Response Gene to Complement 32 is associated with poor patient survival and an inflamed tumor-immune microenvironment in clear cell renal cell carcinoma by Lingling Li, Xiaocui Bu, Shuhui Wang, Yan Liu, Chongdao Chen, Wei Zhang, Peng Zhao

“…In the present study, the expression of Response Gene to Complement 32 (RGC-32) was evaluated using immunohistochemistry. …”
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Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury by Ning Li, Tao-Tao Tang, Menglei Gu, Yu-Qi Fu, Wei-Wei Qian, Nan Nan Ma, An-Ran Shen, Tingting Zhu, Run-Bo Huo, Tao Zhang, Jian-Feng Xie, Lu Zhang, Bi-Cheng Liu, Lin-Li Lv

“…Principle uEV clusters with unique function and origination are profiled in SA-AKI in a screening cohort. Complement receptor CD35 on single uEV (CD35-uEV) displays high diagnostic accuracy for SA-AKI (AUC-ROC 0.89 in validation cohort, n = 134). …”
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Response Gene to Complement 32 promotes cell proliferation and tamoxifen resistance in breast cancer via elevated FoxM1 expression by Xinlei Li, Yan Liu, Zhiqian Wang, Xiaocui Bu, Yu Wang, Wei Zhang, Peng Zhao

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Mapping autoantibody targets of full-length C-reactive protein in systemic lupus erythematosus: importance for neutrophil function and classical complement activation by Jesper Karlsson, Lina Wirestam, Hanna Duàn, Suhana Ahmad, Daniel Appelgren, Helena Enocsson, Jonas Wetterö, Christopher Sjöwall

“…Furthermore, we show that patients with anticardiolipin IgG and/or anti-β2GPI IgG antibodies have a higher number of positive CRP epitopes, and some CRP autoantibody-specificities associate with antiphospholipid antibodies, disease activity, and classical complement activation. In addition, one identified motif was selected, synthesized, and used for studying neutrophil function. …”
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CTSL-2 upon specifically recognizing Vibrio splendidus directly cleaves complement C3 to promote the bacterial phagocytosis and degradation in oyster by Qiuyan Guo, Wenwen Yang, Weishuai Shan, Hongsheng Yao, Xiangqi Shi, Lingling Wang, Jiejie Sun, Linsheng Song

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Role of Autoantibodies Against Self-Proteins, Mitochondrial Cellular Antigens, and Some Complement Proteins (C3 and C4) in Patients with Atherosclerosis by Ali Saad Kadhim, Abdullah Salim Al-Karawi

“…Materials and Methods: The colorimetric method was used to measure the concentration of lipid profiles, whereas the antinuclear antibodies (ANA), anti-mitochondrial antibodies (AMA), and anti-extractable nuclear antigen (ENA) were measured by chemiluminescent immunoassay. Finally, the complement components C3 and C4 were measured using nephelometry. …”
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Transcriptomics and trans-organellar complementation reveal limited signaling of 12-cis-oxo-phytodienoic acid during early wound response in Arabidopsis by Khansa Mekkaoui, Ranjit Baral, Fiona Smith, Moritz Klein, Ivo Feussner, Bettina Hause

“…Trans-organellar complementation reveals that expression of OPR3 or OPR2 in opr2opr3 restores JA-Ile production regardless of localization, whereas mitochondrial targeted OPR1 exhibiting low OPDA/4,5-ddh-JA conversion activity does not. …”
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Clinical and Complement Long-Term Follow-Up of a Pediatric Patient with C3 Mutation-Related Atypical Hemolytic Uremic Syndrome by Anna Bjerre, Grethe Bergseth, Judith Krey Ludviksen, Arne Stokke, Vidar Bosnes, Diana Karpman, Tom Eirik Mollnes

“…She was treated from the start with a constant dose of 300 mg eculizumab every second week from the onset and followed by routine complement analyses for six years. Her complement system was completely inhibited and the dose interval was prolonged from 2 to 3 weeks without alteration of the dose and the complement activity continued to be completely inhibited. …”
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Author Correction: Proteomic analysis of laser captured tubular tissues reveals complement activation and mitochondrial dysfunction in autoimmune related kidney diseases by Mengyun Xiao, Xianggeng Chi, Xiaohui Zhu, Zigan Xu, Yaoshuang Zou, Yue Peng, Shaodong Luan, Jingjing Dong, Yong Dai, Lianghong Yin

