Real-World Outcomes with Complement Inhibitors for Geographic Atrophy: A Comparative Study of Pegacetacoplan versus Avacincaptad Pegol by Rush RB, Klein W, Reinauer RM

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Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection. by Matheswaran Kandasamy, Poon C Ying, Adrian W S Ho, Hermi R Sumatoh, Andreas Schlitzer, Timothy R Hughes, David M Kemeny, B Paul Morgan, Florent Ginhoux, Baalasubramanian Sivasankar

“…Collectively, our findings show that complement has a profound impact on immune regulation by controlling tissue DC trafficking and highlights a potential utility for complement as an adjuvant in novel vaccine strategies.…”
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Cobalt Protoporphyrin IX Attenuates Antibody-Mediated, Complement-Dependent Podocyte Injury: Role of Cobalt and Porphyrin Moieties by Elias A. Lianos, Gia Nghi Phung, Jianping Zhou, Mukut Sharma

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Structure-function analysis of CNGA3-associated achromatopsia patient variants complements clinical genomics in pathogenicity determination by Ditte K. Rasmussen, Young Joo Sun, Joel A. Franco, Aarushi Kumar, Jennifer T. Vu, Alexander G. Bassuk, Vinit B. Mahajan

“…Conclusion Thus, proteoform-based analysis can be a valuable approach for assessing novel variants and complement clinical genomics in its utilization.…”
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Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa by Jillian Eisenhauer, Jillian Eisenhauer, Spencer Dublin, Jihae Choi, Abigail R. Trachtman, Jacqueline D. Chu, David Custodio-Zegarra, Suman Bharti, Bhavya Bhardwaj, Shuangyi Bai, William T. Witt, Maria de la Paz Gutierrez, Sarah J. Miller, Kaitlyn Flowers, Trevor R. F. Smith, Bronwyn M. Gunn, Mariette Barbier, Elizabeth M. Parzych, David B. Weiner, Ami Patel

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Complementing but Not Replacing: Comparing the Impacts of GPT-4 and Native-Speaker Interaction on Chinese L2 Writing Outcomes by Zhaoyang Shan, Zhangyuan Song, Xu Jiang, Wen Chen, Luyao Chen

“…This study suggests that LLMs should be used to complement and not replace human language partners in the L2 pre-writing phase.…”
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Introducing multiple factor analysis (MFA) as a diagnostic taxonomic tool complementing principal component analysis (PCA) by L. Lee Grismer

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Urine Complement Factor Ba Identifies Persistent Acute Kidney Injury and Organ Failures in Critically Ill Adults by Erin K. Stenson, Charles E. Edelstein, Zhiying You, Anna Ostrow, Zoltan Endre, Shinobu Miyazaki-Anzai, Bradley P. Dixon, Halden Scott, Neil Aggarwal, Joshua M. Thurman, Jessica Kendrick

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WCN25-2419 COMPLEMENT COMPONENT 4d(C4d) DEPOSITION AND PROGNOSIS IN LUPUS NEPHRITIS by Riyadh Al-Saegh, Haider J. Kehiish, Ghadeer S. Noah, Ameer R. Al-Saegh, Maha A. Al-Mukhtar, Aya R. Al-Saegh

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Correlation between serum complement C3 levels and cognitive dysfunction in patients with end-stage renal disease by Wu Si-yang, Zhang Jin, Wang Ying, Zhang Pei, Qi Xiang-ming, Wu Yong-gui

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Susceptibility to invasive meningococcal disease: polymorphism of complement system genes and Neisseria meningitidis factor H binding protein. by Declan T Bradley, Thomas W Bourke, Derek J Fairley, Raymond Borrow, Michael D Shields, Peter F Zipfel, Anne E Hughes

“…<h4>Background</h4>Neisseria meningitidis can cause severe infection in humans. Polymorphism of Complement Factor H (CFH) is associated with altered risk of invasive meningococcal disease (IMD). …”
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Visceral fat, cardiovascular risk factors and quality of life in lupus activity categorised via complement C3 by J Alfredo Martinez, Victor Moreno-Torres, María Martínez-Urbistondo, Raquel Castejón, Susana Mellor-Pita, Andrea Higuera-Gómez, Begoña de Cuevillas, Amanda Cuevas-Sierra, Juan-Antonio Vargas

