. Lee, Kostas N. Fountas

“…The purpose of our study was to evaluate fMRI’s accuracy by comparing it to intraoperative cortical stimulation (DCS) mapping. Material and Methods. Eighty-seven patients, with presumed glioma diagnosis, underwent preoperative fMRI and intraoperative DCS for cortical mapping during tumor resection. …”
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A Clinical Trial of Wrist-Ankle Acupuncture for Abirritation during High-Intensity Focused Ultrasound Treatment of Adenomyosis by Chenning Liu, Xiaoyang Lin, Yuhui Liu, Meiduo Zhao, Qiuxian Shen, Li Tang, Yanqin Wang, Xiaojuan Zhou, Huituan Liu, Hongjin Yu

“…The purpose of this research is to assess the efficacy of WAA for relieving pain during HIFU treatment of adenomyosis. Methods: Fifty-eight patients with adenomyosis treated with HIFU were enrolled in this study. …”
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Behavioural responses of common dolphins to naval sonar by Brandon L. Southall, John W. Durban, John Calambokidis, Caroline Casey, James A. Fahlbusch, Holly Fearnbach, Kiirsten R. Flynn, Selene Fregosi, Ari S. Friedlaender, Samantha G. M. Leander, Fleur Visser

“…Social delphinids occur in groups of hundreds of individuals that travel quickly, change behaviour ephemerally and are not amenable to conventional tagging methods, posing challenges in quantifying noise impacts. …”
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Wheat dwarf virus and its impact on the 2020 harvest in some regions of Ukraine by L. Mishchenko, A. Dunich, I. Mishchenko, A. Dashchenko, O. Boyko, O. Skufinskyi, A. Kyrychenko, N. Kozub, T. Mukha

“…Identify the virus that causes symptoms of dwarfism and non-earing of winter wheat (reduced or no ear formation), and investigate its effect on plant yields. Methods. Visual diagnostics, enzyme-linked immunosorbent assay in double sandwich modification (DAS-ELISA), polymerase chain reaction, biometric, determination of yield and its structure, statistical data processing. …”
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SuperCoT-X: Masked Hyperspectral Image Modeling With Diverse Superpixel-Level Contrastive Tokenizer by Miaomiao Liang, Weigang Wu, Huifang Shen, Lingjuan Yu, Xiangchun Yu, Licheng Jiao

“…Comprehensive experiments on five HSI datasets demonstrate that our proposed methods achieve favorable results and are competitive with other self-supervised approaches.…”
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Altered functional network topology and connectivity in female nurses with shift work sleep disorder by Hu-Cheng Yang, Hu-Cheng Yang, Si-Yu Gu, Shu-Fang Wang, Jian-Ping Liu, Shu Wang, Hai-Juan Chen, Li Chen, Chun-Mei Song, Qing-He Li, Zhen-Yu Dai, Ping-Lei Pan

“…However, the brain functional network topology, which provides a comprehensive map of the brain’s information processing architecture, remains partially understood in nurses with SWSD.Methods45 nurses with SWSD and 45 healthy controls (HCs) underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. …”
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Climate change and ocular health: temperature-pollution synergies amplify uveitis burden by Yue Tan, Yue Tan, Yue Tan, Yue Yin, Yue Yin, Yue Yin, Boya Lei, Boya Lei, Boya Lei, Min Zhou, Min Zhou, Min Zhou, Zhengyue Gu, Jingjing You, Tong Lin, Tong Lin, Tong Lin, Lan Gong, Lan Gong, Lan Gong

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A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children by Anna Nikula, Stefan Lundeberg, Malin Ryd Rinder, Mitja Lääperi, Katri Sandholm, Maaret Castrén, Lisa Kurland

“…The objective of this study was to evaluate whether intranasal dexmedetomidine could provide more effective analgesia and sedation during a procedure than intranasal esketamine. Methods This was a double-blind equally randomized (1:1) superiority trial of 30 children aged 1–3 years presenting to the Emergency Department with a laceration or a burn and requiring procedural sedation and analgesia. …”
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Parameters of radical resection in laparoscopic and open colon and rectal cancer surgery by Krdžić Igor, Kenić Marko, Šćepanović Milena, Soldatović Ivan, Ilić-Živojinović Jelena, Radovanović Dragan

“…The aim of this study was to determine whether laparoscopic approach provides all parameters of oncological radicality as open surgery of colorectal cancer. Methods. The study included 122 patients with carcinoma of colon and rectum, divided into two equal groups: patients operated on by laparoscopic and those operated on by open approach. …”
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Folate-Modified Smart Responsive Nanosystems for Enhancing Anti-Tumor Therapy Through Calcium Overload and Chemotherapy by Tang Y, Huang J, Cui C, Yang F, Li K, Gao B, Fu S, Yang X

“…Precise drug delivery via folate-modified nanomaterials is an important measure to improve efficacy and reduce toxicity.Methods: CaCO3 nanoparticles served as the carrier for loading DOX and 5-Fu, followed by encapsulation with folic acid-modified polydopamine (PDA) to form a smart dual drug-carrying nanosystem called FA-DCFP. …”
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Real-World Analysis of the Efficacy and Adverse Events of T-DM1 in Chinese Patients With HER2-Positive Breast Cancer by Gu H, Zhu T, Ding J, Yang Z, Qi S, Guo G

“…Huayan Gu,1,* Teng Zhu,2,* JiaLing Ding,1 Zhi Yang,1 Shuangyi Qi,1 Guilong Guo1 1Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China; 2Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guilong Guo, Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Wenzhou City, Zhejiang Province, People’s Republic of China, Email guoguilong@sina.comPurpose: This study efforts to explore the association of adverse events (AEs) with efficacy in HER2-positive breast cancer patients treated with TDM1.Methods and Materials: This retrospective study included women diagnosed with HER2+ BC treated with TDM1 from January 2012 to December 2023. …”
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CEREBROPROTECTIVE ACTIVITY OF NEW DERIVATIVES OF PIRIMIDINE4 1H ONE PIR9 AND PIR10 IN IRREVERSIBLE OCCLUSION OF THE COMMON CAROTID ARTERY by A. V. Voronkov, N. B. Shabanova, I. P. Kodonidi, I. S. Shatalov

“…The aim of this work is to study the cerebroprotective activity of the new derivatives of Pirimidine-4-(1H)-OHA PIR-9 and PIR-10 in irreversible occlusion of the common carotid artery. Materials and methods. The study was carried out on 120 male rats of the Wistar line, weighing 200-220 g, divided into 6 equal groups. …”
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Nerve Block Extends Nerve Function Recovery in Patients with Diabetic Foot Ulcers by Wei Q, Rong H, Zhang G, Xie Y, Dai W

“…The aim of this study is to investigate the minimum stimulation thresholds of the femoral and sciatic nerves, as well as the duration of nerve block, in patients diagnosed with diabetic foot.Methods: From July 2020 to March 2022, a prospective study was conducted involving patients aged 50– 80 scheduled for distal lower limb surgery. …”
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