Peptide vaccine targeting mutated GNAS: a potential novel treatment for pseudomyxoma peritonei by Ben Davidson, Kjersti Flatmark, Annette Torgunrud, Karianne G Fleten, Hedvig V Juul, Nadia Mensali, Christin Lund-Andersen, Else Marit Inderberg

“…Otherwise, rare activating mutations in the GNAS oncogene are remarkably frequent in PMP and the mutated gene product, guanine nucleotide-binding protein α subunit (Gsα), is a potential tumor neoantigen, presenting an opportunity for targeting by a therapeutic cancer vaccine.Methods Tumor and blood samples were collected from 25 patients undergoing surgery for PMP (NCT02073500). …”
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Astragalus in Acute Pancreatitis: Insights from Network Pharmacology, Molecular Docking, and Meta-Analysis Validation by Xingxin Cao, Suqin Duan, Aiyi Li, Zhanlong He

“…This study aims to systematically elucidate the active compounds and molecular mechanisms underlying Astragalus’ therapeutic effects in AP, and provide clinical evidence supporting its efficacy. (2) Methods: TCMSP and Swiss Target Prediction identified drug targets; GeneCards, DrugBank, and OMIM provided disease targets. …”
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Efficacy of Intravitreal Dexamethasone Implant (Ozurdex^®) in Naïve and Refractory Patients with Different Morphological Subtypes of Diabetic Macular Edema by Panagiotis Stavrakas, Evita Evangelia Christou, Vasileios Nasikas, Chrysoula Koutsiouki, Athanasios Vakalis, Solon Asteriadis, Georgios D. Panos, Paris Tranos

“…<i>Background and Objectives</i>: To investigate anatomical and functional outcomes in different morphological subtypes of diabetic macular edema (DME) treated with an intravitreal dexamethasone implant (Ozurdex) over 6 months follow-up. <i>Materials and Methods</i>: A retrospective, comparative study on patients with DME who received an intravitreal dexamethasone implant. …”
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Efficacy and safety of fluocinolone acetonide intravitreal implant (0.2 µg/day) in patients with post-surgical inflammation associated with macular edema: a case series study by Maria Madeira, Ana Cabugueira, Helena Urbano, Miguel Cordeiro, Marta Guedes

“…This study aimed to evaluate the effectiveness and safety of the fluocinolone acetonide intravitreal (FAc) implant (0.2 µg/day) in patients with refractory PCME. Methods Retrospective, non-interventional, and single center study conducted on patients with PCME treated with 0.2 µg/day FAc implant. …”
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Choroidal Characteristics in 3- to 16-Year-Old Chinese Patients, Measured by Swept-Source OCT/OCT Angiography by Jiali Wu, PhD, Ning Wang, PhD

“…Subjects: A total of 656 eyes (360 children) were included in this study, comprising 143 myopic eyes, 151 emmetropic eyes, and 362 hyperopic eyes. Methods: Ocular biometric measurements, including BCVA, AL, and spherical equivalent (SE) were recorded. …”
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A Hypertrophic Distal Fascicle of the Anterior Tibiofibular Ligament is Associated with a High Rate of Osteochondral Lesions of the Talus by James J. Butler MB BCh BAO, Grace W. Randall BS, Miki Dalmau-Pastor PhD, Charles Lin MD, Lauren Schoof MD, John G. Kennedy MD, MCh, MMSc, FFSEM, FRCS (Orth)

“…In addition, we sought to evaluate the anatomy of the ATiFL to fully elucidate its role in creating chondral wear of the talus. Methods: Retrospective chart review identified 40 patients who underwent arthroscopy of the anterior ankle joint for the management of anterior ankle impingement. …”
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Optical coherence tomography in the evaluation of structural changes in primary open-angle glaucoma with and without elevated intraocular pressure by Trenkić-Božinović Marija, Zlatanović Gordana, Jovanović Predrag, Veselinović Dragan, Đorđević-Jocić Jasmina, Radenković Marija, Resan Mirko

