How far has the globe gone in achieving One Health? Current evidence and policy implications based on global One Health index by Qiyu Zhang, Jingshu Liu, Lefei Han, Xinchen Li, Chensheng Zhang, Zhaoyu Guo, Anqi Chao, Chenxi Wang, Erya Wan, Fumin Chen, Hanqing Zhao, Jiaxin Feng, Jingbo Xue, Lulu Huang, Jin Chen, Zhishan Sun, Zile Cheng, Jingxian Yin, Zhengze He, Liangyu Huang, Logan Wu, Siwei Fei, Siyu Gu, Tiange Jiang, Tianyun Li, Weiye Chen, Nan Zhou, Ne Qiang, Qin Li, Runchao He, Yi Zhang, Min Li, Xiangcheng Wang, Kokouvi Kassegne, Yongzhang Zhu, Leshan Xiu, Qinqin Hu, Kun Yin, Shang Xia, Shizhu Li, Zhaojun Wang, Xiaokui Guo, Xiaoxi Zhang, Xiao-Nong Zhou

“…The goal is to offer profound insights into disparities and progressions in practical One Health implementation, particularly in anticipation of future pandemics.…”
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In-depth characterization of vaccine-induced neoantigen-specific T cells in patients with IDH1-mutant glioma undergoing personalized peptide vaccination by Martin Glas, Florian Battke, Dirk Hadaschik, Martin Schulze, Saskia Biskup, David Reardon, Christina Kyzirakos, Simone Kayser, Oliver Bartsch, Armin Rabsteyn, Henning Zelba, Borong Shao, Annekathrin Reinhardt, Carsten Greve, Lisa Oenning, Pauline Latzer, Tabea Riedlinger, Julian Wünsche, Johannes Harter, Magdalena Feldhahn, Yannick Bantel, Janina Johänning, Jiri Ködding, Olga Maksimovic, Veit Scheble, Alexandra M Miller, Michael Castro, Deborah T Blumenthal

“…Immunogenicity against mutIDH1 was high (89%). We implemented an assay which allowed us to isolate functional antigen-specific CD4+T cells in an HLA-independent manner. …”
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Dysregulated inflammation, oxidative stress, and protein quality control in diabetic HFpEF: unraveling mechanisms and therapeutic targets by Simin Delalat, Innas Sultana, Hersh Osman, Marcel Sieme, Saltanat Zhazykbayeva, Melissa Herwig, Heidi Budde, Árpád Kovács, Mustafa Kaçmaz, Eda Göztepe, Natalie Borgmann, Gelareh Shahriari, Benjamin Sasko, Jan Wintrich, Peter Haldenwang, Wolfgang E. Schmidt, Wiebke Fenske, Muchtiar Khan, Kornelia Jaquet, Andreas Mügge, Domokos Máthé, Viktória E. Tóth, Zoltán V. Varga, Péter Ferdinandy, Ibrahim El-Battrawy, Loek van Heerebeek, Nazha Hamdani

“…The passive stiffness of cardiomyocytes (Fpassive) was assessed in demembranated cardiomyocytes before and after implementing treatments aimed at reducing inflammation (IL-6 inhibition), oxidative stress (Mito-TEMPO), and enhancing PQC (HSP27, HSP70). …”
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Swarm learning network for privacy-preserving and collaborative deep learning assisted diagnosis of fracture: a multi-center diagnostic study by Yi Xie, Yi Xie, Xinmeng Wang, Huiwen Yang, Huiwen Yang, Jiayao Zhang, Honglin Wang, Zineng Yan, Jiaming Yang, Zhiyuan Yan, Zhiwei Hao, Pengran Liu, Yijie Kuang, Zhewei Ye, Zhewei Ye

“…Finally, the SL system was appraised through a prospective cohort to aid 6 clinicians in the preoperative assessment of 112 patients with knee joint injuries.ResultsThe YOLOv8n-cls algorithm demonstrated superior performance in centralized experiments and was adapted for SL implementation. Our SL model achieved robust performance in both balanced (AUROC 0.991 ± 0.003, accuracy 0.960 ± 0.013) and unbalanced (AUROC 0.990 ± 0.005, accuracy 0.944 ± 0.021) datasets. …”
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LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer by Mark Samuels, Christos Karakostas, Simoni Besta, Andrea Lauer Betrán, Katerina Tsilingiri, Charlotte Turner, Reza Shirazi Nia, Niloufar Poudine, Richard Goodyear, William Jones, Apostolos Klinakis, Georgios Giamas

