Mammographic Vascular Microcalcifications as a Surrogate Parameter for Coronary Heart Disease: Correlation to Cardiac Computer Tomography and Proposal of a Classification Score by Jonathan Andreas Saenger, Ela Uenal, Eugen Mann, Stephan Winnik, Urs Eriksson, Andreas Boss

“…Objective: This study develops a BI-RADS-like scoring system for vascular microcalcifications in mammographies, correlating breast arterial calcification (BAC) in a mammography with coronary artery calcification (CAC), and specifying differences between microcalcifications caused by BAC and microcalcifications potentially associated with malignant disease. Materials and Methods: This retrospective single-center cohort study evaluated 124 consecutive female patients (with a median age of 57 years). …”
Get full text

Predicting motor and cognitive outcomes from MRIs of brain structure in children with acquired brain injury: A pilot study by Alex M. Pagnozzi, Kerstin Pannek, Jurgen Fripp, Simona Fiori, Roslyn N. Boyd, Stephen Rose

“…Quantitative structural information from brain images may provide an opportunity to predict patient outcomes; however, due to the high prevalence of severe pathology in children with ABI, quantitative approaches must be robust to injury severity. Methods: In this pilot cross-sectional study, automated quantitative measures were extracted from the MRIs of a cohort of children with ABI (n = 30, 8–16 years, follow up MRI taken 1.8–13.4 years after time of injury) as well as 36 typically developing controls with no brain injury (7–17 years) using a pathology-robust technique. …”
Get full text

Total Hip Arthroplasty vs Hip Resurfacing in Patients Over 65: A Propensity Score–Matched Comparison of Patient-Reported Outcomes by Zachary Wong, BS, Anand Saluja, BA, Louis Andrew Jordan, MS, Jonathan Spaan, MS, Edwin Su, MD

“…We undertook this study to compare the results of HRA vs THA in a population of older patients, with specific focus on patient-reported outcome measures. Methods: A retrospective, propensity-matched study was conducted on patients aged 65 years or older who underwent either HRA or THA via posterior approach. …”
Get full text

Identification of Risk Group for Root Caries and Analysis of Associated Factors in Older Adults Using Unsupervised Machine Learning Clustering by Jiang L, Huang S, Reissmann DR, Schmalz G, Li J

“…The confusion matrix and alluvial diagram were used to visualize the predictive accuracy and composition of the clustering results. …”
Get full text

Brain Functional Connectome Gradients Analysis Study of Chronic Back Pain by YANG Junchao, YIN Xiaolong, HUANG Li, JIANG Feng, LI Zuanfang, LIANG Shengxiang

“…ObjectiveThe aim of this study was to investigate the relationship between changes in functional network hierarchy and pain in patients with chronic back pain (CBP) by analyzing the differences in functional network connectivity gradients between the CBP group and the healthy control group.MethodsData (including basic clinical information such as VAS scores, years of pain, and resting functional MRI images) from the patients with CBP and healthy controls (HC) were obtained from the OpenPain database. …”
Get full text

Early real-world outcomes of intravitreal aflibercept 8 mg in treatment-Naïve neovascular AMD: AI-assisted fluid volume analysis by Jennifer Cattaneo, Eva C. De Oliveira Figueiredo, Andrea Montesel, Sandra Vermeirsch, Chiara M. Eandi

“…Abstract Background This study was conducted as a retrospective, exploratory analysis to assess early anatomical and functional effects of intravitreal aflibercept 8 mg in neovascular age-related macular degeneration (nAMD) in a small cohort of patients. Methods This retrospective study was conducted at the Jules Gonin Eye Hospital in Lausanne, Switzerland, and included treatment-naïve patients with nAMD. …”
Get full text

Optical Coherence Tomography Predictors of Favorable Functional Response in Naïve Diabetic Macular Edema Eyes Treated with Dexamethasone Implants as a First-Line Agent by Alessandro Meduri, Giovanni William Oliverio, Luigi Trombetta, Marta Giordano, Leandro Inferrera, Costantino John Trombetta

