Complement Proteins Identify Rapidly Progressive Diabetic Kidney Disease by Donghwan Yun, Sohyun Bae, Yuqian Gao, Lauren Lopez, Dohyun Han, Carrie D. Nicora, Tae Youn Kim, Kyung Chul Moon, Dong Ki Kim, Thomas L. Fillmore, Yon Su Kim, Avi Z. Rosenberg, Weijie Wang, Pinaki Sarder, Wei-Jun Qian, Maryam Afkarian, Seung Seok Han

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Rationale for targeting complement in COVID‐19 by Anastasia Polycarpou, Mark Howard, Conrad A Farrar, Roseanna Greenlaw, Giorgia Fanelli, Russell Wallis, Linda S Klavinskis, Steven Sacks

Subjects: “…complement proteins…”
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Borrelia burgdorferi complement regulator-acquiring surface protein 2 does not contribute to complement resistance or host infectivity. by Adam S Coleman, Xiuli Yang, Manish Kumar, Xinyue Zhang, Kamoltip Promnares, Deborah Shroder, Melisha R Kenedy, John F Anderson, Darrin R Akins, Utpal Pal

“…Borrelia burgdorferi, the pathogen of Lyme disease, cycles in nature through Ixodes ticks and mammalian hosts. At least five Complement Regulator-Acquiring Surface Proteins (BbCRASPs) are produced by B. burgdorferi, which are thought to assist spirochetes in host immune evasion. …”
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SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteins by Jian Wu, Sanpeng Xu, Zhiqing Li, Boyi Cong, Zongheng Yang, Zhichao Yang, Wanfeng Gao, Shuo Liu, Zhou Yu, Sheng Xu, Nan Li, Jin Hou, Guoping Wang, Xuetao Cao, Shuxun Liu

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Contribution of the Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (ErpC) to Complement Resistance of Borrelia burgdorferi by Claudia Hammerschmidt, Teresia Hallström, Christine Skerka, Reinhard Wallich, Brian Stevenson, Peter F. Zipfel, Peter Kraiczy

“…Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs). …”
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Plasma and complement proteins are essential for the antimicrobial activity of canine platelet lysate by Melikasadat Mollabashi, Melikasadat Mollabashi, Alonza Klopfer, Alonza Klopfer, Thainá Lunardon, Thainá Lunardon, Nikolia Darzenta, Nikolia Darzenta, Emily Davis, Matt Murray, Scarlett M. Sumner, Maria C. Naskou, Maria C. Naskou

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Clinical values of serum Gd-IgA1， complement factor H and complement regulatory proteins in IgA nephropathy by Zou Mei, Xue Hen, Lu Fang-cao, Zheng Guang-yi, Zhao Min

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Luciferase complementation based-detection of G-protein-coupled receptor activity by Hideaki Yano, Ning Sheng Cai, Jonathan A Javitch, Sergi Ferré

“…Protein complementation assays (PCA) are used as pharmacological tools, enabling a wide array of applications, ranging from studies of protein–protein interactions to second messenger effects. …”
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Enhancing the Understanding of Complement Protein Changes in RVO: Insights and Suggestions [Letter] by Zeng X, Sun H

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Outer membrane protein OMP76 of Riemerella anatipestifer contributes to complement evasion and virulence by binding to duck complement factor vitronectin by Sen Li, Yanhua Wang, Rongkun Yang, Xiaotong Zhu, Hongying Bai, Xiaojian Deng, Jiao Bai, Yang Zhang, Yuncai Xiao, Zili Li, Zhengfei Liu, Zutao Zhou

“…Microbes use outer membrane proteins (OMPs) to hijack Vn for complement evasion. …”
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Antibody-free method for protein detection on blots using enzyme fragment complementation by Joe Horecka, Neil W. Charter, Betty L. Bosano, Peter Fung, Phil Kobel, Kun Peng, Richard M. Eglen

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Complement protein and Immunoglobulins Serum levels in Normal Pregnant and Spontaneous Aborted Women by Hiwa Abdulrahman Ahmad, Mehri Mirhaj Muhammd salih, Kamal Ahmed Khidir

