Ensemble Algorithm Based on Gene Selection, Data Augmentation, and Boosting Approaches for Ovarian Cancer Classification by Zne-Jung Lee, Jing-Xun Cai, Liang-Hung Wang, Ming-Ren Yang

“…<b>Background:</b> Ovarian cancer is a difficult and lethal illness that requires early detection and precise classification for effective therapy. …”
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Role of transcriptomics in the study of oral cancer by Prabhu Manickam Natarajan, Vidhya Rekha Umapathy

“…Oral cancer, a formidable public health challenge, demands innovative approaches for early detection and effective treatment. This review explores the transformative role of transcriptomics in oral cancer research, leveraging cutting-edge technologies to decode the RNA landscape of tumors. …”
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MTAP deficiency is highly homogeneous in advanced, muscle-invasive urothelial carcinoma of the urinary bladder by Natalia Gorbokon, Katharina Teljuk, Viktor Reiswich, Florian Lutz, Sebastian Dwertmann Rico, Clara Lühr, Christian Bernreuther, Yaryna Klos Al Bunni, Cosima Völkel, Henning Plage, Maximilian Lennartz, Margit Fisch, Sarah Minner, Ronald Simon, Guido Sauter, Henrik Zecha, Stefan Steurer, Thorsten Schlomm, Tatjana Vlajnic, Lukas Bubendorf, Michael Rink, Martina Kluth, Florian Viehweger, Morton Freytag

“…MTAP IHC is a near perfect surrogate for the detection of homozygous 9p21 (MTAP) deletions. Drugs targeting MTAP deficiency could be highly useful in a relevant subset of invasive urothelial bladder cancers.…”
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In-depth immunochemical characterization of the serum antibody response using a dual-titration microspot assay by Ágnes Kovács, Ágnes Kovács, Zoltán Hérincs, Krisztián Papp, Jakub Zbigniew Kaczmarek, Daniel Nyberg Larsen, Daniel Nyberg Larsen, Pernille Stage, László Bereczki, Eszter Ujhelyi, Tamás Pfeil, Tamás Pfeil, József Prechl

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Autosomal chromosome microdeletions in three adolescent girls with premature ovarian insufficiency: a case report by Ke Yuan, Minfei He, Yanlan Fang, Jianfang Zhu, Li Liang, Chunlin Wang

“…Clinical evaluation, hormonal tests, abdominal ultrasonography, and chromosome karyotyping were performed. Chromosome microarray analysis (CMA) was also performed to detect DNA copy number changes. …”
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Systematic analysis of co-expression network and gene expression profile of differentially expressed lncRNA-mRNA one week after spinal cord injury by Yi Kang, Yijie Song, Zhongju Shi, Qiang Li, Yigang Lv, Mengfan Hou, Cui Ding, Jing Xie, Yongfu Lou, Chi Zhang, Huan Jian, Xueying Li, Hengxing Zhou, Shiqing Feng

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The involvement of the synaptic vesicle cycle in homocysteine induced neurotoxicity in vitro and in vivo by Meng Wang, Xiaoshan Liang, Keqing Jin, Yinyue Liu, Suhui Luo, Qiang Zhang, Xuan Wang, Zhiping Dong, Xumei zhang

“…Pathological damage and apoptosis were detected in the DG, CA3, and CA1 regions of the hippocampus, along with the cortical area. …”
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Integrative in Silico and in vitro validation suggest LINC00963 and SNHG15 as candidate biomarkers for coronary artery disease by Mohammadreza Saberiyan, Parisa Noorabadi, Ozra Kahourian, Ahmad Golestanifar, Negar Jafari, Venus Shahabi Rabori, Pegah Mousavi

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Rapid Whole-Genome Sequencing in Critically Ill Infants and Children with Suspected, Undiagnosed Genetic Diseases: Evolution to a First-Tier Clinical Laboratory Test in the Era of... by Rina Kansal

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Structure preserving t-SNE of matrix framed data by Soohyun Ahn, Johan Lim, Wei Jiang, Sungim Lee, Xinlei Wang

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Genetic testing for diagnosing neurodevelopmental disorders and epilepsy: a systematic review and meta-analysis by Yu-Ming Chang, Yen-Ta Huang, Pei-Chun Lai

