Increased Cardiovascular Mortality in Hemodialysis: The Role of Chronic Inflammation, Complement Activation, and Non-Biocompatibility by Ákos Géza Pethő, Tibor Fülöp, Petronella Orosz, Gábor Szénási, Mihály Tapolyai, László Dézsi

“…This intensified state of inflammation may be linked to the direct exposure of the bloodstream to a bio-incompatible environment in HD; for both complement-mediated and non-complement-mediated reactions, the possible contribution of neutrophil extracellular traps and complement activation-related pseudoallergy are reviewed in detail. …”
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Combinatorial activation of the WNT‐dependent fibrogenic program by distinct complement subunits in dystrophic muscle by Francesca Florio, Sara Vencato, Filomena T Papa, Michela Libergoli, Eyemen Kheir, Imen Ghzaiel, Thomas A Rando, Yvan Torrente, Stefano Biressi

“…Fibro‐adipogenic progenitors and macrophages, which populate the inflamed dystrophic muscles, act as a combinatorial source of WNT activity by secreting distinct subunits of the C1 complement complex. …”
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Activation of complement factor B contributes to murine and human myocardial ischemia/reperfusion injury. by Nicholas Chun, Ala S Haddadin, Junying Liu, Yunfang Hou, Karen A Wong, Daniel Lee, Julie I Rushbrook, Karan Gulaya, Roberta Hines, Tamika Hollis, Beatriz Nistal Nuno, Abeel A Mangi, Sabet Hashim, Marcela Pekna, Amy Catalfamo, Hsiao-Ying Chin, Foramben Patel, Sravani Rayala, Ketan Shevde, Peter S Heeger, Ming Zhang

“…Experimental evidence from murine models indicates that innate immune mechanisms including complement activation via the classical and lectin pathways are crucial. …”
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Complement system is activated in acute inflammatory response to environmental particulates in the lungs by Kerui Zhang, Akiko Honda, Tomoya Sagawa, Natsuko Miyasaka, Binyang Qiu, Raga Ishikawa, Tomoaki Okuda, Takayuki Kameda, Kaori Sadakane, Takamichi Ichinose, Hirohisa Takano

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DYNAMICS OF ACTIVITY OF SOME COMPONENTS OF COMPLEMENT IN TREATMENT OF ATOPIC DERMATITIS IN CHILDREN by S. S. Andina, A. M. Bichucher, N. V. Gora, L. V. Kozlov, O. V. Logunov, O. A. Bashkina, O. V. Rubalsky, A. V. Aleshkin

“…The activity of C9 component involved in the membrane attack of the complement was significantly below normal in children with atopic dermatitis. …”
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Luciferase complementation based-detection of G-protein-coupled receptor activity by Hideaki Yano, Ning Sheng Cai, Jonathan A Javitch, Sergi Ferré

“…Protein complementation assays (PCA) are used as pharmacological tools, enabling a wide array of applications, ranging from studies of protein–protein interactions to second messenger effects. …”
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Plasma and complement proteins are essential for the antimicrobial activity of canine platelet lysate by Melikasadat Mollabashi, Melikasadat Mollabashi, Alonza Klopfer, Alonza Klopfer, Thainá Lunardon, Thainá Lunardon, Nikolia Darzenta, Nikolia Darzenta, Emily Davis, Matt Murray, Scarlett M. Sumner, Maria C. Naskou, Maria C. Naskou

“…Additionally, platelets possess antimicrobial properties, which can be influenced by their manufacturing process, platelet and leukocyte concentration, activation method, and the presence of plasma and complement. …”
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A NEW METHOD TO ASSESS FUNCTIONAL ACTIVITY OF SERUM COMPLEMENT SYSTEM by E. G. Cheremnykh, P. A. Ivanov, M. I. Faktor, N. S. Karpova, E. F. Vasiljeva, K. V. Gusev, O. S. Brusov

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The dynamic genomes of Hydra and the anciently active repeat complement of animal chromosomes by Koto Kon-Nanjo, Tetsuo Kon, Tracy Chih-Ting Koubkova Yu, Diego Rodriguez-Terrones, Francisco Falcon, Daniel E. Martínez, Robert E. Steele, Elly Margaret Tanaka, Thomas W. Holstein, Oleg Simakov

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The stability of complement-mediated bactericidal activity in human serum against Salmonella. by Colette M O'Shaughnessy, Adam F Cunningham, Calman A Maclennan

