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  1. 1

    Luciferase complementation based-detection of G-protein-coupled receptor activity by Hideaki Yano, Ning Sheng Cai, Jonathan A Javitch, Sergi Ferré

    Published 2018-07-01
    “…Methods to detect activities of G protein-coupled receptors (GPCRs) have particular relevance for drug screening. …”
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    Article
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    Urine complement analysis implies complement activation is involved in membranous nephropathy by Yingxue Xu, Yingxue Xu, Yi Li, Yong Zhang, Guisen Li, Guisen Li

    Published 2025-02-01
    “…BackgroundThe onset and progression of membranous nephropathy (MN) have been associated with complement activation, yet the overall characteristics of this activation in the kidneys remain unclear. …”
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    Implementation of Machine Vision Methods for Cattle Detection and Activity Monitoring by Roman Bumbálek, Tomáš Zoubek, Jean de Dieu Marcel Ufitikirezi, Sandra Nicole Umurungi, Radim Stehlík, Zbyněk Havelka, Radim Kuneš, Petr Bartoš

    Published 2025-03-01
    “…The goal of this research was to implement machine vision algorithms in a cattle stable to detect cattle in stalls and determine their activities. …”
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    A Cell-Based Assay to Measure the Activity of the Complement Convertases by Małgorzata Stasiłojć, Grzegorz Stasiłojć, Alicja Kuźniewska, Santiago Rodriguez de Córdoba, Marcin Okrój

    Published 2024-07-01
    “…Aberrant regulation of the convertases is often implicated in the development of rare complement-related diseases. However, analyzing convertase activity poses a significant challenge due to their labile nature and intricate interactions with serum proteins. …”
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    Complement system is activated in acute inflammatory response to environmental particulates in the lungs by Kerui Zhang, Akiko Honda, Tomoya Sagawa, Natsuko Miyasaka, Binyang Qiu, Raga Ishikawa, Tomoaki Okuda, Takayuki Kameda, Kaori Sadakane, Takamichi Ichinose, Hirohisa Takano

    Published 2025-06-01
    “…Short-term exposure (typically ranging from a few hours to 7 days) to particulate matter (PM) elicits acute inflammatory responses with significant activation of complement component C5. However, the relationship between PM-induced complement system activation, acute inflammation, and the contributing factors remains unclear. …”
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    Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs by Lisa Hurler, Erik J. M. Toonen, Erika Kajdácsi, Bregje van Bree, Ricardo J. M. G. E. Brandwijk, Wieke de Bruin, Paul A. Lyons, Paul A. Lyons, Laura Bergamaschi, Laura Bergamaschi, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, György Sinkovits, László Cervenak, Reinhard Würzner, Zoltán Prohászka, Zoltán Prohászka, Stephen Baker, John R. Bradley, Patrick F. Chinnery, Daniel J. Cooper, Gordon Dougan, Ian G. Goodfellow, Ravindra K. Gupta, Nathalie Kingston, Paul J. Lehner, Paul A. Lyons, Nicholas J. Matheson, Caroline Saunders, Kenneth G. C. Smith, Charlotte Summers, James Thaventhiran, M. Estee Torok, Mark R. Toshner, Michael P. Weekes, Gisele Alvio, Sharon Baker, Areti Bermperi, Karen Brookes, Ashlea Bucke, Jo Calder, Laura Canna, Cherry Crucusio, Isabel Cruz, Rnalie de Jesus, Katie Dempsey, Giovanni Di Stephano, Jason Domingo, Anne Elmer, Julie Harris, Sarah Hewitt, Heather Jones, Sherly Jose, Jane Kennet, Yvonne King, Jenny Kourampa, Emily Li, Caroline McMahon, Anne Meadows, Vivien Mendoza, Criona O’Brien, Charmain Ocaya, Ciro Pascuale, Marlyn Perales, Jane Price, Rebecca Rastall, Carla Ribeiro, Jane Rowlands, Valentina Ruffolo, Hugo Tordesillas, Phoebe Vargas, Bensi Vergese, Laura Watson, Jieniean Worsley, Julie-Ann Zerrudo, Laura Bergamaschi, Ariana Betancourt, Georgie Bower, Ben Bullman, Chiara Cossetti, Aloka De Sa, Benjamin J. Dunore, Maddie Epping, Stuart Fawke, Stefan Gräf, Richard Grenfell, Andrew Hinch, Josh Hodgson, Christopher Huang, Oisin Huhn, Kelvin Hunter, Isobel Jarvis, Emma Jones, Maša Josipović, Ekaterina Legchenko, Daniel Lewis, Joe Marsden, Jennifer Martin, Federica Mescia, Francesca Nice, Ciara O’Donnell, Ommar Omarjee, Marianne Perera, Linda Pointon, Nicole Pond, Nathan Richoz, Nika Romashova, Natalia Savoinykh, Rahul Sharma, Joy Shih, Mateusz Strezlecki, Rachel Sutcliffe, Tobias Tilly, Zhen Tong, Carmen Treacy, Lori Turner, Jennifer Wood, Marta Wylot, John Allison, Heather Biggs, Helen Butcher, Daniela Caputo, Debbie Clapham-Riley, Eleanor Dewhurst, Christian Fernandez, Anita Furlong, Barbara Graves, Jennifer Gray, Tasmin Ivers, Emma Le Gresley, Rachel Linger, Mary Kasanicki, Sarah Meloy, Francesca Muldoon, Nigel Ovington, Sofia Papadia, Christopher J. Penkett, Isabel Phelan, Venkatesh Ranganath, Jennifer Sambrook, Katherine Schon, Hannah Stark, Kathleen E. Stirrups, Paul Townsend, Julie von Ziegenweidt, Jennifer Webster, Ali Asaripour, Lucy Mwaura, Caroline Patterson, Gary Polwarth, Katherine Bunclark, Michael Mackay, Alice Michael, Sabrina Rossi, Mayurun Selvan, Sarah Spencer, Cissy Yong, Petra Polgarova

