Pilot Study of Sodium-Glucose Cotransporter 2 Inhibitor Empagliflozin Shows Reduced Intrarenal Complement Activation in Patients With Diabetes and CKD by Mia Jensen, Steffen F. Nielsen, Steffen Thiel, Søren W.K. Hansen, Yaseelan Palarasah, Per Svenningsen, Jesper N. Bech, Frank H. Mose, Boye L. Jensen

Get full text

Complete Complement Factor I (CFI) deficiency: a systematic review of forty-nine patients including three novel cases by Erta Rajabi, Mahsa Choroom Kheirabadi, Nasrin Alipour Olyaei, Anne Molitor, Mohadese Sadat Mousavi Khorshidi, Morteza Heidari, Arash Abbasi, Parastoo Rostami, Mohadese Mahdavi, Raphael Carapito, Mohammad Shahrooei, Seiamak Bahram, Nima Parvaneh

Subjects: “…Complement Factor I…”
Get full text

Use of complement C5-inhibitor eculizumab in patients with infection-associated hemolytic uremic syndrome – a case-series report by Petra Varga, Erika Biró, Andrea Berkes, Erzsébet Lakatos, Edit Szikszay, Zoltán Prohászka, Tamás Szabó

“…Abnormalities of the alternative complement pathway may also contribute to the development of both STEC-HUS and SP-HUS, offering a potential treatment option for complement C5 inhibition. …”
Get full text

Complement and Coagulation Cascade Activation Regulates the Early Inflammatory Mechanism of Resistance of Suckling Lambs Against <i>Haemonchus contortus</i> by José Gabriel G. Lins, Alessandro F. T. Amarante

“…Our data identified potential markers for resistance trait selection in sheep, such as C3 (complement C3), F3 (tissue factor), F5 (coagulation factor V), CFB (complement factor B), and CFI (complement factor I). …”
Get full text

Clinical Holistic Medicine (Mindful, Short-Term Psychodynamic Psychotherapy Complemented with Bodywork) in the Treatment of Experienced Physical Illness and Chronic Pain by Søren Ventegodt, Suzette Thegler, Tove Andreasen, Flemming Struve, Lars Enevoldsen, Laila Bassaine, Margrethe Torp, Joav Merrick

“…We investigated the treatment effect of psychodynamic short-term therapy complemented with bodywork on patients who presented with physical illness at the Research Clinic for Holistic Medicine in Copenhagen. …”
Get full text

Crosstalk between miRNAs, high mobility group box-1 and complement system in epilepsy: relevance of response to valproic acid by Dalia Kamal Mostafa, Dina Elsayed Gaber, Passanite S. Hassaan, Fatma I. Dwedar, Abeer E. Dief, Mona Hassan Fathelbab

Subjects: Get full text

Systemic Administration of a Site-Targeted Complement Inhibitor Attenuates Chronic Stress-Induced Social Behavior Deficits and Neuroinflammation in Mice by Amit Kumar Madeshiya, Brandi Quintanilla, Carl Whitehead, Stephen Tomlinson, Anilkumar Pillai

Subjects: “…complement…”
Get full text

Analysis of Three Complement-Taking Predicates in Spoken Turkish: <i>bil</i>, <i>san</i>, and <i>zannet</i> by Deniz Zeyrek

Subjects: Get full text

Serodeteksi Brucellosis dengan Metode Rose Bengal Test dan Complement Fixation Test pada Sapi Perah di Banyuwangi by Estiary Wilujeng, Suwarno Suwarno, Ratih Novita Praja, Iwan Sahrial Hamid, Maya Nurwartanti Yunita, Prima Ayu Wibawati

Subjects: Get full text

A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples. by Diana Pauly, Benedikt M Nagel, Jörg Reinders, Tobias Killian, Matthias Wulf, Susanne Ackermann, Boris Ehrenstein, Peter F Zipfel, Christine Skerka, Bernhard H F Weber

“…The complement system is an essential part of the innate immune system by acting as a first line of defense which is stabilized by properdin, the sole known positive regulator of the alternative complement pathway. …”
Get full text

