Impact of frailty in older people on health care demand: simulation modelling of population dynamics to inform service planning by Bronagh Walsh, Carole Fogg, Tracey England, Sally Brailsford, Paul Roderick, Scott Harris, Simon Fraser, Andrew Clegg, Simon de Lusignan, Shihua Zhu, Francesca Lambert, Abigail Barkham, Harnish Patel, Vivienne Windle

“…These analyses along with information gathered during stakeholder events were used to inform the development of a prototype system dynamics simulation model (implemented in AnyLogic software) to explore the development and impact of frailty in the population and likely future scenarios over a 10-year time frame. …”
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Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial by Hamish McAllister-Williams, Nicola Goudie, Lumbini Azim, Victoria Bartle, Michael Berger, Chrissie Butcher, Thomas Chadwick, Emily Clare, Paul Courtney, Lyndsey Dixon, Nichola Duffelen, Tony Fouweather, William Gann, John Geddes, Sumeet Gupta, Beth Hall, Timea Helter, Paul Hindmarch, Eva-Maria Holstein, Ward Lawrence, Phil Mawson, Iain McKinnon, Adam Milne, Aisling Molloy, Abigail Moore, Richard Morriss, Anisha Nakulan, Judit Simon, Daniel Smith, Bryony Stokes-Crossley, Paul Stokes, Andrew Swain, Zoë Walmsley, Christopher Weetman, Allan H Young, Stuart Watson

“…However, use of the medication was complicated by the need for complex dose titration and high rates of hypomanic and impulse control symptoms, which would make implementation in routine practice challenging. Further research is required to definitively address whether pramipexole is an effective safe and cost-effective treatment for TRBD. …”
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THE ETHICAL STARTUP? by Alexis Walker

“…But in practice, many organizations have consent procedures and documents that resemble legal contracts more than tools for participant understanding, designed more to limit liability than to foster meaningful participant engagement.[19] Beyond these legal shields, companies owe participants real efforts to support truly informed consent, given the substantial asymmetries in expertise and control that make meaningful consent difficult without institutional support, and the broader ethical imperative to build public trust in data systems where risks are often collective, long-term, and structurally mediated. Companies can implement insights from the robust consent literature, including offering decision support tools such as interactive or pre-highlighted written information, digitally enhanced user support tools, and re-consent cues at key moments, such as when a company is acquired or when scientific developments enable new unanticipated uses of genetic data.[20] If DNA marketplaces have models that presume ongoing user engagement, support to sustain such engagement is essential. …”
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Flow-based Text Style Transfer Model by Zihan ZHANG, Jinqiao DAI, Pin YANG

“…The study employs monotonic rational-quadratic splines and their inverses as building blocks to implement functions <inline-formula><tex-math id="M29-1">$ {f}_{i} $</tex-math><alternatives><graphic specific-use="online" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="202300639_M29-1.jpg"/><graphic specific-use="print" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="202300639_M29-1.png"/></alternatives></inline-formula> and <inline-formula><tex-math id="M30-1">$ {f}_{i}^{-1} $</tex-math><alternatives><graphic specific-use="online" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="202300639_M30-1.jpg"/><graphic specific-use="print" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="202300639_M30-1.png"/></alternatives></inline-formula>, where a monotonically increasing rational quadratic function defines each interval. …”
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Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT by Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger

“…Study 1D: we undertook a process evaluation to examine the implementation of the planned intervention in the SELPHI RCT. …”
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Connectivity guided intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation in moderately severe treatment resistant depression by Richard Morriss, Lucy Webster, Luke Ingram, Mohamed Abdelghani, Adriana Anton, Shaun Barber, Peter Bates, Paul Briley, Clement Boutry, Cassandra Brookes, Edward Cox, Beth Hall, Marilyn James, Matthew Keane, Micheal Kurkar, Sudheer Lankappa, Peter Liddle, Hamish McAllister-Williams, Hyerin Oh, Alexander O’Neill-Kerr, Jehill Parikh, Stefan Pszczolkowski, Ana Suazo Di Paola, Louise Thomson, Yvette Walters, Dorothee Auer

“…Statistical analysis Primary analysis of the primary outcome used the intention-to-treat (ITT) population with the multiple imputation technique being implemented to deal with missing data in instances where participants were missing any of the HDRS-17 scores. …”
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