“…Serum levels of immunoglobulins (IgG, IgM, and IgA), complement proteins (C3 and C4) were determined and analyzed for normal pregnant, abortion and control groups by using Single Radial Immunodiffusion (SRID) technique. …”
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Proteomic profiling of saliva reveals association of complement system with primary Sjögren's syndrome by Mingde Li, Yajun Qi, Guizhen Wang, Su Bu, Ming Chen, Jiahui Yu, Tianyang Luo, Lulu Meng, Anran Dai, Yong Zhou, Shuai Liu, Xingxing Huo

“…The protein–protein interaction (PPI) network was constructed and the core proteins were identified with the STRING website and Cytoscape software. …”
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An inter‐species protein–protein interaction network across vast evolutionary distance by Quan Zhong, Samuel J Pevzner, Tong Hao, Yang Wang, Roberto Mosca, Jörg Menche, Mikko Taipale, Murat Taşan, Changyu Fan, Xinping Yang, Patrick Haley, Ryan R Murray, Flora Mer, Fana Gebreab, Stanley Tam, Andrew MacWilliams, Amélie Dricot, Patrick Reichert, Balaji Santhanam, Lila Ghamsari, Michael A Calderwood, Thomas Rolland, Benoit Charloteaux, Susan Lindquist, Albert‐László Barabási, David E Hill, Patrick Aloy, Michael E Cusick, Yu Xia, Frederick P Roth, Marc Vidal

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Evaluating protein complexes between human aquaporin and calmodulin using biomolecular fluorescence complementation by Jessica Glas, Johanna Landén, Kristina Hedfalk

“…Overall, we present a systematic approach to screen novel membrane protein interactions in vivo, relying on co-expression in yeast of Bimolecular Fluorescence Complementation (BiFC) complexes providing new insights into the regulation of the hAQPs.…”
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Role of Autoantibodies Against Self-Proteins, Mitochondrial Cellular Antigens, and Some Complement Proteins (C3 and C4) in Patients with Atherosclerosis by Ali Saad Kadhim, Abdullah Salim Al-Karawi

“…Conclusion: The antibodies against self-proteins, particularly mitochondrial antigens, are considered risk factors for increasing atherosclerosis plaque and developing unstable angina.…”
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Dynamic Changes in Complement Proteins in the Aqueous Humor and Plasma of Patients Undergoing Ranibizumab Treatment for Retinal Vein Occlusion: A Need for Further Research [Letter] by Liang D, Li X

Subjects: “…complement proteins…”
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Urine Complement Factor Ba Identifies Persistent Acute Kidney Injury and Organ Failures in Critically Ill Adults by Erin K. Stenson, Charles E. Edelstein, Zhiying You, Anna Ostrow, Zoltan Endre, Shinobu Miyazaki-Anzai, Bradley P. Dixon, Halden Scott, Neil Aggarwal, Joshua M. Thurman, Jessica Kendrick

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Humoral complementomics – exploration of noninvasive complement biomarkers as predictors of renal cancer progression by Margot Revel, Mikel Rezola Artero, Houcine Hamidi, Anne Grunenwald, Loris Blasco, Yann A. Vano, Stephane Marie Oudard, Rafael Sanchez-Salas, Petr Macek, Lara Rodriguez Sanchez, Xavier Cathelineau, Benoit Vedié, Catherine Sautes-Fridman, Wolf Herman Fridman, Lubka T. Roumenina, Marie-Agnes Dragon-Durey

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Plasma complement proteins as biomarkers and therapeutic targets in chronic kidney disease: a Mendelian randomization analysis by Yu-Peng Xu, Zheng-Qi Song, Ming-Li Chen, Yang-Li Fang, Hui-Di Zhang

“…This study investigates the causal role of diverse plasma complement proteins in CKD and its clinical types to discover new biomarkers and therapeutic targets.Method Using two-sample Mendelian randomization (MR), we examined the causal relationships between 28 plasma complement proteins and CKD outcomes. …”
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