“…Bioinformatics analysis of clinical data along with in vitro and cell-based assays were implemented to explore the effects of LMTK3-dependent EV protein cargo on the tumour immune microenvironment. …”
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AIRWAVE-SLSTR—An Algorithm to Estimate the Total Column of Water Vapour from SLSTR Measurements over Liquid Surfaces by Elisa Castelli, Stefano Casadio, Enzo Papandrea, Paolo Pettinari, Massimo Valeri, Andrè Achilli, Bojan R. Bojkov, Alessio Di Roma, Camilla Perfetti, Bianca Maria Dinelli

“…The new algorithm, named AIRWAVE-SLSTR, has been implemented in both IDL and Python languages. In the frame of an EUMETSAT contract, AIRWAVE-SLSTR has been applied to a full year of SLSTR measurements (2021) and the retrieved TCWV have been validated with the help of both satellite- and ground-based measurements. …”
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Development of a core patient-centred outcome set for adults living with obesity: a modified delphi-based international consensusResearch in context by Teferi Mekonnen, Leanne Staniford, Spencer Connell, Zofia Das-Gupta, Umanga DeSilva, Yasmine Saoud, Isabel Miller, Mohapradeep Mohan, Simon Nienhuijs, Megha Poddar, Vaishali Chetan Deshmukh, Marli Conradie-Smit, Soo Huat Teoh, Sanjeev Sockalingam, Emilia Huvinen, Paolo Sbraccia, Ronald Liem, Michael Vallis, Kenneth Clare, Tracy Zvenyach, Karen Coulman, Marianela Aguirre Ackermann, Verónica Vázquez-Velázquez, Yudith Preiss Contreras, Josep Vidal, Agbo Urudinachi, María Fernanda Tejeda-Muñoz, Ian Patton, T Alafia Samuels, Morgan Emile Gabriel Salmon Leguede, Georgia Rigas, Ximena Ramos Salas, Michael Crotty, Bruno Halpern, Daniel Bessesen, Laura Pizzi, Omniyat Mohammed Al Hajeri, Arya M. Sharma

“…Interpretation: Adoption of this standardised outcome set enables clinicians, patients, and stakeholders to identify care gaps, monitor outcomes, and evaluate the quality of obesity care against global benchmarks. Implementation can support the creation of a robust international data resource to guide research, inform clinical practice, and shape policy and guidelines for adult obesity treatment. …”
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Cost-consequence analysis of an e-health intervention to reduce distress in dementia carers: results from the iSupport randomised controlled trial by Aimee Spector, Zoë Hoare, Rhiannon Tudor Edwards, Patricia Masterson-Algar, Gill Windle, John Connaghan, Greg Flynn, Kieren Egan, Gwenllian Hughes, Nia Goulden, Joshua Stott, Bethany Anthony, Kodchawan Doungsong, Catherine MacLeod, Kiara Jackson, Suman Kurana, Ryan Innes, Danielle Proctor, Fatene Abakar Ismail

“…Objective The use of e-health interventions has grown in demand due to their accessibility, low implementation costs and their potential to improve the health and well-being of people across a large geographical area. …”
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Scanner-specific optimisation of automated lesion segmentation in MS by David R. van Nederpelt, Giuseppe Pontillo, Mar Barrantes-Cepas, Iman Brouwer, Eva M.M. Strijbis, Menno M. Schoonheim, Bastiaan Moraal, Bas Jasperse, Henk-Jan M.M. Mutsaerts, Joep Killestein, Frederik Barkhof, Joost P.A. Kuijer, Hugo Vrenken

“…However, knowledge on their reliability across scanners is limited, hampering clinical implementation. The aim of this study was to investigate the within-scanner repeatability and between-scanner reproducibility of lesion segmentation tools in pwMS across three different scanners and examine their accuracy compared to manual segmentations with and without optimization. …”
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Biphasic contrast-enhanced [18F]PSMA-1007 PET/CT imaging to improve the detection of local relapse of prostate cancer by Eduards Mamlins, Emil Novruzov, Tadashi Watabe, Yuriko Mori, Mardjan Dabir, Katalin Mattes-György, Christina Antke, Jan Henke, Matthias Boschheidgen, Julian Kirchner, Danny Jazmati, Jan Hausmann, Jan P. Radtke, Günter Niegisch, Jens Cardinale, Juliane Hörner-Rieber, Peter Albers, Gerald Antoch, Frederik L. Giesel, Lars Schimmöller