“…Notably, age, body mass index and insulin resistance were associated with SLE inactivity, while fibrinogen correlated with disease activity as assessed by complement C3 levels. Interestingly, household composition as a sociodemographic variable (alone, couple/children/elderly or other) also showed an independent association with SLE activity.Conclusions Inactive patients with SLE exhibited more adverse cardiovascular risk markers compared with active patients categorised by complement C3, even when glucocorticoid administration was accounted for. …”
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Dynamic Complement Protein Changes in Aqueous Humor and Plasma of Patients With Retinal Vein Occlusion During Ranibizumab Treatment by Guo T, Zhao Y, Liang S, Wang J, Liu H, Zhou Y, Xu H, Chen Z

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Complement opsonization of HIV-1 enhances the uptake by dendritic cells and involves the endocytic lectin and integrin receptor families. by Veronica Tjomsland, Rada Ellegård, Karlhans Che, Jorma Hinkula, Jeffrey D Lifson, Marie Larsson

“…Interaction with the complement system is an underappreciated aspect of HIV-1 infection; even in primary infection, complement fragments are found on virions with potential to affect the interplay between the virus and dendritic cells (DC). …”
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Computer-Based Clinical Examination (CCE) in Surgery: Would It Complement or Replace the OSCE in the Post-COVID-19 Era? by Gamal E H A El Shallaly, Mudather M Bafadni, Hozifa M A Abdelmaged, Maysa H A Hamza

“…It saves time and is popular with the students and tutors. It complements the OSCE in the assessment of clinical competency and allows wide coverage of the curriculum. …”
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Bioactive Sphingolipids, Complement Cascade, and Free Hemoglobin Levels in Stable Coronary Artery Disease and Acute Myocardial Infarction by T. Jadczyk, K. Baranski, M. Syzdol, E. Nabialek, W. Wanha, R. Kurzelowski, M. Z. Ratajczak, M. Kucia, B. Dolegowska, M. Niewczas, J. Zejda, W. Wojakowski

“…Acute myocardial infarction (AMI) and coronary artery bypass graft (CABG) surgery are associated with a pathogen-free inflammatory response (sterile inflammation). Complement cascade (CC) and bioactive sphingolipids (BS) are postulated to be involved in this process. …”
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Blastocyst complementation-based rat-derived heart generation reveals cardiac anomaly barriers to interspecies chimera development by Shunsuke Yuri, Norie Arisawa, Kohei Kitamuro, Ayako Isotani

“…Summary: The use of pluripotent stem cells (PSCs) to generate functional organs via blastocyst complementation is a cutting-edge strategy in regenerative medicine. …”
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Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina by Marcus Karlstetter, Jens Kopatz, Alexander Aslanidis, Anahita Shahraz, Albert Caramoy, Bettina Linnartz‐Gerlach, Yuchen Lin, Anika Lückoff, Sascha Fauser, Katharina Düker, Janine Claude, Yiner Wang, Johannes Ackermann, Tobias Schmidt, Veit Hornung, Christine Skerka, Thomas Langmann, Harald Neumann

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Systemic lupus erythematosus as the paradigm for understanding the complex immune relationships and therapeutic opportunities for targeting complement in autoimmune diseases by V. Michael Holers

“…Complement therapeutics have been increasingly tested and approved for human diseases, often in orphan diseases with strong and apparently causal genetic linkage or mutation-associated features. …”
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Randomised prospective trial to assess the clinical utility of multianalyte assay panel with complement activation products for the diagnosis of SLE by Daniel J Wallace, Thierry Dervieux, Arezou Khosroshahi, Claudia Ibarra, Tyler O'Malley, Elena Massarotti, Roberta Vezza Alexander, Mehrnaz Hojjati, Konstantinos Loupasakis, Jeffrey Alper, Yvonne Sherrer, Maria Fondal, Rajesh Kataria, Tami Powell, Sonali Narain, Arthur Weinstein

“…Objective We compared the physician-assessed diagnostic likelihood of SLE resulting from standard diagnosis laboratory testing (SDLT) to that resulting from multianalyte assay panel (MAP) with cell-bound complement activation products (MAP/CB-CAPs), which reports a two-tiered index test result having 80% sensitivity and 86% specificity for SLE.Methods Patients (n=145) with a history of positive antinuclear antibody status were evaluated clinically by rheumatologists and randomised to SDLT arm (tests ordered at the discretion of the rheumatologists) or to MAP/CB-CAPs testing arm. …”
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