Visceral fat, cardiovascular risk factors and quality of life in lupus activity categorised via complement C3 by J Alfredo Martinez, Victor Moreno-Torres, María Martínez-Urbistondo, Raquel Castejón, Susana Mellor-Pita, Andrea Higuera-Gómez, Begoña de Cuevillas, Amanda Cuevas-Sierra, Juan-Antonio Vargas

“…Notably, age, body mass index and insulin resistance were associated with SLE inactivity, while fibrinogen correlated with disease activity as assessed by complement C3 levels. Interestingly, household composition as a sociodemographic variable (alone, couple/children/elderly or other) also showed an independent association with SLE activity.Conclusions Inactive patients with SLE exhibited more adverse cardiovascular risk markers compared with active patients categorised by complement C3, even when glucocorticoid administration was accounted for. …”
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Dynamic Complement Protein Changes in Aqueous Humor and Plasma of Patients With Retinal Vein Occlusion During Ranibizumab Treatment by Guo T, Zhao Y, Liang S, Wang J, Liu H, Zhou Y, Xu H, Chen Z

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Complement opsonization of HIV-1 enhances the uptake by dendritic cells and involves the endocytic lectin and integrin receptor families. by Veronica Tjomsland, Rada Ellegård, Karlhans Che, Jorma Hinkula, Jeffrey D Lifson, Marie Larsson

“…Interaction with the complement system is an underappreciated aspect of HIV-1 infection; even in primary infection, complement fragments are found on virions with potential to affect the interplay between the virus and dendritic cells (DC). …”
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Computer-Based Clinical Examination (CCE) in Surgery: Would It Complement or Replace the OSCE in the Post-COVID-19 Era? by Gamal E H A El Shallaly, Mudather M Bafadni, Hozifa M A Abdelmaged, Maysa H A Hamza

“…It saves time and is popular with the students and tutors. It complements the OSCE in the assessment of clinical competency and allows wide coverage of the curriculum. …”
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Bioactive Sphingolipids, Complement Cascade, and Free Hemoglobin Levels in Stable Coronary Artery Disease and Acute Myocardial Infarction by T. Jadczyk, K. Baranski, M. Syzdol, E. Nabialek, W. Wanha, R. Kurzelowski, M. Z. Ratajczak, M. Kucia, B. Dolegowska, M. Niewczas, J. Zejda, W. Wojakowski

“…Acute myocardial infarction (AMI) and coronary artery bypass graft (CABG) surgery are associated with a pathogen-free inflammatory response (sterile inflammation). Complement cascade (CC) and bioactive sphingolipids (BS) are postulated to be involved in this process. …”
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Blastocyst complementation-based rat-derived heart generation reveals cardiac anomaly barriers to interspecies chimera development by Shunsuke Yuri, Norie Arisawa, Kohei Kitamuro, Ayako Isotani

“…Summary: The use of pluripotent stem cells (PSCs) to generate functional organs via blastocyst complementation is a cutting-edge strategy in regenerative medicine. …”
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Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina by Marcus Karlstetter, Jens Kopatz, Alexander Aslanidis, Anahita Shahraz, Albert Caramoy, Bettina Linnartz‐Gerlach, Yuchen Lin, Anika Lückoff, Sascha Fauser, Katharina Düker, Janine Claude, Yiner Wang, Johannes Ackermann, Tobias Schmidt, Veit Hornung, Christine Skerka, Thomas Langmann, Harald Neumann

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Systemic lupus erythematosus as the paradigm for understanding the complex immune relationships and therapeutic opportunities for targeting complement in autoimmune diseases by V. Michael Holers

