Advancing pre-clinical surgical education by using intuitive short videos by Marie Perrin, Markus Schäfer, Pierre-Alexandre Bart, Dieter Hahnloser

“…Conclusions This study emphasizes the importance of implementing innovative teaching methods in modern medical education. …”
Get full text

Att arbeta med upplevelsebaserat lärande i universitetsmiljö: Förutsättningar och hinder by Pia Andersson, Tone Försund, Helén Söderqvist

“…ENGLISH ABSTRACT Implementing Experiential Learning in University Settings: Preconditions and Challenges Experiential learning pedagogy, including simulations, role-playing, and practical exercises, has long been a part of many academic programs. …”
Get full text

Influence of an enhanced recovery programme on clinical outcomes and health-related quality of life after pancreaticoduodenectomy ad modum Whipple – an explorative and comparative... by Thomas Andersson, My Engström, Johanna Wennerblom, Hanna Gyllensten, Kristofer Bjerså

“…Abstract Background The introduction of enhanced recovery programmes (ERP) in pancreatic surgery has significantly improved clinical outcomes by decreasing the length of hospital stay, cost and complications without increasing readmissions and reoperations. To complement evidence on these outcomes, there is a need to explore patients’ perspectives of a structured ERP. …”
Get full text

Development of software for collecting cleft-specific data in Malaysia by Al Imran Shahrul, Nik Mukhriz Nik Mustapha, Mas Suryalis Ahmad, O. P. Kharbanda, Aida Nur Ashikin Abd Rahman

“…Various methods have been implemented to ensure data security. Additionally, documentation including video tutorials, consent forms, and hard copy versions has been developed to complement the database. …”
Get full text

Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by Neisseria meningitidis. by Sarah G Earle, Mariya Lobanovska, Hayley Lavender, Changyan Tang, Rachel M Exley, Elisa Ramos-Sevillano, Douglas F Browning, Vasiliki Kostiou, Odile B Harrison, Holly B Bratcher, Gabriele Varani, Christoph M Tang, Daniel J Wilson, Martin C J Maiden

“…In particular, there was a significant peak of association around the fHbp locus, encoding factor H binding protein (fHbp), which promotes bacterial immune evasion of human complement by recruiting complement factor H (CFH) to the meningococcal surface. …”
Get full text

Semantic and Syntactic Aspects of “Bāyestan” in Tārīkh-i Bayhaqī by Mona Valipour

“…Next, we have shown that in the valency of this verb there is either a noun phrase (subject) or a complement clause. Subsequently, we have introduced and discussed two assumptions about the verb bāyestan: either considering the complement clause as the subject and the expletive pro. …”
Get full text

Population Pharmacokinetic and Pharmacokinetic/Pharmacodynamic Analyses of Pegcetacoplan in Patients with Paroxysmal Nocturnal Hemoglobinuria by Ryan L. Crass, Brandon Smith, Sven Adriaens, Sunny Chapel, Grant Langdon

“…Pegcetacoplan, the first complement C3 inhibitor approved for patients with paroxysmal nocturnal hemoglobinuria, targets both intravascular and extravascular hemolysis. …”
Get full text

Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen. by Peter J Hart, Colette M O'Shaughnessy, Matthew K Siggins, Saeeda Bobat, Robert A Kingsley, David A Goulding, John A Crump, Hugh Reyburn, Francesca Micoli, Gordon Dougan, Adam F Cunningham, Calman A MacLennan

“…Here we investigate the role of Vi capsule and antibodies against Vi and O:9 in antibody-dependent complement- and phagocyte-mediated killing of Salmonella. …”
Get full text

Proteins of the SubB family provide multiple mechanisms of serum resistance in Yersinia pestis by François Pierre, Alexandre Baillez, Amélie Dewitte, Agustin Rolandelli, Florent Sebbane

“…The serum complement system is a cornerstone element of the innate immune response. …”
Get full text

Paroxysmal Nocturnal Hemoglobinuria with a Distinct Molecular Signature Diagnosed Ten Years after Allogenic Bone Marrow Transplantation for Acute Myeloid Leukemia by Alberto Santagostino, Laura Lombardi, Gerard Dine, Pierre Hirsch, Srimanta Chandra Misra

“…Paroxysmal nocturnal hemoglobinurea (PNH) is a rare disorder of complement regulation due to somatic mutation of PIGA (phosphatidylinositol glycan anchor) gene. …”
Get full text

Complex neutrosophic vague soft graphs by Suriyakumar g., V. J. Sudhakar, Syed Tahir Hussainy, Mana donganont

“…A revised metric that takes into consideration a cumulative strength and uncertainty of connections within the graph properties, we also present the complement of a complex neutrosophic vague soft graph and the complement of a strong complex neutrosophic vague soft graph. …”
Get full text

Immune Response and Evasion Mechanisms of Plasmodium falciparum Parasites by Esmael Besufikad Belachew

“…Immune-evading mechanisms in mosquito depend mainly on the Pfs47 gene that inhibits Janus kinase-mediated activation. Host complement factor also protects human complement immune attack of extracellular gametes in Anopheles mosquito midgut. …”
Get full text