“…Abstract Background The implementation of PSMA imaging in prostate cancer (PC) management has significantly improved the medical care of patients owing to its clinical impact, particularly with respect to biochemical recurrence. …”
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Global perspectives on challenges, coping strategies, and future preparedness of nursing home staff during COVID-19: a systematic review and meta-synthesis by Xiu-fen Yang, Jia-yi Guo, Wei-si Peng, Bing-dong Wang, Chao-ran Qv, Si-jia Zhou, Rui Sun, Lulu Liao, Wei-wei Zhang, Ling-Yan Liu, Lian-chi Ren, Lin Zou, Shi-hai Xu

“…Three synthesized findings were identified: Challenges (sub-findings: challenges implementing epidemic prevention and control, resource shortage, negative emotions, inadequate departmental communication and coordination, lack of support, physical strain); coping strategies (sub-findings: role adaptation and redefinition, innovative solutions and technology, work organisation and cooperation, positive psychological service, seeking community and organisational support, Improving infection prevention awareness), and suggestions for future preparedness (sub-findings: Enhancing communication and decision-making in response to COVID-19 changes, Optimizing material supply channels and physical space, and increasing medical related team and training). …”
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Effect of aspirin on small for gestational age neonates in pregnancies at high-risk for preeclampsia: a secondary analysis of a cluster randomised clinical trialResearch in context by Yunyu Chen, Long Nguyen-Hoang, Linh Thuy Dinh, Duy-Anh Nguyen, Ritsuko K. Pooh, Arihiro Shiozaki, Mingming Zheng, Yali Hu, Runmei Ma, Aditya Kusuma, Tuangsit Wataganara, Mahesh A. Choolani, Mayumi Kaneko, Suchaya Luewan, Tung-Yao Chang, Noppadol Chaiyasit, Tongta Nanthakomon, Yanmin Jiang, Steven W. Shaw, Wing Cheong Leung, Ainaa Syazana Mohamad, Angela Aguilar, So Ling Lau, Nikki M.W. Lee, Jiao Liu, Daljit S. Sahota, Marc K.C. Chong, Ioannis Papastefanou, Liona C. Poon

“…These findings underscore the importance of implementing the screen-and-prevent program for preterm-PE to reduce early-SGA, and emphasizing the heightened alert in follow-up to optimize the outcomes for late-SGA. …”
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Sex-specific associations between body composition and depression among U.S. adults: a cross-sectional study by Yijing Li, Juan Li, Tianning Sun, Zhigang He, Cheng Liu, Zhixiao Li, Yanqiong Wu, Hongbing Xiang

“…The conventional use of Body Mass Index (BMI) as an indicator of obesity is inherently limited due to its inability to distinguish between fat and lean mass, which limits its predictive utility for depression risk. Implementation of dual-energy X-ray absorptiometry (DXA) investigated sex-specific associations between body composition (fat mass, appendicular lean mass) and depression. …”
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Evidence of the correlation between air pollution and different types of birth defects: based on a distribution-lag non-linear model by Wen Sun, Qingqing Dong, Yingying Zhang, Hui Wang, Youqiang Wang, Wenjie Yuan, Leyao Wang, Xianhong Shi, Yuhong Feng, Haiwei Wang, Xiaodan Wang, Yingbin Ren, Lihong Wang, Lijian Lei, Wenxia Song

“…In light of these findings, we recommend that, while overall regional air quality improvements remain essential, specific targeted measures should be implemented for pregnant women, who represent a particularly vulnerable population. …”
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Feasibility of a tailored, combined intervention with mind-body elements to prevent burnout in healthcare professionals (LAGOM) in a mixed-methods multicenter single-arm trial by Marleen Schröter, Anna K. Koch, Julia Berschick, Julia K. Schiele, Martin Bogdanski, Melanie Steinmetz, Judith Czakert, Wiebke Stritter, Christian S. Kessler, Georg Seifert

