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  1. 3501

    Reduced hemolytic complement activity in the classical pathway (CH50) is a risk factor for poor clinical outcomes of patients with infections: a retrospective analysis of health insurance claims in Japan by Hiroyuki Koami, Hiroyuki Koami, Yutaro Furukawa, Yuri Hirota, Akira Sasaki, Hirotaka Ogawa, Ayaka Matsuoka, Kota Shinada, Kento Nakayama, Ryota Sakurai, Sachiko Iwanaga, Takayuki Onohara, Shogo Narumi, Mayuko Koba, Hirotaka Mori, Hirotaka Mori, Yutaka Umemura, Yutaka Umemura, Kazuma Yamakawa, Kazuma Yamakawa, Kohji Okamoto, Kohji Okamoto, Yuichiro Sakamoto, Yuichiro Sakamoto

    Published 2025-06-01
    “…PurposeTo evaluate whether low CH50 (a comprehensive measure of hemolytic activity of the classical complement pathway) is associated with infection-related coagulopathy, organ dysfunction, and poor clinical outcomes.MethodsThis was a retrospective study using Japanese health insurance claim data (2014-2023). …”
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  2. 3502
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  4. 3504

    Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs by Lisa Hurler, Erik J. M. Toonen, Erika Kajdácsi, Bregje van Bree, Ricardo J. M. G. E. Brandwijk, Wieke de Bruin, Paul A. Lyons, Paul A. Lyons, Laura Bergamaschi, Laura Bergamaschi, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, György Sinkovits, László Cervenak, Reinhard Würzner, Zoltán Prohászka, Zoltán Prohászka, Stephen Baker, John R. Bradley, Patrick F. Chinnery, Daniel J. Cooper, Gordon Dougan, Ian G. Goodfellow, Ravindra K. Gupta, Nathalie Kingston, Paul J. Lehner, Paul A. Lyons, Nicholas J. Matheson, Caroline Saunders, Kenneth G. C. Smith, Charlotte Summers, James Thaventhiran, M. Estee Torok, Mark R. Toshner, Michael P. Weekes, Gisele Alvio, Sharon Baker, Areti Bermperi, Karen Brookes, Ashlea Bucke, Jo Calder, Laura Canna, Cherry Crucusio, Isabel Cruz, Rnalie de Jesus, Katie Dempsey, Giovanni Di Stephano, Jason Domingo, Anne Elmer, Julie Harris, Sarah Hewitt, Heather Jones, Sherly Jose, Jane Kennet, Yvonne King, Jenny Kourampa, Emily Li, Caroline McMahon, Anne Meadows, Vivien Mendoza, Criona O’Brien, Charmain Ocaya, Ciro Pascuale, Marlyn Perales, Jane Price, Rebecca Rastall, Carla Ribeiro, Jane Rowlands, Valentina Ruffolo, Hugo Tordesillas, Phoebe Vargas, Bensi Vergese, Laura Watson, Jieniean Worsley, Julie-Ann Zerrudo, Laura Bergamaschi, Ariana Betancourt, Georgie Bower, Ben Bullman, Chiara Cossetti, Aloka De Sa, Benjamin J. Dunore, Maddie Epping, Stuart Fawke, Stefan Gräf, Richard Grenfell, Andrew Hinch, Josh Hodgson, Christopher Huang, Oisin Huhn, Kelvin Hunter, Isobel Jarvis, Emma Jones, Maša Josipović, Ekaterina Legchenko, Daniel Lewis, Joe Marsden, Jennifer Martin, Federica Mescia, Francesca Nice, Ciara O’Donnell, Ommar Omarjee, Marianne Perera, Linda Pointon, Nicole Pond, Nathan Richoz, Nika Romashova, Natalia Savoinykh, Rahul Sharma, Joy Shih, Mateusz Strezlecki, Rachel Sutcliffe, Tobias Tilly, Zhen Tong, Carmen Treacy, Lori Turner, Jennifer Wood, Marta Wylot, John Allison, Heather Biggs, Helen Butcher, Daniela Caputo, Debbie Clapham-Riley, Eleanor Dewhurst, Christian Fernandez, Anita Furlong, Barbara Graves, Jennifer Gray, Tasmin Ivers, Emma Le Gresley, Rachel Linger, Mary Kasanicki, Sarah Meloy, Francesca Muldoon, Nigel Ovington, Sofia Papadia, Christopher J. Penkett, Isabel Phelan, Venkatesh Ranganath, Jennifer Sambrook, Katherine Schon, Hannah Stark, Kathleen E. Stirrups, Paul Townsend, Julie von Ziegenweidt, Jennifer Webster, Ali Asaripour, Lucy Mwaura, Caroline Patterson, Gary Polwarth, Katherine Bunclark, Michael Mackay, Alice Michael, Sabrina Rossi, Mayurun Selvan, Sarah Spencer, Cissy Yong, Petra Polgarova

    Published 2022-11-01
    Subjects: “…early complement activation…”
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  5. 3505

    Supramolecular Chiral Amplification Mediated by Tiny Structural Changes in Natural Binary Carrier‐Free Hydrogels with Promotion Methicillin‐Resistant Staphylococcus aureus‐Infected wound Healing by Inhibiting the Complement System by Zhijia Wang, Jihui Lu, Wenmin Pi, Ran Xu, Shuchang Yao, Xiang Zhang, Luping Yang, Yihang Zhao, Jichang Wei, Gen Li, Yiqing Huang, Haimin Lei, Xuemei Huang, Penglong Wang

    Published 2025-05-01
    “…This self‐assembled chiral hydrogel based on the inherent anti‐inflammatory and antibacterial activities of phytochemicals (BA, SCU, and CHE) can promote wound healing in bacterial infections by inhibiting the complement system. The phenomenon of supramolecular chirality amplification caused by tiny structural changes discovered in this study provides a horizon for the self‐assembly of natural small molecule drugs to form two‐component chiral supramolecular hydrogels and expands its application in the field of biomaterials.…”
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  6. 3506

    No relationship between non-IgE-mediated mechanisms (complement activation or direct activation of mast cells and basophils) during diclofenac etalhyaluronate (SI-613/ONO-5704)-induced anaphylaxis by Shuhei Takada, Dai Muramatsu, Yasuaki Isoda, Yamato Sasaki, Kei Toyama, Keiji Yoshioka

    Published 2025-12-01
    “…No effect of DEH treatment was found on complement activation, MRGPRX2 agonist activity, direct mast cell activation, or direct basophil activation. …”
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