Low-dimensional spike rate models derived from networks of adaptive integrate-and-fire neurons: Comparison and implementation. by Moritz Augustin, Josef Ladenbauer, Fabian Baumann, Klaus Obermayer

“…The spiking activity of single neurons can be well described by a nonlinear integrate-and-fire model that includes somatic adaptation. …”
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Evaluating the Impact of Video Assistant Referee Implementation in Football: A Four-Season Analysis of Match Performance Trends by Eren Akdağ, Ali Işın, Alberto Lorenzo Calvo, Enrique Alonso Pérez Chao, Sergio L. Jiménez Sáiz

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Examining gender as an issue of policy priority: a case study of four Kenyan health policy implementation strategies by Henry Owoko Odero, Doris Kwesiga, Sally Odunga, Damazo T. Kadengye, Sylvia Kiwuwa-Muyingo

“…This study explores how gender is prioritized in the development and implementation of four Kenyan Health Policy Implementation Strategies (HPIS), offering insight into the role of institutional actors, policy framing, and contextual factors.MethodsA qualitative case study was conducted involving content analysis of four HPIS documents - KASF II 2020, NSP-NCD 2021, NSP-TB 2019, and COVID-TTS 2019 - and semi-structured interviews with 16 policy stakeholders. …”
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Abuse of law as a form of opposition to the implementation of the law in the context of modern scientific discourse and law enforcement practice by N. I. Sukhova

“…In addition, theoretical knowledge that has no outlet to practice loses their importance and does not contribute the simplification of practical activities to implementing the law. The main conclusions of the research are expressed in the provisions that the abuse of law plays the role of legal fact, associated with the onset of harmful consequences or the threat of their occurrence. …”
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Hygienic characteristics of changes in the nutritional status of adult population in the Omsk region during the implementation of Demography national project by O. V. Kozubenko, Yu. V. Menshchikova, M. S. Turchaninova, M. P. Menshchikov, E. А. Vilms

“…The prevalence of various nutritional disorders among the adult population of the Omsk region reduced, as the implementation of the federal project «Strengthening Public Health» under the national project "Demography" improved the provision of vitamins.…”
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Barriers and facilitators to the implementation of the Assessment of Burden of Chronic Conditions tool in Dutch primary care: a context analysis by Onno C P Van Schayck, Danny Claessens, Esther A Boudewijns, Liset van Dijk, Marcia Vervloet, Lotte C E M Keijsers, Annerika H M Gidding-Slok

“…HCPs expected several major barriers to the implementation of the ABCC tool:too many different digital environments, high complexity in access, lack of time, no integration of the ABCC tool in guidelines and care standards, and patients not willing to adopt an active role in their care process. …”
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Cohort profile: Design and implementation of the Danish Physiotherapy Research Database for patients receiving primary care with chronic disease by Erhard Næss-Schmidt, Nils-Bo de Vos Andersen, David Høyrup Christiansen, Jørgen Feldbæk Nielsen, Peter William Stubbs

“…Although the PhysDB-FCP is promising, the tool requires optimisation before it is implemented regionally and/or nationally.…”
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Protocol for the comparison of remote versus face-to-face osteoarthritis management programs (COASTAL): A randomized implementation trial by Shiwen Yuan, Jocelyn L. Bowden, Jillian P. Eyles, Vicky Duong, Stephen Messier, Elena Losina, Jean Frederic Levesque, Andrew M. Briggs, Michelle M. Dowsey, Leticia Alle Deveza, Nicole M. Rankin, Christian J. Barton, Blake F. Dear, Carin Pratt, Jonathan Smithers, Louise Hardy, Caroline Bills, Julia Thompson, Tom Buttel, Daniel Ewald, Kevin Cheng, Nicola Ware, Daniel Richardson, Erica Morgan, Monique Strelnikow, Venkatesha Venkatesha, Alexandra Warhurst, Vineeta Kurien, Scott Chery, David J. Hunter

“…Design: COASTAL (ACTRN12624000996561) comprises two aims: the primary aim is a three-arm, non-inferiority, comparative-effectiveness, type I hybrid implementation RCT; and the secondary aim is a superiority trial to compare the three interventions separately to an untreated, non-randomized control group. …”
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Implementation of 16S rRNA Gene for Fish and Shrimp Barcoding in Mangrove Ecosystems in North Sumatra and Aceh, Indonesia by Hatika Hairani, Rizka Amelia, Ipanna Enggar Susetya, Arida Susilowati, Yuntha Bimantara, Tadashi Kajita, Mohammad Basyuni

