Substance P- and Insulin-like Growth Factor 1-derived Tetrapeptides for Neurotrophic Keratopathy Related to Leprosy: A Clinical Trial by Shoko Kondo, MD, Yoshiko Okano, MD, PhD, Satoshi Iraha, MD, PhD, Shoji Tokunaga, PhD

“…Purpose: Neurotrophic keratopathy is part of the leprosy sequelae and causes progressive deterioration of visual acuity. Although leprosy is bacteriologically curable, there is currently no efficient treatment. …”
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Effect of Forbrain Cognitive Training Intervention Prescriptions Based on Risk Factors on Patients with Cognitive Impairment After Traumatic Brain Injury by ZHANG Xueru, WANG Hongbin, CUI Huiying, HAO Xijun, CHEN Changxiang

“…ObjectiveTo observe the effect of Forbrain cognitive training intervention prescriptions based on risk factors on cognitive function and activities of daily living in patients with cognitive impairment after traumatic brain injury (TBI).MethodsA total of 120 patients with cognitive impairment after TBI treated in Tangshan Workers' Hospital from October 2021 to May 2022 were randomly divided into control group, observation group 1 and observation group 2 according to Excel random function, with 40 cases in each group. …”
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Hydrophobic and Hydrophilic IOLs in Patients with Uveitis – A Randomised Clinical Trial by Pålsson S, Schuborg C, Sterner B, Andersson Grönlund M, Zetterberg M

“…Sara Pålsson,1,2 Claes Schuborg,2,3 Bertil Sterner,1,2 Marita Andersson Grönlund,1,4 Madeleine Zetterberg1,2 1Department of Clinical Neuroscience/Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 2Region Västra Götaland, Sahlgrenska University Hospital, Department of Ophthalmology, Mölndal, Sweden; 3Guldhedskliniken, Gothenburg, Sweden; 4Department of Ophthalmology, Faculty of Medicine and Health, Örebro University, Örebro, SwedenCorrespondence: Madeleine Zetterberg, Sahlgrenska University Hospital, Department of Ophthalmology, Mölndal, SE 431 80, Sweden, Tel +46 31 33 43 31 50, Fax +46 31 41 29 04, Email madeleine.zetterberg@vgregion.sePurpose: To compare inflammatory response, visual acuity, and complications of two intraocular lenses (IOLs) in patients with and without uveitis.Setting: Tertiary referral centre at Sahlgrenska University Hospital/Mölndal, Sweden.Design: Prospective randomised controlled trial.Patients and Methods: Patients with and without uveitis eligible for cataract surgery were randomised to receive a hydrophobic or a hydrophilic square-edged intraocular lens (IOL). …”
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Appropriate Use of Transesophageal Echocardiogram for Infective Endocarditis: A Single Center Experience by Robby Singh, Moumita Naidu, Yousef Bader, David Freeman, Marcel Zughaib

“…Using these criteria as a guide, we devised a quality assessment study to investigate how well TEEs performed at our institution fit the appropriate use criteria specifically for the diagnostic workup of infective endocarditis. Methods. A retrospective chart review was performed for all TEEs performed in 2017 with the indication of endocarditis. …”
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Functional and Anatomical Outcomes of Faricimab in Previously Treated Wet Age-Related Macular Degeneration: Systematic Review and Pooled Analysis by Ali Khodor, Jonathan T. Caranfa, Tavish Nanda, Raul E. Ruiz-Lozano, Manuel E. Quiroga-Garza, Stephanie Choi, Ali Chehab, Eugenia M. Ramos-Dávila, Jeffrey S. Heier, Chirag P. Shah, Andre J. Witkin

“…Methods The PubMed, Embase, and Google Scholar databases were searched for studies reporting outcomes of treatments for previously treated cases of wAMD. …”
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Identification of a Novel Subtype of Ocular Hypertensive Eyes with the Lowest Risk of Progression Under Treatment by Asma Poursoroush, Vida Abedi, Xiaoqin Huang, Jiang Li, Alireza Vafaei Sadr, Amy L. de Jongh Curry, Louis R. Pasquale, Michael V. Boland, Chris A. Johnson, Siamak Yousefi

“…Abstract Introduction Our aim in this work is to identify a subtype of ocular hypertensive eyes that benefited the most from topical hypertensive medication. Methods We included 1636 patients (817 patients in the active group and 819 in the observation group) who participated in the Ocular Hypertension Treatment Study (OHTS). …”
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Five-year Outcome of Aflibercept Administration with “Treat and Extend” for Neovascular Age-Related Macular Degeneration by Wada I, Oshima Y, Fukuda Y, Shiose S, Kano K, Ishikawa K, Nakao S, Kaizu Y, Hasegawa E, Kannan R, Ishibashi T, Sonoda KH

