Effectiveness of Iptacopan Versus C5 Inhibitors in Complement Inhibitor‐Naive Patients With Paroxysmal Nocturnal Haemoglobinuria by Matthew Holt, Richard J. Kelly, Jilles M. Fermont, Soudeh Ansari, Marion Dahlke, Isabelle Brindel, Lynda Maafa, Flore Sicre deFontbrune, Régis Peffault deLatour

“…The single‐arm phase 3 APPOINT‐PNH trial (NCT04820530) investigating iptacopan monotherapy in complement inhibitor‐naive patients demonstrated significant haemoglobin concentration improvements. …”
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Target complement factor H / serum amyloid a signaling in trichloroethylene-induced immune kidney injury by Haibo Xie, Bo Liang, Jingyi Zhao, Chen You, Qirui Bai, Rui Li, Jian Chen, Pengcheng Zhou, Luolun Dong, Ruixuan Cheng, Jiaxiang Zhang, Qixing Zhu

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Complement factor h gene abnormalities in haemolytic uraemic syndrome: from point mutations to hybrid gene. by Marina Noris, Giuseppe Remuzzi

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Participatory science to complement professional data: Towards conservation of declining native freshwater fish, the crucian carp by Kiran Thomas, Lukáš Kalous, Marek Brabec, Petr Velenský, Milan Gottwald, Daniel Bartoň, Sandip Tapkir, Yevdokiia Stepanyshyna, Zuzana Šmejkalová, Marek Šmejkal

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Gut microbial dysbiosis activates the classical complement pathway in a short-term morphine treatment model by Nicolas Vitari, Richa Jalodia, Junyi Tao, Udhghatri Kolli, Salma Singh, Lily V. Rodriguez, Umakant Sharma, Sabita Roy

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An RNase H‐Like gene complements resistance to Bean common mosaic necrosis virus in Phaseolus vulgaris by Alvaro Soler‐Garzón, Phillip N. Miklas

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Evolving understanding of Guillain-Barré syndrome pathophysiology and the central role of the classical complement pathway in axonal injury by Kenneth C. Gorson

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Activated Immune and Complement C3 Are Potential Contributors in MASH via Stimulating Neutrophil Extracellular Traps by Ao Liu, Xiaoling Deng, Shuhui Hou, Yuwen Xi, Keshu Xu

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Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease by Celia Luchena, Jone Zuazo-Ibarra, Elena Alberdi, Carlos Matute, Estibaliz Capetillo-Zarate

“…Microglial cells are involved in synapse pruning during development via the complement pathway. Moreover, recent evidence points towards a key role played by glial cells in synapse loss during AD. …”
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Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation. by Jacqueline U McDonald, Marcela Rosas, Gordon D Brown, Simon A Jones, Philip R Taylor

“…We have re-investigated the role of the complement system and the non-opsonic pattern recognition receptors dectin-1 and dectin-2 in the recognition of fungal particles by inflammatory neutrophils, monocytes and macrophages. …”
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The role of complement C1q in atrial fibrillation: a marker for disease progression and surgical outcomes by Yuefeng Ju, MaoJing Wang, Yang Ji, Zhihui Wang, Wenzhuo Wang, Feiyue Liu, Qing Zhao

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Levodopa / opicapone as a complement to STN-DBS in clinical practice. A retrospective single-centre analysis. by Moritz A. Loeffler, Philipp Klocke, Idil Cebi, Alireza Gharabaghi, Daniel Weiss

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Increased Autoreactivity of the Complement-Activating Molecule Mannan-Binding Lectin in a Type 1 Diabetes Model by Jakob Appel Østergaard, Marieta Milkova Ruseva, Talat Habib Malik, Ingeborg Torp Hoffmann-Petersen, Matthew Caleb Pickering, Steffen Thiel, Troels Krarup Hansen

“…Identification of new drug targets is therefore of paramount importance. The complement system is emerging as a potential new target. …”
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The role of complement in the immunopathogenesis of acetylcholine receptor antibody-positive generalized myasthenia gravis: bystander or key player? by Iliana Michailidou, Anastasia Patsiarika, Evangelia Kesidou, Marina Kleopatra Boziki, Marina Kleopatra Boziki, Dimitrios Parisis, Christos Bakirtzis, Elisabeth Chroni, Nikolaos Grigoriadis, Nikolaos Grigoriadis

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WCN24-550 SINGLE DOSE OF IPTACOPAN TREATMENT RAPIDLY DESCREASES PLASMA COMPLEMENT Bb LEVELS by Robert Schmouder, Guido Junge, Julie Milojevic, Prasanna Kumar Nidamarthy, Kenneth Kulmatycki

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Systematic Review of the Link Between Oxford MEST-C Classification and Complement Activation in IgA Nephropathy by Gabriel Ștefan, Eric Alamartine, Christophe Mariat, Nicolas Maillard

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Influence of Cow Dung Extract Complemented with Nutrient Solution on the Growth Performance of Lettuce (Lactuca sativa L) by Abu Raihan, Md. Jahedur Rahman, Chand Sultana Chandni, Sabina Yasmin, Md. Shahajahan Ali, M. Mokbul Hossain

“…Limited studies have focused on plant growth performance using organic-based solutions complemented with mineral elements in a hydroponic system. …”
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Influenza-specific antibody-mediated and complement-dependent cellular cytotoxicity-inducing antibodies in vaccinated and infected pigs by Mithilesh Singh, Gabriela Mansano do Nascimento, Sankar Renu, Dina Bugybayeva, Olaitan C. Shekoni, Raksha Suresh, Jennifer Schrock, Sara Dolatyabi, Diego G. Diel, Prosper N. Boyaka, Gourapura J. Renukaradhya

“…In addition to neutralizing activity, antibodies can contribute to protection against viral infections through antibody-dependent cellular cytotoxicity (ADCC) and antibody-mediated complement-dependent cell cytotoxicity (CDC) mediated via Fcy receptors. …”
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Moss-derived human complement factor H modulates retinal immune response and attenuates retinal degeneration by Mandy Hector, Verena Behnke, Paulina Dabrowska-Schlepp, Andreas Busch, Andreas Schaaf, Thomas Langmann, Anne Wolf

Subjects: “…Complement factor H…”
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Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle by Jonas Brorson, Lin Lin, Jakob Wang, Amanda Bæk, Tine Borum Billeskov, Frederik Forsberg Thybo, Jesper Just, János Haskó, Christen Ravn, Rehne L. Hansen, Mats Bue, Jens Otto Lunde Jørgensen, Yonglun Luo, Niels Jessen, Jean Farup

“…Spatial correlation analysis unveils FAPs and monocytes/macrophages co-localization and intercellular communication, mediated by complement factor C3. Immunostaining confirms C3 expression in FAPs and FAP secretion of C3, suggesting a role in phagocytosis of necrotic muscle cells. …”
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