WCN25-2706 COMPLEMENT GENE MUTATIONS IN PATIENTS WITH CHRONIC KIDNEY DISEASE ON DIALYSIS (CKD-D) OF UNKNOWN ETIOLOGY: OUR EXPERIENCE FROM CENTRAL INDIA by Amit Pasari, MANISH BALWANI, CHARULATA BAWANKULE, KAPIL SEJPAL, PRASAD GURJAR, PRANJAL KASHIV, SHUBHAM DUBEY, SUNNY MALDE, TWINKLE PAWAR, VIJAY JEYACHANDRAN

Get full text

The same human complement factor B allele of major histocompatibility complex (MHC) class III allele is conserved in chimpanzee and gorilla, stressing its immune importance by Antonio Arnaiz-Villena, Christian Vaquero-Yuste, Ignacio Juarez, José Manuel Martín-Villa, Fabio Suarez-Trujillo

“…We have put forward that complement alleles should be studied together with all other MHC genes. …”
Get full text

WCN24-1680 PREVALENCE AND CLINICAL CHARACTERISTICS OF KIDNEY TRANSPLANTS IN COMPLEMENT 3 GLOMERULOPATHY PATIENTS: RESULTS FROM A REAL-WORLD, MULTI-COUNTRY SURVEY by Richard Lafayette, Raisa Sidhu, Clare Proudfoot, Katharina Pannagl, Briana Ndife, Serge Smeets, Kathleen Murphy, Raymond Przybysz, Jonathan de Courcy, Susanna Libby, Smeeta Sinha

Get full text

Evidence for Correlation between Novel Autoantibody against Phospholipid Named Neoself Anti-β2-GPI/HLA-DR Antibody and Complement Consumption in Infertile Patients by Hirotaka Matsumi

“…In the innate immune system, the inflammatory response to pathogenic stimuli is initiated by complement activation. Minimal vasculitis associated with complement consumption in infertile patients may be an underlying mechanism for impaired implantation. …”
Get full text

WCN24-1688 SELF-REPORTED QUALITY OF LIFE IN COMPLEMENT 3 GLOMERULOPATHY PATIENTS DELINEATED BY CKD STAGE: A REAL-WORLD, MULTI-COUNTRY SURVEY by Richard Lafayette, Raisa Sidhu, Clare Proudfoot, Katharina Pannagl, Briana Ndife, Serge Smeets, Kathleen Murphy, Raymond Przybysz, Jonathan de Courcy, Susanna Libby, Smeeta Sinha

Get full text

X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and cervical cancer risk: a huge systematic review and meta-analysis. by Ya Li, Fei Liu, Shi-Qiao Tan, Yan Wang, Shang-Wei Li

“…<h4>Background</h4>Previous studies investigating the association between X-ray repair cross-complementation group 1(XRCC1) polymorphisms and cervical cancer (CC) risk has provided inconsistent results. …”
Get full text

Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation by Nirmal K. Banda, Larry W. Moreland, Kevin D. Deane, Dmitri Simberg, Robert I. Scheinman, Rachel M. Frank, Jennifer A. Seifert, Accelerating Medicines Partnership (AMP) RA/SLE Network, Rachel Lau, Costantino Pitzalis, Myles J. Lewis, V. Michael Holers

“…Abstract Factor H (FH) is a negative regulator of the alternative pathway (AP) of complement however, five human factor H-related (FHR) proteins, can also function ex vivo as positive regulators. …”
Get full text

Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations. by Lora Boteva, IMAGEN, Yee Ling Wu, Josefina Cortes-Hernández, Javier Martin, Timothy J Vyse, Michelle M A Fernando

“…Genetic variants resulting in non-expression of complement C4A and C4B genes are common in healthy European populations and have shown association with a number of diseases, most notably the autoimmune disease, systemic lupus erythematosus. …”
Get full text

Elevated Plasma Complement C1Q Measured Subacutely after Traumatic Brain Injury Is Associated with Poor Functional Outcome Independent of Initial Injury Severity by Tracy Butler, Kewei Chen, Abigail Patchell, Xiangling Mao, Dikoma Shungu, Diany Paola Calderon, Jeanne T. Paz, Sudhin A. Shah

“…This study investigates the role of complement factor 1q (C1Q) in TBI recovery. Motivated by our rodent studies showing that thalamic inflammation post-TBI is dependent on C1Q and that blocking C1Q during the subacute period can prevent thalamic inflammation and improve aspects of TBI outcome, particularly sleep, we measured plasma C1Q levels 3–6 months post-injury in 27 patients with TBI ranging from complicated mild to severe, as well as 30 controls. …”
Get full text

