Clinicopathological differences in the activation pattern of the complement system between pediatric and adult lupus nephritis: a single centered retrospective study in Korea by Min Ji Park, Man Hoon Han, Mee-seon Kim, Yong-Jin Kim, Sang Jin Lee, Dongsub Kim, Hee Sun Baek, Min Hyun Cho

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Some Human Anti-Glycan Antibodies Lack the Ability to Activate the Complement System by Nadezhda Shilova, Alexey Nokel, Alexander Lipatnikov, Nailya Khasbiullina, Yuri Knirel, Ludmila Baidakova, Alexander Tuzikov, Sergei Khaidukov, Polina Obukhova, Stephen Henry, Batozhab Shoibonov, Emin Salimov, Robert Rieben, Nicolai Bovin

“…Antibodies to blood group systems ABO and Forssman, xeno-antigens, a number of polysaccharides from various strains of <i>S. enterica</i>, <i>E. coli</i> and <i>P. alcalifaciens</i>, as well as small fragments of bacterial polysaccharides were recognized by complement-activating antibodies as expected. A complement-activating antibody was affinity-isolated on glycan-Sepharose from human serum, and, in the presence of the complement, it lysed red blood cells coated with the same glycan (kodecytes, where glycans expressed on biological membranes), while an isolated complement non-activating antibody did not, which confirms the validity of the solid-phase PGA results. …”
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Tocilizumab modulates the activity of the classical and alternative complement pathways in rheumatoid arthritis patients by Iván Ferraz-Amaro, Iván Ferraz-Amaro, Sergio Santos-Concepción, Javier Castro-Hernández, Maria Vanesa Hernández-Hernández, Beatriz Tejera Segura, Cristina Luna, Esmeralda Delgado-Frias, Federico Díaz-González, Federico Díaz-González, Federico Díaz-González

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Humoral complementomics – exploration of noninvasive complement biomarkers as predictors of renal cancer progression by Margot Revel, Mikel Rezola Artero, Houcine Hamidi, Anne Grunenwald, Loris Blasco, Yann A. Vano, Stephane Marie Oudard, Rafael Sanchez-Salas, Petr Macek, Lara Rodriguez Sanchez, Xavier Cathelineau, Benoit Vedié, Catherine Sautes-Fridman, Wolf Herman Fridman, Lubka T. Roumenina, Marie-Agnes Dragon-Durey

Subjects: “…Activation fragments…”
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Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS‐mutant Cancers by Yafang Wang, Lansong Xu, Lijun Ling, Mingyue Yao, Shangxuan Shi, Chengcheng Yu, Yingnian Li, Jie Shen, Hualiang Jiang, Chengying Xie

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Systematic Review of the Link Between Oxford MEST-C Classification and Complement Activation in IgA Nephropathy by Gabriel Ștefan, Eric Alamartine, Christophe Mariat, Nicolas Maillard

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The specific contributions of factor H and factor I in controlling fluid phase activation of the alternative complement pathway by Nancy A. Turner, Joel L. Moake

“…Abstract The immediate defense provided by the alternative complement pathway (AP) is under constant control by fluid phase regulators, factor H (FH) and factor I (FI), to prevent nonessential activation. …”
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Impact of the Graphene Production Methods Sonication and Microfluidization on In Vitro and In Vivo Toxicity, Macrophage Response, and Complement Activation by Jan-Lukas Førde, Abdelnour Alhourani, Tian Carey, Adrees Arbab, Kari E. Fladmark, Silje Skrede, Tom Eirik Mollnes, Lars Herfindal, Hanne R. Hagland

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A Prospective Study on Complement Activation Distinguishes Focal Segmental Glomerulosclerosis from Minimal Change Disease by Alexandra Cambier, Natacha Patey, Virginie Royal, François Gougeon, Dominique S. Genest, Soumeya Brachemi, Guillaume Bollée, Clémence Merlen, Arnaud Bonnefoy, Anne-Laure Lapeyraque, Stéphan Troyanov

Subjects: “…complement activation…”
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A Scoping review on the implementation of active recreational activities by Louie Petere Gula

“…It was found out that the implementation of active recreational activities offers different health benefits to the youth, physical literacy and orientation and motivation played a vital role in the implementation of the recreational activities. …”
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IGFBP2 and IGFBP4 interact to activate complement pathway in diabetic kidney disease by Jieling Liang, Yangxiao Huang, Daping Peng, Yali Xie, Yifei Liu, Xiuxia Lu, Junfa Xu

