Complement Activation: An Emerging Player in the Pathogenesis of Cardiovascular Disease by Angela M. Carter

“…An increasing body of evidence supports a functional role for complement activation in the pathogenesis of CVD through pleiotropic effects on endothelial and haematopoietic cell function and haemostasis. …”
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Roadmap for the Development and Implementation of Entrustable Professional Activities to Enable Effective Clinical Training by Saurabh RamBihariLal Shrivastava, Shubhada Gade, Sunita Vagha

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Complement C3 inhibition reduces complement activation in clinical platelet concentrates but does not counteract platelet storage lesions by Linnea I. Andersson, Per Sandgren, Dick J. Sjöström, Camilla Mohlin, Kim Hägerström, Ivar Tjernberg, Tom Eirik Mollnes, Per H. Nilsson

“…While C3 inhibition effectively reduced complement activation in stored platelet concentrates, it did not mitigate platelet storage lesions.…”
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Zinc supplementation inhibits complement activation in age-related macular degeneration. by Dzenita Smailhodzic, Freekje van Asten, Anna M Blom, Frida C Mohlin, Anneke I den Hollander, Johannes P H van de Ven, Ramon A C van Huet, Joannes M M Groenewoud, Yuan Tian, Tos T J M Berendschot, Yara T E Lechanteur, Sascha Fauser, Chris de Bruijn, Mohamed R Daha, Gert Jan van der Wilt, Carel B Hoyng, B Jeroen Klevering

“…Furthermore, we investigated the effect of zinc on complement activation in vitro. …”
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Complement activation drives the phagocytosis of necrotic cell debris and resolution of liver injury by Sofie Vandendriessche, Matheus Silvério Mattos, Emilia Laura Bialek, Sara Schuermans, Paul Proost, Pedro Elias Marques

“…Using human neutrophils, we showed that absence of C3 or C1q caused a reduction in the volume of necrotic debris that is phagocytosed, indicating that complement promotes effective debris uptake in mice and humans. …”
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Complement activation by the artificial surface of cardiopulmonary bypass is a persistent clinical problem by Joel David Bierer, Roger Stanzel, Mark Henderson, Tony El-Rabahi, John Sapp, Pantelis Andreou, Jean S. Marshall, David Conrad, David Horne

“…Circuit exposure time was a predictor of only C3a concentration in multivariable generalized linear mixed-effects models. Despite modern biocompatibility technology, there is significant alternative complement activation during ex-vivo sanguineous CPB prime preparation. …”
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The stability of complement-mediated bactericidal activity in human serum against Salmonella. by Colette M O'Shaughnessy, Adam F Cunningham, Calman A Maclennan

“…Up to three freeze-thaw cycles had no effect on the persistence of bactericidal activity and hemolytic complement assays confirmed no effect on complement function. …”
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Plasma and complement proteins are essential for the antimicrobial activity of canine platelet lysate by Melikasadat Mollabashi, Melikasadat Mollabashi, Alonza Klopfer, Alonza Klopfer, Thainá Lunardon, Thainá Lunardon, Nikolia Darzenta, Nikolia Darzenta, Emily Davis, Matt Murray, Scarlett M. Sumner, Maria C. Naskou, Maria C. Naskou

“…Additionally, platelets possess antimicrobial properties, which can be influenced by their manufacturing process, platelet and leukocyte concentration, activation method, and the presence of plasma and complement. …”
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Luciferase complementation based-detection of G-protein-coupled receptor activity by Hideaki Yano, Ning Sheng Cai, Jonathan A Javitch, Sergi Ferré

“…Protein complementation assays (PCA) are used as pharmacological tools, enabling a wide array of applications, ranging from studies of protein–protein interactions to second messenger effects. …”
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Tocilizumab modulates the activity of the classical and alternative complement pathways in rheumatoid arthritis patients by Iván Ferraz-Amaro, Iván Ferraz-Amaro, Sergio Santos-Concepción, Javier Castro-Hernández, Maria Vanesa Hernández-Hernández, Beatriz Tejera Segura, Cristina Luna, Esmeralda Delgado-Frias, Federico Díaz-González, Federico Díaz-González, Federico Díaz-González