“…To evaluate efficacy and safety of intravitreal dexamethasone 0.7 mg implant in treatment-naïve DME patients and to assess the utility of OCT structural biomarkers as predictors of functional response after treatment. Methods. Thirty-nine eyes of 39 diabetic patients with center involving DME were enrolled. …”
Get full text

Survey on the Knowledge, Attitudes, and Practice Patterns of Ophthalmologists in the Philippines on the Diagnosis and Management of Dry Eye Disease by Margarita I. Echavez, MD, Ruben Lim Bon Siong, MD

Get full text

Measurements of white-to-white corneal diameter and anterior chamber parameters using the Pentacam AXL wave and their correlations in the adult Saudi population by Wafa M. Alotaibi, Naveen Challa, Saif Hassan Alrasheed, Rahaf Nasser Abanmi

Get full text

Vitrectomy with or without internal limiting membrane peeling for idiopathic epiretinal membrane: A meta-analysis. by Wei-Cheng Chang, Chin Lin, Cho-Hao Lee, Tzu-Ling Sung, Tao-Hsin Tung, Jorn-Hon Liu

“…<h4>Objective</h4>To compare the clinical outcomes of vitrectomy with and without ILM peeling for idiopathic ERM.<h4>Methods</h4>Databases, including PubMed, Embase, Cochrane, Web of Science, Google Scholar, CNKI databases, FDA.gov, and ClinicalTrials.gov, published until July 2016, were searched to identify studies comparing the clinical outcomes following vitrectomy with ERM and ILM peeling and with only ERM peeling, for treating idiopathic ERM. …”
Get full text

Efficacy and safety of faricimab for neovascular age-related macular degeneration: a systematic review and network meta-analysis by Francisco Rodríguez, Daniel Samacá-Samacá, Claudia Hernández-Castillo, Laura Prieto-Pinto, Carolina Sardi, Hugo Ocampo, Joshua Kock, Fabián Hernández

“…Objective To evaluate the efficacy and safety of faricimab compared with other anti-vascular endothelial growth factor (anti-VEGF) agents in treating neovascular age-related macular degeneration (nAMD) patients.Methods and analysis A systematic review (SR) was conducted up to January 2023. …”
Get full text

Efficacy of Cheiranthus Cheiri in the Treatment of Pericoronitis: A Double-blind, Randomized, Placebo-controlled Trial with Molecular Docking by Shubhamoy Ghosh, Aritra Roy Chowdhury, Sarbendu Paul, Avipsha Sarkar, Abhijit Rana, Mousumi Koley, Indrani Halder, Suman Chandra, Subhranil Saha

“…Subsequently, molecular docking of CC was performed to predict the binding affinity of ligands to receptor proteins. Materials and Methods: A 14-day, double-blind, randomized (2:1), placebo-controlled trial was undertaken at the Dental Outpatient Department of D. …”
Get full text

Intraocular pressure and ocular biomechanical parameters vary between generations of the ocular response analyzer in healthy and ectatic eyes by Phillip T. Yuhas, Maddison M. Fortman, Michael Nye, Ashraf M. Mahmoud, Cynthia J. Roberts, Cynthia J. Roberts

Get full text

Cervical transcutaneous vagal neuromodulation in chronic pancreatitis patients with chronic pain: A randomised sham controlled clinical trial. by Janusiya Anajan Muthulingam, Søren Schou Olesen, Tine Maria Hansen, Christina Brock, Asbjørn Mohr Drewes, Jens Brøndum Frøkjær

“…We investigated the pain-relieving effects of transcutaneous vagal nerve stimulation in comparison to sham treatment in chronic pancreatitis patients.<h4>Methods</h4>We conducted a randomised double-blinded, sham-controlled, crossover trial in patients with chronic pancreatitis. …”
Get full text

