Comparing the effectiveness of implementation strategies to improve liver and colon cancer screening for Veterans: protocol for a large cluster-randomized implementation study by Shari S. Rogal, Vera Yakovchenko, Timothy R. Morgan, Jason A. Dominitz, Heather McCurdy, Anna Nobbe, Nsikak R. Ekanem, Chaeryon Kang, Rachel I. Gonzalez, Angela Park, Jennifer Anwar, Brittney Neely, Sandra Gibson, Carolyn Lamorte, Jasmohan S. Bajaj, Heather M. Patton, Yiwen Yao, Andrew J. Gawron

“…Implementation Science…”
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Implementing evidence into practice for the management of frozen shoulder: engaging with key stakeholders and evaluating barriers and facilitators using the Consolidated Framework for Implementation Research by Natalie Louise Clark, Melissa Johnson, Lucksy Kottam, Stephen Brealey, Joy Adamson, Amar Rangan, The UK FROST Stakeholder Group

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Implementing TeamMAPPS: Formative qualitative findings from the dissemination and implementation study of a new evidence-based team science intervention by Stephen Molldrem, Heidi Luft, Jeffrey S. Farroni, Elizabeth J. Lyons, Kevin Wooten

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Are codesigned programmes more difficult to implement? A qualitative study of staff perceptions on the implementation of a new youth mental health programme by Michelle Kehoe, Rick Whitehead, Kathleen deBoer, Denny Meyer, Liza Hopkins, Maja Nedeljkovic

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Shedding of membrane complement inhibitors CD59 and CD46 into the circulation is associated with poor prognosis in acute coronary syndrome patients: a cohort study by Baojun Zhong, Ben King, Homa Waziri, Troels Yndigegn, Daniel Engelbertsen, Harry Björkbacka, Jan Nilsson, Isabel Goncalves, Anna M. Blom, Alexandru Schiopu

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The relationship between the levels of total sialic acid and complement proteins, C 3 and C 4, in the chemotherapy-untreated and –treated patients with acute lymphoblastic leukemia by Haider S. Abid, Ghassan M. Sulaiman, Majid S.J. Al-Zaidy

“…Thus, these results suggest that, despite the apparently similar behavior of the levels of TSA and the complement proteins before and after chemotherapy, TSA can not be used as an indicator to monitor the levels of complement proteins in response to chemotherapy. …”
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WCN25-267 DETERMINATION OF NEUTROPHIL TO ALBUMIN RATIO, NEUTROPHIL TO C3 COMPLEMENT RATIO AND ALBUMIN TO GLOBULIN RATIO IN THE ASSESSMENT OF LUPUS NEPHRITIS ACTIVITY by Violeta Rabrenovic, Milorad Rabrenovic, Milica Petrovic, Dejan Pilcevic, Nemanja Rancic

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WCN24-912 IMAGINATION: A GLOBAL PHASE 3 TRIAL OF RO7434656, AN ANTISENSE OLIGONUCLEOTIDE INHIBITOR OF COMPLEMENT FACTOR B, IN IGA NEPHROPATHY by Jonathan Barratt, Jürgen Flöge, Vishal Duggal, Nadine Schmit, Ji Cheng, Jeannette Lo, Brad Rovin

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WCN25-2825 KIDNEY TRANSPLANTATION IN PRESENCE OF COMPLEMENT GENE MUTATIONS IN BOTH RECIPIENTS AND THEIR ASYMPTOMATIC KIDNEY DONORS: OUR EXPERIENCE FROM CENTRAL INDIA by Vijay Jeyachandran, AMIT PASARI, MANISH BALWANI, CHARULATA BAWANKULE, KAPIL SEJPAL, PRASAD GURJAR, PRANJAL KASHIV, SHUBHAM DUBEY, SUNNY MALDE, SUSHRUT GUPTA, VIJAY JEYACHANDRAN, VIJAY KATEKHAYE

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WCN25-716 EFFECT OF IPTACOPAN ON PROTEINURIA AND COMPLEMENT BIOMARKERS IN IgA NEPHROPATHY (IgAN): INTERIM ANALYSIS OF THE PHASE 3 APPLAUSE-IgAN STUDY by Dmitrij Kollins, Olympia Papachristofi, Thomas Hach, Marie-Anne Valentin, Tobias Merkel, Ronny Renfurm, Vlado Perkovic

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Does Brand Attitude Complement Influencer Credibility in Shaping Purchase Intention of Indian GenZ Consumers? [version 1; peer review: 2 approved] by Varalakshmi Alapati, Pranav Vilas Chavare, Smitha Nayak, Ramona Birau