“…Although it subsequently declined, it sustained the initial visual acuity. The average macular thickness (CMT) was significantly reduced and maintained throughout the follow-up period. …”
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Comparison of Intravitreal Dexamethasone Implant and Ranibizumab in Vitrectomized Eyes with Diabetic Macular Edema by Jia-Kang Wang, Tzu-Lun Huang, Pei-Yao Chang, Wei-Ting Ho, Yung-Ray Hsu, Fang-Ting Chen, Yun-Ju Chen

“…This retrospective study aimed to compare the efficacy of intravitreal ranibizumab (IVR) and intravitreal dexamethasone implant (IDI) for pseudophakic vitrectomized eyes with diabetic macular edema (DME) in a single institution. Methods. Pseudophakic vitrectomized eyes with treatment-naïve center-involved DME were enrolled, with one eye in each patient. …”
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Dry Eye Cross-Sectional Study – Philippines: Comparison with the Asia Dry Eye Society Criteria and OCULUS Keratograph 5M Findings by Ruben Lim Bon Siong, MD, Bobbie Marie Santos, MD, Keshia Duyongco-Lenon, MD, Jessica Marie Abaño, MD, Reynaldo Santos, MD, Ivo John Dualan, MD

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Comparative Evaluation of the Effectiveness of Manual and Electric Toothbrushes in Blind Children: A Randomised Controlled Trial by PS Thanalakshme, R Ramesh

“…Materials and Methods: A randomised controlled clinical trial conducted at a high school for the blind in Palayamkottai, Tirunelveli district, Tamil Nadu, India on 120 blind chidren aged 6-12 years. …”
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Transitioning from Aflibercept to Biosimilar Ranibizumab in Diabetic Macular Edema (DME): (The TRANSFORM-DME Trial) a Multicenter Observational Study by Chakraborty D, Sinha TK, Maiti A, Boral SK, Das A, Mondal S, Nandi K, Bhattacharya R

“…Debdulal Chakraborty,1 Tushar Kanti Sinha,1 Aniruddha Maiti,2 Subhendu Kumar Boral,1 Arnab Das,1 Soumen Mondal,1 Krishnendu Nandi,3 Ranabir Bhattacharya1 1Department of Vitreoretinal Services, Disha Eye Hospitals, Kolkata, West Bengal, India; 2Department of Vitreoretinal Services, Global Eye Hospitals, Kolkata, West Bengal, India; 3Department of Vitreoretinal Services, Netralayam Superspeciality Eye Care, Kolkata, West Bengal, IndiaCorrespondence: Debdulal Chakraborty, Department of Vitreo-Retinal Services, Disha Eye Hospitals, Kolkata, West Bengal, India, Tel +91 33 6636 0000, Email devdc@rediffmail.comPurpose: To evaluate visual and anatomical outcomes following a switch from intravitreal Aflibercept (IVI AFL) (T1) to biosimilar Ranibizumab (B-RBZ) (T2) in patients with diabetic macular edema (DME).Methods: This was a multicenter observational study, analysing medical records of consecutive, treatment-naïve centre-involving DME patients having a baseline visual acuity (VA) of ≥ 55 Early Treatment Diabetic Retinopathy Study (ETDRS) letters. …”
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A study of the quality of life in patients with diverticular colon disease, after suffering attacks of diverticulitis by A. L. Levchuk, A. E. Abdullaev

“…The objective of the study was to evaluate the quality of life of patients with DCD after several episodes of exacerbations of the disease.Methods abd materials. A study was conducted with the participation of 110 patients treated at the State Clinical Hospital in Vladimir from 2019–2024 with DCD. …”
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Cross-sectional design and protocol for Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI) by Gerald McGwin, Linda M Zangwill, Nicholas Evans, Shannon McWeeney, Cecilia S Lee, Bhavesh Patel, Jeffrey C Edberg, Cynthia Owsley, Aaron Lee, Cecilia Lee, Sally L Baxter, Michael Snyder, Samantha Hurst, Nicole Ehrhardt, Christopher Chute, Dawn S Matthies, Julia P Owen, Amir Bahmani, Sally Baxter, Edward Boyko, Aaron Cohen, Jorge Contreras, Garrison Cottrell, Virginia de Sa, Jeffrey Edberg, Irl Hirsch, Michelle Hribar, T.Y. Alvin Liu, Bonnie Maldenado, Sara Singer, Bradley Voytek, Joseph Yracheta, Linda Zangwill

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Breaking Barriers to Better Care: A Narrative Review on the Adoption of Single-Fraction Palliative Radiotherapy for Bone Metastases in Low- and Middle-Income Countries by Erika Galietta, Costanza M. Donati, Maria Vadala’, Francesco Cellini, Von Kaganda Bomboka, Romina Rossi, Milly Buwenge, Tigeneh Wondemagegnehu, Biniyam Tefera Deressa, A.F.M. Kamal Uddin, Mostafa A. Sumon, Marco Maltoni, Alessio G. Morganti