Efficacy of Intravitreal Brolucizumab Switch in Pachychoroid Neovasculopathy by Nicolò Ribarich, Marco Battista, Lisa Checchin, Riccardo Sacconi, Francesco Bandello, Giuseppe Querques

“…Abstract Introduction This study aimed to evaluate the anatomical and functional outcomes of switching to intravitreally administered brolucizumab (Beovu®, Novartis) in patients affected by pachychoroid neovasculopathy (PNV) who were considered as non-responders to previous anti-vascular endothelial growth factor (anti-VEGF) therapies, defined as the persistence of intraretinal fluid (IRF), subretinal fluid (SRF), or subretinal hyper-reflective material (SHRM). Methods Twenty-three eyes of 21 patients with exudative PNV, who were switched to brolucizumab between April 2021 and December 2023, were retrospectively enrolled. …”
Get full text

Crisis versus extended care: bimodal distribution of length of stay in psychiatric inpatients by Andreas B. Hofmann, Tobias R. Spiller, Jeremy A. Rapaport, Philipp Homan, Erich Seifritz, Stefan Vetter, Stephan T. Egger, Achim Burrer

“…While previous research has established that LoS distributions are typically right-skewed across medical specialties, detailed characterizations of these distributions within psychiatric settings remain limited, particularly regarding variations across diagnostic categories. Methods We conducted a retrospective cross-sectional analysis of 17,687 psychiatric hospitalizations at the University Hospital of Psychiatry Zurich between 2013 and 2020. …”
Get full text

Evaluation of a Bayesian Belief Network tool for translating science and informing policy: the case of antibiotic misuse in Tanzania by Miss Madeleine Clarkson, Dr Katherine L Keenan, Dr Edward Lavender, Prof Stephen E Mshana, Dr Martha F Mushi, Prof Matthew TG Holden, Dr V Anne Smith

“…To assess BNNs’ capacity to live up to this promise, we make a previously derived BBN for antibiotic misuse into a web-based interactive tool and evaluated it with non-specialists. Methods: A BBN of determinants of antibiotic misuse in Tanzanian urinary tract infection patients was incorporated into a web-based application, which included an interactive tool plus other relevant information, such as educational materials. …”
Get full text

Survey of Glaucoma Practice Patterns Among Members of The Philippine Glaucoma Society by Edgar Felipe U. Leuenberger, MD, DPBO, James Paul S. Gomez, MD, DPBO, Karlo Paolo L. Alejo, MD, DPBO, Robert Edward T. Ang, MD, DPBO, Maria Zita Zagala-Meriales, MD, DPBO, Pamela C. Allarey, MD, DPBO, Aldo Mar B. Cariaga, MD, DPBO, John Mark S. De Leon, MD, DPBO, Sammy L. Ang, MD, DPBO

“…Objective: To identify the glaucoma clinical practice patterns among the members of the Philippine Glaucoma Society (PGS) from 2015 to 2016 using an online survey. Methods: An online link was sent to each consenting PGS member which directed them to two poll sites. …”
Get full text

UAV-OVD: Open-Vocabulary Object Detection in UAV Imagery via Multi-Level Text-Guided Decoding by Lijie Tao, Guoting Wei, Zhuo Wang, Zhaoshuai Qi, Ying Li, Haokui Zhang

“…Although the majority of existing methods are developed under closed-set assumptions, and some recent studies have begun to explore open-vocabulary or open-world detection, their application to UAV imagery remains limited and underexplored. …”
Get full text

The Use of Large Language Models and Their Association With Enhanced Impact in Biomedical Research and Beyond by Huzi Cheng, Wen Shi, Bin Sheng, Aaron Y. Lee, Josip Car, Varun Chaudhary, Atanas G. Atanasov, Nan Liu, Yue Qiu, Qingyu Chen, Tien Yin Wong, Yih‐Chung Tham, Ying‐Feng Zheng

Get full text