Omega-3 fatty acid supplementation from late pregnancy to early lactation attenuates the endocannabinoid system and immune proteome in preovulatory follicles and endometrium of Hol... by P. dos S. Silva, Y. Butenko, G. Kra, S. Malitsky, M. Itkin, Y. Levin, U. Moallem, M. Zachut

“…Proteomic analysis of GRC showed that n-3 FA supplementation increased the abundance of FA-binding-protein-5, which is involved in intracellular transport of eCB, as well as the abundances of the cytokine receptor like factor-2 and glutathione-S-transferase-LANCL1, whereas it reduced the abundances of several complement proteins: complement factors I, D, H, complement components C7 chain and C8 β chain, and complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP). …”
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A Study of the Subjective Assessment of the Readiness and Ability of Students and Working Tutors for Tutor Support in the Context of Inclusive Education by E.V. Samsonova, Yu.A. Bystrova, A.Yu. Shemanov, L.M. Prokopyeva

“…We developed a subjective assessment model based on competency and activity approaches that includes 4 questionnaires: the attitude towards inclusion, the intention to implement inclusive practices, the reflection of difficulties and self-efficacy in implementing inclusive practices. …”
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Information Need and Information Seeking Behaviour by Nazan Özenç Uçak

“…Information need causes information seeking behaviour and these concepts complement each other. Information need and information seeking behaviour are effected by many factors. …”
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MECHANISMS OF CYTOKINE STORM DEVELOPMENT IN COVID-19 AND NEW POTENTIAL TARGETS OF PHARMACOTHERAPY by V. I. Petrov, A. A. Amosov, A. S. Gerasimenko, O. V. Shatalova, A. V. Ponomareva, A. N. Akinchits, I. S. Kulakova, V. S. Gorbatenko

“…A search was carried out for the following keywords and combinations: COVID-19, renin-angiotensin-aldosterone system, bradykinin, complement system, hyaluronic acid, pharmacotherapy.Results. …”
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Advances in Research on the Release of von Willebrand Factor from Endothelial Cells through the Membrane Attack Complex C5b-9 in Sepsis by Liu Y, Zhao W, Huang Q, Wan L, Ren Z, Zhang B, Han C, Yang J, Zhang H, Zhang J

“…Additionally, investigating complement regulatory molecules such as CD59 may unlock novel therapeutic avenues. …”
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RESULTS OF AN OBSERVATIONAL PROSPECTIVE STUDY OF THE EFFICACY AND SAFETY OF BELIMUMAB (BENLYSTA®) IN SYSTEMIC LUPUS ERYTHEMATOSUS IN REAL CLINICAL PRACTICE by E. A. Aseeva, S. K. Soloviev, A. A. Mesnyankina, T. M. Reshetnyak, N. E. Lopatina, S. I. Glukhova, E. L. Nasonov

“…There was a significant decrease in anti-DNA antibodies and an increase in complement C4 level at 5 and 3 months of therapy, respectively. …”
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Related factor analysis of anemia in patients with type 2 diabetic kidney disease by Zhang Jing, Chen Guang-mei, Fan Wen-xing, Su Feng

“…Objective To explore the related factors of anemia in patients with type 2 diabetic kidney disease（DKD）.Methods In this retrospective study, 334 patients with a clinical diagnosis of type 2 DKD were recruited and divided into anemia and non-anemia groups.The relationships of anemia with clinical manifestations and laboratory findings were analyzed.Binary Logistic regression analysis was performed for evaluating the related factors in type 2 DKD patients of different genders.Results Significant inter-group differences existed in complement（C4）,serum creatinine（Scr）,cystatin C（CysC）,retinol binding protein（RBP）,ferritin（SF）,urinary albumin/creatinine（UACR）,diabetes duration, body mass index（BMI）,hemoglobin（Hb）,glycosylated hemoglobin（HbA1 c）,complement（C3）,albumin（Alb）,indirect bilirubin（IDBIL）,estimated ball filtration rate（eGFR）,cholesterol（TC）,iron（Fe）and calcium（Ca）for males（P<0.05）;for females, Scr, CysC,RBP,UACR,Hb, Alb, Fe, IDBIL,eGFR,C3 and Ca were significantly different between two groups（P<0.05）.Logistic regression analysis showed that BMI,eGFR and Alb were associated with anemia in males（P<0.05）;BMI,eGFR and Ca were correlated with anemia in females（P<0.05）.Conclusions Anemia in type 2 diabetic kidney disease patients is closely correlated with deterioration of renal function, disorder of iron metabolism, hypocalcemia, malnutrition and microinflammation.…”
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Crovalimab: A Novel Approach in the Management of Paroxysmal Nocturnal Hemoglobinuria by Laiba Jalal, Marium Ahmed, Anum Khalid

“…ABSTRACT Background and Aims Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare acquired clonal blood disorder caused by mutations in the PIGA gene, leading to complement‐mediated hemolysis. Currently available terminal complement inhibitors, such as Eculizumab and Ravulizumab, pose several challenges, including the need for frequent intravenous infusions and the potential for resistance due to C5 polymorphisms. …”
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Acceleration of Wound Healing by α-gal Nanoparticles Interacting with the Natural Anti-Gal Antibody by Uri Galili