“…The research was divided into four activities: sample collection, DNA isolation, PCR amplification, and data analysis. …”
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The REFRACT trial: implementation of Bayesian power priors in a randomised, sequential phase II adaptive platform trial by Charlotte Gaskell, Kim Linton, Mark Bishton, Graham McIlroy, Siân Lax, Sonia Fox, Louise Hopkins, Rebecca Collings, Malcolm Rhodes, Tania Seale, Aimee Jackson

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Evaluation of One Health approach measures implemented in response to the human rabies outbreak in the Maxakali Indigenous Land, Brazil by Dilceu Silveira Tolentino Júnior, Maryana Santos Vasconcelos Marques, Jomar Otávio Zatti Pereira, Roberto Carlos de Oliveira

“…The coordination mechanisms between the Rabies Working Group of the Ministry of Health, composed of the National, State and District Strategic Information Centers for Health Surveillance, the Field Epidemiology Training Program, the Special Secretariat for Indigenous Health, the State Secretariat of Health of Minas Gerais, the Agricultural Institute of Minas Gerais, the Municipal Secretariats of Health and Environment of Bertópolis, hospitals in the region and the Fire Department of Minas Gerais were assessed. Results Training activities were carried out for health team professionals; a post-exposure prophylaxis scheme was implemented for susceptible contacts and a pre-exposure prophylaxis scheme was implemented by the vaccination team for all village residents; the animal anti-rabies vaccine was administered to 100% of the canine and feline population in Aldeia Pradinho, within a focal and perifocal radius of 3 to 5 km from the outbreak site. …”
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Implementation of singing groups for postnatal depression: experiences of participants and professional stakeholders in the SHAPER-PND randomised controlled trial by Emeline Han, Rachel Davis, Rachel Davis, Tayana Soukup, Tayana Soukup, Alexandra Bradbury, Julie Williams, Maria Baldellou Lopez, Lorna Greenwood, Rebecca Bind, Carolina Estevao, Tim Osborn, Hannah Dye, Kristi Priestley, Lavinia Rebecchini, Katie Hazelgrove, Manomani Manoharan, Anthony Woods, Nikki Crane, Andy Healey, Paola Dazzan, Nick Sevdalis, Carmine M. Pariante, Daisy Fancourt, Ioannis Bakolis, Ioannis Bakolis, Alexandra Burton

“…BackgroundThere is a rapidly growing evidence base for the effectiveness of creative health interventions in improving mental health, but few studies have explored implementation and scaling of these interventions. The aim of this study was to evaluate the perceived acceptability, appropriateness, and feasibility of a ten-week singing group programme (Breathe Melodies for Mums (M4M)) for mothers experiencing symptoms of postnatal depression (PND) and their babies as well as the programme ingredients that affected these implementation outcomes.MethodsA mixed methods design was adopted. …”
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Implementation of model-informed precision dosing for tamoxifen therapy in patients with breast cancer: A prospective intervention study by Ruben Y.M. van Nijnatten, Sanne M. Buijs, Bram C. Agema, Raphaël M.J. Fischer, Inge Ghobadi Moghaddam-Helmantel, Caroline M.E. Contant, Felix E. de Jongh, Auke M.T. Huijben, Manon Kop, Annemieke van der Padt-Pruijsten, Hanneke J.M. Zuetenhorst, Ron H.N. van Schaik, Birgit C.P. Koch, A. Jager, Stijn L.W. Koolen, Ron H.J. Mathijssen

“…It is converted by CYP2D6 into endoxifen, its most active metabolite. Patients with endoxifen plasma concentrations <16 nM face a higher risk of recurrence. …”
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Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: Cluster randomised controlled trial. by Toity Deave, Adrian Hawkins, Arun Kumar, Mike Hayes, Nicola Cooper, Michael Watson, Joanne Ablewhite, Carol Coupland, Alex Sutton, Gosia Majsak-Newman, Lisa McDaid, Trudy Goodenough, Kate Beckett, Elaine McColl, Richard Reading, Denise Kendrick

“…Evidence-based interventions to promote fire safety practices exist, but the impact of implementing a range of these interventions in children's services has not been assessed. …”
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Implementation of a Quality Improvement and Clinical Decision Support Tool for Cancer Diagnosis in Primary Care: Process Evaluation by Sophie Chima, Barbara Hunter, Javiera Martinez-Gutierrez, Natalie Lumsden, Craig Nelson, Dougie Boyle, Kaleswari Somasundaram, Jo-Anne Manski-Nankervis, Jon Emery

