Gene Expression Profiling in Wild-Type and PPAR𝛼-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR𝛼-Independent Effects by Mitchell B. Rosen, Judith R. Schmid, J. Christopher Corton, Robert D. Zehr, Kaberi P. Das, Barbara D. Abbott, Christopher Lau

“…Hence, in addition to its ability to modestly activate PPAR𝛼, PFOS induces a variety of PPAR𝛼-independent effects as well.…”
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Inference of cell type content from human brain transcriptomic datasets illuminates the effects of age, manner of death, dissection, and psychiatric diagnosis. by Megan Hastings Hagenauer, Anton Schulmann, Jun Z Li, Marquis P Vawter, David M Walsh, Robert C Thompson, Cortney A Turner, William E Bunney, Richard M Myers, Jack D Barchas, Alan F Schatzberg, Stanley J Watson, Huda Akil

“…Subjects with Schizophrenia had reduced red blood cell gene expression, resembling the hypofrontality detected in fMRI experiments. Finally, in datasets containing samples with especially variable cell content, we found that controlling for predicted sample cell content while evaluating differential expression improved the detection of previously-identified psychiatric effects. …”
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Alterations of circulating exosomal microRNAs in an LPS‐induced depression model of male mice: Potential role in the anti‐depressive effects of acupuncture by Jade Heejae Ko, Ka Yoon Chun, Seung‐Nam Kim

“…Using an LPS‐induced depression model, we examined acupuncture's effects on depression‐like behaviors and circulating exosomal miRNAs in serum. …”
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Effects of Benzo[a]Pyrene Exposure on Lung Cancer: A Mechanistic Study of Epigenetic m6A Levels and YTHDF1 by Siyi Xu, Jie Li, Sheng Yang, Panpan Yang, Yiru Niu, Yiling Ge, Geyu Liang

“…TMT labeling-based proteomic analysis and clinical lung tissue microarray assays demonstrated that CDK6 and MAP3K6 were positively correlated with YTHDF1 expression. …”
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Limited Effects of an eIF2αS51A Allele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer’s Disease by Katharina Paesler, Kan Xie, Moritz M. Hettich, Magdalena E. Siwek, Devon P. Ryan, Susanne Schröder, Anna Papazoglou, Karl Broich, Ralf Müller, Astrid Trog, Alexander Garthe, Gerd Kempermann, Marco Weiergräber, Dan Ehninger

“…Increased phosphorylation of eIF2α alters translational control and may thereby have adverse effects on synaptic plasticity, learning, and memory. …”
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The N-6 methyladenosine dynamics in STEMI and the effect of IL-6 inhibition - a hypothesis generating sub-study of the ASSAIL-MI trial by Tuva B. Dahl, Tuva B. Dahl, Ana Quiles-Jiménez, Kaspar Broch, Kaspar Broch, Anne Kristine Anstensrud, Anne Kristine Anstensrud, Lars Gullestad, Lars Gullestad, Lars Gullestad, Geir Ø. Andersen, Geir Ø. Andersen, Ola Kleveland, Jonas Øgaard, Jonas Øgaard, Vigdis Bjerkeli, Vigdis Bjerkeli, Azita Rashidi, Kuan Yang, Kirsten B. Holven, Kirsten B. Holven, Pål Aukrust, Magnar Bjørås, Magnar Bjørås, Camilla Huse, Camilla Huse, Camilla Huse, Bente Halvorsen, Bente Halvorsen

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Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect and potential mechanism of nomilin against triple-negative breas... by Zhixuan Wu, Haoyi Xiang, Xiaowu Wang, Rongrong Zhang, Yangyang Guo, Liangchen Qu, Jingyao Zhou, Yanyi Xiao

“…Conclusion For the first time, the research effectively discovered the objectives and mechanisms of nomilin in combating TNBC using network pharmacology, molecular docking, molecular dynamics simulation, proteome microarray and experimental confirmation, presenting a hopeful approach for treating TNBC. …”
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DETERMINATION OF THE THERAPEUTIC EFFECT OF VULPINIC ACID AND VULPINIC ACID-RESPONSIVE miR-197-3P IN BREAST CANCER TREATMENT BY IN VITRO AND IN VIVO STUDIES by Demet Cansaran Duman

“…Breast cancer is the most common type of cancer in women and an effective treatment method has not been developed yet. …”
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Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic... by Sabrina Le Bouter, Marianne Rodriguez, Nolwen Guigal-Stephan, Sophie Courtade-Gaïani, Laura Xuereb, Catherine de Montrion, Vincent Croixmarie, Thierry Umbdenstock, Claire Boursier-Neyret, Michel Lonchampt, Manuel Brun, Catherine Dacquet, Alain Ktorza, Brian-Paul Lockhart, Jean-Pierre Galizzi

“…Rosiglitazone (RSG), developed for the treatment of type 2 diabetes mellitus, is known to have potent effects on carbohydrate and lipid metabolism leading to the improvement of insulin sensitivity in target tissues. …”
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Therapeutic effects of adipose tissue-derived mesenchymal stem cells on ER stress in a murine model of metabolic dysfunction-associated steatohepatitis: an in vivo and in vitro stu... by Norihiko Ogawa, Akihiro Seki, Alessandro Nasti, Ho Yagi, Masatoshi Yamato, Hiiro Inui, Hiroki Nomura, Takuya Komura, Hidetoshi Nakagawa, Kouki Nio, Hajime Takatori, Tetsuro Shimakami, Masao Honda, Shuichi Kaneko, Yoshio Sakai, Taro Yamashita