Response gene to complement 32 promotes tumorigenesis by mediating DNA damage repair and inhibits CD8+ T cells infiltration in diffuse large B-cell lymphoma by Xiyuan Zhang, Xiyuan Zhang, Tiange Lu, Chunlei Shi, Mengfei Ding, Ling Wang, Xinting Hu, Xin Wang, Xin Wang

Subjects: “…response gene to complement 32 (RGC32)…”
Get full text

How to design effective educational videos for teaching evidence-based medicine to undergraduate learners – systematic review with complementing qualitative research to develop a practicable guide by Lukas Niekrenz, Cord Spreckelsen

“…In particular, studies on the requirements and design goals of educational videos need to be complemented by qualitative research using grounded theory methodology.Methods Due to the paucity of randomized controlled trials in this area, there is an urgent need to generate recommendations based on a broader fundament than a literature search alone. …”
Get full text

Complement 3 (C3) within the hypothalamic arcuate nucleus is a potential key mediator of the effect of enhanced nutrition on reproductive development in young bull calves by Kate Keogh, Stephen Coen, Pat Lonergan, Sean Fair, David A Kenny

“…Results Bioinformatic analyses were undertaken to determine differentially expressed transcripts (FDR < 0.1; fold change > 1.5) between the dietary treatment groups, resulting in the identification of 1 differentially expressed miRNA (miR-2419-3p) and 83 differentially expressed mRNA in the ARC region. mRNA target gene prediction identified Complement 3 (C3) as a target of miR-2419-3p, suggesting a relationship between the two transcripts. …”
Get full text

Designing and Implementing Content-Based Courses in English with a Non-Language Faculty at a Public Colombian University Diseño e implementación de cursos basados en contenido en inglés con docentes no expertos en lenguas en una universidad pública colombiana by Leidy Natalia Salazar Valencia, Claudia Patricia Díaz Mosquera, Fabio Alberto Arismendi Gómez

“…This article reports the findings of an investigation into the experience of a group of eight professors from undergraduate programs in hard sciences who participated in a multi-site study to implement content-based (CB) courses in English. The professors, who had a high level of proficiency in English, worked in collaboration with language faculty. …”
Get full text

Y a-t-il analogie entre les opérations sous-jacentes aux constructions V ØNs et VPA ? by Sophie Dufossé-Sournin

Subjects: Get full text

Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection by Liqiang Zhang, Yize Henry Li, Karen Kibler, Simona Kraberger, Arvind Varsani, Julie Turk, Nora Elmadbouly, Emily Aliskevich, Laurel Spaccarelli, Bereket Estifanos, Junior Enow, Isabela Rivabem Zanetti, Nicholas Saldevar, Efrem Lim, Jessika Schlievert, Kyle Browder, Anjali Wilson, Fernando Arcos Juan, Aubrey Pinteric, Aman Garg, Henna Monder, Rohan Saju, Savanah Gisriel, Bertram Jacobs, Timothy L Karr, Esther Borges Florsheim, Vivek Kumar, John Wallen, Masmudur Rahman, Grant McFadden, Brenda G Hogue, Alexandra R Lucas

Subjects: “…complement…”
Get full text

Novel Treatment Paradigms: Primary IgA Nephropathy by Haresh Selvaskandan, Jonathan Barratt, Chee Kay Cheung

Subjects: Get full text

MODULATION OF ANTIBODY MEDIATED LYMPHOCYTOLYSIS IN VITRO UNDER A MAGNETIC VECTOR POTENTIAL by V. N. Novoseletsky, V. Yu. Abramov, V. M. Zaiko, N. B. Bogdanova, E. M. Trukhan

Subjects: “…antibody-mediated complement-dependent lymphocytolysis…”
Get full text

Individualised therapeutic approach to the patient with atypical haemolytic-uraemic syndrome by Ivana Mikačić, Nikolina Marić

Subjects: Get full text

Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy by Leo Starck, Vuokko Nummi, Eira Poikonen, Anna-Elina Lehtinen, Pia Kivelä, Nathalie Friberg, Jukka Torvikoski, Maija Toropainen, Seppo Meri

Subjects: Get full text

C1q deficiency with severe skin manifestations: A case report from Pakistan by Kashmala Hussain, Shamila Ladak, Fizza Akbar, Salman Kirmani, Sadaf Altaf

Subjects: Get full text