“…Addressing these in future studies may optimize the implementation process. Further work is needed to determine if a scaled-back approach, which meets the time and resource availability of a busy general practice, can effectively facilitate the implementation of CDS tools. …”
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Contextual barriers to infection prevention and control program implementation in hospitals in Latin America: a mixed methods evaluation by Valeria Fabre, Clara Secaira, Carolyn Herzig, Elizabeth Bancroft, Maria Paula Bernachea, Lucy Anchiraico Galarza, Bowen Aquiles, Ana Belén Arauz, Maria Del Carmen Bangher, Marisa Liliana Bernan, Sol Burokas, Alfredo Canton, Iris L. Cazali, Angel Colque, Marisabel Comas, Rosa Verónica Contreras, Wanda Cornistein, Maria Gabriela Cordoba, Silvia Mabel Correa, Gustavo Costilla Campero, Marta Isabel Chamorro Ayala, Nuria Chavez, Gabriela De Ascencao, Carlos Cruz García, Clara Esquivel, Cecilia Ezcurra, Leonardo Fabbro, Leandro Falleroni, Johana Fernandez, Sandra Ferrari, Veronica Freire, Maria Isabel Garzón, José Anel Gonzales, Lucrecia Guaymas, Fausto Guerrero-Toapanta, Diego Laplume, Sandra Lambert, César Guillermo Lemir, Paola Romina Lazarte, Itzel L. Lopez, Herberth Maldonado, Guadalupe Martínez, Diego M. Maurizi, Florencia Mesplet, Cristina Moreno Izquierdo, Gabriela Luciana Moya, Mariela Nájera, Yanina Nuccetelli, Argelis Olmedo, Belén Palacio, Florencia Pellice, Carla Lorena Raffo, Carolina Ramos, Fanny Reino, Viviana Rodriguez, Federico Romero, Juan José Romero, Graciela Sadino, Nancy Sandoval, Mariana Suarez, Maria Victoria Suayter, Maria Alejandra Ureña, Marisol Valle, Ligia Vence Reyes, Silvia Vera Amate Perez, Hugo Videla, Silvina Villamandos, Olmedo Villarreal, Maria Alejandra Viteri, Eduardo Warley, Rodolfo E. Quiros

“…Abstract Background Infection prevention and control (IPC) programs are essential to prevent and control the spread of multidrug-resistant organisms in healthcare facilities (HCFs). The current implementation of these programs in Latin America remains largely unknown. …”
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Development of a Customizable Web-Based Dashboard for Remote Blood Pressure Monitoring: Feasibility and Usability Implementation Study by Joshua Wollen, Thuy Nguyen, Charles Coton, Gina DeWildt, Gabretta Cooksey, Audrey Cohen, Nicholas Hoang, Munachi Okpala, Michael Gonzalez, Mengxi Wang, Chigozirim Izeogu, Elmer Bernstam, Charles Green, Sean Savitz, Jose-Miguel Yamal, Anjail Sharrief

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MODERN PECULIARITIES OF THE MEDICAL EXPOSURE LEVELS FORMING OF THE TATARSTAN REPUBLIC POPULATION DURING X-RAY PROCEDURES IMPLEMENTATION by S. A. Ryzhkin, S. I. Ivanov, M. A. Patjashina, R. K. Ismagilov, N. A. Akopova, S. V. Loginova, D. R. Nasybullin

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Obesity enhances ovarian cancer chemotherapy efficacy through C1q-mediated tumor targeting and immune activation by Shiyi Xu, Nana Bie, Xinzhuang Su, Xiaojuan Zhang, Shiyu Li, Haojie Liu, Tuying Yong, Qing Chen, Xiangliang Yang, Lu Gan

“…Mechanistically, the protein corona, particularly enriched with complement component 1q (C1q) in the plasma of obese mice, significantly enhances the internalization of PLD by ovarian cancer cells and elicits strong immunogenic cell death (ICD) effects. …”
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Complement Attack against Aspergillus and Corresponding Evasion Mechanisms by Cornelia Speth, Günter Rambach

“…We describe the various ways of complement activation by Aspergillus and the antifungal effects of the system, and also show proven and probable mechanisms of Aspergillus for complement evasion.…”
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