Urine complement analysis implies complement activation is involved in membranous nephropathy by Yingxue Xu, Yingxue Xu, Yi Li, Yong Zhang, Guisen Li, Guisen Li

“…BackgroundThe onset and progression of membranous nephropathy (MN) have been associated with complement activation, yet the overall characteristics of this activation in the kidneys remain unclear. …”
Get full text

Complement Activation: An Emerging Player in the Pathogenesis of Cardiovascular Disease by Angela M. Carter

“…An increasing body of evidence supports a functional role for complement activation in the pathogenesis of CVD through pleiotropic effects on endothelial and haematopoietic cell function and haemostasis. …”
Get full text

Can Cell Bound Complement Activation Products Predict Inherited Complement Deficiency in Systemic Lupus Erythematosus? by Naveen Raj, Barry Waters

“…Activation of the classical pathway complement system has long been implicated in stimulating immune complex mediated tissue destruction in systemic lupus erythematosus (SLE). …”
Get full text

Complement Activation in BK Polyoma Virus Nephropathy: What’s the Story? by M. Barry Stokes

Get full text

Complement activation in wasp venom-induced acute kidney injury by Rui Cheng, Liang Xu, Jianhua Gong, Fanglin Yu, Ying Lv, Hai Yuan, Fengqi Hu

Subjects: Get full text

Nanobody‐mediated complement activation to kill HIV‐infected cells by Maria Lange Pedersen, Dennis Vestergaard Pedersen, Mikael Becher Lykkegaard Winkler, Heidi Gytz Olesen, Ole Schmeltz Søgaard, Lars Østergaard, Nick Stub Laursen, Anna Halling Folkmar Rahimic, Martin Tolstrup

“…We developed a novel therapeutic modality to direct complement activity to the surface of HIV‐1‐infected cells. …”
Get full text

Angiotensinogen and C3 compete for renin-induced complement activation by Ann-Charlotte Kristoffersson, Albin Sköld, Charlotte Welinder, Markus Wendler, Gabriella Kalliokoski, Zivile Bekassy, Diana Karpman

Get full text

Complement C3 inhibition reduces complement activation in clinical platelet concentrates but does not counteract platelet storage lesions by Linnea I. Andersson, Per Sandgren, Dick J. Sjöström, Camilla Mohlin, Kim Hägerström, Ivar Tjernberg, Tom Eirik Mollnes, Per H. Nilsson

“…We investigated the impact of complement C3 inhibition on complement activation and platelet storage lesions in clinical platelet concentrates. …”
Get full text

SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteins by Jian Wu, Sanpeng Xu, Zhiqing Li, Boyi Cong, Zongheng Yang, Zhichao Yang, Wanfeng Gao, Shuo Liu, Zhou Yu, Sheng Xu, Nan Li, Jin Hou, Guoping Wang, Xuetao Cao, Shuxun Liu

Subjects: Get full text

Simultaneous activation of complement and coagulation by MBL-associated serine protease 2. by Anders Krarup, Russell Wallis, Julia S Presanis, Péter Gál, Robert B Sim

“…The lectin pathway is one pathway of three by which the complement system is activated. The characteristic protease of this pathway is Mannan-binding lectin (MBL)-associated serine protease 2 (MASP2), which cleaves complement proteins C2 and C4. …”
Get full text

Cell-bound complement activation products associate with lupus severity in SLE by Richard A Furie, Daniel J Wallace, Judith A James, Susan Manzi, Amit Saxena, Rosalind Ramsey-Goldman, Chaim Putterman, John Conklin, Anca Askanase, Jill P Buyon, Elena Massarotti, Roberta Vezza Alexander, Sonali Narain, Cristina Arriens, Kenneth C Kalunian, Christopher E Collins, Ghalib A Bello, Joseph Ahearn

“…Objectives To evaluate the association between lupus severity and cell-bound complement activation products (CB-CAPs) or low complement proteins C3 and C4.Methods All subjects (n=495) fulfilled the American College of Rheumatology (ACR) classification criteria for SLE. …”
Get full text

