COLEC10 is mutated in 3MC patients and regulates early craniofacial development. by Mustafa M Munye, Anna Diaz-Font, Louise Ocaka, Maiken L Henriksen, Melissa Lees, Angela Brady, Dagan Jenkins, Jenny Morton, Soren W Hansen, Chiara Bacchelli, Philip L Beales, Victor Hernandez-Hernandez

“…We previously reported that lectin complement pathway genes COLEC11 and MASP1/3 are mutated in 3MC syndrome patients. …”
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Low-density lipoprotein apheresis shows a rapid response to proteinuria due to C3 glomerulonephritis: a case report and literature review by Hideki Matsumura, Yuko Fujii, Tomoko Tanaka, Maki Kagitani, Akira Ashida

“…Genetic testing identified a rare complement B factor mutation linked to complement pathway dysregulation. …”
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Reactive astrocyte-derived neurotoxicity is mitigated by vitronectin in traumatic brain injury mouse model by Minori Yamashita, Nito Nakahira, Kei Hashimoto, Hirono Kobayashi, Mari Nakashima, Hiroko Ikeshima-Kataoka, Yasunori Miyamoto

“…Therefore, VN plays a role in mitigating neurodegeneration after TBI by suppressing complement C3 secretion from reactive astrocytes.…”
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Expressing uncertainty in Human-Robot interaction. by Christoph Bartneck, Elena Moltchanova

“…Hence, it would be advisable to complement the use of words with numerical expression of uncertainty. …”
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Treatment of atypical hemolytic uremic syndrome with eculizumab in a patient presenting with neuropsychiatric prodrome: a case report by Hanze Yang, Jingdong Zhang, Hao Wu, Hongzhao Xu, Zhonggao Xu

“…Atypical hemolytic uremic syndrome (aHUS) is a rare thrombotic microangiopathy (TMA) caused by dysregulation of the complement system. It is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. …”
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Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia by Megumi Andoh, Natsuki Shinoda, Yusuke Taira, Tasuku Araki, Yuka Kasahara, Haruki Takeuchi, Masayuki Miura, Yuji Ikegaya, Ryuta Koyama

“…This increased susceptibility is reversed by genetic depletion of microglial complement receptors. Thus, localized, nonapoptotic caspase activity guides complement-dependent microglial synaptic phagocytosis and remodels neuronal circuits.…”
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Calamities and Counterfactuals: A Historical View of Polarity Reversal by Debra Ziegeler

“…In the present study, the historical development of the two adverbs will be considered in investigating recent data from Late Modern English, in which a majority of counterfactual uses appear with a complement referring to undesirable events, sometimes expressed hyperbolically. …”
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An Approach to Neutrosophic Hyper Soft Rough Matrix and its Application by J. Boobalan, E. Mathivadhana

“…We discuss various operators on NHSRM such as addition, multiplication, scalar multiplication and complement. Additionally, we develop several properties, including associativity, distributivity and De Morgan’s laws, utilizing operators such as union, intersection, complement, arithmetic mean, weighted arithmetic mean, geometric mean, weighted geometric mean, harmonic mean and weighted harmonic mean. …”
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Some Results on Pure Submodules Relative to Submodule by Baghdad Science Journal

“…In this paper, the properties of the following concepts were studied: Pure essential submodules relative to submodule T of M (Simply T-pure essential),Pure closed submodules relative to submodule T of M (Simply T-pure closed) and relative pure complement submodule relative to submodule T of M (Simply T-pure complement) and T-purely extending. …”
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Shrub encroachment in pastures in the Alps by Olivier Camacho, Laurent Dobremez, Alain Capillon

“…To ensure their forage system and to simplify their work, farmers tend to establish grazing units that are oversized in relation to the needs of their animals. They implement compensatory practices that consist of mechanical maintenance as a complement to grazing to limit the dynamics of woody species. …”
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Des broussailles dans les prairies alpines by Olivier Camacho, Laurent Dobremez, Alain Capillon

“…To ensure their forage system and to simplify their work, farmers tend to establish grazing units that are oversized in relation to the needs of their animals. They implement compensatory practices that consist of mechanical maintenance as a complement to grazing to limit the dynamics of woody species. …”
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Age-Related Macular Degeneration in the Aspect of Chronic Low-Grade Inflammation (Pathophysiological ParaInflammation) by Małgorzata Nita, Andrzej Grzybowski, Francisco J. Ascaso, Valentín Huerva

“…The complement system, mainly alternative pathway, mediates chronic autologous pathophysiological parainflammation in dry and exudative AMD, especially in the Y402H gene polymorphism, which causes hypofunction/lack of the protective complement factor H (CFH) and facilitates chronic inflammation mediated by C-reactive protein (CRP). …”
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Macrophage Depletion Reduces Disease Pathology in Factor H-Dependent Immune Complex-Mediated Glomerulonephritis by Alexander Jacob, Michael Phelps, Shane Fraher, Marcos Lopez, Anthony Chang, Richard J. Quigg, Jessy J. Alexander

