Successful treatment of transplant-associated thrombotic microangiopathy with iptacopan: a non-adult case study by Shijie Bao, Kaikai Huang, Xiao Huang, Huamin Zhu, Zhiqiang Sun

“…The pathogenesis of TA-TMA involves abnormal activation of the complement system—particularly of the alternative pathway—resulting in endothelial injury and microthrombosis. …”
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Advances in understanding the role of pentraxin-3 in lung infections by Li Ma, Dongmei Li, Yiyang Wen, Dongmei Shi, Dongmei Shi

“…It plays a crucial role in regulating complement activation, enhancing the ability of myeloid cells to recognize pathogens, and exerting various immune effects. …”
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Individualised therapeutic approach to the patient with atypical haemolytic-uraemic syndrome by Ivana Mikačić, Nikolina Marić

“…Atypical haemolytic-uraemic syndrome (aHUS) is a rare disease associated with uncontrolled activation of the alternative complement pathway, leading to thrombotic microangiopathy (TMA). …”
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The Role of von Willebrand Factor in the Pathogenesis of C3 Glomerulopathy by Zixin Hua, Yunying Chen, Shasha Han, Xiaojuan Yu, Ying Tan, Feng Yu, Min Chen, Minghui Zhao

“…Introduction: C3 glomerulopathy (C3G) is caused by dysregulation of complement activation. Our previous study found that patients with C3G showed rare variants in von Willebrand factor (vWF). …”
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Practical Application and Influence of “Avigen duck” Immunomodulator to White Pekin Ducks Humoral Immune Factors by Tsvetoslav KOYNARSKI, Preslava PETROVA-TSENIN, Reneta PETROVA

“…Bactericidal proteins are played here lysozyme and complement, interferon, as well as beta-lysine. Adding appropriate active compounds to the bird's diet to activate the innate immune response are subject to studies by many authors. …”

Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection by Liqiang Zhang, Yize Henry Li, Karen Kibler, Simona Kraberger, Arvind Varsani, Julie Turk, Nora Elmadbouly, Emily Aliskevich, Laurel Spaccarelli, Bereket Estifanos, Junior Enow, Isabela Rivabem Zanetti, Nicholas Saldevar, Efrem Lim, Jessika Schlievert, Kyle Browder, Anjali Wilson, Fernando Arcos Juan, Aubrey Pinteric, Aman Garg, Henna Monder, Rohan Saju, Savanah Gisriel, Bertram Jacobs, Timothy L Karr, Esther Borges Florsheim, Vivek Kumar, John Wallen, Masmudur Rahman, Grant McFadden, Brenda G Hogue, Alexandra R Lucas

“…Serine protease inhibitors (SERPINS) regulate activated proteases. The myxoma virus‐derived Serp‐1 protein is a secreted immunomodulatory serpin that targets activated thrombotic, thrombolytic, and complement proteases as a self‐defense strategy to combat clearance. …”
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Exogenous proline promotes serum killing of Klebsiella pneumoniae by Tian-Shun Kou, Yan-Yan Shang, Qi-Chao Zhang, Si-Qi Tian, Juan Li, Li-Na Yang, Ling Min, Bo Peng

“…Furthermore, we demonstrated that proline activates the pyruvate/TCA cycle, increases proton motive force, and enhances complement proteins binding to bacterial surface, forming membrane attack complex to kill serum-resistant K. pneumoniae. …”
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MODULATION OF ANTIBODY MEDIATED LYMPHOCYTOLYSIS IN VITRO UNDER A MAGNETIC VECTOR POTENTIAL by V. N. Novoseletsky, V. Yu. Abramov, V. M. Zaiko, N. B. Bogdanova, E. M. Trukhan

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Inflammation Parameters, Xanthine Oxidase and Anti-Xanthine Oxidase Antibodies in Synovial Fluid of Patients Suffering from Arthritis by Nadjet Hanachi, Lekhmici Arrar

“…Levels of complement components (C3 and C4) were highest in the group of mono-/oligo-arthritis and lowest in RA. …”
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Developing an implementation fidelity measure for a family healthy weight program by Caitlin A. Golden, Paul A. Estabrooks, Kate A. Heelan, R. Todd Bartee, Gwenndolyn C. Porter, Emiliane L. Pereira, Bryce M. Abbey, Tzeyu L. Michaud, Jennie L. Hill

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Tailoring remote patient management to optimise cardiovascular risk management in primary care: a mixed-methods implementation study informing large-scale implementation by Margot Rakers, Nicoline van Hattem, Eric Hiddink, Petra van Peet, Rimke Vos, Niels Chavannes, Douwe Atsma, Tobias Bonten, Hendrikus van Os

