Plasma complement proteins as biomarkers and therapeutic targets in chronic kidney disease: a Mendelian randomization analysis by Yu-Peng Xu, Zheng-Qi Song, Ming-Li Chen, Yang-Li Fang, Hui-Di Zhang

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Correction: Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID‑19 requiring lung transplantation by Pooja Shivshankar, Stacey L. Mueller‑Ortiz, Aleksey Y. Domozhirov, Weizhen Bi, Scott D. Collum, Marie-Francoise Doursout, Manish Patel, Isabella N. LeFebvre, Bindu Akkanti, Simon Yau, Howard J. Huang, Rahat Hussain, Harry Karmouty-Quintana

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Isolation and Characterization of a New Peroxisome Deficient CHO Mutant Cell Belonging to Complementation Group 12 by K. Ghaedi

“…By this method, we have isolated one CHO cell mutant, ZPEG403, which was found to belong to complementation group G (CG-G). Expression of the human peroxin, Pex3p cDNA encoding a 373-amino-acid peroxisomal membrane protein morphologically and biochemically restored peroxisome biogenesis, including peroxisomal membrane assembly, in ZPEG403 cells. …”
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The predictive value of NLR, SII, and complement 3 in treatment response for systemic lupus erythematosus with immune thrombocytopenia by Ziqiang Zheng, Ziqiang Zheng, Jiali Liu, Taoyuan He, Taoyuan He, Chang Liu

“…The median SII values were 145.7 (43.7-238.7) for the CR group, 57.2 (20.5-90.2) for the PR group, and 117.8 (80.7-238.6) for the NR group. Additionally, complement 3 levels were significantly lower in the CR group compared to the PR and NR groups (P=0.010). …”
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Assessing Patients with Chronic Pain Using the Basic Personality Inventory as a Complement to the Multidimensional Pain Inventory by Howard J Burton, Stephen A Kline, Robin Hargadon, Barry S Cooper, Roger D Shick, May C Ong-Lam

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FUNCTIONAL ACTIVITY OF COMPLEMENT CLASSIC WAY ACTIVATION COMPONENTS AND ART1CULAS DAMAGE IN RHEUMATOID ARTRITIS by D. L. Goryachev, T. V. Lebedeva

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Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH). by Hugh P Morgan, Haydyn D T Mertens, Mara Guariento, Christoph Q Schmidt, Dinesh C Soares, Dmitri I Svergun, Andrew P Herbert, Paul N Barlow, Jonathan P Hannan

“…Factor H (FH) is a soluble regulator of the human complement system affording protection to host tissues. …”
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Visualizing interactions along the Escherichia coli twin-arginine translocation pathway using protein fragment complementation. by Jan S Kostecki, Haiming Li, Raymond J Turner, Matthew P DeLisa

“…To visualize these interactions, we have adapted bimolecular fluorescence complementation (BiFC) to detect protein-protein interactions along the Tat pathway of living cells. …”
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The specific contributions of factor H and factor I in controlling fluid phase activation of the alternative complement pathway by Nancy A. Turner, Joel L. Moake

“…Abstract The immediate defense provided by the alternative complement pathway (AP) is under constant control by fluid phase regulators, factor H (FH) and factor I (FI), to prevent nonessential activation. …”
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Successful targeting of the alternative complement cascade with iptacopan for the treatment of IgA nephropathy: a case report by Leonore Ingold, Michael Dickenmann, Thomas Menter, Helmut Hopfer, Patricia Hirt-Minkowski

“…Iptacopan is an oral inhibitor of complement factor B that effectively blocks the alternative complement pathway. …”
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WCN24-2270 COMPLEMENT SYSTEM IS OVERACTIVATED IN PATIENTS WITH IGA NEPHROPATHY AFTER COVID-19 INFECTION by Hong Cheng, Wei-yi Guo, Guo-qin Wang, Ling-qiang Kong, Li-jun Sun, Xiao-yi Xu, Wen-rong Cheng, Hongrui Dong