“…Complement therapeutics have been increasingly tested and approved for human diseases, often in orphan diseases with strong and apparently causal genetic linkage or mutation-associated features. …”
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Randomised prospective trial to assess the clinical utility of multianalyte assay panel with complement activation products for the diagnosis of SLE by Daniel J Wallace, Thierry Dervieux, Arezou Khosroshahi, Claudia Ibarra, Tyler O'Malley, Elena Massarotti, Roberta Vezza Alexander, Mehrnaz Hojjati, Konstantinos Loupasakis, Jeffrey Alper, Yvonne Sherrer, Maria Fondal, Rajesh Kataria, Tami Powell, Sonali Narain, Arthur Weinstein

“…Objective We compared the physician-assessed diagnostic likelihood of SLE resulting from standard diagnosis laboratory testing (SDLT) to that resulting from multianalyte assay panel (MAP) with cell-bound complement activation products (MAP/CB-CAPs), which reports a two-tiered index test result having 80% sensitivity and 86% specificity for SLE.Methods Patients (n=145) with a history of positive antinuclear antibody status were evaluated clinically by rheumatologists and randomised to SDLT arm (tests ordered at the discretion of the rheumatologists) or to MAP/CB-CAPs testing arm. …”
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Complement and coagulation cascade cross-talk in endometriosis and the potential of Janus Kinase inhibitors—a network meta-analysis by Monika Golinska, Monika Golinska, Aleksander Rycerz, Matylda Sobczak, Jedrzej Chrzanowski, Konrad Stawiski, Wojciech Fendler, Wojciech Fendler, Wojciech Fendler

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Randomized phase I trial outcomes show safe and sustainable inhibition of classical and lectin complement pathways by empasiprubart by Inge Van de Walle, Laura Bracke, Heidi Gytz Olesen, Tonke van Bragt, Stéphanie Cadour, Phillip De Decker, Giorgia Ciurlia, Erwin Pannecoucke, Emma K. Persson, Olivier Van de Steen, Xinghong Leng, Gregers Rom Andersen, Domenica Gandini, C. Erik Hack

“…Abstract Activation of classical and lectin complement pathways contributes to several human diseases. …”
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Enhancing Financial Decision-Making: Real Options Complementing the Net Present Value Technique in the Financial Services Sector by Ferina Marimuthu, Kyle Fitzgerald

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Maximizing Performance of Geopolymer Mortar: Optimizing Basalt and Carbon Fiber Content Composition by Katarzyna Ewa Buczkowska, Petr Louda, Artem Sharko, Oleksandr Sharko, Dmitry Stepanchikov, Ludek Jancik, Piotr Los, Kinga Plawecka, Van Su Le

Subjects: “…algorithm-built hybrid implementation…”
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Transition Approaches towards Positive Energy Districts: A Systematic Review by Giulia Turci, Paolo Civiero, Isabel Aparisi-Cerdá, Ilaria Marotta, Gilda Massa

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Great expectations for collective management: the mismatch between supply and demand for catchment groups by Jim Sinner, Marc Tadaki, Margaret Kilvington, Edward Challies, Paratene Tane, Christina Robb

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Perspectives on Enhanced Measurement-Based Care Among Healthcare Providers, Adults, Adolescent Patients with Major Depressive Disorder and Pediatric Family Members: A Multicenter O... by Zhang H, Sun P, Wang X, Yang X, He Y, Yang T, Su Y, Fu Y, Li Q, Sun J, Liu J, Murphy JK, Michalak EE, Lam RW, Chen J, Fang Y

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Classifying and Designing the Educational Methods with Information Communications Technoligies by I. N. Semenova, A. V. Slepukhin

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THE APPLICATION OF MODERN TOOLS OF PREINVESTMENT ANALYSIS by D. D. Kuznetsova, T. M. Rogulenko

Subjects: “…risks of investment project implementation…”
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HOW SOFTWARE COMPANY ENGINEERS PERCEIVE CHANGES IN PRODUCTION by DENIS SVYATOSLAVOVICH Paschenko

Subjects: “…changes implementation management…”
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FPGA Hardware Acceleration of AI Models for Real-Time Breast Cancer Classification by Ayoub Mhaouch, Wafa Gtifa, Mohsen Machhout

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