“…Abstract Background Identifying the genetic causes of neurodevelopmental disorders (NDDs) and epilepsy is crucial for effective treatment and genetic counseling. Our objective was to determine the diagnostic yield of chromosomal microarray (CMA) and next-generation sequencing (NGS) methods—including targeted sequencing (TS), whole-exome sequencing (WES), and whole-genome sequencing (WGS)—in individuals with NDDs or epilepsy. …”
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First African case report of hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome due to inverted duplication and deletion of chromosome 10p by Tumelo M. Satekge, Glenrose Rikhotso, Bianca Rossouw, Bronwyn Dillon, Fiona Baine-Savanhu

“…Here, we report the first African case of HDR syndrome to be confirmed by chromosomal microarray analysis (CMA). Case presentation A 3-month-old female presented with focal seizures due to severe hypocalcaemia associated with low parathyroid hormone. …”
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Case Report: Prenatal diagnosis of novel compound heterozygous variants in WDR35 gene causing short-rib thoracic dysplasia 7 with or without polydactyly by Jianlong Zhuang, Junyu Wang, Zhengping Huang, Yu’e Chen, Chunnuan Chen

“…In this article, we report a novel deletion compound combined with a causative variant in WDR35 gene leading to short-rib thoracic dysplasia 7 (SRTD7) with or without polydactyly using WES.MethodsThis study involved a Chinese fetus with clinical features of skeletal dysplasia on ultrasound imaging, in whom chromosome abnormalities and copy number variants (CNVs) were detected by chromosomal microarray analysis (CMA), and sequence variants were detected by WES. …”
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Identification of three small nucleolar RNAs (snoRNAs) as potential prognostic markers in diffuse large B‐cell lymphoma by Mei‐wei Li, Feng‐xiang Huang, Zu‐cheng Xie, Hao‐yuan Hong, Qing‐yuan Xu, Zhi‐gang Peng

“…Results Twelve prognosis‐correlated snoRNAs were selected from the DLBCL patient cohort of microarray profiles, and a three‐snoRNA signature consisting of SNORD1A, SNORA60, and SNORA66 was constructed. …”
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A hybrid of an automated multi-filter with a spatial bound particle swarm optimization for gene selection and cancer classification by Anas Arram, Masri Ayob, Musatafa Abbas Abbood Albadr, Dheeb Albashish, Alaa Sulaiman

“…Cancer is one of the most dangerous diseases and a leading cause of death globally. Therefore, early detection of cancer is critical for effective treatments. …”
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Serum profiling of the antibody response to HPV in women with or without abnormal cervical cytology undergoing cervical cancer screening by Radwa Ewaisha, Mack T. Ruffin, Stacy Williams, Yunro Chung, Yunro Chung, Cecilia R. DeGraffinreid, Electra D. Paskett, Electra D. Paskett, Paul L. Reiter, Ji Qiu, Dean E. Brenner, Karen S. Anderson

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Evaluating the Nuclear Reaction Optimization (NRO) Algorithm for Gene Selection in Cancer Classification by Shahad Alkamli, Hala Alshamlan

“…This complexity necessitates advanced optimization methods for effective gene selection. <b>Methods</b>: This study introduces and evaluates the Nuclear Reaction Optimization (NRO)—drawing inspiration from nuclear fission and fusion—for identifying informative gene subsets in six benchmark cancer microarray datasets. …”
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INTEGRAL ANALYSIS OF GENOMIC AND TRANSCRIPTOMIC CHANGES IN CLEAR CELL RENAL CELL CARCINOMA IN THE RUSSIAN POPULATION by S. A. Solodskikh, A. V. Panevina, A. G. Novikova, J. D. Dvoretskaya, M. V. Gryaznova, A. A. Starkov, A. Yu. Maslov, A. A. Mikhailov, K. Khinolupos, V. N. Popov

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Identification of potential biomarkers and pathways related to major depressive disorder by integrated bioinformatic analysis and experimental validation by Ying Zeng, Lu-Qi Peng, Mei Zhang, Rong Zhong, Ke-Chao Nie, Wei Huang

“…Objective: To identify promising biomarkers for the pathogenesis of major depressive disorder (MDD). Methods: Microarray chips of MDD patients, including the GSE98793, GSE52790, and GSE39653 datasets, were obtained from the Gene Expression Omnibus database. …”
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RESPONSE TO NEOADYAVANT CHEMOTHERAPY WITH PLATINUM-BASED DRUGS IN BREAST CANCER PATIENTS WITH BRCA1 DELETION IN TUMOR by M. M. Tsyganov, N. A. Tarabanovskaya, I. V. Deryusheva, M. K. Ibragimova, P. V. Kazantseva, A. M. Pevzner, E. M. Slonimskaya, N. V. Litviakov

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