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Genotypic and phenotypic diversity of Lactobacillus rhamnosus clinical isolates, their comparison with strain GG and their recognition by complement system. by Eija Nissilä, François P Douillard, Jarmo Ritari, Lars Paulin, Hanna M Järvinen, Pia Rasinkangas, Karita Haapasalo, Seppo Meri, Hanna Jarva, Willem M de Vos

“…The capacity of the L. rhamnosus strains to activate serum complement was studied using immunological assays for complement factor C3a and the terminal pathway complement complex (TCC). …”
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Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective by Didar Murad, Rehan Zafar Paracha, Maryum Nisar

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Specific surface-modified iron oxide nanoparticles trigger complement-dependent innate and adaptive antileukaemia immunity by Yuanyuan Li, Wen Wu, Qihui Liu, Qiong Wu, Ping Ren, Xi Xi, Haiyan Liu, Jiarui Zhao, Wei Zhang, Zizhun Wang, Yuanyuan lv, Bin Tian, Shuang Sun, Jiaqi Cui, Yangyang Zhao, Jingyuan Wu, Mingyuan Gao, Fangfang Chen

“…Mechanistically, IONP-COOH indirectly binds to C3b after activating the complement alternative pathway, subsequently enhancing phagocytosis of macrophages and activating adaptive immunity mediated by complement corona. …”
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Narrow Band Imaging complements Eosinophilic Esophagitis Reference Score in predicting inflammatory infiltration in patients with dysphagia by Kotryna Truskaite, Laura Vossen Engblom, Greger Lindberg, Aldona Dlugosz

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Complement-Mediated Hemolytic Uremic Syndrome Due to MCP/CD46 Mutation: A Case Report by Abdul Muhsen Abdeen MD, Jowan Al-Nusair MD, Malik Samardali MD, Mohamed Alshal MD, Amro Al-Astal MD, Zeid Khitan MD

“…Thrombotic microangiopathy (TMA) is a severe condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end-organ damage, often involving the kidneys. Complement-mediated hemolytic uremic syndrome (cHUS), a rare form of TMA, arises from dysregulated alternative complement pathway activation, frequently due to genetic mutations. …”
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The Study of Serum Complement C3, C4 and Immunoglobulin E IgE in Psoriasis Patients by Baghdad Science Journal

“…The present study was aimed to find out the role of humoral immunity in the pathogenesis of psoriasis. Complements C3, C4 and immunoglobulin IgE .The study included 55 Iraqi patients with psoriasis 30 (15 females ,15 males) were untreated with any drugs. …”
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Venom from Bothrops lanceolatus, a Snake Species Native to Martinique, Potently Activates the Complement System by Marie Delafontaine, Isadora Maria Villas-Boas, Giselle Pidde, Carmen W. van den Berg, Laurence Mathieu, Joël Blomet, Denise V. Tambourgi

“…Here, we investigated the ability of B. lanceolatus venom to activate the Complement system (C) in order to improve the understanding of venom-induced local inflammation. …”
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Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy by Amanda K. Slagle, Amanda K. Slagle, Nicolo Ghiringhelli Borsa, Kai Wang, Amanda O. Taylor, Nicole C. Meyer, Michael B. Jones, William D. Walls, Angela F. M. Nelson, Sarah M. Roberts, Mingyao Sun, Elena Goicoechea de Jorge, Santiago Rodriguez de Cordoba, Diana I. Jalal, Diana I. Jalal, Carla M. Nester, Yuzhou Zhang, Richard J. H. Smith, Richard J. H. Smith

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Impact of the Graphene Production Methods Sonication and Microfluidization on In Vitro and In Vivo Toxicity, Macrophage Response, and Complement Activation by Jan-Lukas Førde, Abdelnour Alhourani, Tian Carey, Adrees Arbab, Kari E. Fladmark, Silje Skrede, Tom Eirik Mollnes, Lars Herfindal, Hanne R. Hagland

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