Taxus chinensis-Derived Nanovesicles Alleviate Mouse Colitis by Inhibiting Inflammatory Cytokines and Restoring Gut Microbiota by Gong Q, Hu J, Pu C, Zhao Z, Guo Y

“…Among these, plant-derived nanovesicles (NVs) have garnered significant attention for their potential in treating colitis.Methods: In this study, we extracted NVs from the leaves (LNVs) and stems (SNVs) of Taxus, a well-known natural anti-cancer plant. …”
Get full text

Intratumoral and Peritumoral Radiomics Based on DCE-MRI for Prediction of Microvascular Invasion Grading in Solitary Hepatocellular Carcinoma (≤3 cm) by Li Y, Li H, Feng Y, Lu L, Zhang J, Jia N

“…Yinqiao Li,* Helin Li,* Yayuan Feng, Lun Lu, Juan Zhang, Ningyang Jia Department of Radiology, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, People’s Republic of China*These authors contributed equally to this workCorrespondence: Juan Zhang; Ningyang Jia, Department of Radiology, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, People’s Republic of China, Email zhangjuan0801@126.com; ningyangjia@163.comPurpose: To explore the application value of clinical indicators, radiological features, and magnetic resonance imaging (MRI) radiomics to predict the grading of MVI in nodular hepatocellular carcinoma (≤ 3cm).Methods: A total of 131 patients with hepatocellular carcinoma (HCC) and confirmed microvascular invasion (MVI) who underwent surgical resection between January 2016 and December 2022 were retrospectively analyzed. …”
Get full text

HGH1 Promotes Breast Cancer Progression Through the PI3K/AKT/NF-κB Signaling Pathway: Potential Role for Prognosis and Targeted Therapy by Hu W, Si D, Liu C, Tie D, Xu D, Li N

“…Wenyu Hu,1,* Dikun Si,1,* Chenxi Liu,2,* Danchen Tie,1 Dongdong Xu,1 Nanlin Li1 1Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Nanlin Li, Email nanlin-74@163.comIntroduction: Previous studies have shown that the HGH1 gene is associated with poor prognosis in a variety of cancers, but its specific function and molecular mechanism in the pathological process of breast cancer remain unclear.Methods: The relationship between expression of HGH1 and overall survival in BC patients was analyzed. …”
Get full text

Physiological adaptations and myocellular stress in short-term, high-frequency blood flow restriction training: A scoping review. by Victor Sabino de Queiros, Nicholas Rolnick, Phelipe Wilde de Alcântara Varela, Breno Guilherme de Araújo Tinôco Cabral, Paulo Moreira Silva Dantas

“…<h4>Objectives</h4>To provide a comprehensive overview of short-term, high-frequency blood flow restriction training, including main adaptations, myocellular stress, limitations in the literature, and future perspectives.<h4>Methods</h4>A systematic search of electronic databases (Scopus, PubMed®, and Web of Science) was performed from the earliest record to April 23, 2022. …”
Get full text

Comparison between Bolus Intracoronary versus Bolus Intravenous Injection Regimens of Eptifibatide during Primary Percutaneous Coronary Intervention in Patients with Anterior ST-Se... by Mohamed Hassan Nab, Shaimaa Mostafa, Khaled Elrabat, Hamza Kabil, Neama Elmelegy

“…The current study aimed to examine the safety and efficacy of I/C vs I/V bolus regimen dose of eptifibatide during primary percutaneous coronary intervention (PPCI).Material and methods. Prospective, controlled, randomized study enrolled 100 patients with acute anterior ST-segment elevation myocardial infarction (STEMI) eligible for PPCI equally divided into 2 groups (group A received bolus I/C eptifibatide and group B received it I/V) followed by 12-hour continuous I/V infusion. …”
Get full text

Cluster Set Resistance Training Reduces Autonomic Perturbations Compared to Traditional Protocols in Trained Healthy Young Individuals: A Clinical Study by Bianca de Souza Soares, Maria Clara Gomes Alves, Carlos Eduardo Cantelmo, Bruna Cristina de Oliveira Barros, Gustavo Vieira de Oliveira

“…Objectives: This study investigates the effects of cluster set resistance training (RT) on heart rate variability (HRV) parameters in young, healthy individuals. Methods: This trial was registered in the Brazilian Clinical Trials Registry (ReBEC) under the identification number RBR-9857xj3 on 7 December 2024. …”
Get full text