“…The study supports the acceptability and feasibility of implementing LAGOM in the healthcare setting, with initial indications of effectiveness. …”
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Chronic kidney disease prevalence and outcomes in patients with type 2 diabetes or prediabetes at high cardiovascular risk: results from the CINEMA program by Sanjana Datla, Zainab Albar, Elke Eaton, Jodie Porges, Matthew Nennstiel, Claire Sullivan, Lloyd Greene, Sadeer G. Al-Kindi, Elizabeth Montgomery, Aparna Padiyar, Mikhail Kosiborod, Melissa L. Magwire, Mahboob Rahman, Sanjay Rajagopalan, Ian J. Neeland

“…Enhanced screening for CKD, appropriate risk stratification, and aggressive implementation of guideline-directed medical therapies may lead to improved long-term outcomes.…”
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Prospective evaluation of septic shock patients in a tertiary care educational university hospital: a series of 1892 cases by Gamze Şanlıdağ Işbilen, Deniz Akyol Seyhan, Merve Mert Vahabi, Buse Kenanoğlu, Dilşah Başkol Elik, Seichan Ketentzi, Oğuzhan Acet, Nazlihan Yalçin, Cansu Bulut Avşar, Ayşe Öna, Arda Kaya, Şükrü Dirik, Uğur Öna, Buğra Özkar, Damla Akdağ, Derya Kaya, Gunel Guliyeva, Cansu Tol, Meltem Ceylan, Gökhan Vatansever, Melike Demir, Serhat Uysal, Hilal Sipahi, Şöhret Aydemir, Meltem Taşbakan, Bilgin Arda, Oğuz Reşat Sipahi

“…BACKGROUND: Despite advancements and the early implementation of targeted therapies,sepsis-related mortality remains high. …”
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Profile of molecular markers of Sulfadoxine-Pyrimethamine-resistant Plasmodium falciparum in individuals living in southern area of Brazzaville, Republic of Congo by Jean Claude Djontu, Marcel Tapsou Baina, Jacque Dollon Mbama Ntabi, Abel Lissom, Dieu Merci Umuhoza, Naura veil Assioro Doulamo, Christevy Jeanney Vouvoungui, Reauchelvy Kamal Boumpoutou, Alain Maxime Mouanga, Etienne Nguimbi, Francine Ntoumi

“…Background: Although the seasonal and perennial malaria chemopreventions are not implemented in the Republic of Congo, resistance to Sulfadoxine-pyrimethamine (SP) threatens the intermittent preventive treatment during pregnancy (IPTp-SP) and others treatments using the drug. …”
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Pre-assembled ECMO: Enhancing efficiency and reducing stress in refractory cardiac arrest care by Tharusan Thevathasan, Sonia Lech, Andreas Diefenbach, Elisa Bechthold, Tim Gaßmann, Sebastian Fester, Georg Girke, Wulf Knie, Benjamin T. Lukusa, Sebastian Kühn, Steffen Desch, Ulf Landmesser, Carsten Skurk

“…Conclusion: Aseptically pre-assembled and pre-primed ECMO circuits maintain sterility for multiple weeks, significantly reducing ECMO initiation times and alleviating psychological strain on the ECPR team. Consequently, implementing these circuits in ECPR centers could enhance both patient outcomes and healthcare provider well-being.…”
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High-risk neuroblastoma in Mexico: from multimodal treatment to immunotherapy. Regarding the first case treated with naxitamab by Alberto Olaya Vargas, Haydee Salazar-Rosales, Marcela Caballero-Palacios, Nideshda Ramírez-Uribe, Gerardo López-Hernández, Erika Morales-Martinez, María Cervantes-Delgado, Liliana Velasco Hidalgo, Araceli Castellanos-Toledo, Rocío Cárdenas-Cardos, Rocío Cárdenas-Cardos, Ana Niembro-Zúñiga, Roberto Rivera-Luna, Alberto Olaya-Nieto, Jesús Ponce-Cruz, Jaime Shalkow-Klincovstein, Yadira Melchor-Vidal, Rodrigo Díaz-Machorro

“…Despite intensive care, he progressed to brain death, with neurotoxicity suspected as the cause.DiscussionThe primary objective of implementing novel immunotherapeutic strategies, in addition to improving event-free survival (EFS) and overall survival (OS) in patients diagnosed with high-risk neuroblastoma, is to reduce adverse effects and lower both short- and long-term mortality. …”
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