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3021
Bioinformatic Characterization of the Functional and Structural Effect of Single Nucleotide Mutations in Patients with High-Grade Glioma
Published 2024-10-01“…A structural comparison between normal and mutated residues for disease-associated coding SNPs was performed using TM-aling and the SWISS MODEL. …”
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3022
Structural Strength Analysis Method of Urban Rail Transit Vehicle under Traction and Braking Conditions
Published 2025-02-01“…[Objective] Excessive traction and braking loads are significant factors contributing to inducing fatigue cracks in the welded joints of the ′TBB (traction beam-bolster beam-buffer beam) structure′ in urban rail transit vehicles. To effectively mitigate the risk of structural cracking, it is essential to thoroughly investigate the methods for analyzing the structural strength of vehicles under traction and braking conditions during design phase. …”
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3023
Digital twin-based structural health monitoring and measurements of dynamic characteristics in balanced cantilever bridge
Published 2025-09-01“…This study developed a digital twin (DT) and structural health monitoring (SHM) system for a balanced cantilever bridge, utilizing advanced measurement techniques to enhance accuracy. …”
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3024
Structural insights into calcium-dependent CIB2-TMC1 interaction in hair cell mechanotransduction
Published 2025-02-01“…Utilizing X-ray crystallography, we elucidate the high-resolution structure of the mammalian CIB2-TMC1 complex. Structural analyses reveal that cation-bound CIB2 forms a negatively charged surface that aligns with a positively charged surface on the TMC1 N-terminus. …”
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3025
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3026
Functional and structural brain remodeling in patients with degenerative cervical myelopathy following cervical decompression surgery
Published 2025-05-01“…Methods In this prospective cohort study, we conducted an analysis of data from 54 patients with DCM both before and after surgery, as well as 57 healthy controls (HC), using functional MRI in combination with high-resolution structural MRI. …”
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3027
The impact of the structural state of the tubulin cytoskeleton on chlorophyll fluorescence indicators and auxin content in Solanum tuberosum
Published 2024-11-01“…Information on the dependence of light reactions of photosynthesis on the structural state of cytoskeletal elements is extremely limited. …”
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3028
The Relationship between Personality Structures and Moral Development: Mediating Role of Mind Reading in the Students of Farhangian University of Kerman
Published 2024-03-01“…Objective: The present investigation was conducted with the objective of exploring the relationship between personality structures, as conceptualized by the neo-approach, and moral development, taking into consideration the mediating role of mind reading. …”
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3029
Associations of Prenatal Socioeconomic Status and Childhood Working Memory: A Structural Equation Modeling Approach
Published 2025-04-01“…Study Design: We used data from a prospective birth cohort study in Mexico City, Mexico, with N = 515 children aged 6–9 years. …”
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3030
Comparative Analysis of Mitogenomes in Leafhopper Tribe Deltocephalini (Hemiptera: Cicadellidae: Deltocephalinae): Structural Conservatism and Phylogeny
Published 2024-12-01“…ABSTRACT Previous studies on the gene order and composition of leafhopper mitochondrial genomes have revealed a high level of conservation in overall genome structure. Some members of Deltocephalinae, the largest subfamily, exhibit tRNA gene rearrangements; however, few mitogenomes have been sequenced in this group and the degree of structural variation within tribes remains unclear. …”
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3031
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3033
Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design
Published 2025-12-01“…In addition, we mapped the locations of missense mutations in MID1 associated with X-linked Opitz syndrome, suggesting that some of these mutations impair the conformational stability of the protein. Taken together, our data provide intriguing insights into the structural and functional divergence of TRIM family PRYSPRY domains, their potential druggability and substrate recognition, and the challenges of ligand design.…”
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3034
Longitudinal structural MRI-based deep learning and radiomics features for predicting Alzheimer’s disease progression
Published 2025-08-01“…Early diagnosis is imperative for optimizing clinical management and selecting proper therapeutic interventions. Structural magnetic resonance imaging (MRI) markers have been widely investigated for predicting the conversion of MCI to AD, and recent advances in deep learning (DL) methods offer enhanced capabilities for identifying subtle neurodegenerative changes over time. …”
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3035
Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W
Published 2024-09-01“…The functional analysis was accompanied by structural investigation of PRKN p.R275W. We observed lower PRKN protein in fibroblasts with compound heterozygous p.R275W mutations. …”
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3036
Relationships between structural stigma, societal stigma, and minority stress among gender minority people
Published 2025-01-01“…We tested variables identified in the literature as measures of structural stigma inclusive of societal stigma (LGBT + Business Climate Index, state voting behaviors, and Google Trends search data), the most commonly used structural stigma variable (State Policy Environment Tally), and proxy variables (region, population density) for comparison. …”
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3037
Tracing the aggregation pathway of the scaffold protein DISC1: Structural implications for chronic mental illnesses
Published 2025-06-01“…Disrupted in schizophrenia 1 (DISC1) is a pleiotropic scaffold protein that is postulated to comprise large disordered regions and four distinct structured segments with a high proportion of helical or coiled-coil fold. …”
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3038
Development and distribution characteristics of geohazards based on sedimentary-structural evolution in Xide County, southwest Sichuan
Published 2025-05-01“…The wide and gentle fold structures in red beds are the disaster-prone environment for landslide. …”
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Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture
Published 2024-10-01“…Even though we observed model instability in our application of genomic SEM to high-dimensional data, jointly modeling the genetic architecture of complex traits and investigating multivariate genetic links across neuroimaging phenotypes offers new insights into the genetics of cortical structure and relationships to psychopathology.…”
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