“…The levels of IGFBP2 and IGFBP4 increased in DKD mice, accompanied by the activation of the complement pathway, and a deterioration in renal function. …”
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Bevacizumab-associated glomerular microangiopathy: a case report and literature review by Rui Jiang, Rui-zhi Yu, Hai-feng Yang, Li-xin Wang, Jun-jie Lin

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The Association of Complements, TGF-β, and IL-6 with Disease Activity, Renal Damage, and Hematological Activity in Patients with Naïve SLE by Yuliasih Yuliasih, Lita Diah Rahmawati, Nabilatun Nisa’, Cahaya Prastayudha

“…The purpose of this study was to reveal the association between complement 3 (C3), complement 4 (C4), interleukin-6 (IL-6), and transforming growth factor-β (TGF-β) with SLE disease activity, renal damage, and hematological activity in patients with naïve SLE. …”
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SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis by Laura Gebetsberger, Zahra Malekshahi, Aron Teutsch, Gabor Tajti, Frédéric Fontaine, Nara Marella, André Mueller, Lena Prantl, Hannes Stockinger, Heribert Stoiber, Anna Ohradanova-Repic

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Implementation of Antimicrobial Stewardship Activities in India by Arzoo Sahni, Arti Bahl, Rashi Martolia, Sudhir Kumar Jain, Sujeet Kumar Singh

“…To address this issue, this systematic review attempts to study the implementation activities of AMSP in the country by the means of literature review. …”
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Evaluation of the Implementation of Waste Bank Activities by Irdam Ahmad

“…This study aims to evaluate the activities of WB in Jakarta and to find out the government's contribution in developing WB. …”
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Complement Activation is More Pronounced in the Kidneys of Critically Ill Patients With COVID-19 Than in Those With Bacterial Sepsis by Firas F. Alkaff, Grietje G. Talen, Marius C. van den Heuvel, Meint Volbeda, Matijs van Meurs, Jill Moser, Mohamed R. Daha, Jacob van den Born, Stefan P. Berger

“…Nonetheless, no study has compared the complement activation between these 2 types of AKI. …”
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Complement Activation in Association with Markers of Neutrophil Extracellular Traps and Acute Myocardial Infarction in Stable Coronary Artery Disease by Karsten E. Kluge, Miriam S. Langseth, Trine B. Opstad, Alf Å. Pettersen, Harald Arnesen, Theis Tønnessen, Ingebjørg Seljeflot, Ragnhild Helseth

“…Complement activation and neutrophil extracellular traps (NETs) have both been suggested to drive atherosclerotic plaque progression. …”
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Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina by Marcus Karlstetter, Jens Kopatz, Alexander Aslanidis, Anahita Shahraz, Albert Caramoy, Bettina Linnartz‐Gerlach, Yuchen Lin, Anika Lückoff, Sascha Fauser, Katharina Düker, Janine Claude, Yiner Wang, Johannes Ackermann, Tobias Schmidt, Veit Hornung, Christine Skerka, Thomas Langmann, Harald Neumann

“…Its pathophysiology is linked to reactive oxygen species (ROS) and activation of the complement system. Sialic acid polymers prevent ROS production of human mononuclear phagocytes via the inhibitory sialic acid‐binding immunoglobulin‐like lectin‐11 (SIGLEC11) receptor. …”
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Randomised prospective trial to assess the clinical utility of multianalyte assay panel with complement activation products for the diagnosis of SLE by Daniel J Wallace, Thierry Dervieux, Arezou Khosroshahi, Claudia Ibarra, Tyler O'Malley, Elena Massarotti, Roberta Vezza Alexander, Mehrnaz Hojjati, Konstantinos Loupasakis, Jeffrey Alper, Yvonne Sherrer, Maria Fondal, Rajesh Kataria, Tami Powell, Sonali Narain, Arthur Weinstein

“…Objective We compared the physician-assessed diagnostic likelihood of SLE resulting from standard diagnosis laboratory testing (SDLT) to that resulting from multianalyte assay panel (MAP) with cell-bound complement activation products (MAP/CB-CAPs), which reports a two-tiered index test result having 80% sensitivity and 86% specificity for SLE.Methods Patients (n=145) with a history of positive antinuclear antibody status were evaluated clinically by rheumatologists and randomised to SDLT arm (tests ordered at the discretion of the rheumatologists) or to MAP/CB-CAPs testing arm. …”
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