Complement Activation is More Pronounced in the Kidneys of Critically Ill Patients With COVID-19 Than in Those With Bacterial Sepsis by Firas F. Alkaff, Grietje G. Talen, Marius C. van den Heuvel, Meint Volbeda, Matijs van Meurs, Jill Moser, Mohamed R. Daha, Jacob van den Born, Stefan P. Berger

“…Nonetheless, no study has compared the complement activation between these 2 types of AKI. …”
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Complement Activation in Association with Markers of Neutrophil Extracellular Traps and Acute Myocardial Infarction in Stable Coronary Artery Disease by Karsten E. Kluge, Miriam S. Langseth, Trine B. Opstad, Alf Å. Pettersen, Harald Arnesen, Theis Tønnessen, Ingebjørg Seljeflot, Ragnhild Helseth

“…Complement activation and neutrophil extracellular traps (NETs) have both been suggested to drive atherosclerotic plaque progression. …”
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Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina by Marcus Karlstetter, Jens Kopatz, Alexander Aslanidis, Anahita Shahraz, Albert Caramoy, Bettina Linnartz‐Gerlach, Yuchen Lin, Anika Lückoff, Sascha Fauser, Katharina Düker, Janine Claude, Yiner Wang, Johannes Ackermann, Tobias Schmidt, Veit Hornung, Christine Skerka, Thomas Langmann, Harald Neumann

“…Its pathophysiology is linked to reactive oxygen species (ROS) and activation of the complement system. Sialic acid polymers prevent ROS production of human mononuclear phagocytes via the inhibitory sialic acid‐binding immunoglobulin‐like lectin‐11 (SIGLEC11) receptor. …”
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Randomised prospective trial to assess the clinical utility of multianalyte assay panel with complement activation products for the diagnosis of SLE by Daniel J Wallace, Thierry Dervieux, Arezou Khosroshahi, Claudia Ibarra, Tyler O'Malley, Elena Massarotti, Roberta Vezza Alexander, Mehrnaz Hojjati, Konstantinos Loupasakis, Jeffrey Alper, Yvonne Sherrer, Maria Fondal, Rajesh Kataria, Tami Powell, Sonali Narain, Arthur Weinstein

“…Objective We compared the physician-assessed diagnostic likelihood of SLE resulting from standard diagnosis laboratory testing (SDLT) to that resulting from multianalyte assay panel (MAP) with cell-bound complement activation products (MAP/CB-CAPs), which reports a two-tiered index test result having 80% sensitivity and 86% specificity for SLE.Methods Patients (n=145) with a history of positive antinuclear antibody status were evaluated clinically by rheumatologists and randomised to SDLT arm (tests ordered at the discretion of the rheumatologists) or to MAP/CB-CAPs testing arm. …”
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The mental-health patient-activation measure: assessing validity, reliability, and responsiveness in outpatient settings by Tatiana Skliarova, Mariela L. Lara-Cabrera, Mathias Forsberg Brobakken, Jørn Heggelund, Einar Vedul-Kjelsås, Ismail Cüneyt Güzey, Hege Hafstad, Solveig Klaebo Reitan, Mona Nygård

Subjects: “…Exercise training implementation…”
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The use of public funds for environmental preservation and environmental education activities in the light of the Polish Supreme Audit Office reports by Maciej Serowaniec

Subjects: “…implementation of public funds…”
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Developing an implementation fidelity measure for a family healthy weight program by Caitlin A. Golden, Paul A. Estabrooks, Kate A. Heelan, R. Todd Bartee, Gwenndolyn C. Porter, Emiliane L. Pereira, Bryce M. Abbey, Tzeyu L. Michaud, Jennie L. Hill

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Move4Future: implementation and effects of a pilot physical exercise programme for children and youth at risk from multi-problem families by Cristiana Mercê, Vera Simões, Liliana Ramos, Miguel Silva, Nancy Brígida, Anabela Vitorino, Marco Branco, Rafael Oliveira

