Atypical Hemolytic Uremic Syndrome Triggered by COVID‐19 Infection in a Pediatric Patient With CD46 Mutation by Parsa Lorestani, Parisa Maleki Dana, Mohamad Reza Tohidi

“…This case highlights the potential of COVID‐19 to trigger complement‐mediated TMA and emphasizes the importance of prompt diagnosis, genetic assessment, and targeted complement inhibition in managing aHUS.…”
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A Novel Way to Relate Ontology Classes by Ami T. Choksi, Devesh C. Jinwala

“…As a result, there is a possibility that the tools will produce error prone inference results for relations, namely, sub-, union, intersection, equivalent relations, and those dependent on these relations, namely, complement. To verify whether a class is complement of other involves utilization of sub- and equivalent relations. …”
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Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1820 (Tarperprumig) in Healthy Adults: Results of a Phase I Study by Avner Sandhu, Tong Shen, Paz Martin Herrero, Chao‐Xing Yuan, Samirah Qureshi, Xiaoyu Jiang, Ye Sheng, Christoph Gasteyger, Yang Dai

“…ABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement‐mediated diseases. …”
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Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis. by Oluwatoyin A Asojo, Alan Kelleher, Zhuyun Liu, Jeroen Pollet, Elissa M Hudspeth, Wanderson C Rezende, Mallory Jo Groen, Christopher A Seid, Maha Abdeladhim, Shannon Townsend, Waldione de Castro, Antonio Mendes-Sousa, Daniella Castanheira Bartholomeu, Ricardo Toshio Fujiwara, Maria Elena Bottazzi, Peter J Hotez, Bin Zhan, Fabiano Oliveira, Shaden Kamhawi, Jesus G Valenzuela

“…Unlike its native counterpart, rSALO(P) does not inhibit the classical pathway of complement; however, antibodies to rSALO(P) inhibit the anti-complement activity of sand fly salivary gland homogenate. …”
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C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damage. by Claudia Duehrkop, Yara Banz, Rolf Spirig, Sylvia Miescher, Marc W Nolte, Martin Spycher, Richard A G Smith, Steven H Sacks, Robert Rieben

“…C1 INH did not primarily act via inhibition of the complement system, but via the kinin and coagulation cascade. …”
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Renal Transplant Patients Biopsied for Cause and Tested for C4d, DSA, and IgG Subclasses and C1q: Which Humoral Markers Improve Diagnosis and Outcomes? by James C. Cicciarelli, Nathan A. Lemp, Youngil Chang, Michael Koss, Katrin Hacke, Noriyuki Kasahara, Kevin M. Burns, David I. Min, Robert Naraghi, Tariq Shah

“…Cumulative DSA above 10,000 MFI were associated with C4d deposition and complement fixation. There was no significant correlation between graft loss and C1q positivity, and IgG subclass analysis seemed to be a better correlate for complement fixing antibodies in the C4d+ patient group.…”
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Urinary V‐Set Ig Domain‐Containing Protein 4 and Immune Complexes for Tracking Lupus Nephritis and Renal Pathology by Aygun Teymur, Chenling Tang, Fariz Nazir, Neda Ostadnejad, Qi Cai, Ramesh Saxena, Tianfu Wu

“…Objective This study aims to investigate whether V‐set Ig domain‐containing protein 4 (VSIG4; also known as complement receptor of the Ig superfamily [CRIg]) forms immune complexes (ICxs) with IgG and complement component 3 (C3) in the kidneys of patients with lupus nephritis (LN) and to assess the potential of urinary VSIG4 and VSIG4‐ICx as noninvasive biomarkers of LN. …”
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Plasma biomarkers of brain atrophy in Alzheimer's disease. by Madhav Thambisetty, Andrew Simmons, Abdul Hye, James Campbell, Eric Westman, Yi Zhang, Lars-Olof Wahlund, Anna Kinsey, Mirsada Causevic, Richard Killick, Iwona Kloszewska, Patrizia Mecocci, Hilkka Soininen, Magda Tsolaki, Bruno Vellas, Christian Spenger, Simon Lovestone, AddNeuroMed Consortium

“…These proteins are complement components C3 and C3a, complement factor-I, γ-fibrinogen and alpha-1-microglobulin. …”
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<p>Glandular and non-glandular cuticular organs on the idiosoma of Gamasina mites (Acari: Mesostigmata)</p> by Maria L. Moraza