“…ADSCs were harvested, cultured, and treated to assess their effects on ER stress. In vitro experiments investigated palmitic acid-induced ER stress in hepatocytes and the effects of ADSCs on hepatic stellate cells and inflammatory markers. …”
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RETRACTED ARTICLE: LncRNA HAND2-AS1 exerts anti-oncogenic effects on bladder cancer via restoration of RARB as a sponge of microRNA-146 by Liping Shan, Wei Liu, Yunhong Zhan

“…Methods LncRNA and miRNA microarray was conducted to explore different expressed RNA in primary bladder cancer specimens. …”
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Effect of Garlic Organic Sulfides on Gene Expression Profiling in HepG2 Cells and Its Biological Function Analysis by Ingenuity Pathway Analysis System and Bio-Plex-Based Assays by Chenghao Lv, Caiqiong Wang, Ping Li, Yiwen Huang, Xiangyang Lu, Meng Shi, Chaoxi Zeng, Si Qin

“…The aim of the present study was to investigate the effect of DADS, DATS, and DTS on the gene expression profiling of human hepatocellular carcinoma cells (HepG2) by application of microarray and specialized analysis software, GO, Bio-Plex-based cytokines assay and IPA and analyze their structure-activity relationship according to antioxidant, anti-inflammatory, and metabolic-related properties. …”
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Implementation of Valid HPV Diagnostics for the Early Detection of Cervical Cancer in Molecular Pathology: HPV 3.5 LCD-Array (Chipron GmbH) vs. PapilloCheck^® (Greiner Bi... by Jan Jeroch, Melanie Winter, Anna Bieber, Agnes Boger, Christina Schmitt, Silvana Ebner, Morva Tahmasbi Rad, Henning Reis, Peter. J. Wild

“…This study compares the two hybridisation-based DNA-microarray systems “HPV 3.5 LCD-Array” (Chipron GmbH) and “PapilloCheck^®” (Greiner Bio-One GmbH), based on their ability to detect and differentiate HPV infections in 42 different cervical smears. …”
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The Features of a Humoral Immune Response Development during the Acute Phase of ixodes Tick-Borne Borreliosis (Based on Multiplex Analysis with the Immunochip) by V. G. Pomelova, E. I. Korenberg, T. I. Kuznetsova, N. S. Osin

“…Therefore, additional detection of IgM to recombinant proteins did not improve significantly the overall sensitivity of the latter PHOSPHAN variant. …”
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Evaluating the potential of anti-dsRNA antibodies as an alternative viral sensing tool in encephalitides of different species by Madeleine de le Roi, Hannah Gerhards, Adnan Fayyad, Adnan Fayyad, Mathias Boelke, Stefanie Christine Becker, Asisa Volz, Ingo Gerhauser, Wolfgang Baumgärtner, Christina Puff

“…Molecular methods like multiplex PCR and microarrays are considered to be often less sensitive than Next Generation Sequencing, whereas the latter is time-consuming and costly. …”
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Combined Use of Gene Expression Modeling and siRNA Screening Identifies Genes and Pathways Which Enhance the Activity of Cisplatin When Added at No Effect Levels to Non-Small Cell... by Ada W Y Leung, Stacy S Hung, Ian Backstrom, Daniel Ricaurte, Brian Kwok, Steven Poon, Steven McKinney, Romulo Segovia, Jenna Rawji, Mohammed A Qadir, Samuel Aparicio, Peter C Stirling, Christian Steidl, Marcel B Bally

“…Here, we report on studies designed to uncover how tumour cells respond to sub-lethal doses of cisplatin. A microarray study revealed changes in gene expressions that occurred when A549 cells were exposed to a no-observed-effect level (NOEL) of cisplatin (e.g. the IC10). …”
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Ultrasensitive Bead-Based Immunoassay for Real-Time Continuous Sample Flow Analysis by Yuri M. Shlyapnikov, Elena A. Shlyapnikova

“…The flow cell is integrated with a microarray-based signal detection module, where beads with bound analyte scan the microarray surface and are retained on it by single specific interactions, assuring ultra-high sensitivity of the method. …”
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Synchrotron Radiation-Induced X-Ray Emission to Identify Metal Ions in Preparations of Purified Protein by Thomas Pfister, Huan Feng, Eckard Wimmer, Keith W. Jones

“…Thus, SRIXE may have wide use as a particularly effective method for rapidly determining trace metals in microarray samples.…”
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Using rule-based machine learning for candidate disease gene prioritization and sample classification of cancer gene expression data. by Enrico Glaab, Jaume Bacardit, Jonathan M Garibaldi, Natalio Krasnogor

“…Microarray data analysis has been shown to provide an effective tool for studying cancer and genetic diseases. …”
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Determination of Viral Nucleic Acid in the Human Blood by M. A. Abdurashitov, N. A. Netesova

“…Many acute viral infections cause similar clinical symptoms, therefore, establishing the etiology of a viral disease requires the use of whole complexes of serological or PCR tests designed to detect a particular type of pathogen. Modern methods of molecular biology allow early diagnosis of viral diseases at a time when serological diagnostic methods are not yet effective. …”
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