“…Methods. This prospective study included 38 patients (38 eyes) with primary open-angle glaucoma with normal intraocular pressure (NTG) and 50 patients (50 eyes) with primary open-angle glaucoma with elevated intraocular pressure (HTG), paired by the same degree of structural glaucomatous changes in the optic nerve head and by age. …”
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Role of Urokinase-Type Plasminogen Activator Receptor in the Regulation of Angiogenic Properties of Sca1+ Vasculogenic Progenitor Cells by К. V. Dergilev, Z. I. Tsokolaeva, I. B. Beloglazova, Yu. D. Vasilets, D. O. Traktuev, N. B. Kulbitsky, E. V. Parfenova

“…After acute ischemic injury, the accumulation of vasculogenic progenitor cells (8+2 and 27+7 cells per visual field, respectively; P = 0.032) and vascularization processes (85+11 and 166+25 capillaries per visual field, respectively; P = 0.033) were observed in myocardium of uPAR-/- animals, compared with wild-type animals. …”
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STRATEGI KOMUNIKASI PEMASARAN DAZZLE DALAM MENINGKATKAN BRAND AWARENESS MELALUI MEDIA SOSIAL INSTAGRAM @PROMODAZZLE by Auni Candra Trianaputri, Suranto Aw

“…This research uses qualitative methods with a descriptive approach. The data collection of this research were interview and documentation techniques. …”
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Comparative efficacy of photodynamic therapy (PDT), ranibizumab, aflibercept monotherapy, and combination therapies for polypoidal choroidal vasculopathy: a network meta-analysis o... by Miguel A. Quiroz-Reyes, Erick A. Quiroz-Gonzalez, Miguel A. Quiroz-Gonzalez, Virgilio Lima-Gomez

“…This systematic review and meta-analysis aimed to evaluate the effectiveness of combination treatments that include antivascular endothelial growth factor (anti-VEGF) agents, such as ranibizumab and aflibercept, along with photodynamic therapy (PDT), in comparison to monotherapy options for managing PCV. Methods A comprehensive literature search was performed in PubMed, Web of Science, and the Cochrane Library, following the PRISMA guidelines. …”
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Tracing Missing Surgical Specimens: A Quality Improvement Strategy for Adverse Events Based on Root Cause Analysis by Huang LL, Yang JH, Hong WW, Wang BL, Chen HF

“…This event underscored systemic vulnerabilities in specimen handling processes and catalyzed an investigation into how healthcare systems manage medical errors to uphold patient safety.Methods: Using root cause analysis (RCA), we dissected the workflow gaps and organizational factors contributing to the specimen loss. …”
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Neuroprotective Activity of Rasayana Formulation and Effect of Shigru Pallava Eye Drops on Intraocular Pressure as an Add-on Therapy Compared to the Standard of Care in Primary Ope... by Manjusha Rajagopala, Deenadayal Devarajan

“…Additionally, topical Arka (distilled extract) of Shigru Pallava (SP) has been used traditionally for glaucoma and may have an IOP-lowering effect. Methods This is an open-label, two-arm, parallel-group randomized controlled trial with a 2:3 (control: intervention) allocation ratio. …”
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New options for treating acute pain after laparoscopic cholecystectomy by O.V. Pylypenko, O.V. Kravets

“…The aim of our study was to compare and evaluate the effectiveness of postoperative pain control when using multimodal analgesia and when combining it with a right-sided QL block in patients with acute cholecystitis who underwent laparoscopic surgery. Materials and methods. We examined 62 patients with acute cholecystitis who underwent laparoscopic surgery. …”
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Åfficacy of nutraceutical drug in the intermediate and wet forms of age-related macular degeneration by E. N. Eskina, A. V. Belogurova, A. A. Gvetadze, A. S. Smorchkova

