Neuroprotective role of sialic-acid-binding immunoglobulin-like lectin-11 in humanized transgenic mice by Tawfik Abou Assale, Negin Afrang, Jannis Wissfeld, German Cuevas-Rios, Christine Klaus, Bettina Linnartz-Gerlach, Harald Neumann

“…Brains of 24-month-old Siglec-11 tg mice also exhibited lower gene transcription of complement components 3, 4, and integrin alpha M (C3, C4, and Itgam), along with the complement C1q subcomponents a-c (C1qa, C1qb, and C1qc). …”
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Beneath the surface in autoimmune hemolytic anemia: pathogenetic networks, therapeutic advancements and open questions by Alessandro Costa, Alessandro Costa, Olga Mulas, Olga Mulas, Angela Maria Mereu, Mercede Schintu, Marianna Greco, Giovanni Caocci, Giovanni Caocci

“…Glucocorticoids remain the standard first-line therapy for warm AIHA; in contrast, CAD/CAS is increasingly managed with agents targeting B-cell function or complement activation, including rituximab and sutimlimab. …”
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Evaluation of the Stability of Performance of the Analytical Test Method Used for Determination of Anticomplementary Activity of Human Immunoglobulin Preparations by O. G. Kornilova, E. A. Khusnatdinova, E. S. Konovalova, R. A. Volkova

“…Materials and methods: anticomplementary activity was determined by the complement fixation test in accordance with the general monograph of the State Pharmacopoeia of the Russian Federation (14th ed.) …”
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Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia by Jin Li, Xiaoqian Wang, Yaoyao Chen, Xianlei Sun, Liyan Fu, Qingxuan Xin, Huilin Zhang, Bo Qin, Nannan Sun, Yingmei Li, Yan Xu, Hui Yang, Dawei Huo, Yong Dong, Shuya Wang, Mengyun Zhao, Quande Lin, Fang Wang, Baohong Yue, Yanxia Gao, Yong Jiang, Rongqun Guo

“…In this study, using flow cytometry (FCM), proteomics, and single‐cell RNA sequencing of samples from patients with ITP, it is shown that exosome‐mediated lectin complement pathway is involved in the pathogenesis of ITP, which triggers and enlarges the complement activation cascade without effective regulation because of downregulated CD55. …”
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Determinants of response to daratumumab in Epstein-Barr virus-positive natural killer and T-cell lymphoma by Jennifer Yang, Anand D Jeyasekharan, Joanne Lee, Wee Joo Chng, Tae-Hoon Chung, Nurulhuda Mustafa, Adina Huey Fang Nee, Jing Yuan Chooi, Sabrina Hui Min Toh, Viknesvaran Selvarajan, Shuangyi Fan, Siok Bian Ng, Michelle Poon, Esther Chan, Yen Lin Chee, Longen Zhou

“…Increasing the CD38:CIP ratio through sequential CIP knockdown, followed by CD38 upregulation via All-Trans Retinoic Acid treatment, potently augments complement-mediated lysis in cells previously resistant to daratumumab. …”
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Serum adipsin levels in rheumatic diseases: defining its role in disease activity and progression in rheumatoid arthritis and axial spondyloarthritis by Marta Novella-Navarro, Marta Novella-Navarro, Laura González-Sánchez, Laura González-Sánchez, Borja Hernández-Breijo, Rebeca Pérez De Diego, Pilar Sánchez-Corral, Margarita López-Trascasa, Margarita López-Trascasa, Maria-Eugenia Miranda-Carús, Maria-Eugenia Miranda-Carús, Alejandro Villalba, Alejandro Villalba, Alejandro Balsa, Alejandro Balsa, Eugenio De Miguel, Eugenio De Miguel, Chamaida Plasencia-Rodríguez, Chamaida Plasencia-Rodríguez, Fernando Corvillo

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Potential reduction of global colorectal cancer, 1990–2021 by Zilin Luo, Xuesi Dong, Le Wang, Yadi Zheng, Chenran Wang, Jiaxin Xie, Xiaolu Chen, Liang Zhao, Yongjie Xu, Wei Cao, Fei Wang, Lingbin Du, Ni Li

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Tobacco use and readiness to treat tobacco users among primary healthcare professionals in Soweto by Ann N. Alagidede, Olufemi B. Omole

“…Background: Despite its hampering influence on the willingness of healthcare professionals (HCPs) to implement tobacco cessation treatments, the tobacco use status of these professionals remains understudied in South Africa. …”
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Digital Literacy Practices in Language Pedagogy: Blended Learning/Flipped Classroom on English Language Teaching in Indonesia by Fauris Zuhri, Slamet Setiawan, Syafi'ul Anam

“…This study describes how English language teachers can develop and implement digital literacy practices in English classes. …”
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Professional training on of the protocol of reception with risk classification in pediatrics by Francisca Elisângela Teixeira Lima, Fernanda Jorge Magalhães, Alline Falconieri de Moura, Ana Paula Oliveira Queiroz, Diliane Paiva de Melo Matos, Michelle Sampaio Bezerra

“…The aim of this research was to report the experience of training a multidisciplinary team to implement the protocol RREC in pediatrics. This is an experience report of a training course of the multidisciplinary team to implement the protocol in a municipal pediatric hospital in Fortaleza, Ceará, Brazil. …”
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The influence of IS1301 in the capsule biosynthesis locus on meningococcal carriage and disease. by Elisabeth Kugelberg, Bridget Gollan, Christopher Farrance, Holly Bratcher, Jay Lucidarme, Ana Belén Ibarz-Pavón, Martin C J Maiden, Ray Borrow, Christoph M Tang