“…The decrease in the alternative pathway was significant at weeks 12 and 24, but not at week 52 of TCZ treatment. TCZ had no effect on the lectin cascade throughout the follow-up.ConclusionTCZ reduces the activity of the classical and alternative pathways of the complement system in RA patients regardless of the improvement in disease activity. …”
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The Effectiveness of Implementing the Independent Curriculum in Shaping an Innovative Generation in Indonesia by Dian Vitasari, Dwi Noviani, Lisa Anggraini, Desy Safitri, Abdulhafiz Hile

“…This study aims to analyze the effectiveness of the implementation of the Independent Curriculum in shaping an innovative generation in Indonesia. …”
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The Implementation of Lesson Study Based Learning Management and the Effect toward Students’ Activeness in Lecturing by Imam Gunawan

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Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS‐mutant Cancers by Yafang Wang, Lansong Xu, Lijun Ling, Mingyue Yao, Shangxuan Shi, Chengcheng Yu, Yingnian Li, Jie Shen, Hualiang Jiang, Chengying Xie

“…Co‐targeting of CDK9 and KRAS/MAPK signaling pathways eliminates ERK‐MYC activation and prevents feedback activation mediated by receptor tyrosine kinases, leading to more effective control of KRAS‐mutant cancers and overcoming KRASi resistance. …”
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Cost-effectiveness of support for health professionals to implement physical activity promotion: a protocol for within-trial and modelled economic evaluations of the PROMOTE-PA effectiveness-implementation hybrid trial by Kirsten Howard, Anne Tiedemann, Catherine Sherrington, Michael Noetel, Marina Pinheiro, Leanne Hassett, Sakina Chagpar, Belinda Wang, Georgina Clutterbuck, Jennifer N Baldwin, Daniel Cheung, Kate Purcell, Roslyn Savage

“…Promotion of Physical Activity by Health Professionals is a hybrid type 1 effectiveness-implementation cluster randomised trial designed to evaluate the impact of physical activity promotion by health professionals (n=30 clusters) on physical activity participation in their patients (n=720). …”
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Implementation of Antimicrobial Stewardship Activities in India by Arzoo Sahni, Arti Bahl, Rashi Martolia, Sudhir Kumar Jain, Sujeet Kumar Singh

“…There seems to be a lot of scope in improving the implementation activities by building and strengthening of components such as use of information technology in monitoring and surveillance, use of antibiotic cycling and sensitizing staff, and broadening the role of different staff members to develop an effective program in the nation which meets the goals of National Action Plan-AMR.…”
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Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina by Marcus Karlstetter, Jens Kopatz, Alexander Aslanidis, Anahita Shahraz, Albert Caramoy, Bettina Linnartz‐Gerlach, Yuchen Lin, Anika Lückoff, Sascha Fauser, Katharina Düker, Janine Claude, Yiner Wang, Johannes Ackermann, Tobias Schmidt, Veit Hornung, Christine Skerka, Thomas Langmann, Harald Neumann

“…Its pathophysiology is linked to reactive oxygen species (ROS) and activation of the complement system. Sialic acid polymers prevent ROS production of human mononuclear phagocytes via the inhibitory sialic acid‐binding immunoglobulin‐like lectin‐11 (SIGLEC11) receptor. …”
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Strategies to Ensure Effective Implementation of Peer Mentoring for Research by Saurabh RamBihariLal Shrivastava, Anup Mukund Marar, Prateek Sudhakar Bobhate

“…The process of implementation of peer mentoring in research is a challenging one and it must be carefully planned to effectively respond to the potential concerns. …”
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Effective implementation of ESG principles under technological sovereignty by Dovbiy Irina, Egorova Alexandra, Danilov Ilia

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Effective Implementation of Digital Technologies in the Field of Gas Supply by Beloglazova T. N., Romanova T. N.

“…The effectiveness of digital technologies is assessed taking into account the volume of gas consumption. …”
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Cobalt Protoporphyrin IX Attenuates Antibody-Mediated, Complement-Dependent Podocyte Injury: Role of Cobalt and Porphyrin Moieties by Elias A. Lianos, Gia Nghi Phung, Jianping Zhou, Mukut Sharma

“…Metalloporphyrins (MPs) that induce heme oxygenase (HO)-1 were shown to attenuate complement-mediated glomerular injury, with cobalt protoporphyrin IX (CoPPIX) being the most effective. …”
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