The specific contributions of factor H and factor I in controlling fluid phase activation of the alternative complement pathway by Nancy A. Turner, Joel L. Moake

“…Abstract The immediate defense provided by the alternative complement pathway (AP) is under constant control by fluid phase regulators, factor H (FH) and factor I (FI), to prevent nonessential activation. …”
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Candidiasis: Insights into Virulence Factors, Complement Evasion and Antifungal Drug Resistance by Nidaa Riaz Gaffar, Nisha Valand, Umakhanth Venkatraman Girija

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Rheumatoid Factor, Complement, and Mixed Cryoglobulinemia by Peter D. Gorevic

“…Low serum level of complement component 4 (C4) that occurs in mixed cryoglobulinemia (MC) may be due to in vivo or ex vivo activation of complement by the classical pathway. …”
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Clinical values of serum Gd-IgA1， complement factor H and complement regulatory proteins in IgA nephropathy by Zou Mei, Xue Hen, Lu Fang-cao, Zheng Guang-yi, Zhao Min

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Complement factor H in molecular regulation of angiogenesis by Li Jiang, Wang Kaili, Starodubtseva Maria N., Nadyrov Eldar, Kapron Carolyn M., Hoh Josephine, Liu Ju

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A surface lipoprotein on Pasteurella multocida binds complement factor I to promote immune evasion. by Quynh Huong Nguyen, Chun Heng Royce Lai, Michael J Norris, Dixon Ng, Megha Shah, Christine Chieh-Lin Lai, David E Isenman, Trevor F Moraes

“…Here, we report that PmSLP binds host complement factor I (FI) and facilitates cleavage of complement components C3b and C4b independently of any cofactors (e.g., FH, C4BP), thereby allowing the pathogen to evade host defence. …”
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Correlation of the Complement Decay Accelerating Factor, Tumour Necrosis Factors-alpha, and Interleukin-1 Beta with the Response to Rituximab in Rheumatoid Arthritis Patients by Haidar Mohammed Hussein, Ali Abdulhussein Kasim

“…The study aims to investigate the potential association of serum levels of the complement decay accelerating factor (DAF), as well as the pro-inflammatory cytokines, tumour necrosis factor-alpha (TNF-α) and interleukin-1 Beta (IL-1β); with response to RTX treatment in rheumatoid arthritis patients. …”
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Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy by Amanda K. Slagle, Amanda K. Slagle, Nicolo Ghiringhelli Borsa, Kai Wang, Amanda O. Taylor, Nicole C. Meyer, Michael B. Jones, William D. Walls, Angela F. M. Nelson, Sarah M. Roberts, Mingyao Sun, Elena Goicoechea de Jorge, Santiago Rodriguez de Cordoba, Diana I. Jalal, Diana I. Jalal, Carla M. Nester, Yuzhou Zhang, Richard J. H. Smith, Richard J. H. Smith

Subjects: “…Factor H…”
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Factor H-related 2 levels dictate FHR dimer composition by Bert R. J. Veuskens, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Karin van Leeuwen, Maaike Derlagen, Nadia C. H. Keijzer, Mark Hoogenboezem, Taco W. Kuijpers, Richard B. Pouw

“…Dimerization is hypothesized to further increase their antagonistic function with complement regulator factor H (FH). So far, only FHR-1 homodimers and FHR-1/2 heterodimers could be quantified in a direct way. …”
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Regulation of anti-microbial autophagy by factors of the complement system by Christophe Viret, Aurore Rozières, Rémi Duclaux-Loras, Gilles Boschetti, Stéphane Nancey, Mathias Faure

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Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. by Jian Zhao, Hui Wu, Melanie Khosravi, Huijuan Cui, Xiaoxia Qian, Jennifer A Kelly, Kenneth M Kaufman, Carl D Langefeld, Adrienne H Williams, Mary E Comeau, Julie T Ziegler, Miranda C Marion, Adam Adler, Stuart B Glenn, Marta E Alarcón-Riquelme, BIOLUPUS Network, GENLES Network, Bernardo A Pons-Estel, John B Harley, Sang-Cheol Bae, So-Young Bang, Soo-Kyung Cho, Chaim O Jacob, Timothy J Vyse, Timothy B Niewold, Patrick M Gaffney, Kathy L Moser, Robert P Kimberly, Jeffrey C Edberg, Elizabeth E Brown, Graciela S Alarcon, Michelle A Petri, Rosalind Ramsey-Goldman, Luis M Vilá, John D Reveille, Judith A James, Gary S Gilkeson, Diane L Kamen, Barry I Freedman, Juan-Manuel Anaya, Joan T Merrill, Lindsey A Criswell, R Hal Scofield, Anne M Stevens, Joel M Guthridge, Deh-Ming Chang, Yeong Wook Song, Ji Ah Park, Eun Young Lee, Susan A Boackle, Jennifer M Grossman, Bevra H Hahn, Timothy H J Goodship, Rita M Cantor, Chack-Yung Yu, Nan Shen, Betty P Tsao

