Retrospective Cross-Sectional Study of Quadratic-Linear Correlations Between Cephalometric Measurements and Profile Esthetics in Adult Orthodontic Patients by Visessan Pornsirianand, Janeta Chavanavesh, Pimsiri Kanpittaya, Anupap Somboonsavatdee

“…This study used quadratic and/or linear regression to identify cephalometric variables related to profile attractiveness, expanding on previous bivariate analyses. Methods: This retrospective cross-sectional study comprised 180 post-treatment lateral cephalograms of 18 to 37 year-old orthodontic patients, equally distributed among 3 profile types (concave, straight, and convex), each comprising 60 cases with balanced sex representation. …”
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Ameliorative effect of Naja haje venom against arthritic influence of Freund's complete adjuvant FCA in paw and ankle of male rats by Nabil A. Soliman, Amr A. Shalaby, Mayada R. Farag, Shimaa Kamal, Sara M. Abdelkarem Alashqar, Mohamed Ahmed Ammar, Suzan Attia Mawed

“…Aim: While there are a number of therapeutic options for arthritis, their side effects restrict their use and encourage the search for alternative, natural remedies. Methods: In male rats, we examined the anti-inflammatory and anti-arthritic properties of Naja haje venom (NHV). …”
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Comparing recommended doses of angiotensin receptor blockers and ACE inhibitors (CORD Study) by J. Spinar, J. Vftovec, M. Soucek, L. Dusek, T. Pavlik

“…The CORD Study compared effectiveness and tolerability of losartan and ramipril in patients with arterial hypertension (AH).Material and methods. The study included two groups, A and B. In Group A (n=4016; mean age 62,6+11,6 years; 53,1% women), the patients with blood pressure (BP) <160/100 mm Hg and ACE inhibitor therapy lasting for >3 months were switched from ACE inhibitors to losartan. …”
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Deep Learning and Radiomics in Triple-Negative Breast Cancer: Predicting Long-Term Prognosis and Clinical Outcomes by Cheng C, Wang Y, Zhao J, Wu D, Li H, Zhao H

“…They are extensions of conventional imaging diagnostic methods and have demonstrated tremendous potential in image segmentation, reconstruction, recognition, and classification. …”
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SPP1 as a Prognostic and Immunotherapeutic Biomarker in Gliomas and Other Cancer Types: A Pan-Cancer Study by Wang K, Wan J, Zheng R, Xiao Y, Lv F, Ge H, Yang G, Cheng Y

“…This study investigates the role of Secreted Phosphoprotein 1 (SPP1) as a prognostic and immunotherapeutic biomarker in gliomas and other cancers through pan-cancer analysis.Methods: A comprehensive pan-cancer analysis was conducted using datasets from UCSC TCGA Pan-Cancer, TCGA-GBM, UALCAN, and single-cell sequencing data from GEO and TISCH. …”
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Different patterns of pre-excitation in a large Italian cohort of asymptomatic non-competitive athletes evaluated by telecardiology screening: Prevalence and ECG features by Martina Molinari, Sergio Setti, Natale Daniele Brunetti, Nicola Di Nunno, Maria Alberta Cattabiani, Giuseppe Molinari

“…Aim of the study: To evaluate and detail the prevalence of the Wolff-Parkinson-White (WPW) syndrome in a large Italian cohort of young NCA. Methods: In a 4-year period 216,424 consecutive NCA (118,851 males; 55%) underwent preparticipation ECG screening through a Telecardiology System. …”
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Disruption of Gut Microbiota and Associated Fecal Metabolites in Collagen-Induced Arthritis Mice During the Early Stage by Wu D, Yin M, Cao D, Zhang X, Zhu Y, Wei Y, Li Y, Wen C, Zhou J

“…Further revealing the microbiota and related metabolic disorders in the preclinical stage of RA (pre-RA) is of great significance for exploration of disease mechanisms.Methods: DBA/1 mice were injected with type II collagen on days 0 and 21 to establish collagen-induced arthritis (CIA) mouse model. …”
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L-shaped correlation between serum alpha-1-acid glycoprotein concentration and urinary albumin creatinine ratio in females: a cross-sectional survey by Junjie Wang, Junjie Wang, Li Xiao, Yuxuan Zhang, Zhou Li

