Problems of Assessing the Compliance of Professional Activities of Practical Psychologists with the Requirements of the Implemented Standards (once again about experts and expertise in practical psychology) by Zabrodin Y.M., Pakhalyan V.E.

“…The analysis of the state of the problem of expertise in practical psychology is carried out, in the context of tasks arising in connection with the implementation ? introduction of standards of professional activity. …”
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Problems of Commodity Nomenclatures Implementation in the International Trade on the Example of Chapter 56 “Nonwovens” of the EAEU Commodity Nomenclature of Foreign Eco nomic Activity by E. V. Zhiryayeva, V. G. Koltsova

“…The article examines the problems of using the Commodity Nomenclature of Foreign Economic Activity. The following problems are highlighted: the lag of the Harmonized Commodity Description and Coding System from the development of technologies; disagreement of countries with the decisions of the Harmonized System Committee; mistakes in texts; difficulties with the implementation of the classification decisions of the Federal Customs Service and Eurasian Economic Commission. …”
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Implementation of a Priority-based Energy Management Scheme with a common control strategy for PV and battery integrated Shunt Active Filters by Muhammad Rayyan Fazal, Mohamad Alaa Eddin Alali, Tanguy Phulpin, Romain Le Forestier, Christophe Goasguen

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Testing the Recruitment Frequency, Implementation Fidelity, and Feasibility of Outcomes of the Heart Failure Activity Coach Study (HEALTHY): Pilot Randomized Controlled Trial by Andreas Blomqvist, Maria Bäck, Leonie Klompstra, Anna Strömberg, Tiny Jaarsma

“…ObjectiveWe tested the recruitment frequency, implementation fidelity, and feasibility of outcomes of the Activity Coach app that was developed using an existing mobile health (mHealth) tool, Optilogg, to support older adults with HF to be more physically active and less sedentary. …”
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Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective by Didar Murad, Rehan Zafar Paracha, Maryum Nisar

“…In conclusion, this study explains the regulatory mechanisms of the hemostatic and complement systems and illustrates how the biopathway machinery sustains the balance between activation and inhibition. …”
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The role of complement in the immunopathogenesis of acetylcholine receptor antibody-positive generalized myasthenia gravis: bystander or key player? by Iliana Michailidou, Anastasia Patsiarika, Evangelia Kesidou, Marina Kleopatra Boziki, Marina Kleopatra Boziki, Dimitrios Parisis, Christos Bakirtzis, Elisabeth Chroni, Nikolaos Grigoriadis, Nikolaos Grigoriadis

“…In antiacetylcholine receptor (AChR) antibody-positive (Ab+) generalized myasthenia gravis (MG), complement activation has long been considered a principal driver of pathology. …”
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Estimation of Complement Components (C3 and C4) and hs-CRP Level in Kidney Failure Patients by Zaid N. Elia, Nisreen W. Mustafa

“…Several kidney diseases associated with complement activation. Complement activation occurs in progressive chronic kidney disease and may contribute to the chronic inflammation that is characteristically found in the kidney. …”
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Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation. by Jacqueline U McDonald, Marcela Rosas, Gordon D Brown, Simon A Jones, Philip R Taylor

“…We have used in vivo and ex vivo models to study the recognition and response of these cells: i) We confirm previous observations regarding the importance of complement to neutrophil but not monocytic responses; ii) We show that dectin-1 is important for driving inflammatory cell recruitment to fungal stimuli and that it biases the immediate inflammatory response to one that favors neutrophil over monocyte recruitment; iii) We show that dectin-2 contributes to the physical recognition of fungal particles by inflammatory monocytes/macrophages, but is also expressed on neutrophils, where we show it has the potential to contribute to cellular activation; iv) Additionally, we show that serum-opsonization has the potential to interfere with non-opsonic recognition of fungal particles by dectin-1 and dectin-2, presumably through masking of ligands. …”
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Target complement factor H / serum amyloid a signaling in trichloroethylene-induced immune kidney injury by Haibo Xie, Bo Liang, Jingyi Zhao, Chen You, Qirui Bai, Rui Li, Jian Chen, Pengcheng Zhou, Luolun Dong, Ruixuan Cheng, Jiaxiang Zhang, Qixing Zhu

“…The aberrant activation of the intracellular complement system is a significant characteristic of trichloroethylene (TCE) -induced immune kidney injury. …”
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Complement-Mediated Hemolytic Uremic Syndrome Due to MCP/CD46 Mutation: A Case Report by Abdul Muhsen Abdeen MD, Jowan Al-Nusair MD, Malik Samardali MD, Mohamed Alshal MD, Amro Al-Astal MD, Zeid Khitan MD

“…Thrombotic microangiopathy (TMA) is a severe condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end-organ damage, often involving the kidneys. Complement-mediated hemolytic uremic syndrome (cHUS), a rare form of TMA, arises from dysregulated alternative complement pathway activation, frequently due to genetic mutations. …”
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KLF4 overexpression protects against complement-mediated endothelial injury in transplant-associated thrombotic microangiopathy by Shuhui Jiang, Jiaqian Qi, Tingting Pan, Zhenzhen Yao, Siyi Lu, Yifei Han, Depei Wu, Yue Han

“… Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe complication of hematopoietic stem cell transplantation, marked by excessive complement activation, endothelial injury, and microangiopathy. …”
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Evolving understanding of Guillain-Barré syndrome pathophysiology and the central role of the classical complement pathway in axonal injury by Kenneth C. Gorson

“…Given its evolutionary role in antibody binding and activating the classical complement pathway, the complement component C1q has been proposed as a therapeutic target in GBS. …”
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Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH). by Hugh P Morgan, Haydyn D T Mertens, Mara Guariento, Christoph Q Schmidt, Dinesh C Soares, Dmitri I Svergun, Andrew P Herbert, Paul N Barlow, Jonathan P Hannan

“…It selectively inhibits amplification of C3b, the activation-specific fragment of the abundant complement component C3, in fluid phase and on self-surfaces and accelerates the decay of the alternative pathway C3 convertase, C3bBb. …”
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Plasma complement proteins as biomarkers and therapeutic targets in chronic kidney disease: a Mendelian randomization analysis by Yu-Peng Xu, Zheng-Qi Song, Ming-Li Chen, Yang-Li Fang, Hui-Di Zhang

“…The identified causal associations highlight the relevance of complement activation in CKD progression, suggesting future potential for clinical applications in early diagnosis, risk stratification, and therapeutic intervention.…”
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Moss-derived human complement factor H modulates retinal immune response and attenuates retinal degeneration by Mandy Hector, Verena Behnke, Paulina Dabrowska-Schlepp, Andreas Busch, Andreas Schaaf, Thomas Langmann, Anne Wolf

“…Results Light-exposed mice treated with moss-derived recombinant human full-length CFH showed reduced complement activation and MAC deposition in the retina. …”
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Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration by Paul Tamburini, Dennis Vestergaard Pedersen, Denise Devore, Josh Cone, Rekha Patel, Todd Hunter, Fang Sun, Gregers Rom Andersen, Jeffrey Hunter

“…The bispecific antibody tarperprumig (ALXN1820) was developed as a treatment option for diseases involving dysregulated complement alternative pathway (AP) activity that could be administered in small volumes, either subcutaneously or intravenously. …”
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Enhancing home-based physical activity for neurodivergent children: adapting the InPACT at Home program with AI and universal design by Tania Sapre, Haylie L. Miller, Anna Schwartz, Leah R. Ketcheson, Alanna Price, Kerry Winkelseth, Jeanne M. Barcelona, Ronald F. Zernicke, Ronald F. Zernicke, Rebecca E. Hasson

“…AI was employed to generate and refine prompts like “Provide simplified step-by-step instructions for a jumping jack, suitable for a neurodivergent child” and “Condense the step-by-step instructions for a jumping jack, suitable for a neurodivergent child”.DiscussionThe adaptation of the existing InPACT at Home program was guided by dissemination and implementation science frameworks, aiming to increase equitable access to structured youth physical activity opportunities for neurodivergent children. …”
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Specific surface-modified iron oxide nanoparticles trigger complement-dependent innate and adaptive antileukaemia immunity by Yuanyuan Li, Wen Wu, Qihui Liu, Qiong Wu, Ping Ren, Xi Xi, Haiyan Liu, Jiarui Zhao, Wei Zhang, Zizhun Wang, Yuanyuan lv, Bin Tian, Shuang Sun, Jiaqi Cui, Yangyang Zhao, Jingyuan Wu, Mingyuan Gao, Fangfang Chen

“…Mechanistically, IONP-COOH indirectly binds to C3b after activating the complement alternative pathway, subsequently enhancing phagocytosis of macrophages and activating adaptive immunity mediated by complement corona. …”
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Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy by Amanda K. Slagle, Amanda K. Slagle, Nicolo Ghiringhelli Borsa, Kai Wang, Amanda O. Taylor, Nicole C. Meyer, Michael B. Jones, William D. Walls, Angela F. M. Nelson, Sarah M. Roberts, Mingyao Sun, Elena Goicoechea de Jorge, Santiago Rodriguez de Cordoba, Diana I. Jalal, Diana I. Jalal, Carla M. Nester, Yuzhou Zhang, Richard J. H. Smith, Richard J. H. Smith

“…Additionally, an in vitro C3b deposition assay was used to characterize the functional impact of FHR-1 on local complement activity.ResultsIn this study, we confirm that CFHR3-CFHR1 copy number impacts C3G risk. …”
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Genotypic and phenotypic diversity of Lactobacillus rhamnosus clinical isolates, their comparison with strain GG and their recognition by complement system. by Eija Nissilä, François P Douillard, Jarmo Ritari, Lars Paulin, Hanna M Järvinen, Pia Rasinkangas, Karita Haapasalo, Seppo Meri, Hanna Jarva, Willem M de Vos

“…All L. rhamnosus strains activated complement in serum and none of them bound complement regulators. …”
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