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WCN24-551 CKD PROGRESSION IN PATIENTS WITH COMPLEMENT 3 GLOMERULOPATHY (C3G) IN A US MULTI-CENTER ASSESSMENT by Briana Ndife, Carolina Aldworth, Kathleen P. Murphy, Jennifer Nguyen, Irina Pivneva, Marie Louise Edwards, Annika Anderson, James Signorovitch, Pietro Canetta

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PREVENTION OF SEVERE INFECTIONS IN PATIENTS WITH GENETIC DISORDERS OF THE COMPLEMENT SYSTEM REGULATION TREATING WITH ECULIZUMAB: PRESS RELEASE ON THE INTERDISCIPLINARY EXPERT COUNCIL MEETING by Editorial article

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Response to “Features of Postpartum Hemorrhage-Associated Thrombotic Microangiopathy and Role of Short-Term Complement Inhibition”: Still a Long Way to Go by Cédric Rafat, Laurent Mesnard, Yosu Luque

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Correction: Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence. by Yanyu Wang, Sarah A Jenkins, Chunfang Gu, Ankita Shree, Margarita Martinez-Moczygemba, Jennifer Herold, Marina Botto, Rick A Wetsel, Yi Xu

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Normothermic Machine Perfusion Reconstitutes Porcine Kidney Tissue Metabolism But Induces an Inflammatory Response, Which Is Reduced by Complement C5 Inhibition by Eline de Boer, Eline de Boer, Marina Sokolova, Marina Sokolova, Neeltina M. Jager, Camilla Schjalm, Camilla Schjalm, Marc G. Weiss, Olav M. Liavåg, Hanno Maassen, Hanno Maassen, Harry van Goor, Ebbe Billmann Thorgersen, Ebbe Billmann Thorgersen, Kristin Pettersen, Dorte Christiansen, Judith Krey Ludviksen, Bente Jespersen, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Henri G. D. Leuvenink, Henri G. D. Leuvenink, Søren E. Pischke, Søren E. Pischke, Søren E. Pischke

“…This study aimed to assess the effect of complement inhibition on NMP induced inflammatory responses. …”
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Time course of organ and hematological response to complement blockage in transplant-associated thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation by Tatiana A. Rudakova, Julia Yu Vlasova, Olesya V. Paina, Olga A. Slesarchuk, Marina A. Gorodnova, Tatiana S. Schegoleva, Oleg V. Goloshchapov, Tatiana A. Bykova, Elena V. Morozova, Lyudmila S. Zubarovskaya, Ivan S. Moiseev, Alexander D. Kulagin

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Impact of complement C3 levels on the development of healthcare-associated infections in intensive care patients: a retrospective case-control study by Chenjuan Wang, Binhao Chen, Zhekai Ying, Mengyuan Shen, Yiling Luo, Tianchen Lin, Dandan Feng, Dongdong Yang, Zhongheng Zhang, Jiannong Wu

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WCN24-1027 THE ALTERNATIVE COMPLEMENT PATHWAY IN SHIGA TOXIN-PRODUCING ESCHERICHIA COLI– ASSOCIATED HEMOLYTIC UREMIC SYNDROME (STEC-HUS) by Patricia G. Vallés, Mariana Luna, Victoria Bocanegra, Raúl Marino, Valeria Costantino, Andrea Gil Lorenzo, Valeria Cacciamani, Santiago Rodríguez de Córdoba

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WCN25-4201 POST-PARTUM THROMBOTIC MICROANGIOPATHY: IN THE ERA OF COMPLEMENT INHIBITORS, PLASMA EXCHANGE IS STILL WORTH TRYING IN DEVELOPING COUNTRIES by Rajesh Kumar, Dr Adarsh Kumar, Dr Sanjiv Mahajan

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Integrative cross‐tissue analysis unveils complement‐immunoglobulin augmentation and dysbiosis‐related fatty acid metabolic remodeling during mammalian aging by Feng Zhang, Rong Li, Yasong Liu, Jinliang Liang, Yihang Gong, Cuicui Xiao, Jianye Cai, Tingting Wang, Qiang You, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Yingcai Zhang, Yang Yang, Hua Li, Jia Yao, Qi Zhang, Jun Zheng

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Dual RNA-seq reveals the complement protein C3-mediated host-pathogen interaction in the brain abscess caused by Staphylococcus aureus by Qiyuan Jin, Yaxuan Zhai, Rui Qiang, Xin Ma, Chenhao Zhao, Jinqi Zhong, Jijie Li, Qi Chen, Mingxiao Han, Hong Du, Qifei Cong, Haifang Zhang

“…ABSTRACT This study aimed to elucidate the complement protein C3-mediated host-pathogen interaction in the brain abscess caused by Staphylococcus aureus infection. …”
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