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Two complementing in vivo selection systems based on CCA-trimming exonucleases as a tool to monitor, select and evaluate enzymatic features of tRNA nucleotidyltransferases by Karolin Wellner, Josefine Gnauck, Dorian Bernier, Stephan H. Bernhart, Heike Betat, Mario Mörl

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Polymorphic factor H-binding activity of CspA protects Lyme borreliae from the host complement in feeding ticks to facilitate tick-to-host transmission. by Thomas Hart, Ngoc Thien Thu Nguyen, Nancy A Nowak, Fuming Zhang, Robert J Linhardt, Maria Diuk-Wasser, Sanjay Ram, Peter Kraiczy, Yi-Pin Lin

“…Bbsl produces a polymorphic surface protein, CspA, that binds to a complement regulator, Factor H (FH) to block complement activation in vitro. …”
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Apobec-1 complementation factor regulates cell migration and apoptosis through Dickkopf1 by acting on its 3′ untranslated region in MCF7 cells by Xin Yan, Qianyin Li, Dongsheng Ni, Yajun Xie, Qingling He, Qianya Wan, Yamin Liu, Zhongshi Lyu, Zhaomin Mao, Qin Zhou

“…A1CF (apobec-1 complementation factor) acts as a component of the apolipoprotein-B messenger RNA editing complex. …”
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Predictive Value of Excision Repair Cross Complementation Group 1 (ERCC1) by Immunohistochemistry for Determining Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancers by Atif Ali Hashmi, Yumna Ajaz, Muhsana Sajjad, Fazail Zia, Muhammad Irfan, Syed Muhammad Abu Bakar, Erum Yousuf Khan, Naveen Faridi

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PdMoPtCoNi High Entropy Nanoalloy with d Electron Self‐Complementation‐Induced Multisite Synergistic Effect for Efficient Nanozyme Catalysis by Xuewei Yang, Jianxing Feng, Yuechun Li, Wenxin Zhu, Yifan Pan, Yaru Han, Zhonghong Li, Haijiao Xie, Jianlong Wang, Jianfeng Ping, Wenzhi Tang

“…Density functional theory calculations demonstrate that the enhanced electron abundance of HEA NWs near the Fermi level (EF) is facilitated via the self‐complementation effect among the diverse transition metal sites, thereby boosting the electron transfer efficiency at the catalytic interface through the cocktail effect. …”
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Does Brand Attitude Complement Influencer Credibility in Shaping Purchase Intention of Indian GenZ Consumers? [version 3; peer review: 2 approved] by Varalakshmi Alapati, Pranav Vilas Chavare, Smitha Nayak, Ramona Birau

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N-terminomics profiling of host proteins targeted by excretory-secretory proteases of the nematode Angiostrongylus vasorum identifies points of interaction with canine coagulation and complement cascade. by Nina Germitsch, Tobias Kockmann, Manuela Schnyder, Lucienne Tritten

“…A total of eight dog proteins were significantly cleaved at higher levels upon exposure to A. vasorum ESP: of these, three were coagulation factors (factor II, V and IX) and three were complement proteins (complement C3, C4-A and C5). Comparison with human motif sequence orthologues revealed known cleavage sites in coagulation factor IX and II (prothrombin). …”
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Efficacy and safety of complement inhibitors in patients with geographic atrophy associated with age-related macular degeneration: a network meta-analysis of randomized controlled trials by Huan Wang, Jiaqi Zheng, Qing Zhang, Zhongping Tian, Yuhang Sun, Tianyi Zhu, Yanlong Bi, Yanlong Bi, Li Zhang, Li Zhang

Subjects: “…complement inhibitors…”
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The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia. by Omar Sharif, Riem Gawish, Joanna M Warszawska, Rui Martins, Karin Lakovits, Anastasiya Hladik, Bianca Doninger, Julia Brunner, Ana Korosec, Roland E Schwarzenbacher, Tiina Berg, Robert Kralovics, Jacques Colinge, Ildiko Mesteri, Susan Gilfillan, Andrea Salmaggi, Admar Verschoor, Marco Colonna, Sylvia Knapp

“…Mechanistically, we detected that in the absence of TREM-2, pulmonary macrophages selectively produced elevated complement component 1q (C1q) levels. We found that these increased C1q levels depended on peroxisome proliferator-activated receptor-δ (PPAR-δ) activity and were responsible for the enhanced phagocytosis of bacteria. …”
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