Study on the Mechanism of Artesunate in Modulating AR Epithelial Injury and Th2-Type Inflammatory Status by Bao Y, Zhang Z, Shi B, Chen Q, Zhang Y, Zhu X

“…Youwei Bao,&ast; Zhiqiang Zhang,&ast; Binbin Shi, Qi Chen, Ying Zhang, Xinhua Zhu Department of Otorhinolaryngology Head and Neck Surgery, The second Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xinhua Zhu, Department of Otorhinolaryngology Head and Neck Surgery, The second Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China, Email entzxh@126.comObjective: To evaluate the therapeutic efficacy of Artesunate (ART) in a mouse model of allergic rhinitis (AR) induced by house dust mite (HDM) and explore its underlying mechanism.Experimental Methods: Transcriptome sequencing (RNA-seq) analysis identified differentially expressed genes (DEGs) in nasal mucosa between healthy and allergic mice, with Gene Set Enrichment Analysis (GSEA) revealing STING pathway activation. …”
Get full text

Transparent memory tests with even repeating addresses for storage devices by V. N. Yarmolik, I. M. Mrozek, V. A. Levantsevich, D. V. Demenkovets

“…Mathematical models describing the faulty states of storage devices and the methods used for their detection are investigated. …”
Get full text

Association Between Hysterectomy and Accelerated Aging: Protective Effect of Dietary Fiber and Mediating Role of Creatinine by Qian W, Xu B, Fang Y, Wu X

“…Wen Qian,1,&amp;ast; Binkai Xu,2,&amp;ast; Yuan Fang,1 Xian Wu1 1Department of Operation, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center of Nanjing Medical University, Changzhou, Jiangsu Province, People’s Republic of China; 2Department of Surgery, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center of Nanjing Medical University, Changzhou, Jiangsu Province, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Xian Wu, Email wxcz0519@163.comObjective: To investigate the association between hysterectomy and accelerated aging, with a focus on the mediating effect of renal function and protective role of dietary fiber intake.Methods: The cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2010. …”
Get full text

IL-6 and CD4+/CD8+ are Important Indicators for Predicting Prognosis in Elderly AECOPD Patients: A Retrospective Study by Liu Q, Wang Y, Cao X, Zhang S, Xie J

“…Qingqing Liu,1,2,&ast; Yanhui Wang,1,2,&ast; Xueshuai Cao,1,2 Shan Zhang,1,2 Juan Xie1,2 1Department of General Medicine, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, People’s Republic of China; 2Center of Community-Based Health Research, Fudan University, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Juan Xie, Email abclux@126.comPurpose: Evaluating the role of IL-6 and CD4+/CD8+ in predicting the prognosis of elderly patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).Patients and Methods: This study retrospectively enrolled 413 elderly patients who were hospitalized for AECOPD between January 2019 and December 2021. …”
Get full text

A Nomogram for Predicting Survival in Patients with SARS-CoV-2 Omicron Variant Pneumonia Based on Admission Data by Yang Y, Li D, Nie J, Wang J, Huang H, Hang X

“…This study aimed to develop a nomogram for predicting survival using chest computed tomography (CT) imaging features and laboratory test results based on admission data.Patients and Methods: A total of 436 patients with SARS-CoV-2 pneumonia (323 and 113 in the training and validation groups, respectively) were enrolled. …”
Get full text

Effects of Curcumin on Iron Overload in Rats by Gülüzar Özbolat, Arash Alizadeh Yegani

“…This study investigated the effects of curcumin on iron overload in rats. Methods: Forty male Wistar rats weighing 139.78 ± 11.95 gm (Mean ± SD) were divided into three equal groups: (i) controls; (ii) iron overload group that received six doses of iron dextran 1000 mg/kg–1 by intraperitoneal injections (i.p.); and (iii) iron overload curcumin group that received six doses of curcumin (1000 mg/kg BW by i.p.).  …”
Get full text

Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular Stiffness by Biener L, Budimovska A, Skowasch D, Pizarro C, Frisch BC, Nickenig G, Stumpf MJ, Schaefer CA, Schahab N

“…Blood eosinophil count (BEC) is implicated in both eosinophilic asthma and arterial wall inflammation.Objective: To explore the possible association of BEC in asthma and abdominal aortic artery changes.Methods: 112 outpatients were prospectively enrolled in this exploratory study. …”
Get full text

