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    A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples. by Diana Pauly, Benedikt M Nagel, Jörg Reinders, Tobias Killian, Matthias Wulf, Susanne Ackermann, Boris Ehrenstein, Peter F Zipfel, Christine Skerka, Bernhard H F Weber

    Published 2014-01-01
    “…The complement system is an essential part of the innate immune system by acting as a first line of defense which is stabilized by properdin, the sole known positive regulator of the alternative complement pathway. …”
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    Model-driven redox pathway manipulation for improved isobutanol production in Bacillus subtilis complemented with experimental validation and metabolic profiling analysis. by Haishan Qi, Shanshan Li, Sumin Zhao, Di Huang, Menglei Xia, Jianping Wen

    Published 2014-01-01
    “…These results demonstrated that model-driven complemented with metabolic profiling analysis could serve as a useful approach in the strain improvement for higher bio-productivity in further application.…”
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    When do shared e-scooters complement or compete with public transport? A mixed-method review and comparison with bike sharing by Mahesha Jayawardhena, Alexa Delbosc, Graham Currie, Geoff Rose

    Published 2025-03-01
    “…This study aims to explore the definitions of ‘complement’ and ‘compete’ in literature and to identify the circumstances where e-scooters complement or compete with public transport using a mixed-method literature review. …”
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    Complement-mediated virus infectivity neutralisation by HLA antibodies is associated with sterilising immunity to SIV challenge in the macaque model for HIV/AIDS. by Mark Page, Ruby Quartey-Papafio, Mark Robinson, Mark Hassall, Martin Cranage, James Stott, Neil Almond

    Published 2014-01-01
    “…We propose that complement-augmented virus neutralisation is a key factor in inducing sterilising immunity and may be difficult to achieve with HIV/SIV Env-based vaccines. …”
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    CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray. by Corinna Lau, Ståle Nygård, Hilde Fure, Ole Kristoffer Olstad, Marit Holden, Knut Tore Lappegård, Ole-Lars Brekke, Terje Espevik, Eivind Hovig, Tom Eirik Mollnes

    Published 2015-01-01
    “…The first line of defense against intruding pathogens and endogenous damage signals is pattern recognition by e.g., complement and Toll-like receptors (TLR). Combined inhibition of a key complement component (C3 and C5) and TLR-co-receptor CD14 has been shown to attenuate certain systemic inflammatory responses. …”
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    Deterioration in Clinical Status Is Not Enough to Suspend Eculizumab: A Genetic Complement-Mediated Atypical Hemolytic Uremic Syndrome Case Report by Luca Calvaruso, Alessandro Naticchia, Pietro Manuel Ferraro, Gisella Vischini, Stefano Costanzi

    Published 2019-01-01
    “…Mutations in CFI gene coding for complement regulation factors and in THBD gene coding for endothelial cell receptor thrombomodulin could predispose to the disease and hypertension can trigger the onset. …”
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