“…The aim of this study was to explore their correlation in order to advance our understanding of the mechanisms underlying kidney damage.MethodsThis study included 2579 female participants with serum AGP and UACR from the National Health and Nutrition Examination Survey (2015-2018). …”
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Gender disparities in literacy: an analysis of regional and age-group variations in Somalia by Mukhtaar Axmed Cumar, Abdisalan Hassan Muse, Befekadu Zeleke Kidane, Jibril Abdikadir Ali

“…Further studies employing qualitative methods and longitudinal designs are recommended to deepen understanding of the dynamics underlying these disparities.…”
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Identification and Quantification of the Component Composition of the Active Substance Gentamicin Sulfate by ¹Н and ¹³С NMR Spectroscopy by S. V. Moiseev, N. E. Kuz’mina, E. Yu. Severinova, E. P. Simonova, V. V. Kosenko

“…These characteristic signals provided spectral markers indicative of the gentamicins of interest in the sample, with normalised integrated intensities equal to the mole fractions of the analytes. The authors compared NMR and HPLC measurements of the active substance composition.Conclusions. …”
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Challenges in Thirst Management for Intubated Patients in the ICU: A Qualitative Study of Healthcare Provider and Patient Perspectives by Yuan Y, He LF, Luo Q, Zhang X, Chen F, Hu RJ

“…You Yuan,1,* Li-Feng He,1,* Qian Luo,1 Xia Zhang,1 Fang Chen,1 Ru-Jun Hu1– 3 1Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 2Department of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 3School of Nursing, Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ru-Jun Hu, Department of Nursing, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi, Guizhou Province, 563000, People’s Republic of China, Tel +86 15085060545, Email hurujunok@163.comObjective: This study aims to examine the challenges associated with thirst management among patients undergoing tracheal intubation in intensive care units (ICUs), and to inform the development of more effective clinical strategies.Methods: A qualitative research design was employed using semi-structured interviews with 32 participants, including healthcare professionals and patients who had experienced tracheal intubation and associated thirst in the ICU. …”
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A Ferritin-Based Eg95 Nanoparticle Vaccine Adjuvanted with pCpG Eliciting Robust Immune Responses Against Cystic Echinococcosis in Mice Model by Gao X, Zhu X, Liu X, Zhou C, Shang Y, Wu T, Jia H, Zhang Z, Li Y, Xin T

“…The commercial Quil-A-adjuvanted Eg95 vaccine was empirically effective for CE control; however, it is expensive and has side effects and insufficient immunity.Purpose: This study aimed to employ a novel adjuvant consisting of a delivery system and an immune potentiator and assess its adjuvanticity to Eg95 antigen, thereby developing a safe and cost-effective novel vaccine against the disease.Methods: A ferritin-based Eg95 nanoparticle antigen was prepared and then mixed with a plasmid containing the TLR9 agonist CpG to formulate a novel nanovaccine. …”
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CURRENT APPROACH TO DEVELOPMENT OF BIOSIMILAR PRODUCTS CONTAINING MONOCLONAL ANTIBODIES AS AN ACTIVE SUBSTANCE – NON-CLINICAL AND CLINICAL STUDIES OF THE FIRST RUSSIAN RITUXIMAB BI... by S. M. Alekseev, K. D. Kaplanov, R. A. Ivanov, E. V. Chernyaeva

“…Evaluation of pharmacokinetics, pharmacodynamics, safety and efficacy of rituximab biosimilar (Acellbia,  BIOCAD, Russia) used as  monotherapy in patients with indolent B-cell non-Hodgkin’s lymphoma in comparison with the parameters of innovator rituximab – MabThera.Materials and methods. 92 patients (aged 18 years and older with diagnosed CD20-positive follicular non-Hodgkin’s lymphoma, stage II-IV by Ann Arbor, 1-2 histologic grade, or marginal zone lymphoma) were enrolled into the study. …”
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Tofacitinib in early active axial spondyloarthritis: protocol of a randomized double-blind, placebo-controlled, multicenter phase IV study, FASTLANE by Valeria Rios Rodriguez, Lidia Sánchez-Riera, Hildrun Haibel, Caroline Höppner, Murat Torgutalp, Fabian Proft, Judith Rademacher, Elke Binder, Annette Diehl, Ivana Vranic, Yuxi Zhao, Rajiv Mundayat, Arne Yndestad, Denis Poddubnyy