“…The effectiveness of nutraceutical drug containing oxycarotenoids, vitamins and trace elements, aimed at inhibiting the progression of the dry form of age-related macular degeneration (AMD) has been demonstrated in clinical studies.The purpose of this research is to evaluate the effectiveness of long-term use of a nutraceutical drug in reducing the risk of intermediate AMD evolving into wet AMD, and assess whether it is worth using in patients with wet AMD to reduce the average yearly number of intravitreal injections of angiogenesis inhibitors.Materials and methods. In the first part of the study, we monitored 46 patients with intermediate AMD threatening the progression of the disease (those with multiple confluent drusen, drusenoid, pigment epithelium detachment) for a year: some of them received the drug while others had no nutraceutical support. …”
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The clinical outcomes of lamellar keratomileusis in patients with human immunodeficiency virus positivity by Bo Mei, Yu Li, Dian Zhao, Dan Su, Chun-Yang Zhou, Yue-Hua Zhou

“…We sought to assess the safety, efficacy, predictability, and stability of lamellar keratomileusis in patients with HIV. Methods A study was conducted with 14 patients (28 eyes) HIV-positive patients at Ineye Hospital of Chengdu University of Traditional Chinese Medicine, who underwent lamellar keratomileusis. …”
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Analysis of retinal microstructure and electrophysiology in eyes following pars plana vitrectomy and membrane peeling for vitreomacular interface disorders by I-Hsien Chen, Meng-Syuan Li, Chia-Li Tseng, Hung-Pin Tu, Shwu-Jiuan Sheu

“…Abstract Purpose To investigate the relationship between retinal structural biomarkers using spectral-domain optical coherence tomography (SD-OCT) and macular function before and after surgery. Methods Forty-four eyes of 44 patients were included. …”
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The Vascular Architecture of Macular Neovascularization in Age-Related Macular Degeneration as a Predictor of Therapy Requirements: A 3-Year Longitudinal Analysis by Michael Grün, Kai Rothaus, Martin Ziegler, Clemens Lange, Albrecht Lommatzsch, Henrik Faatz

“…This study aimed to analyze the vascular characteristics of macular neovascularizations (MNVs) to identify potential biomarkers that could predict the required injection frequency throughout the disease course. <b>Methods:</b> In all patients, the initial diagnosis of nAMD was confirmed using optic coherence tomography (OCT), fluorescein angiography, and OCT angiography (OCTA). …”
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Indications and Outcomes of Intraocular Lens Explantation in a Tertiary Eyecare Center in Hungary between 2006 and 2020 by Márton Magyar, Nóra Szentmáry, László Ujváry, Gábor László Sándor, Frank Schirra, Zoltán Zsolt Nagy, Gábor Tóth

“…Our study aimed to evaluate the indications and outcomes of intraocular lens (IOL) explantation surgeries in a tertiary eyecare center in Hungary. Materials and Methods. This retrospective study included all IOL explantation surgeries performed between 2006 and 2020 at the Department of Ophthalmology of Semmelweis University, Budapest, Hungary. …”
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Effect of femtosecond laser-assisted cataract surgery for cataracts after pars plana vitrectomy: a prospective randomized controlled study by Lin Wen, Hao Lian, Yi Liu, Bin Wei, Yan Deng, Jianqi Hu, Ying Wu, Min Zhang, Yaoqin Fan, Li Xu

“…Abstract Objective To compare the efficacy of femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification surgery (CPS) in treating postvitrectomy cataracts. Methods Prospective randomized controlled study. Patients who underwent cataract surgery after pars plana vitrectomy (PPV) were randomly divided into the FLACS group and the CPS group. …”
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[Translated article] Subchondral bone damage has no influence in 12-week clinical outcome in patients with knee osteoarthritis treated with intraarticular platelet-rich plasma: A r... by R. Escribano Rey

“…Objective: To determine if subchondral bone damage can influence the clinical results of intraarticular platelet-rich-plasma (PRP) treatment in knee osteoarthritic patients. Material and methods: A retrospective review of patients treated with intraarticular PRP injections for knee osteoarthritis who previously underwent a magnetic resonance (MR) of the knee was performed. …”
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