“…However, barriers to single-fraction palliative radiotherapy adoption in low- and middle-income countries remain. Materials and Methods: This narrative review examines the barriers to single-fraction palliative radiotherapy adoption for bone metastases in low- and middle-income countries and explores possible solutions. …”
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Flash glucose monitoring system help reduce the frequency of hypoglycemia and hypoglycemic fear behavior in type 1 diabetes patients by Lining Dong, Junxian Li, Yanyun Hu, Ruoting Chai, Ye Zhu, Liying Zhu, Nengguang Fan, Zhijian Zhang, Jiemin Pan, Jinhua Yan, Fang Liu, Fang Liu

“…In order to more effectively identify and discriminate the occurrence of hypoglycemic events in patients with T1DM, this study aims to evaluate the impact of two distinct glucose monitoring systems—Flash Glucose Monitoring (FGM) and Continuous Glucose Monitoring (CGM)—on the management of blood glucose levels and the emotional responses associated with hypoglycemic episodes in individuals with T1DM.MethodIn this study, a total of 113 patients with type 1 diabetes mellitus were enrolled and allocated to two groups for the implementation of Glucose Monitoring Systems (GMS). …”
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‘Don't Assume, Ask’: A Collaboration With Consumers, Interpreters, Clinicians and Health Service Staff to Increase Video Telehealth in Culturally and Linguistically Diverse Groups... by Jaimon T. Kelly, Monica L. Taylor, Victor M. Gallegos‐Rejas, Susan Pager, Soraia de Camargo Catapan, Karen Lucas, Angel Bogicevic, Anthony C. Smith, Centaine Snoswell, Helen M. Haydon, Emma E. Thomas

“…ABSTRACT Objective We aimed to understand gaps in telehealth use across culturally and linguistically diverse (CALD) populations in a metropolitan Australian setting and elicit solutions to support inclusive telehealth‐delivered care. Methods Three workshops (one in‐person, two online) were conducted with purposefully recruited consumers (N = 6, including 2 who were also interpreters; representing six different language and cultural backgrounds) and clinical and nonclinical staff (N = 14) between July and October 2022. …”
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Association of exposure duration, modality, and polycythaemia with hyperuricaemia among han male immigrants at high altitudes: a cross-sectional study by Yanlin Zhu, Liwen Mo, Jie He, Xianglian Li, Yi Li, Dan Xiao, Huichang Jia, Jian Li, Fan Zhang, Yue Cheng

“…The correlations between different altitude exposure durations and exposure modalities with hyperuricaemia have not yet been reported.Methods In this cross-sectional study, qualified subjects were selected from two units on the Qinghai–Tibet Plateau and underwent a questionnaire survey (age, altitude exposure time, altitude exposure form), anthropometric measurements (body mass index [BMI], blood pressure [BP], and heart rate [HR]), and laboratory tests (white blood cell count [WBC], haemoglobin [HB], platelet count [PLT], and serum uric acid [SUA]). …”
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Computed Tomography-Based Radiomic Nomogram to Predict Occult Pleural Metastasis in Lung Cancer by Xiaoyi Zhao, Heng Zhao, Kongxu Dai, Xiangyu Zeng, Yun Li, Feng Yang, Guanchao Jiang

“…This study aimed to develop and validate a predictive model that integrates clinical information with chest CT radiomic features to preoperatively identify patients at risk of OPM. Methods: This study included 50 patients diagnosed with OPM during surgery as the positive training cohort and an equal number of nonmetastatic patients as the negative control cohort. …”
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Feasibility and efficacy of a multicomponent exercise medicine programme in patients with pancreatic cancer undergoing neoadjuvant therapy (the EXPAN trial): study protocol of a du... by Hao Luo, Robert U Newton, Daniel A Galvão, Dennis R Taaffe, Andrew Dean, Nigel Spry, Colin Tang, Kevin Jasas, Mikael Johansson, Ian Yusoff

“…However, evidence from randomised controlled trials (RCTs) supporting exercise in patients with borderline resectable or locally advanced pancreatic cancer (PanCa) undergoing neoadjuvant therapy (NAT) are lacking.Methods and analysis The EXPAN trial is a dual-centre, two-armed, phase I RCT. …”
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Acute alcohol intoxication among adolescents in Italy, the Netherlands and Belgium: a cross-national hospital chart comparison study by Stijn Verhulst, Nico van der Lely, Andrea Orsi, Giancarlo Icardi, Guido Van Hal, Hanna van Roozendaal, Louise Pigeaud, Allegra Ferrari, Loes de Veld, Inge Glazemakers, Jozef De Dooy

“…Data on alcohol intoxication among adolescents provide valuable insights in this context.Methods To gain insight into the demographic and clinical characteristics of acute alcohol intoxication (AAI) across European countries, we analysed emergency department data on AAI among adolescents (aged 14–17) from 2015 to 2023 in three urban regions: Genoa (Italy), Delft (the Netherlands) and Antwerp (Belgium).Results Out of 1826 admissions, Belgium had the highest median annual admission rate (51 per 10 000 adolescents), followed by the Netherlands (49 per 10 000) and Italy (37 per 10 000). …”
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