“…Design: This is a phase IV, randomized, double-blind, placebo-controlled, multicenter clinical trial. Methods and analysis: The study will recruit 104 patients aged ⩾18 and ⩽45 years with active early axSpA (chronic back pain ⩽2 years), inadequate response to at least one NSAID, and objective signs of active inflammation (on magnetic resonance imaging (MRI) of sacroiliac joints (SIJs) or elevated C-reactive protein). …”
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Evaluation of Clinical Symptoms of Unilateral S1 Nerve Injury Caused by Disc Herniation the via High Resolution MRI and DTI by Zhang C, Hao W, Guo X, Zhang Y, Fu H, Zhang J

“…ChaoYang Zhang,1,* Wei Hao,1,* Xiaobo Guo,2 Yuna Zhang,1 Hao Fu,1 Jiashan Zhang1 1Department of Radiology, Jincheng General Hospital, Jincheng, Shanxi, People’s Republic of China; 2Department of Orthopaedics, Jincheng General Hospital, Jincheng, Shanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: ChaoYang Zhang, Email Zhangchaoyang8717@163.comBackground: The status of the herniated disc or nucleus pulposus and the extent of injury and clinical symptoms of the compressed S1 nerve fiber bundle were evaluated by high-resolution Magnetic resonance imaging (MRI) and Diffusion tensor imaging (DTI) techniques.Methods: Forty-two clinically proven patients with unilateral S1 nerve root compression were selected as the case group (n=42), and 20 healthy volunteers were selected as the control group (n=20). …”
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Autologous bone marrow-derived progenitor cell transplantation for myocardial regeneration after acute infarction by Obradović Slobodan, Rusović Sinisa, Balint Bela, Ristić-Anđelkov Anđelka, Romanović Radoslav, Baskot Branislav, Vojvodić Danilo, Gligić Branko

“…This pilot trial reports investigation of safety and feasibility of autologous bone marrow-derived progenitor cell therapy for faster regeneration of the myocardium after infarction. Methods and results. Four male patients (age range 47-68 years) with the first extensive anterior, ST elevation, acute myocardial infarction (AMI), were treated by primary angioplasty. …”
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Mobile-based peer-led theoretically-designed intervention on continued breastfeeding among Iranian mothers by Afsoon Tizvir, Sakineh Rakhshanderou, Yadollah Mehrabi, Leili Mazar, Samira Daneshvar, Mohtasham Ghaffari

“…Abstract Background This study addresses the determination of educational intervention—based on the Theory of Planned Behavior (TPB)—effectiveness on continued breastfeeding among Iranian mothers attending health centers, considering low researchers’ attention to the continued breastfeeding index despite its important impact on children’s health. Methods The present study was conducted among 230 mothers with exclusively breastfed infant (115 in the intervention group and 115 in the control group). …”
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Effect of minimally invasive posterior veneer Preparation designs on failure load and mode after fatigue (in-vitro study) by Islam Mohamed Mady, Ahmed Safwat El Kady, Moustafa Nabil Aboushelib, Mohamed Hussein A. Hussein

“…The purpose of the study is to compare the failure load and mode after fatigue among three types of veneer preparation designs for restoring premolars. Methods 64 human premolars were equally divided into four groups. …”
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The Diagnostic Performance of AFP, AFP-L3, DCP, CA199, and Their Combination for Primary Liver Cancer by Liu Y, Jiang W, Li X, Zhao H, Wang S

“…This study aims to identify novel biomarkers to improve the diagnostic ability of PLC.Patients and Methods: This study included 94 patients with PLC, 128 patients with benign liver disease (BLD), and 79 normal controls (NC) were included. …”
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Effect of Selected Kinesiology Taping Applications on Reducing Pain and Accelerating Rehabilitation in Children with Osgood-Schlatter Disease by Krzysztof Kuchmacz, Kinga Żmijewska, Magdalena Mikos, Natalia Kuchmacz, Natalia Madej-Chmiel, Artur Gądek

“…Subjects were divided into 2 equal groups: the study group (n=30) and the control group (n=30). …”
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