The mitigating effect of dietary β-glucan against fipronil-induced intoxication in Nile Tilapia (Oreochromis niloticus): Histopathological, immunological, hematological, and bioche... by Fawiziah Khalaf Alharbi

“…Aim: The goal of this study was to determine how dietary β-1,3-glucan can protect Nile Tilapia (Oreochromis niloticus) fish from fipronil's harmful effects. Methods: We randomly divided 240 fish into four equal groups. …”
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Service Users’ Perspectives on an Integrated Electronic Care Record in Mental Health Care: Qualitative Vignette and Interview Study by Timothy Kariotis, Megan Prictor, Kathleen Gray, Shanton Chang

“…ObjectiveThis study aimed to understand mental health care service users’ perspectives on an IECR and how it should be used in practice when receiving care. MethodsTen people with lived experience of accessing multiple services in Australia’s mental health care system were provided with 2 vignettes that depicted fictional service users making decisions about an IECR. …”
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Regulated Pricing Decisions and Diagnostic Test Choices in Personalized Medicine: Navigating the Implications Within Legal Frameworks by Cui Z, Liu X, Feng Z, Huang Z

“…In this context, this study investigates whether the government should regulate the price of personalized medicine and how the government’s regulated pricing decisions affect drug manufacturers’ diagnostic test choices.Methods: A stylized analytical model was developed, employing game-theoretic analysis. …”
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Weighted explainable federated learning for privacy-preserving and scalable energy optimization in autonomous vehicular networks by Muhammad Saleem, Ali Arishi, Muhammad Sajid Farooq, M.A. Khan, Khan M. Adnan

“…The framework also integrates Explainable AI (XAI) methods to improve interpretability, transparency, and regulatory compliance. …”
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Postoperative Outcomes of Modified Carnoy’s Solution versus 5-Fluorouracil for Chemical Cauterisation following Enucleation and Peripheral Ostectomy in Patients with Odontogenic Ke... by Nidhi Vijay Kumar Bodiwala, Nitin Bhola

“…Aim: To compare and evaluate the postoperative outcomes, specifically the RR, of MCS vs 5FU used for chemical cauterisation following enucleation and peripheral ostectomy in patients with OKC. Materials and Methods: An experimental in-vivo study will be conducted in the Department of Oral and Maxillofacial Surgery, Sharad Pawar Dental College, Datta Meghe Institute of Higher Education and Research (DMIHER), Sawangi (M), Wardha, Maharashtra, India, from April 2023 to March 2024. …”
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Caregiver Burden and Associated Factors Among Informal Caregivers of Hospitalized Elderly Patients in China: A Latent Profile Analysis by Lv H, Yang S, Zhang Y, Wang Y, Zhang L, Wang J, Jiang H

“…Hui Lv,1,2,* Shujie Yang,1,* Yuxi Zhang,1 Yingyue Wang,3 Lijiang Zhang,1 Jingjing Wang,1 Hui Jiang1 1Institutes of Health Central Plains, Xinxiang Medical University, Xinxiang, Henan Province, People’s Republic of China; 2The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan Province, People’s Republic of China; 3School of Health Management, Xinxiang Medical University, Xinxiang, Henan Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Jiang, Institutes of Health Central Plains, Xinxiang Medical University, No. 601 Jinsui Road, Xinxiang, Henan Province, 453003, People’s Republic of China, Email jiangh233@126.comBackground: Caregiver burden is a critical issue in healthcare, particularly among informal caregivers of hospitalized elderly patients, as it can significantly impact both the caregivers’ well-being and the quality of patient care.Objective: This study aims to identify the latent profiles of caregiver burden among informal caregivers of hospitalized elderly patients and the factors associated with caregiver burden.Methods: 506 pairs of hospitalized elderly patients and their informal caregivers were interviewed using the Sociodemographic questionnaire, Caregiver Burden Inventory, Perceived Social Support Scale, Generalized Anxiety Disorder, and Barthel Index. …”
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Myosin 1b Inhibits the Phenotype of HemECs to Affect the Progression of Infantile Hemangiomas by Li N, Gong X, Cao Z, Li Z, Wang L, Huo R, Fu C