“…Up to three freeze-thaw cycles had no effect on the persistence of bactericidal activity and hemolytic complement assays confirmed no effect on complement function. …”
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Recombinant complement receptor 2 radiolabeled with [99mTc(CO)3]+: a potential new radiopharmaceutical for imaging activated complement. by Adam Badar, Sarah DeFreitas, James M McDonnell, Norhakim Yahya, David Thakor, Reza Razavi, Richard Smith, Steven Sacks, Gregory E D Mullen

“…We describe the design and synthesis of a new Tc-99m labeled bioconjugate for imaging activated complement, based on Short Consensus Repeats 1 and 2 of Complement Receptor 2 (CR2), the binding domain for C3d. …”
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Viscereal leishmaniasis: Pathogenetic basis of clinic variety by Đokić Milomir

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FUNCTIONAL ACTIVITY OF COMPLEMENT CLASSIC WAY ACTIVATION COMPONENTS AND ART1CULAS DAMAGE IN RHEUMATOID ARTRITIS by D. L. Goryachev, T. V. Lebedeva

“…A relationship between X - ray joints changes and functional activity of classical pathway complement components in R4 was investigated. 31 patients with the moderate activity ofRA (ARA 1987) have been examined. …”
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The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. by Youssif M Ali, Nicholas J Lynch, Kashif S Haleem, Teizo Fujita, Yuichi Endo, Soren Hansen, Uffe Holmskov, Kazue Takahashi, Gregory L Stahl, Thomas Dudler, Umakhanth V Girija, Russell Wallis, Aras Kadioglu, Cordula M Stover, Peter W Andrew, Wilhelm J Schwaeble

“…Three different pathways, the classical, alternative and lectin pathways, mediate complement activation. While there is limited information available on the roles of the classical and the alternative activation pathways of complement in fighting streptococcal infection, little is known about the role of the lectin pathway, mainly due to the lack of appropriate experimental models of lectin pathway deficiency. …”
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Complement activation in tumor microenvironment after neoadjuvant therapy and its impact on pancreatic cancer outcomes by Xiaofei Zhang, Ruoxin Lan, Yongjun Liu, Venu G. Pillarisetty, Danting Li, Chaohui L. Zhao, Suparna A. Sarkar, Weiguo Liu, Iman Hanna, Mala Gupta, Cristina Hajdu, Jonathan Melamed, Michael Shusterman, Jessica Widmer, John Allendorf, Yao-Zhong Liu

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Current Understanding of the Pathogenesis of ANCA-Associated Vasculitis and Novel Treatment Options Targeting Complement Activation by Konstantinos Drouzas, Petros Kalogeropoulos, George Liapis, Sophia Lionaki

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Africanized honeybee venom (Apis mellifera) promotes human complement activation split products storm by Felipe Silva de França, Felipe Silva de França, Ricardo de Oliveira Orsi, Dayanne Carla Fernandes, Dayanne Carla Fernandes, Thyago Bispo Leonel, Thyago Bispo Leonel, Denise V. Tambourgi, Denise V. Tambourgi

Subjects: “…complement pathways activation…”
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The Lectin Pathway–A Dominant Pattern of the Complement System Activation in Primary Focal Segmental Glomerulosclerosis? by Nikola Zagorec, Ivica Horvatić, Petar Šenjug, Slavica Sović, Krešimir Galešić, Danica Galešić Ljubanović

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Clinicopathological differences in the activation pattern of the complement system between pediatric and adult lupus nephritis: a single centered retrospective study in Korea by Min Ji Park, Man Hoon Han, Mee-seon Kim, Yong-Jin Kim, Sang Jin Lee, Dongsub Kim, Hee Sun Baek, Min Hyun Cho

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Some Human Anti-Glycan Antibodies Lack the Ability to Activate the Complement System by Nadezhda Shilova, Alexey Nokel, Alexander Lipatnikov, Nailya Khasbiullina, Yuri Knirel, Ludmila Baidakova, Alexander Tuzikov, Sergei Khaidukov, Polina Obukhova, Stephen Henry, Batozhab Shoibonov, Emin Salimov, Robert Rieben, Nicolai Bovin

“…Antibodies to blood group systems ABO and Forssman, xeno-antigens, a number of polysaccharides from various strains of <i>S. enterica</i>, <i>E. coli</i> and <i>P. alcalifaciens</i>, as well as small fragments of bacterial polysaccharides were recognized by complement-activating antibodies as expected. A complement-activating antibody was affinity-isolated on glycan-Sepharose from human serum, and, in the presence of the complement, it lysed red blood cells coated with the same glycan (kodecytes, where glycans expressed on biological membranes), while an isolated complement non-activating antibody did not, which confirms the validity of the solid-phase PGA results. …”
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