“…Systemic lupus erythematosus (SLE), a complex polygenic autoimmune disease, is associated with increased complement activation. Variants of genes encoding complement regulator factor H (CFH) and five CFH-related proteins (CFHR1-CFHR5) within the chromosome 1q32 locus linked to SLE, have been associated with multiple human diseases and may contribute to dysregulated complement activation predisposing to SLE. …”
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Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration by Andjela Sekulic, Sarah M. Herr, Kelly Mulfaul, Inga-Marie Pompös, Silvia Winkler, Carola Dietrich, Benedikt Obermayer, Robert F. Mullins, Thomas Conrad, Peter F. Zipfel, Florian Sennlaub, Christine Skerka, Olaf Strauß

“…Abstract Age-related macular degeneration (AMD), a multifactorial type of retinal degeneration represents the most common cause for blindness in elderly. Polymorphisms in complement factor-H increase, while absence of factor-H-related protein-1 (FHR1) decreases the AMD risk, currently explained by their opposing relationship. …”
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Complete recovery after complement factor I deficiency associated fulminant acute hemorrhagic leukoencephalitis: a case report by Fanni Szumutku, Léna Szabó, Zoltán Liptai, Edit Varga, Tímea Seszták, Péter Barsi, Ádám Goschler, Gábor Szarvas, Klára Horváth, Simon Péter Nagy, Zoltán Prohászka, Ágnes Szilágyi, Sarolta Dobner

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Sequential Increase in Complement Factor I, iC3b, and Cells Expressing CD11b or CD14 in Cutaneous Vasculitis by Dina Rahkola, Tiina Lipitsä, Hanna Siiskonen, Anita Naukkarinen, Ilkka T. Harvima

“…Mast cells contribute to the pathogenesis of cutaneous vasculitis through complement C3 that is cleaved to C3b and then to iC3b by complement factor I. …”
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Complete Complement Factor I (CFI) deficiency: a systematic review of forty-nine patients including three novel cases by Erta Rajabi, Mahsa Choroom Kheirabadi, Nasrin Alipour Olyaei, Anne Molitor, Mohadese Sadat Mousavi Khorshidi, Morteza Heidari, Arash Abbasi, Parastoo Rostami, Mohadese Mahdavi, Raphael Carapito, Mohammad Shahrooei, Seiamak Bahram, Nima Parvaneh

Subjects: “…Complement Factor I…”
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Apobec-1 complementation factor regulates cell migration and apoptosis through Dickkopf1 by acting on its 3′ untranslated region in MCF7 cells by Xin Yan, Qianyin Li, Dongsheng Ni, Yajun Xie, Qingling He, Qianya Wan, Yamin Liu, Zhongshi Lyu, Zhaomin Mao, Qin Zhou

“…A1CF (apobec-1 complementation factor) acts as a component of the apolipoprotein-B messenger RNA editing complex. …”
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Complement Factor C7 Contributes to Lung Immunopathology Caused by Mycobacterium tuberculosis by Kerry J. Welsh, Cole T. Lewis, Sydney Boyd, Michael C. Braun, Jeffrey K. Actor

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Activation of complement factor B contributes to murine and human myocardial ischemia/reperfusion injury. by Nicholas Chun, Ala S Haddadin, Junying Liu, Yunfang Hou, Karen A Wong, Daniel Lee, Julie I Rushbrook, Karan Gulaya, Roberta Hines, Tamika Hollis, Beatriz Nistal Nuno, Abeel A Mangi, Sabet Hashim, Marcela Pekna, Amy Catalfamo, Hsiao-Ying Chin, Foramben Patel, Sravani Rayala, Ketan Shevde, Peter S Heeger, Ming Zhang

“…Whether factor B (fB), a component of the alternative complement pathway required for amplification of complement cascade activation, participates in the pathophysiology of myocardial I/R injury has not been addressed. …”
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Glycoproteomics analysis of complement factor H and its complement-regulatory function during Streptococcus pneumoniae-associated hemolytic uremic syndrome by Laura M. Baas, Kioa L. Wijnsma, Fokje Zijlstra, Nicole C. A. J. van de Kar, Lieke ter Steeg, Antonia H. M. Bouts, Marloes A. H. M. Michels, Marloes A. H. M. Michels, Jeroen D. Langereis, Dirk Lefeber, Dirk Lefeber, Hans J. C. T. Wessels, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel

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Outer membrane protein OMP76 of Riemerella anatipestifer contributes to complement evasion and virulence by binding to duck complement factor vitronectin by Sen Li, Yanhua Wang, Rongkun Yang, Xiaotong Zhu, Hongying Bai, Xiaojian Deng, Jiao Bai, Yang Zhang, Yuncai Xiao, Zili Li, Zhengfei Liu, Zutao Zhou

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