WCN24-479 CHARACTERISTICS OF PATIENTS WITH COMPLEMENT 3 GLOMERULOPATHY (C3G) IN A US MULTI-CENTER ASSESSMENT by Briana Ndife, Carolina Aldworth, Kathleen P. Murphy, Jennifer Nguyen, Irina Pivneva, Marie Louise Edwards, Annika Anderson, James Signorovitch, Pietro Canetta

Get full text

Anti-dengue virus antibodies that elicit complement-mediated lysis of Zika virion correlate with protection from severe dengue disease by Antonio G. Dias, Jr., Elias M. Duarte, Jose Victor Zambrana, Jaime A. Cardona-Ospina, Sandra Bos, Vicky Roy, Julia Huffaker, Guillermina Kuan, Angel Balmaseda, Galit Alter, Eva Harris

“…Various antibody properties, notably antibody-dependent complement deposition, correlated with protection against DHF/DSS. …”
Get full text

Model-driven redox pathway manipulation for improved isobutanol production in Bacillus subtilis complemented with experimental validation and metabolic profiling analysis. by Haishan Qi, Shanshan Li, Sumin Zhao, Di Huang, Menglei Xia, Jianping Wen

“…These results demonstrated that model-driven complemented with metabolic profiling analysis could serve as a useful approach in the strain improvement for higher bio-productivity in further application.…”
Get full text

When do shared e-scooters complement or compete with public transport? A mixed-method review and comparison with bike sharing by Mahesha Jayawardhena, Alexa Delbosc, Graham Currie, Geoff Rose

“…This study aims to explore the definitions of ‘complement’ and ‘compete’ in literature and to identify the circumstances where e-scooters complement or compete with public transport using a mixed-method literature review. …”
Get full text

Complement-mediated virus infectivity neutralisation by HLA antibodies is associated with sterilising immunity to SIV challenge in the macaque model for HIV/AIDS. by Mark Page, Ruby Quartey-Papafio, Mark Robinson, Mark Hassall, Martin Cranage, James Stott, Neil Almond

“…We propose that complement-augmented virus neutralisation is a key factor in inducing sterilising immunity and may be difficult to achieve with HIV/SIV Env-based vaccines. …”
Get full text

Viral infections and related fatal adverse events associated with complement inhibitors for PNH: a real-world pharmacovigilance analysis in FAERS by Jinman Zhong, Chang Chen, Yunman Xu, Yueping He, Jiewen Tan, Dan Xiong

Subjects: “…complement inhibitor…”
Get full text

Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS‐mutant Cancers by Yafang Wang, Lansong Xu, Lijun Ling, Mingyue Yao, Shangxuan Shi, Chengcheng Yu, Yingnian Li, Jie Shen, Hualiang Jiang, Chengying Xie

Subjects: Get full text

Oxidative Stress and Complement Activation in Aqueous Cells and Vitreous from Patient with Vitreoretinal Diseases: Comparison Between Diabetic ERM and PDR by Lucia Dinice, Pamela Cosimi, Graziana Esposito, Fabio Scarinci, Andrea Cacciamani, Concetta Cafiero, Luca Placentino, Guido Ripandelli, Alessandra Micera

Subjects: Get full text

Optimised protocol for monitoring SARS-CoV-2 in wastewater using reverse complement PCR-based whole-genome sequencing. by Harry T Child, Paul A O'Neill, Karen Moore, William Rowe, Hubert Denise, David Bass, Matthew J Wade, Matt Loose, Steve Paterson, Ronny van Aerle, Aaron R Jeffries

Get full text

CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray. by Corinna Lau, Ståle Nygård, Hilde Fure, Ole Kristoffer Olstad, Marit Holden, Knut Tore Lappegård, Ole-Lars Brekke, Terje Espevik, Eivind Hovig, Tom Eirik Mollnes

“…The first line of defense against intruding pathogens and endogenous damage signals is pattern recognition by e.g., complement and Toll-like receptors (TLR). Combined inhibition of a key complement component (C3 and C5) and TLR-co-receptor CD14 has been shown to attenuate certain systemic inflammatory responses. …”
Get full text