“…Nanxi Li, Xiangan Gong, Zhongying Cao, Zhiyu Li, Luying Wang, Ran Huo,* Cong Fu* Department of Plastic and Aesthetic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ran Huo; Cong Fu, Department of Plastic and Aesthetic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jingwu Road, Huaiyin District, Jinan, Shandong Province, 250021, People’s Republic of China, Tel +86-15168889001 ; +86-15154101889, Email huoran@medmail.com.cn; cong3399@163.comPurpose: To investigate the role of myosin 1b (Myo1b) in infantile hemangiomas (IHs).Patients and Methods: The expression of Myo1b in IHs and normal skin tissues was evaluated using immunohistochemical techniques. …”
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Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis by Ding X, Bai Z, Wang W, Gu Y, Li Z, Fan Y

“…In this study, a Mendelian randomization (MR) analysis was utilized to discover the causal associations between FI and AGA.Methods: Genome-wide association study (GWAS) data for FI and AGA were retrieved, and bidirectional MR analysis was conducted. …”
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Testing a new micro-osteoperforation modality on the rate of orthodontic tooth movement in a rabbit model by Banan Khazaal Al Obaidy, Afrah Khazal Al Hamdany, Ahmed M A Al-Saidya

“…The current study objective was to test and compare the impact of a new micro-osteoperforation (MOP) modality with 2 other modalities on the rate of tooth movement (RTM) in rabbits. Methods. The sample comprises 45 adult male albino rabbits aged 24 weeks and divided equally into 3 groups regarding MOP modalities; a single vertical MOP (1V-MOP), a single vertical MOP + 2 horizontal MOPs (1V+2H-MOP), as the new MOP design; and 3 horizontal MOPs (3H-MOP). …”
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Investigation of efficiency and quality of functioning of led lighting elements of electrical systems at the maximum permissible ambient temperature by R. H. Tukshaitov, N. V. Rozhencova, A. R. Denisova

“…It is shown that a filament LED lamp with 4 filaments, if it is operated for 4.5 hours a day in conditions of elevated ambient temperature, can work for almost more than one year. METHODS. The resource of filament and typical LED lamps of different power is considered in comparative terms when they are operated at a relatively high ambient temperature.RESULTS. …”
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Hepato-protective and repro-protective power of immulant (echinacea purpurea) against chlorpyrifos toxicity via apoptotic genes signaling pathway by Ahlam G. Khalifa, Fadwa A. Elroby, Asmaa K. Abdelghany

“…The study target is to evaluate the anti-apoptotic effect of IM against CPF toxicity. Methods Thirty-two adult male white albino rats were separated into four groups in equal (n = 8 rats per each) as follows: control group (C), chlorpyrifos group (CPF): rats administered CPF at a dose of 6.75 mg/kg b.wt, chlorpyrifos +immulant group (CPF + IM): rats orally gavaged CPF + IM at a dose of 6.75 mg/kg + 150 mg\kg b.wt, and immulant group (IM): rats given IM at a dose of 150 mg\kg b.wt. …”
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Validation of an AI-Powered Smart Dry Powder Inhaler (RS01X) for Asthma and COPD in a Clinical Setting by Chamaon D, Sportel E, Elferink ECM, van der Palen J

“…The objective was to validate the smart DPI compared to an external inhalation profile recorder (IPR).Methods: This monocenter cross-sectional study with 97 participants comprises patients with COPD, asthma and healthy participants. …”
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Targeting AGE-RAGE Signaling Pathway with Hujin Decoction Ameliorates MAFLD in HepG2 Cells by Zhang Z, Shi J, Liu F, Zhou J, Shen Q, Shi X