Zinc supplementation inhibits complement activation in age-related macular degeneration. by Dzenita Smailhodzic, Freekje van Asten, Anna M Blom, Frida C Mohlin, Anneke I den Hollander, Johannes P H van de Ven, Ramon A C van Huet, Joannes M M Groenewoud, Yuan Tian, Tos T J M Berendschot, Yara T E Lechanteur, Sascha Fauser, Chris de Bruijn, Mohamed R Daha, Gert Jan van der Wilt, Carel B Hoyng, B Jeroen Klevering

“…Furthermore, we investigated the effect of zinc on complement activation in vitro. AMD patients with high levels of complement catabolism at baseline exhibited a steeper decline in serum complement activation (p<0.001) during the three month zinc supplementation period compared to patients with low complement levels. …”
Get full text

Emerging role of complement system in the induction of neuroinflammation in adenylosuccinate lyase deficiency disorder by Albert Frank Magnusen, Robert James Hopkin, Charles Vorhees, Elizabeth Wilson, Molly Moehlman, Barbara Hallinan, Craig Erickson, Melissa P. DelBello, Luca Marsili, Nicole G. Coufal, Manoj Kumar Pandey

Subjects: Get full text

The Emerging Role of Complement Lectin Pathway in Trypanosomatids: Molecular Bases in Activation, Genetic Deficiencies, Susceptibility to Infection, and Complement System-Based Therapeutics by Ingrid Evans-Osses, Iara de Messias-Reason, Marcel I. Ramirez

“…These new components at the complement world are very efficient. Mannan-binding lectin (MBL) and ficolin not only recognize many molecular patterns of pathogens rapidly to activate complement but also display several strategies to evade innate immunity. …”
Get full text

Complement activation drives the phagocytosis of necrotic cell debris and resolution of liver injury by Sofie Vandendriessche, Matheus Silvério Mattos, Emilia Laura Bialek, Sara Schuermans, Paul Proost, Pedro Elias Marques

“…We found that independently of the type of necrotic liver injury, either acetaminophen (APAP) overdose or thermal injury, complement proteins C1q and (i)C3b were deposited specifically on necrotic lesions via the activation of the classical pathway. …”
Get full text

Complement activation by the artificial surface of cardiopulmonary bypass is a persistent clinical problem by Joel David Bierer, Roger Stanzel, Mark Henderson, Tony El-Rabahi, John Sapp, Pantelis Andreou, Jean S. Marshall, David Conrad, David Horne

“…Abstract Activation of the alternative complement pathway by artificial extracorporeal surfaces is relevant to several clinical applications such as cardiac surgery with cardiopulmonary bypass (CPB), thoracic organ transplantation and hemodialysis. …”
Get full text

A Cell-Based Assay to Measure the Activity of the Complement Convertases by Małgorzata Stasiłojć, Grzegorz Stasiłojć, Alicja Kuźniewska, Santiago Rodriguez de Córdoba, Marcin Okrój

“…Aberrant regulation of the convertases is often implicated in the development of rare complement-related diseases. However, analyzing convertase activity poses a significant challenge due to their labile nature and intricate interactions with serum proteins. …”
Get full text

Association between circulatory complement activation and hypertensive renal damage: a case–control study by Zhongli Wang, Tingting Zhang, Xinyu Wang, Jianlong Zhai, Lili He, Sai Ma, Qingjuan Zuo, Guorui Zhang, Yifang Guo

“…Objective The aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage.Methods Serum complement C3, complement Factor H (CFH) and AP activation were assessed in 66 participants with established essential hypertension with renal damage (RD). …”
Get full text

Catastrophic antiphospholipid syndrome accompanied by complement regulatory gene mutation by Serim Pul, Betül Sözeri, Cemile Pehlivanoğlu, Deniz Filinte, Özde Nisa Türkkan, Mehtap Sak, Neslihan Çiçek, Serçin Güven, Ece Demirci Bodur, İbrahim Gökçe, Harika Alpay

Subjects: Get full text

Inhibition of complement activation, myeloperoxidase, NET formation and oxidant activity by PIC1 peptide variants. by Pamela S Hair, Adrianne I Enos, Neel K Krishna, Kenji M Cunnion

“…<h4>Background</h4>A product of rational molecular design, PA-dPEG24 is the lead derivative of the PIC1 family of peptides with multiple functional abilities including classical complement pathway inhibition, myeloperoxidase inhibition, NET inhibition and antioxidant activity. …”
Get full text