AXL tyrosine kinase inhibitor TP-0903 induces ROS trigger neuroblastoma cell apoptosis via targeting the miR-335-3p/DKK1 expression by Tsai-Yi Tseng, Shao-Hsuan Kao, Shun-Fa Yang, Yi-Chen Lin, Chu-Liang Lin, Juei-Liang Chen, Chien-Min Chen, Yi-Hsien Hsieh

“…TP-0903, a multi-kinase inhibitor, shows inhibitory effects on NB but the mechanistic act is not completely explored. …”
Get full text

In Vitro Examination of Fungal and Root Extracts Inspired by Traditional Medicine for Potential Periorbital Eye Infrastructure Treatments by James V. Gruber, Nicole Terpak, Sebastien Massard, Xiang Chen, John Craffey, Robert Holtz

“…Consumers spend considerable amounts of resources combatting these effects. If consumers could treat some of the sources of these problems, in advance of the inevitable influences of aging, a kind of prejuvenation of the eye infrastructure, then perhaps the inevitable outcomes of aging apparent around the eyes could be slowed. …”
Get full text

Parent-of-origin testing of prenatal copy number variations: a retrospective study of 167 family cases by Yuefang Liu, Yuan Peng, Zhe Liang, Qiong Pan

“…Here, among 2273 pregnant women undergoing prenatal diagnosis, 236 CNVs were reported by chromosomal microarray analysis (CMA) including 69 full-penetrance pCNVs, 44 low-penetrance pCNVs, 113 VUS CNVs and 10 LP CNVs. …”
Get full text

Expression and prognostic significance of MLH1 and GPRC5C in resectable hepatocellular carcinoma by Jun Lu, Lei Li, Qing Chen, Bingqi Li, Siqian Ren, Meng Yuan, Meng Meng, Jian Lei, Yuntao Bing, Hangyan Wang, Zhaolai Ma, Dianrong Xiu, Chunhui Yuan

“…However, their expression and prognostic significance in hepatocellular carcinoma (HCC) has not been elucidated, especially for GPRC5C. Methods We detected MLH1 and GPRC5C expression using the tissue microarray-based immunohistochemical staining in tumor and matched adjacent non-tumor liver (ANL) specimens from 230 patients who underwent radical resection for HCC. …”
Get full text

Overexpression of cyclin‐dependent kinase 1 in esophageal squamous cell carcinoma and its clinical significance by Han‐Jie Zhang, Gang Chen, Shang‐Wei Chen, Zong‐Wang Fu, Hua‐Fu Zhou, Zhen‐Bo Feng, Jun‐Xian Mo, Chang‐Bo Li, Jun Liu

“…Microarray and external RNA‐seq data from 664 cases of ESCC and 1733 cases of control tissues were used to verify the difference in CDK1 expression between the two groups. …”
Get full text

Analysis of gene expression difference and biological process in chorionic villi of unexplained recurrent spontaneous abortion by Linling Shi, Lun Wei, Meiqiu Lu, Hongmei Ding, Le Bo

“…Abstract Objective To explore the biological relationship between the regulatory signal pathways involved in differentially expressed genes and recurrent spontaneous abortion (RSA) by analyzing the gene expression microarray data of unexplained RSA. Methods The gene expression profile data of chorionic villi from unexplained recurrent abortion with normal karyotype and selective induced abortion were compared. …”
Get full text

Maternal plasma cell-free DNA nucleosome footprints can reveal changes in gene expression profiles during pregnancy and pre-eclampsia by Kun Li, Zhiwei Guo, Fenxia Li, Shijing Lu, Min Zhang, Xingyu Wei, Chao Sheng, Wenbo Hao, Xuexi Yang

“…These results are consistent with prior microarray and RNA-sequencing data. Conclusions The depth of the cfDNA nucleosome footprint in maternal plasma can be used to reflect changes in the gene expression profile during pregnancy and pre-eclampsia. …”
Get full text

Targeting glial fibrillary acidic protein in glaucoma: a monoclonal antibody approach to modulate glial reactivity and neuroinflammation for neuroprotection by Chaoqiang Guan, Linglin Zhang, Kristian Nzogang Fomo, Jie Yang, Norbert Pfeiffer, Franz H. Grus

“…This study aimed to assess the neuroprotective effects of a monoclonal antibody (mAb) targeting GFAP in glaucoma and to elucidate the underlying mechanisms. …”
Get full text

Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment by Jie Wang, Hong Ni, Yu Wang, Luyao Wei, Hanqing Ding, Zhongzhao Guo, Hao Pan, Ying Yu, Jia Luo, Weidong Pan, Deheng Wang, Zun-Ji Ke

“…Methods We conducted backcrossing between COX-1 knockout (KO) and 5 × FAD mice to evaluate the effect of COX-1 deficiency on neuroinflammation. In addition, single-cell sequencing and microarray datasets from public databases and ingenuity pathway analysis in vitro were employed to explore gene expression profiles in the brains of AD mice. …”
Get full text

Long Noncoding RNA and mRNA m6A Modification Analyses of Periodontal Ligament Stem Cells from the Periodontitis Microenvironment Exposed to Static Mechanical Strain by Weifu Sun, Jia Liu, Xu Zhang, Xiaochen Zhang, Jie Gao, Xin Chen, Xian Wang, Wen Qin, Zuolin Jin

“…However, the regulatory effects of lncRNA and mRNA m6A modification on PDLSCs have not been studied. …”
Get full text