“… The idiosoma of orthoadenic Gamasina (Mesostigmata) bears a maximum complement of 47 pairs of discernible cuticular organs that are distinct from setae. …”
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Protective role for properdin in progression of experimental murine atherosclerosis. by Tanja Steiner, Lorenza Francescut, Simon Byrne, Timothy Hughes, Archana Jayanthi, Irina Guschina, John Harwood, Katherine Cianflone, Cordula Stover, Sheila Francis

“…Deficiency of Factor B of the alternative pathway (AP) of complement is beneficial in LDLR(-/-) mice fed a high fat diet. …”
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Proteasome inhibitors related thrombotic microangiopathy: a systematic and comprehensive review by Can Chen, Yiwei Li, Pengfei Shi, Shenxian Qian

“…Comprehensive evaluation of the complement system, including genetic mutations, function, and associated complement inhibitory factor antibodies, should be included in the assessment of PI-TMA. …”
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C1-inactivator is upregulated in glioblastoma. by Karolina Förnvik, Aida Maddahi, Oscar Persson, Kurt Osther, Leif G Salford, Henrietta Nittby Redebrandt

“…Still, the role of the complement system has almost been forgotten in glioma research. …”
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Changes in retinal pigment epithelium related to cigarette smoke: possible relevance to smoking as a risk factor for age-related macular degeneration. by Ai Ling Wang, Thomas J Lukas, Ming Yuan, Nga Du, James T Handa, Arthur H Neufeld

“…RPE phagocytic activity was not altered but there were increased lysosomal activity, exocytotic activity and complement pathway components. Retinas from mice exposed to cigarette smoke contained markers for mtDNA damage, exosomes and complement pathway components surrounding Bruch's membrane. …”
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COLEC10 is mutated in 3MC patients and regulates early craniofacial development. by Mustafa M Munye, Anna Diaz-Font, Louise Ocaka, Maiken L Henriksen, Melissa Lees, Angela Brady, Dagan Jenkins, Jenny Morton, Soren W Hansen, Chiara Bacchelli, Philip L Beales, Victor Hernandez-Hernandez

“…We previously reported that lectin complement pathway genes COLEC11 and MASP1/3 are mutated in 3MC syndrome patients. …”
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The possibility of using e-learning tools for the development of the cognitive activity of students by T. A. Chernykh, Yu. A. Rubtsova

“…E-learning tools not only complement the educational process, but also become an integral part to increase efficiency and learning outcome. …”
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Low-density lipoprotein apheresis shows a rapid response to proteinuria due to C3 glomerulonephritis: a case report and literature review by Hideki Matsumura, Yuko Fujii, Tomoko Tanaka, Maki Kagitani, Akira Ashida

“…Genetic testing identified a rare complement B factor mutation linked to complement pathway dysregulation. …”
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Reactive astrocyte-derived neurotoxicity is mitigated by vitronectin in traumatic brain injury mouse model by Minori Yamashita, Nito Nakahira, Kei Hashimoto, Hirono Kobayashi, Mari Nakashima, Hiroko Ikeshima-Kataoka, Yasunori Miyamoto

“…Therefore, VN plays a role in mitigating neurodegeneration after TBI by suppressing complement C3 secretion from reactive astrocytes.…”
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Expressing uncertainty in Human-Robot interaction. by Christoph Bartneck, Elena Moltchanova

“…Hence, it would be advisable to complement the use of words with numerical expression of uncertainty. …”
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Treatment of atypical hemolytic uremic syndrome with eculizumab in a patient presenting with neuropsychiatric prodrome: a case report by Hanze Yang, Jingdong Zhang, Hao Wu, Hongzhao Xu, Zhonggao Xu

“…Atypical hemolytic uremic syndrome (aHUS) is a rare thrombotic microangiopathy (TMA) caused by dysregulation of the complement system. It is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. …”
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Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia by Megumi Andoh, Natsuki Shinoda, Yusuke Taira, Tasuku Araki, Yuka Kasahara, Haruki Takeuchi, Masayuki Miura, Yuji Ikegaya, Ryuta Koyama

“…This increased susceptibility is reversed by genetic depletion of microglial complement receptors. Thus, localized, nonapoptotic caspase activity guides complement-dependent microglial synaptic phagocytosis and remodels neuronal circuits.…”
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