“…Binding of anti-Gal to α-gal nanoparticles in wounds activates the complement cascade, resulting in formation of chemotactic complement cleavage peptides that induce rapid recruitment of many macrophages. …”
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Augmenting Satellite Remote Sensing with AERONET-OC for Plume Monitoring in the Chesapeake Bay by Samantha Lynn Smith, Stephanie Schollaert Uz, J. Blake Clark, Dirk Aurin

“…This study explores the potential of the recently installed NASA Aerosol Robotic Network Ocean Color (AERONET-OC) in the Chesapeake Bay, USA, both for comparison with satellite remote sensing and to complement the satellite observations by filling temporal gaps at a fixed site. …”
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Comparative analysis of official controls and voluntary certifications in ensuring food safety compliance: a review by Mauro Conter, Martina Rega, Luca Lamperti, Laura Andriani, Cristina Bacci, Silvia Bonardi

“…In recent years, voluntary third-party assurance programs have emerged as a complement to public regulations. This review explores their role, advantages, and challenges within this evolving regulatory landscape. …”
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Adenovirus infection in adults: reactive response of polymorphonuclear neutrophilic leukocytes study by V. D. Moskaliuk, I. V. Balaniuk, A. S. Sydorchuk, Kh. I. Vozna, M. O. Andruschak, I. V. Rudan

“…Clinical diagnosis was confirmed by the serological method of complement fixation test in paired sera and using adenoviruses common soluble complement-fixing antigen. …”
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A pilot genome-scale profiling of DNA methylation in sporadic pituitary macroadenomas: association with tumor invasion and histopathological subtype. by Chao Ling, Matthew Pease, Lingling Shi, Vasu Punj, Mark S Shiroishi, Deborah Commins, Daniel J Weisenberger, Kai Wang, Gabriel Zada

“…We hypothesized that alterations in DNA methylation are associated with PA invasion and histopathology subtype, and that genome-scale methylation analysis may complement current classification methods for sporadic PAs. …”
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Antibody-Mediated Rejection: An Evolving Entity in Heart Transplantation by Sharon Chih, Andrzej Chruscinski, Heather J. Ross, Kathryn Tinckam, Jagdish Butany, Vivek Rao

“…AMR results from activation of the humoral immune arm and the production of donor-specific antibodies (DSA) that bind to the cardiac allograft causing myocardial injury predominantly through complement activation. The diagnosis of AMR has evolved from a clinical diagnosis involving allograft dysfunction and the presence of DSA to a primarily pathologic diagnosis based on histopathology and immunopathology. …”
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Comparative xylose metabolism among the Ascomycetes C. albicans, S. stipitis and S. cerevisiae. by Doreen Harcus, Daniel Dignard, Guylaine Lépine, Chris Askew, Martine Raymond, Malcolm Whiteway, Cunle Wu

“…The gre3 and xyl2 mutants are efficiently complemented by the XYL1 and XYL2 from S. stipitis. Intriguingly, the S. cerevisiae GRE3 gene can complement the Cagre3 mutant, while the ScSOR1 gene can complement the Caxyl2 mutant, showing that S. cerevisiae contains the enzymatic capacity for converting xylose to xylulose. …”
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Immunogenicity and safety of meningococcal vaccines, MenACWY-CRM and 4CMenB, in groups at increased risk for meningococcal disease by Shravani Bobde, Chiranjiwi Bhusal, Catherine A. Cosgrove, Woo-Yun Sohn

“…Introduction Individuals with immunocompromising conditions (e.g. asplenia, complement deficiency, HIV infection) or with high exposure to Neisseria meningitidis (e.g. laboratory workers, those in outbreak settings) have an increased risk of meningococcal disease. …”
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Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor h binding protein. by Ilse Jongerius, Hayley Lavender, Lionel Tan, Nicola Ruivo, Rachel M Exley, Joseph J E Caesar, Susan M Lea, Steven Johnson, Christoph M Tang

“…The bacterium recruits factor H (fH), a negative regulator of the complement system, to its surface via fH binding protein (fHbp), providing a mechanism to avoid complement-mediated killing. fHbp is an important antigen that elicits protective immunity against the meningococcus and has been divided into three different variant groups, V1, V2 and V3, or families A and B. …”
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Elucidating structural variability in p53 conformers using combinatorial refinement strategies and molecular dynamics by Deborah F. Kelly, Maria J. Solares, William J. Dearnaley

“…Low molecular weight proteins and protein assemblies can now be investigated using cryo-electron microscopy (EM) as a complement to traditional structural biology techniques. …”
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Health-promoting text messages to patients with hypertension-A randomized controlled trial in Swedish primary healthcare. by Beata Borgström Bolmsjö, Jenny Bredfelt, Susanna Calling, Hanna Glock, Veronica Milos Nymberg, Kristina Bengtsson Boström, Ulf Jakobsson, Peter Nymberg, Jon Pallon, Mattias Rööst, Moa Wolff

“…Health-promoting one-way text messages could be a beneficial complement to antihypertensive drugs. However, this has yet to be proven in a primary healthcare setting. …”
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On the road to universal coverage of postnatal care: considerations for a targeted postnatal care approach for at-risk mother–baby dyads in low-income and middle-income countries i... by Joseph de Graft-Johnson, Preston Izulla, Angela Muriuki, Melanie Yahner, Michael Kiragu

“…Risk-stratified PNC approaches complement broader UHC efforts by providing an equity lens to identify the most vulnerable mother–baby dyads. …”
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