“…Previously we have shown that insertion of IS1301 in the sia/ctr intergenic region (IGR) of serogroup C Neisseria meningitidis (MenC) isolates from Spain confers increased resistance against complement-mediated killing. Here we investigate the significance of IS1301 in the same location in N. meningitidis isolates from the UK. …”
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Role of differential gene expression in the occurrence and development of diabetic nephropathy by Chen Li-ting, Yue Rui, Wang Xi-yue, Kong Fan-wu

“…Objective The pathogenesis of diabetic nephropathy is rather complex.It is an abnormal metabolic process involving multiple genes and multiple steps.Therefore it is necessary to search for genes playing a key role in the occurrence and development of diabetic kidney disease（DKD）.Methods Bioinformatic was utilized for selecting the relevant data of DKD.And R software was employed for conducting differential gene screening for locating the key genes affecting DKD.Results There were 133 differential genes screened in GSE30528,704 differential genes in GSE1009 and 134 differential genes in GSE30529.Moreover, these genes are generally involved in renal development, collagen trimer aggregation, complement and coagulation cascade and AGE-RAGE signaling.Conclusion The genes VEGFA,MAGI2 and NPHS1 involved in the differentiation of glomerular filtering cells affect the glomerular structural changes in DKD;Genes S100 A9,FCER1 G,C3 AR1,CXCL1,ITGB2,COL1 A2 and LUM involved in tubulointerstitial inflammatory cell activation and collagen formation affect tubulointerstitial fibrosis in DKD;COL4 A3 and its family genes of AGE-RAGE signaling pathway, as well as F2 R,F5,F3,C3 genes of complement and coagulation cascade reaction are involved in the development of DKD.…”
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SOME IMMUNE INDICATORS IN PATIENTS WITH AIRWAY OBSTRUCTION AND CONCOMITANT INTESTINAL PARASITOSES by GULZAR R. Alieva, AIGYUN V. Alkhasova

“…No considerable intergroup differences in circulatory immune complexes and complement components were revealed. Conclusion. Concomitant parasitoses do not cause severe immune disorders in patients with airway obstruction.…”
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Advances in artificial intelligence and precision nutrition approaches to improve maternal and child health in low resource settings by Saurabh Mehta, Samantha L. Huey, Shah Mohammad Fahim, Srishti Sinha, Kripa Rajagopalan, Tahmeed Ahmed, Rob Knight, Julia L. Finkelstein

“…Precision nutrition has the potential to complement program monitoring, efficacy evaluation, and ultimately to inform design of interventions to improve maternal and child health.…”
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Cryotomography of budding influenza A virus reveals filaments with diverse morphologies that mostly do not bear a genome at their distal end. by Swetha Vijayakrishnan, Colin Loney, David Jackson, Worawit Suphamungmee, Frazer J Rixon, David Bhella

“…Bacilliform virions contained an ordered complement of RNPs while longer filamentous particles were narrower and mostly appeared to lack this feature, but often contained fibrillar material along their entire length. …”
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Thermoregulation of Meningococcal fHbp, an Important Virulence Factor and Vaccine Antigen, Is Mediated by Anti-ribosomal Binding Site Sequences in the Open Reading Frame. by Edmund Loh, Hayley Lavender, Felicia Tan, Alexander Tracy, Christoph M Tang

“…The meningococcus can evade the human complement system using a range of strategies that include recruitment of the negative complement regulator, factor H (CFH) via factor H binding protein (fHbp). …”
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Host transcriptome response to Mycoplasma bovis and bovine viral diarrhea virus in bovine tissues by Anna K. Goldkamp, Randy G. Atchison, Shollie M. Falkenberg, Rohana P. Dassanayake, John D. Neill, Eduardo Casas

“…Hyperactivation of complement pathway genes may contribute to damage to the thymus and influence severity of co-infection. …”
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Componentes bioactivos y propiedades inmunofarmacológicas de un extracto hidrosoluble crudo del micelio de Pleurotus spp by Humberto Joaquin Morris Quevedo, Miguel Alcántara Vila, Gabriel Llaurado Maury, Yamila Lebeque, Roberto Fontaine Álvarez

“…Objectives: to determine the major macromolecular components and phytochemicals and evaluate the in vitro inmunopharmacological activity of the extract on the alternative pathway of complement and cytotoxic activity on human leukemia NB4 cells. …”
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A narrative review of acute post-streptococcal glomerulonephritis in Nepali children by Ajaya Kumar Dhakal, Devendra Shrestha, Divya KC, Shankar Prasad Yadav

“…The anti-streptolysin O titre was positive in 34-72.7% of patients, while complement C3 levels were depressed in 61.9–100% of cases. …”
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Study of associations of blood proteins with development of unstable atherosclerotic plaques in coronary arteries by quantitative proteomics by E. M. Stakhneva, E. V. Kashtanova, Ya. V. Polonskaya, E. V. Striukova, V. S. Shramko, E. V. Sadovski, A. V. Kurguzov, I. S. Murashov, A. M. Chernyavskii, Yu. I. Ragino

“…It took place with a simultaneous decrease in the levels of α 2-antiplasmin, heparin cofactor II, coagulation factor XII, plasminogen, prothrombin, vitronectin, complement proteins (C1, C3, C7, C9), and complement factor B. …”
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