“…Complement factor H (FH) is a key regulator of the alternative pathway of complement, in man and mouse. …”
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Clinicopathological features of 60 cases of asymptomatic hematuria and/or proteinuria by GUO Chun-hua, LIN Chong-yun

“…Objective To investigate the clinicopathological features of asymptomatic hematuria and/or proteinuria.Methods The clinicopathological features were analyzed and correlated in 60 cases of asymptomatic hematuria and/or proteinuria.According to 24-h urine protein excretion >150 mg,60 cases were divided into simple hematuria group(n= 14,6 males and 8 females) and proteinuria groupCsimple proteinuria or proteinuria with hematuria)(n = 46,18 males and 28 females).The study population also was divided into IgA nephropathy group(n = 36,11 males and 25 females) and nonIgA nephropathy group(n=24,13 males and 11 females) by mesangial IgA deposition,and the statistical analysis was carried out respectively.Results The pathological features in proteinuria group were more severe and serum uric acid was higher in proteinuria group than in simple hematuria group[(305.5 ± 90.8) vs.(376.7 + 86.7) μmol/L,t=-2.27,P = 0.03],showed statistical significant difference,but there were no differences in serum creatinine,Cystatin C(CysC),serum IgA and complement C3.The creatinine levels of IgA nephropathy group was higher than Non-IgA nephropathy[(71.5 + 21.6) vs.(59.2 ± 14.8) μmol/L,t = 2.09,P = 0.04],but no differences in Cys C,serum uric acid,serum IgA Complement C3 and 24-hour urinary protein.Moreover,except 24-hour urinary protein,all the values were within the normal range of reference values.Conclusions Renal lesion can not be sensitively marked by clinical features,such as serum creatinine,Cys C,serum uric acid,serum IgA,Complement C3,24-hour urinary protein:renal biopsy is the criteria for diagnosis.So far,there is a lack of uniform scoring system to assess renal lesion.…”
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РОЛЬ ТРОМБОЦИТОВ В ПАТОГЕНЕЗЕ БАКТЕРИАЛЬНЫХ ИНФЕКЦИЙ by N. B. Serebryannaya, P. P. Yakutseni, N. N. Klimko

“…In the antibacterial immunity, platelets attract neutrophils, monocytes and activate the complement system. In this case, platelets act together with these cells and proteins, promoting the full disclosure of the microbicidal potential of phagocytes and complement. …”
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Methods to evaluate the performance of a multicomponent meningococcal serogroup B vaccine by Ray Borrow, Laura Tomasi Cont, Daniela Toneatto, Stefania Bambini, Shravani Bobde, Woo-Yun Sohn, Alessia Biolchi, Vega Masignani, Peter T. Beernink, Maria Lattanzi

“…A new method, the endogenous complement hSBA assay, has been developed to evaluate a vaccine’s ability to induce a bactericidal immune response in clinical trials, in conditions that approximate real-world settings through the use of each vaccinee’s serum as a source of complement and by testing against a panel of 110 epidemiologically representative MenB strains. …”
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The Plausibility of Distance and Computer-Assisted Learning in an era of Fuel Subsidy Removal: a Case Study of the Main Campus of Lagos State University by Мохаммед Акінола Акомолафе, Оладжиде Абіодун Обі

“…Hence, the present research offers distance computer-assisted learning via Open and Distance Learning (ODL) as a complement to traditional or conventional learning in tertiary institutions in Nigeria. …”
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Resolution of the Expert council “Unsolved problems of targeted therapy for paroxysmal nocturnal hemoglobinuria in Russia” by A. D. Kulagin, E. A. Lukina, V. V. Ptushkin, M. P. Kostinov, E. G. Arshanskaya, T. N. Babaeva, T. I. Ksenzova, Z. T. Fidarova, M. V. Marchenko

“…During the Expert Council, the following aspects of targeted APG therapy were considered: • criteria for the suboptimal response of patients with APG to therapy with inhibitors of the 5th component of complement (C5); • efficacy and safety of the use of pegcetacoplan in APG in patients with insufficient efficacy of inhibitors of the C5 component of complement; • vaccination issues before starting therapy with complement inhibitors and the possibility of conducting treatment with pegcetacoplan at home.…”
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Phospholipid Binding Protein C Inhibitor (PCI) Is Present on Microparticles Generated In Vitro and In Vivo. by Katrin Einfinger, Sigrun Badrnya, Margareta Furtmüller, Daniela Handschuh, Herbert Lindner, Margarethe Geiger

“…Among the proteins co-precipitating with protein C inhibitor, complement factors, especially complement factor 3, were most striking. …”
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Global aHUS Registry Analysis of Patients Switching to Ravulizumab From Eculizumab by Franz Schaefer, Imad Al-Dakkak, Katerina Anokhina, David Cohen, Larry A. Greenbaum, Gema Ariceta

“…Ravulizumab, a next-generation terminal complement inhibitor, provides immediate, complete, and sustained complement C5 inhibition. …”
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