    Published 2022-11-01
    “…Measurement of the complexes reveals information about the involvement of the respective pathways in complement-mediated diseases. Two sandwich ELISAs detecting C1s/C1-INH and MASP-1/C1-INH complex were developed and tested thoroughly, and it was investigated whether C1s/C1-INH and MASP-1/C1-INH complexes could serve as markers for either early CP or LP activation. …”
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    Article
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    Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies by Yang Yang, Ying Zhang, Yuan Li, Xinjin Zhou, Kazuho Honda, Dedong Kang, Muxi Wang, Jing-Hua Yang, Zongping Xia, Yuan Wei, Lu Liu, Ruimin Hu, Takashi Takaki, Guolan Xing

    Published 2025-01-01
    “…Abstract Increasing evidence points toward an essential role for complement activation in the pathogenesis of diabetic kidney disease (DKD). …”
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    Implementation of Intrusion detection and prevention with Deep Learning in Cloud Computing by Doddi Srilatha, N. Thillaiarasu

    Published 2023-01-01
    “…An administrator is employed to identify network security breaches in their organizations by using a Network Intrusion Detection and Prevention System (NIDPS), which is presented in this paper that can detect and preventing a wide range of well-known network attacks. …”
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    Mapping autoantibody targets of full-length C-reactive protein in systemic lupus erythematosus: importance for neutrophil function and classical complement activation by Jesper Karlsson, Lina Wirestam, Hanna Duàn, Suhana Ahmad, Daniel Appelgren, Helena Enocsson, Jonas Wetterö, Christopher Sjöwall

    Published 2025-05-01
    “…Furthermore, we show that patients with anticardiolipin IgG and/or anti-β2GPI IgG antibodies have a higher number of positive CRP epitopes, and some CRP autoantibody-specificities associate with antiphospholipid antibodies, disease activity, and classical complement activation. In addition, one identified motif was selected, synthesized, and used for studying neutrophil function. …”
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    A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples. by Diana Pauly, Benedikt M Nagel, Jörg Reinders, Tobias Killian, Matthias Wulf, Susanne Ackermann, Boris Ehrenstein, Peter F Zipfel, Christine Skerka, Bernhard H F Weber

    Published 2014-01-01
    “…Here, we generated a novel blocking monoclonal antibody (mAb) against properdin and devised a new diagnostic assay for this important complement regulator. Mouse mAb 1340 specifically detected native properdin from human samples with high avidity. …”
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    Pulse Compression Probing for Active Islanding Detection by Nicholas Piaquadio, N. Eva Wu, Morteza Sarailoo

    Published 2025-06-01
    “…This active islanding detection scheme can be implemented on existing inverter switching sequences and has a detection time of 167–223 ms, well within the detection time specified by existing standards. …”
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    Automatic Detection of Defects Using Active Thermography by Miguel Gómez, David Castro

    Published 2025-03-01
    “…Finally, an automated method based on the Signal-to-Noise Ratio (SNR) value is implemented for defect detection, with which defects of a 5 mm diameter and a 3 mm depth can be detected. …”
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