“…Zixuan Zhang,1,* Jiaxi Shi,2,* Fuxuan Liu,1 Jing Zhou,1 Qi Shen,3 Xuguang Shi1 1School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People’s Republic of China; 2The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People’s Republic of China; 3Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuguang Shi, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China, Tel +8613602740975, Email sxg6902@126.comPurpose: To explore the mechanism and substance basis of HJD for the treatment of MAFLD based on system pharmacology.Patients and Methods: The ingredients of HJD in vitro and in vivo were detected by UPLC-MS/MS, then network pharmacology and molecular docking technology were used to predict the mechanism and substance basis, then the establishment of in vitro MAFLD model was confirmed by oil red O staining and ELISA technology, and finally the mechanism was verified by PCR, WB and flow cell technology.Results: System pharmacology determined that succinic acid, Ginsenoside Rh4, Caffeic acid, 7-Methoxycoumarin, 5-Acetylsalicylic acid and other ingredients were the basis of pharmacodynamic substances, while RAGE[Advanced glycosylation end product-specific receptor (RAGE)], BCL2[Apoptosis regulator Bcl-2 (BCL2)], and CASP3[Caspase-3 (CASP3)] were predicted as the core targets, and AGE-RAGE was the key pathway. …”
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Comprehensive Analysis of Metabolic Changes in Mice Exposed to Corilagin Based on GC-MS Analysis by Xu B, Wang C, Zhu X, Zhu L, Han G, Cui C

“…The aim of this study was to explore the pharmacological mechanism of Corilagin.Methods: This study utilized gas chromatography-mass spectrometry (GC-MS) to analyze central target tissues, comprehensively exploring the pharmacological mechanism of Corilagin in mouse models. …”
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Evaluation of Iron Overload Between Age Groups Using Magnetic Resonance Imaging and Its Correlation with Iron Profile in Transfusion-dependent Thalassemia by Pustika Amalia Wahidiyat, Stephen Diah Iskandar, Damayanti Sekarsari

“…This study aimed to explore the degree of iron overload in various organs, iron deposition difference between children and adults, also its correlation with serum marker of iron overload. Methods: this was a cross-sectional study of TDT patients who had been evaluated by MRI T2* examination in Cipto Mangunkusumo Hospital from 2014 to 2018. …”
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A measure of the difference between test sets for generating controlled random tests by V. N. Yarmolik, V. V. Petrovskaya, I. Mrozek

“…The limitations of using the Hamming and Damerau – Levenshtein distances to obtain a measure of the difference between test sets are shown.Methods . Based on the characteristic of the interval used in the theory of the chain of successive events, a new measure of the difference between two symbolic test sets is determined. …”
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Analysis of Tumor and Tumor-Like Entities Tested on the Orthopaedic In-Training Examination From 2012 to 2023 by Sean Kelly, MD, Braden Goldberg, MD, Eli Bryk, MD, FAAOS, FAOA, FACS, Vincent Vigorita, MD

“…This study aims to describe such trends. Methods:. This study analyzed OITE questions from 2012 to 2023, focusing on tumors and tumor-like conditions of bone and soft tissue to guide resident preparation and core curriculum design. …”
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Symbiotic anti-oxidant, anti-glycation, and anti-inflammatory qualities of a combination of thiamine and niacin protected type-2 diabetic male rats against both macro and micro-vas... by Sina Mahdavifard, Hamid Reza Malekzadeh

“…Therefore, we aimed to study the impact of the combination of thiamine and niacin on hepatic NF-kβ signaling, metabolic profile, and Glo-I activity in male rats with type-2 diabetes (T2DM).Materials and Methods: Forty male rats were divided equally into five groups: control, diabetic, diabetic treated with thiamine (180 mg/l in drinking water), niacin (180 mg/l), and a combination of both. …”
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Combining Supervised and Reinforcement Learning to Build a Generic Defensive Cyber Agent by Muhammad Omer Farooq, Thomas Kunz

“…The framework demonstrates consistently improved performance over a range of existing methods, as validated through extensive empirical evaluation. …”
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User experience with pregnancy tracker mobile apps: Findings from comment-based qualitative study. by Md Alamgir Hossain, Janet Perkins, Md Tanvir Hasan, Sharon Low Bee Lian, Ribica Chowdhury, Md Tanzirul Alam, Anisuddin Ahmed, Mohammad Sohel Shomik, Shams El Arifeen, Ahmed Ehsanur Rahman, Aniqa Tasnim Hossain, M Shafiqur Rahman

“…<h4>Methods</h4>This study explored the dynamics between users' experiences and multifaceted dimensions of advanced features, high-quality materials and information, strict privacy policies, problem-solving abilities, and the usefulness of app features and contents. …”
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