CD55 upregulation in T cells of COVID-19 patients suppresses type-I interferon responses by Maria G. Detsika, Maria Sakkou, Vassiliki Triantafyllidou, Dimitris Konstantopoulos, Eirini Grigoriou, Katherina Psarra, Edison Jahaj, Ioanna Dimopoulou, Stylianos E. Orfanos, Alexandra Tsirogianni, George Kollias, Anastasia Kotanidou

“…Complement regulatory proteins, including CD55, control complement overactivation thus eliminating complement deposition and cell lysis. …”
Get full text

Impact of rheumatoid factors on the function of therapeutic monoclonals specific for PD-1/PD-L1 by Barry D. Hock, Liping Goddard, Lachlan J. Dobson, Sean A. MacPherson, John L. O’Donnell, Judith L. McKenzie, Alexander D. McLellan

“…Although RF provided avelumab with the ability to induce CDC in assays using rabbit complement, no CDC was observed in the presence of human complement. …”
Get full text

The change and clinical significance of the serum uric acid levels in patients with lupus nephritis by WANG Yi-ya, WU Yong-gui

“…Objective To observe the serum uric acid levels in patients with lupus nephritis(LN)and explore its relationship with renal damage.Methods A retrospective analysis of the data of110 cases for nephrology renal biopsy and diagnosis of LN patients was made in the First Affiliated Hospital of Medical University of Anhui from January July 2015 to July 2017.The patients were divided into the two groups:LN patients with or without hypemricemia.All patients were collected for clinical pathological indicators,including age,gender,serum creatinine,urea nitrogen,serum uric acid,complement C3,complement C4,immunoglobulin A,immunoglobulin M,immunoglobulin G,24-h urine protein,anti-double-stranded DNA,-Smith,-SSA,-SSB,-RNP antibodies and pathological types,and scored for activity index,chronic index and systemic lupus erythematosus disease activity index.Results The clinical indicators,including the incidence rate of hypertension,level of blood serum creatinine and urea nitrogen,and the renal pathological scores,including acitive index and chronic index,in the LN patients with hyperuricemia group were higher than that in normal uric acid group,and estimate glomerular filtration rate was lower than that in normal uric acid group,the difference was statistically significant(P<0.05).However,there was no significant difference between the two groups in the other factors such as age,sex,complement C3,complement C4,immunoglobulin A,immunoglobulin M,immunoglobulin G,24-h urine protein,systemic lupus erythematosus disease activity index score and positive rate of anti-double-stranded DNA,-Smith,-SSA,-SSB,-RNP antibodies(P>0.05).Further analysis showed that the level of serum uric acid was positively correlated with serum creatinine,renal pathological classification and renal pathological scores,negatively correlate with estimate glomerular filtration rate(P<0.05).Conclusions LN patients with hyperuricemia had more severe renal damage than those in normal uric acid.Hyperuricemia is an important indicator for poor prognosis in patients with LN.…”
Get full text

Philosophical Reflection on Holism and Reductionism in Nutrition Science by Eline Baltussen, Marcel Verweij

“…Holism offers an alternative perspective that could complement these limitations, on the condition that they are similar enough on an ontological and epistemological level. …”
Get full text

The relationship between vitamin D status and disease activity in Iraqi systemic lupus erythematosus patients by Zamin Abdulhusssein Al-Sarray, Raghad Hassan Hussein, Ali Hussein Al-Hafidh, Izzat Abdulsatar Al-Rayahi

“…The mean levels of serum complement protein 3, complement protein 4 and vitamin D levelswere significantly lower in the patient groups compared to the controls (p<0.05). …”
Get full text

Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria by Steve Biko Otieno, Alaa Altahan, Fnu Kaweeta, Saradasri Karri, Fnu Alnoor, Robert Johnson

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been demonstrated to be able to activate complement, making patients with deficiency in negative complement regulation, such as paroxysmal nocturnal hemoglobinuria (PNH), particularly vulnerable to complement-mediated cell damage. …”
Get full text

Delayed Onset of Thrombotic Microangiopathy (TMA) upon Prolonged Carfilzomib Therapy in Multiple Myeloma: A Case Report and Comprehensive Review by Andrea Ceglédi, Ágnes Király, Andrea Várkonyi, Szabolcs Tasnády, Hajnalka Andrikovics, Mónika Fekete, Bálint G. Szabó, Zsuzsanna Szemlaky, Ágnes Szilágyi, György Sinkovits, Zoltán Prohászka, Marienn Réti, Gábor Mikala

“…An immediate workup raised a strong suspicion for TMA, confirmed by laboratory findings of schistocytosis and complement activation. Following the immediate discontinuation of carfilzomib, the patient underwent 18 plasmapheresis (PEX) sessions and received supportive fresh frozen plasma transfusions, which resulted in the complete remission of TMA symptoms without the need for complement inhibitory therapy. …”
Get full text

Learning object development for the Anatomy teaching in Nursing by Rafael Lustosa Ribeiro, Valéria Aparecida Masson, Maiza Claudia Vilela Hipolito, Lucia Tobase, Edenir Aparecida Sartorelli Tomazini, Heloisa Helena Ciqueto Peres

“…Methods: this is a methodological study on the construction of the learning object to complement the studies in the subject, using the Analysis, Design, Development, Implementation and Evaluation model in the instructional design. …”
Get full text