Pericytes in castration-resistant prostate cancer associated with disease progression and immunotherapy response: insights from single-cell analysis by Yifeng Qiu, Yuhan Wang, Jiahe Liu, Kai Sun, Shigeo Horie, Zhitong Bing, Qi Hou

“…Our investigation is designed to decipher the biological effects of pericytes on CRPC and their interactions with the tumor microenvironment. …”
Get full text

Therapeutic role of aripiprazole in cartilage defects explored through a drug repurposing approach by Jun-Ku Lee, Hyunjeong Yeo, Sujin Choi, Kyeong Mi Kim, Hannah Kim, Sung-Sahn Lee, Hyun Il Lee, Younghoon Jeong, Hyun-Ju An, Soonchul Lee

“…Furthermore, aripiprazole effectively enhanced cartilage regeneration in the rat model. …”
Get full text

LncRNA-mRNA co-expression network in the mechanism of butylphthalide treatment for ischemic stroke by Yangfang An, Lingyun Huang, Jun Li, Zhuo Chen, Jizhang Cai, Biao Wang, Qiong Zhou

“…This study investigated the effects of butylphthalide treatment on the lncRNA-mRNA co-expression network in ischemic stroke patients. …”
Get full text

Exogenous TSG-6 treatment alleviates DSS-induced colitis in mice by modulating Pou2f3 and promoting tuft cells differentiation by Shaopeng Yang, Yuqi Li, Rongwei Ruan, Jiangping Yu, Bo Zhu, Haibin Lou, Xiaolan Zhang, Shi Wang

“…Results TSG-6 treatment significantly attenuated DSS-induced colitis symptoms and inflammatory cell infiltration. Microarray analysis revealed that TSG-6 decreased pro-inflammatory cytokine levels in colon tissue. …”
Get full text

Upregulated MicroRNA-155 Expression in Peripheral Blood Mononuclear Cells and Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Li Long, Ping Yu, Yanying Liu, Shiyao Wang, Ru Li, Jinxia Shi, Xiaoping Zhang, Yanmei Li, Xiaolin Sun, Bin Zhou, Liufu Cui, Zhanguo Li

“…This study was to screen for the miRNAs differently expressed in peripheral blood mononuclear cells (PBMC) of RA, to further identify the expression of miR-155 in RA PBMC and fibroblast-like synoviocytes (FLS), and to evaluate the function of miR-155 in RA-FLS. Methods. Microarray was used to screen for differentially expressed miRNAs in RA PBMC. miR-155 expression in PBMC and FLS of RA were identified by real-time PCR. …”
Get full text

The significance of Trk receptors in pancreatic cancer by Matthew D Johnson, Brandon Stone, Bryan J Thibodeau, Andrew M Baschnagel, Sandra Galoforo, Laura E Fortier, Billie Ketelsen, Samreen Ahmed, Zakiya Kelley, Alaa Hana, Thomas G Wilson, John M Robertson, Robert P Jury, George D Wilson

“…A specific inhibitor of TrkA, B, and C, AstraZeneca 1332, was investigated in vitro and in vivo in combination with radiation. A tissue microarray was constructed from 77 pancreatic ductal adenocarcinoma patients who had undergone neoadjuvant chemoradiation and the Trk receptor, and neurogenic differentiation 1 expression was assessed and correlated with overall survival. …”
Get full text

Involvement of Urokinase-Type Plasminogen Activator Receptor in the Formation of a Profibrotic Microenvironment in the Epicardial Region by K. V. Dergilev, Z. I. Tsokolayeva, I. B. Beloglazova, Yu. D. Vasilets, D. O. Traktuyev, B. N. Kulbitsky, E. V. Parfenova

“…We used histological and immunofluorescent staining, microarray analysis of proinflammatory cytokine levels, and a method for assessing the migratory properties of epicardial cells.Results. …”
Get full text

KRT6A, KRT6B, PKP1, and PKP3 as key hub genes in esophageal cancer: A combined bioinformatics and experimental study by Shayan Marhamati, Morvarid Hamrahjoo, Zeinab Seyedkhan, Mahdi Bahmani, Nasrin Ziamajidi, Iraj Khodadadi, Mohadese Pouryani, Roghayeh Abbasalipourkabir

“…In this study, we downloaded the microarray datasets GSE157808 and GSE92396 from the Gene Expression Omnibus (GEO). …”
Get full text

Mechanism of immune escape mediated by receptor tyrosine kinase KIT in thyroid cancer by Zhen Luo, Jin Xu, Dayong Xu, Jiaojiao Xu, Rongjun Zhou, Keping Deng, Zheng Chen, Fang Zou, Libo Yao, Yuqin Hu

“…Methods The expression microarray of TC was acquired through the GEO database, and the difference analysis and Kyoto encyclopedia of genes and genomes pathway enrichment analysis were carried out. …”
Get full text

Identification and characterization of the anti-viral interferon lambda 3 as direct target of the Epstein-Barr virus microRNA-BART7-3p by Juliane Blümke, Marcus Bauer, Christoforos Vaxevanis, Andreas Wilfer, Ofer Mandelboim, Claudia Wickenhauser, Barbara Seliger, Simon Jasinski-Bergner

“…To determine novel targets of EBV-miRs involved in immune surveillance, ebv-miR-BART7-3p, an EBV-encoded miR with high expression levels during the different lytic and latent EBV life cycle phases, was overexpressed in human HEK293T cells. Using a cDNA microarray-based comparative analysis, 234 (229 downregulated and 5 upregulated) deregulated human transcripts were identified in ebv-miR-BART7-3p transfectants, which were mainly involved in cellular processes and molecular binding. …”
Get full text