“…Methods We conducted a mixed-methods study over six months in four primary care practices in the Netherlands, evaluating two patient groups: (i) patients with a BMI < 25 received a blood pressure monitor alone (BP Box), and (ii) patients with a BMI > 25 or cardiovascular disease received a combination of a BP monitor, a scale, and an activity tracker (Lifestyle Box). Baseline and six-month follow-up assessments were performed using linear mixed-effects models, and implementation outcomes were evaluated using the RE-AIM framework. …”
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Text message intervention delivered from Australian general practices to improve breast cancer survivors’ physical activity and cardiovascular risk factors: protocol for the EMPOWER-SMS-GP effectiveness implementation randomised controlled trial by Karice K Hyun, Christine Mitchell, Julie Redfern, Nashid Hafiz, Rebecca Raeside, Brooke Nickel, Carolyn Ee, Jennifer McIntosh, Elisabeth Elder, Raymond J Chan, David Mizrahi, Stephanie R Partridge, Anna C Singleton, Allyson Ruth Todd, Kirsty E Stuart

“…This randomised controlled trial (RCT) aims to evaluate the effectiveness and implementation of a text message intervention called EMPOWER-SMS-GP in Australian general practices.Methods and analysis Multi-centre single-blind hybrid I RCT (n=678; 1:1 allocation) comparing EMPOWER-SMS-GP (n=339) to usual care (n=339) at 6 months (postintervention), 12, 18 and 24 months (maintenance) and parallel mixed-methods process evaluation using the Reach, Effectiveness, Adoption, Implementation and Maintenance framework. …”
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Complement component C1q initiates extrinsic coagulation via the receptor for the globular head of C1q in adventitial fibroblasts and vascular smooth muscle cells by Christopher T. Freda, Wei Yin, Berhane Ghebrehiwet, David A. Rubenstein

“…Elucidating links between these two processes may provide a clearer understanding of these diseases, allowing for the design of more effective treatments. The activation of complement component 1 (C1) is a crucial contributor to innate immunity and is associated with significant concentrations of circulating C1q. …”
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DEVELOPMENT OF RURAL TOURISM AND AGROTOURISM IN ROMANIA BY IMPLEMENTING EUROPEAN PROGRAMS by Andrei Radu IOVA, Mariana NĂSTASE, Elena LASCĂR

“…The rural tourism and agrotourism activities interfere, complement and support each other, forming a sector to be organized specifically taking account its geographical, economic, social specific etc., the specificity of its products and the role they should play in the development of the rural area. …”
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Methods of electrochemical energy storage control: classification and aspects of implementing by Sergiy Plaksin, Mykola Zhytnyk, Ruslana Levchenko, Svitlana Ostapovska

“…It is shown that if the storage operates in dynamic modes, such as buffer, starter or main energy source mode, when connecting high-power resistors, it is necessary to take into account such parameters as activation resistance and activation capacitance characterizing storage’s resistance capabilities and presenting valuable information for choosing the method of storage control. …”
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TOOLS OF ACTIVIZATION OF INNOVATIVE AND INVESTMENT ACTIVITY IN THE CREATIVE ECONOMY by Oksana Dubskaya, Elena Dubskaya, Yuliya Marakulina

“…Use of innovations, implementation of modern scientific and technical development as the results of intellectual activity in the production and release of high technology products are becoming more important than the simple expansion of production on the traditional basis, as products created on the basis of transformation of new knowledge into innovation; more competitive not only on the level of the individual enterprise, but also on the level of all country.…”
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Integration and evaluation of implementation strategies to improve guideline-concordant bladder cancer surveillance: a prospective observational study by Lisa Zubkoff, A. Aziz Ould Ismail, Laura Jensen, David A. Haggstrom, Soham Kale, Muta M. Issa, Jeffrey J. Tosoian, Mohummad Minhaj Siddiqui, Kennedi Bloomquist, Elisabeth R. Kimball, Susan Zickmund, Florian R. Schroeck

“…Methods Prior work used Implementation Mapping to develop nine implementation strategies: change record systems, educational meetings, champions, tailoring, preparing patients to be active participants, external facilitation, remind clinicians, audit & feedback, and a blueprint. …”
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Predictors of dropping out from a home tele-exercise programme: A cohort study derived from a randomised controlled trial by Gustavo Yuki, Luiz Hespanhol, Lisa Mohr, Adelle Kemlall Bhundoo, David Jiménez-Pavón, Bernhard Novak, Stefano Nuccio, Jose Daniel Jiménez García, Julian David Pillay, Lorenzo Rum, Celso Sánchez Ramírez, Lutz Vogt, Jan Wilke

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Grade Point Average System of Assessment: the Implementation Peculiarities in Russia by B. A. Sazonov

“…The paper analyzes the specificity, as well as flaws and faults of implementing the Grade Point Average (GPA) system of students’ personal assessment in Russian higher schools. …”
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Implementation of MobileNet Architecture for Skin Cancer Disease Classification by Haniifa Aliila Faudyta, Jesica Trivena Sinaga, Egia Rosi Subhiyakto

“…The model architecture includes Global Average Pooling, a Dense layer with 1024 units and ReLU activation, and a Dropout layer with a 0.2 probability. …”
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