Effects of mini-dose esketamine–dexmedetomidine combination supplemented intravenous analgesia on postoperative sleep quality in elderly patients after total knee arthroplasty: a p... by Xiaoyan Wang, Xiaoli Ji, Jinfeng Liu, Caicai Liu, Yanhua Luo

“…However, the effectiveness of mini-dose esketamine–dexmedetomidine supplemented intravenous analgesia on postoperative sleep quality remains to be elucidated.Methods and analysis 110 elderly patients undergoing total knee arthroplasty will be randomly assigned to different regimens of patient-controlled intravenous analgesia with a total volume of 100 mL in either the experimental group (sufentanil 1.5 µg/kg+esketamine 25 mg+dexmedetomidine 100 µg) or the control group (sufentanil 1.5 µg/kg+equal vol of placebo, ie, saline). …”
Get full text

Nanotherapeutics for Macrophage Network Modulation in Tumor Microenvironments: Targets and Tools by Li R, Huang J, Wei Y, Wang Y, Lu C, Liu J, Ma X

“…In conclusion, nanotherapeutics targeting macrophages remains immense potential for the development of macrophage-mediated tumor treatment methods and will further enhance our understanding, diagnosis, and treatment of various malignants.Keywords: engineered macrophages, nanomedicine, cancer therapy, anti-tumor immunity…”
Get full text

The Application and Efficacy of Medication Safety Officer-Based Multidisciplinary Management in Reducing Adverse Drug Reaction and Improving Intravenous Management by Zhang X, Yan M, Qu X, Li Y, Liu L, Liu C

“…This study evaluates the effectiveness of medication safety officer (MSO)-based multidisciplinary management on managing IV fluids in children’s outpatient and emergency departments, aiming to reduce adverse drug reaction (ADR) and standardize IV infusion management.Methods: Implementing MSO-based multidisciplinary management integrates multidisciplinary supervision, information system optimization, and fostering medication safety culture. …”
Get full text

Using a Systems Thinking Approach to Increase Coastal Community Resilience against Environmental Shocks: A Case Study of Valiathura Coastal Area, India by Baker Matovu, Meltem Alkoyak-Yildiz, Isaac Lukambagire, Linda A. Etta, Yasin Bbira, Expedito Nuwategeka

Get full text

Hippocampal Anti-inflammatory Effect of Electroacupuncture at Baihui and Shenting on Cognitive Dysfunction Induced by Systemic Inflammation by CHEN Xiaomei, PANG Lina, WANG Zhifu

“…ObjectiveTo investigate the hippocampal anti-inflammatory mechanism of electroacupuncture at Baihui and Shenting on cognitive dysfunction induced by Lipopolysaccharide (LPS) intraperitoneal injection.MethodsA total of 45 clean grade adult C57BL/6 male mice (bodyweight 18-22 g) were randomly divided into control group, endotoxic brain injury group (model group) and endotoxic brain injury + electroacupuncture group (EA group). …”
Get full text

The sero-prevalence of brucellosis in cattle and their herders in Bahr el Ghazal region, South Sudan. by Nuol Aywel Madut, Adrian Muwonge, George William Nasinyama, John Bwalya Muma, Jacques Godfroid, Ambrose Samuel Jubara, James Muleme, Clovice Kankya

“…Furthermore, we characterize the drivers associated with the disease at the human-animal interface in Bahr el Ghazal region, South Sudan.<h4>Methods</h4>A total of 893 and 87 animal and human sera respectively were examined between December 2015 and May 2016. …”
Get full text

Comparison of Learning Curves and Clinical Outcomes in Unilateral Biportal Endoscopic Spinal Surgery Versus Percutaneous Transforaminal Endoscopic Surgery: A Cumulative Sum Analysi... by Yuan S, Chen R, Mei Y, Fan N, Wang T, Wang A, Du P, Xi Y, Zang L

“…This study aimed to evaluate the learning curves for unilateral biportal endoscopic spinal surgery (UBESS) and percutaneous transforaminal endoscopic surgery (PTES) by performing cumulative sum (CUSUM) analysis and to assess their efficacies in managing degenerative spinal diseases.Patients and Methods: This retrospective cohort study included 100 consecutive patients who underwent PTES and 100 consecutive patients who received UBESS. …”
Get full text