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    Current landscape of paroxysmal nocturnal hemoglobinuria in the era of complement inhibitors and regulators by Julia J. Shi, Yusuf M. Ozcan, Carlos I. Ayala Santos, Hetalkumari Patel, Jamile Shammo, Taha Bat

    Published 2024-12-01
    “…Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder which is caused by mutations in phosphatidylinositol glycan class A leading to hemolysis of red blood cells via complement inhibition. The first treatment for PNH, eculizumab, was FDA approved in 2007. …”
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  7. 147

    A cytosolic glyoxylate shunt complements the canonical photorespiratory pathway in Arabidopsis by Xiaotong Jiang, Amanda M. Koenig, Berkley J. Walker, Jianping Hu

    Published 2025-04-01
    “…Our genetic, transcriptomic and metabolic profiling analyses together reveal a connection between cytosolic glyoxylate and a non-canonical photorespiratory route mediated by HPR2, which we name the photorespiratory glyoxylate shunt. This shunt complements the canonical photorespiratory pathway and is especially critical when high photorespiratory fluxes are required and when the major photorespiratory pathway is deficient. …”
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    Evolutionary plasticity in nematode Hox gene complements and genomic loci arrangement by Joseph Kirangwa, Dominik R. Laetsch, Erna King, Lewis Stevens, Mark Blaxter, Oleksandr Holovachov, Philipp Schiffer

    Published 2024-11-01
    “…Here, we explored Hox gene complements in high-quality genomes of 80 species from all major clades of Nematoda to understand the evolution of this key set of body pattern genes and especially to probe the origins of the “dispersed” cluster observed in C. elegans. …”
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  11. 151

    The stability of complement-mediated bactericidal activity in human serum against Salmonella. by Colette M O'Shaughnessy, Adam F Cunningham, Calman A Maclennan

    Published 2012-01-01
    “…The complement cascade includes heat-labile proteins and care is required when handling serum in order to preserve its functional integrity. …”
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  12. 152

    The Complement System: An Important New Therapeutic Target in IgA Nephropathy by Karshana J. Kalyanaraman, Joshua M. Thurman

    Published 2024-12-01
    “…Key Messages: Several complement inhibitors are currently in clinical trials for IgAN. …”
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