“…Thus, this study aimed to analyze the effects of implementing the Move4Future pilot program, in children and adolescents, on the following variables: i) anxiety levels, ii) body composition, iii) physical fitness, and iv) physical activity levels. …”
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Cobalt Protoporphyrin IX Attenuates Antibody-Mediated, Complement-Dependent Podocyte Injury: Role of Cobalt and Porphyrin Moieties by Elias A. Lianos, Gia Nghi Phung, Jianping Zhou, Mukut Sharma

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Investigating Teachers’ Attitudes Towards Implementing Drama Activities in the Algerian Secondary School Textbooks A Case Study: Second Year Textbook “Getting Through” by Farouk ZAABAB ZAABAB

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Maximizing science communication skills in a primary scientific literature-based cancer biology course: practical implementation methods by Kristen C. Johnson

“…To address these challenges, a scaffolded journal club approach was implemented in a Cancer Biology course. The course utilized Hypothes.is web-based annotations, methods presentations, figure annotations, and structured discussions to promote active engagement with the literature. …”
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Activity-based Detection of HIF stabilizers: a Future-proof Complementing Method in Doping Control? by L.K. Janssens, L. De Wilde, P. Van Eenoo, C.P. Stove

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Terminal complement complexes with or without C9 potentiate antimicrobial activity against Neisseria gonorrhoeae by Evan R. Lamb, Alison K. Criss

“…Complement activation generates the membrane attack complex (MAC), a 10–11 nm diameter pore formed by complement proteins C5b through C8 and polymerized C9. …”
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Prediction of activity of low-molecular inhibitors of the classic complement pathway using computational screening approach by D. M. Karlinsky, A. P. Kaplun, M. E. Popov

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Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation by Pooja Shivshankar, Stacey L. Mueller-Ortiz, Aleksey Y. Domozhirov, Weizhen Bi, Scott D. Collum, Marie-Francoise Doursout, Manish Patel, Isabella N. LeFebvre, Bindu Akkanti, Simon Yau, Howard J. Huang, Rahat Hussain, Harry Karmouty-Quintana

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Functional mass spectrometry indicates anti-protease and complement activity increase with COVID-19 severity by Douglas D. Fraser, Douglas D. Fraser, Swapan Roy, Matt Kuruc, Maritza Quintero, Logan R. Van Nynatten, Gediminas Cepinskas, Gediminas Cepinskas, Haiyan Zheng, Amenah Soherwardy, Devjit Roy

“…Our data suggests that COVID-19 is associated with both a protease storm and complement activation, with the former somewhat balanced with increased anti-protease activity. …”
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Vinyl carbamate activates the alternative complement pathway in glomerular endothelial cells and induces membranoproliferative glomerulonephritis by Athena Gong, Deepak Malhotra, william Gunning, Lance Dworkin, Mengxuan Chen

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Maternal and perinatal outcomes after implementation of a more active management in late- and postterm pregnancies in Sweden: A population-based cohort study. by Karin Källén, Mikael Norman, Charlotte Elvander, Christina Bergh, Verena Sengpiel, Henrik Hagberg, Teresia Svanvik, Ulla-Britt Wennerholm

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Security systems’ status with the use of technical means of video recording and video surveillance: international experience, perspectives for implementation in the activities of the National police of Ukraine by V. A. Korshenko, V. V. Chumak, M. V. Mordvyntsev, D. V. Pashniev

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Physical activity coaching for adults with mobility limitations: protocol for the ComeBACK pragmatic hybrid effectiveness-implementation type 1 randomised controlled trial by Kirsten Howard, Anne Tiedemann, Catherine Sherrington, Tammy Hoffmann, Kim L Bennell, Colin Greaves, Rana S Hinman, Nicholas F Taylor, Andrew Milat, Marina Pinheiro, Leanne Hassett, Maria Crotty, Lisa Harvey, Daniel Treacy, Matthew Jennings, Maayken van den Berg, Siobhan Wong, Catherine Kirkham, Elizabeth Ramsay, Sandra O'Rourke

“…The hybrid effectiveness-implementation design (type 1) will be used to enable the collection of secondary implementation outcomes at the same time as the primary effectiveness outcome. …”
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